Medizin: neue Gesundheitspublikationen – Seite 151

07.09.2026journal-article

Clinical Kidney Journal

Single or multiple nutritional hormone receptor modulators for chronic kidney disease

Hiddo J L Heerspink

Abstract The global rise in obesity and type 2 diabetes mellitus (T2DM) has contributed substantially to the increasing burden of chronic kidney disease (CKD), cardiovascular disease, and heart failure, highlighting the need for therapeutic strategies capable of addressing multiple components of the cardio-renal-metabolic axis. Incretin-based therapies have undergone an evolution from glucose-lowering agents to treatments with broad metabolic, cardiovascular, and renal effects. Glucagon-like peptide-1 (GLP-1) recep …

07.09.2026journal-article

Cancers

Focused Ultrasound Therapies for Brain, Liver, Prostate, and Breast Cancer Applications: Clinical Evidence and Future Directions

Nassib Abou Heidar, Daniel Sheeran, Divine Nwafor, Olivia C. Sears, Shayan Moosa, Lynn T. Dengel, Kirsten Greene, Alan H. Matsumoto

Focused ultrasound (FUS) is an emerging and evolving minimally invasive therapeutic platform that is helping to redefine the management of malignant diseases. Clinical translation is advancing rapidly, with several completed and ongoing clinical trials demonstrating the safety, feasibility, and early efficacy of FUS in the treatment of cancer. This manuscript provides a synthesis of some of the available clinical data and device platforms being used and evaluates the results from completed and active clinical trial …

07.09.2026journal-article

International Journal of Medical Science and Clinical Research Studies

Re-Epithelialization of Donor Sites and Meshed Skin Grafts Using Cryopreserved Cultured Cutaneous Allograft (Epifast®): Experience in Patients with Extensive Burns

Sergio Morales Acosta, Julio Cesar Villicaña Guillen, Arleth Castillo Aguilar, Angel Elian Flota Blanco, Areli Bath-Sheba González Graciano, Ivan Zuñiga Coronel, Natalia Avila Alba, Nancy Andrea Juárez Ferrusquía

Extensive full-thickness burns remain a major challenge in reconstructive surgery because limited donor-site availability frequently delays definitive wound coverage and increases the risk of infection, prolonged hospitalization, and hypertrophic scarring. Cryopreserved cultured cutaneous allografts have emerged as temporary biological dressings capable of promoting wound healing and accelerating re-epithelialization. This study aimed to evaluate the re-epithelialization time of donor sites and meshed split-thickne …

07.09.2026journal-article

Actuators

An Intelligent Bearing Fault Diagnosis Model with Physics-Information Fusion: Design and Interpretability Mechanism Research

Zhenyang Yu, Fei Shao, Qian Xu, Xingkun Xie, Lixiang He, Yinchuan Hou

To address the issue of limited interpretability in current deep learning-based bearing fault diagnosis methods, this study proposes a convolutional neural network model incorporating spectral physical constraints. The model integrates data-driven learning with physical constraints by embedding the spectral features of bearing faults as prior knowledge into the network architecture during training. This guides the model to adaptively learn spectral features closely associated with fault mechanisms. Experimental res …

07.09.2026journal-article

Spine

A Shorter Surgical Interval May be Associated with Improved Patient-reported Outcomes in Hip-spine Syndrome

Joshua Mathew, Mitchell K. Ng, Jonathan Dalton, William Green, Gregorio Baek, Yasmine Eichbaum, Yulia Lee, Morgan Hitchner, Andrew Vanichkachorn, Gil Barksdale, Anthony Buzzetta, Torsten Fras, Dipti Venkatesh, Brandon Martinazzi, Ali Farooqi, Alec Giakas, Paul Mastrokostas, Jeffrey A. Rihn, Ian David Kaye, Mark F. Kurd, Jose A. Canseco, Alan S. Hilibrand, Alexander R. Vaccaro, Gregory D. Schroeder, Christopher K. Kepler

Study Design. Retrospective Cohort Study Objective. This study aimed to: (1) identify demographic differences based on the interval between surgeries; (2) compare differences in perioperative outcomes; (3) determine whether the interval between hip/spine surgery influences patient-reported outcomes (PROMs). Summary of Background Data. The presence of concurrent hip and spine disease in hip-spine syndrome creates a unique challenge in surgical decision-making given overlapping disease, with ideal timing between inde …

07.09.2026journal-article

American Journal of Medical Quality

Algorithmic Convergence Across Machine Learning Models Identifies Robust Strategic Priorities for Improving Patient Experience

Richard H. Savel, Payam Benson, Carmen Collins, Jill Fennimore, Dwight McBee, Kwaku Gyekye, Ije Akunyili, Marc Milano, Ruric Andy Anderson

Background: Improved patient experience is associated with enhanced clinical outcomes. The Hospital Consumer Assessment of Healthcare Providers and Systems Overall Rating of the Hospital (ORH) can be considered a quality metric for health systems. We hypothesized that machine learning models could identify actionable predictors of a less-than-top-box ORH score across a multihospital system and sought to determine whether these predictors were consistent across model architectures and hospital size. Methods: We anal …

07.09.2026journal-article

Sensors

Real-Time SpO2 Estimation from Chest Reflectance Photoplethysmography: Algorithm Development and Clinical Validation Against Arterial SaO2

WooYong Lee, Jaeyeon Shin, MiHye Song, Mi-Kyung Song, Kyung Mi Kim, Gyu-Jeong Noh, SungPil Cho

Peripheral oxygen saturation (SpO2) estimation using photoplethysmography (PPG) is typically based on the pulsatile components of red and infrared (IR) PPG signals acquired from peripheral sites, such as the finger or earlobe. Although these sites provide strong PPG signals, they are less suitable for integrated monitoring with electrocardiography (ECG), including arrhythmia detection. Simultaneous acquisition of PPG and ECG from a chest-worn device may therefore enable continuous and integrated physiological monit …

07.09.2026journal-article

British Journal of Clinical Psychology

Neuroticism, extraversion, and self‐compassion as mediators of therapeutic outcomes: Long‐term effectiveness of a brief group adaptation of the Unified Protocol in a clinical sample of university students

Antonio Ayuso‐Bartol, María Ángeles Gómez‐Martínez, Aitor Vicente‐Arruebarrena, Laura Jiménez‐Gómez, Alejandra Rebeca Melero‐Ventola, Marina Wöbbeking Sánchez

Abstract Objectives Emotional symptoms are highly prevalent among university students and are a frequent reason for seeking care in university psychological services. The Unified Protocol for the transdiagnostic treatment of emotional disorders ( UP ) may offer an efficient intervention for this context. this study examined the effectiveness of a brief face‐to‐face group adaptation of the UP in treatment‐seeking university students, 12‐month follow‐up effects, and whether neuroticism, extraversion, and self‐compass …

07.09.2026journal-article

Journal of Addiction Medicine

Addiction Consult Service Associated With Improved Rates of 30-day Treatment Engagement After Emergency Department and Hospital Discharge: A Propensity-weighted Analysis

Erik S. Anderson, Lauren Sirey, Andrea Jakubowski, Megan Heeney, Michelle Patregnani, Monish Ullal, Andrew A. Herring

Objectives: Addiction consult services (ACS) are an effective intervention for hospitalized patients with substance use disorders (SUD); however, their effectiveness for patients discharged from the emergency department (ED) is not well established. We aim to examine the association of ACS with 30-day engagement in outpatient treatment among ED and hospitalized patients at a multi-hospital safety-net health system. Methods: We conducted a retrospective study of patients discharged after ED and inpatient visits with …

07.09.2026journal-article

Advanced Healthcare Materials

A Self‐Adjuvant Photothermal Carbon Dot‐Based Nanovaccine for Multimodal Nasopharyngeal Cancer Treatment and Prophylaxis

Ruiqi Ji, Yijun Mei, Zhiqiang Wang, Mingwu Shen, Xiangyang Shi

ABSTRACT Developing a “full‐cycle” strategy that integrates both treatment and prophylaxis remains a central challenge against nasopharyngeal carcinoma (NPC). Here, a biomimetic nanovaccine (CDC/Toy@CCM) is designed by coating toyocamycin (Toy)‐loaded redox‐responsive carbon dot clusters (CDCs) with homologous cancer cell membranes (CCMs). The obtained nanovaccine exhibits an average size of 70.7 nm, a high drug loading capacity (12.3%), and a superior photothermal conversion efficiency of 48.7%. The nanovaccine le …

07.09.2026journal-article

Japanese Journal of Clinical Oncology

Splicing modulation as an emerging therapeutic strategy in cancer: molecular mechanisms, clinical development, and future perspectives

Xinbate Jingele, Qinxinru Sun, Xiaoyang Li, Xinyu Li, Ayana Kon, Xuerui Tao, Akihide Yoshimi

Abstract Aberrant pre-mRNA splicing is a pervasive feature of cancer and an emerging therapeutic vulnerability. Recurrent mutations in core spliceosomal components, including SF3B1, SRSF2, U2AF1, and ZRSR2, are common in myeloid malignancies, while dysregulated splicing regulators and cis-acting splice-site alterations shape cancer-relevant isoform programs across solid tumors. Together with high transcriptional output, rapid proliferation, and oncogene-driven RNA-processing demand, these alterations can reduce the …

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07.09.2026journal-article

Journal of Clinical Practice and Medical Research

Prevalence and Determinants of Multidrug-Resistant Tuberculosis among People Living with HIV: A Systematic Review and Meta-Analysis

Munirat Isah Hussaini, David Ishaleku, Manason Garkuwa Rubainu, Bisayo Adetuyi Ogundipe, Timan Taryuta Eliya, Moses Akuki Attahghen, Bukola Adeyanju Dorcas

Multidrug-resistant tuberculosis is a major challenge for TB control, having added effects on human immunodeficiency virus (HIV) positive individuals who are more prone to TB acquisition and delays in diagnosis, as well as negative outcomes from treatment. This systematic review and meta-analysis reviewed and pooled data regarding multidrug-resistant TB prevalence and determinants among HIV purgent TB patients. Observational studies between January 2010 and July 2023 were selected for this study from PubMed, Google …

07.09.2026journal-article

Asian Journal of Pharmaceutical and Clinical Research

QUANTITATIVE CORONARY ANGIOGRAPHIC ASSESSMENT OF SEGMENT-SPECIFIC CORONARY ARTERY MORPHOMETRY IN CORONARY ARTERY DISEASE: A HOSPITAL-BASED CASE–CONTROL STUDY

VENKATESWARLU YADAVALLI, ANBALAGAN GNANAVEL, PRAVEEN THAMMISETTI, SARAVANAKUMAR SUNDARESAN, KARTHICK SELVARAJ

Objectives: The objective of the study was to compare segment-specific coronary artery morphometry between patients with angiographically confirmed coronary artery disease (CAD) and individuals with normal or near-normal coronary arteries using quantitative coronary angiography (QCA). Methods: This hospital-based case–control study included 200 adults aged 30–60 years who underwent clinically indicated coronary angiography, comprising 100 patients with angiographically confirmed CAD and 100 angiographic controls. T …

07.09.2026journal-article

Physics in Medicine & Biology

Learning-enhanced hybrid planar-SPECT dosimetry for voxel-level Monte Carlo dose estimation in radionuclide therapy

Zhengkun Dong, Xiao Jin, Xiangxi Meng, Wei Liu, Nan Li, Zhi Yang, Qiushi Ren, Jiangyuan Yu, Zhaoheng Xie

Abstract Objective. Quantitative imaging-based dosimetry is essential for optimizing [177Lu]Lu-DOTATATE peptide receptor radionuclide therapy (PRRT), yet full multi–time-point (MTP) SPECT/CT is difficult to implement in routine clinical practice. This study proposes a hybrid planar–SPECT framework for organ-level TIA estimation and STP-constrained voxel-level Monte Carlo dose analysis from a single post-therapy SPECT/CT acquisition. Approach. The proposed framework integrates single-time-point (STP) SPECT/CT with s …

07.09.2026journal-article

Muscle & Nerve

High‐Resolution Ultrasound for Diagnosing Severity of Traumatic Peripheral Nerve Injuries‐in‐Continuity: A Systematic Review, Meta‐Analysis of Individual Participants' Data, and Illustrative Patient Series

Jackson M. Cathey, Christian F. Zirbes, Kevin M. Klifto, Daniel Y. Joh, Caroline M. Wu, Robert J. French, Eliana B. Saltzman, Neill Y. Li

ABSTRACT Introduction/Aims High‐resolution ultrasound (HRUS) may help evaluate traumatic peripheral nerve injuries (PNIs), but the sonographic features that distinguish low‐ from high‐grade injury remain poorly defined. This study evaluated the utility of HRUS for differentiating injury severity by synthesizing data from the literature and applying these findings to an illustrative institutional patient series. Methods We queried for studies reporting HRUS findings in iatrogenic/traumatic PNI resulting in neuraprax …

07.09.2026journal-article

Cerasus Journal of Medicine

Routine Metabolic and Inflammatory Biomarkers as Predictors of Renal Recovery Following Outpatient Treatment of Urinary Tract Infection

Erol Karavar, Kamil Konur

Objective: Urinary tract infection (UTI) can cause transient deterioration of renal function, particularly in patients with comorbidities. Although renal function often improves after successful treatment, factors predicting recovery remain unclear. This study investigated the association between routine metabolic and inflammatory biomarkers and renal recovery following outpatient UTI treatment.Methods: This retrospective single-center cohort study included adult outpatients diagnosed with UTI (January 2022–June 20 …

07.09.2026journal-article

Clinical Otolaryngology

Olfactory Threshold Can Be Reliably Tested With Sniffin' Sticks in Non‐Clinical Settings: Associations Shown in a Diverse, General Population

Marta Rokosz, Xenia Reinert, Antje Haehner, Thomas Hummel

ABSTRACT Objective The olfactory threshold part of the Sniffin' Sticks test is widely used to assess chemosensory function, yet most studies are conducted in controlled laboratory or clinical environments with selective samples. This study examined odour threshold performance with the Sniffin' Sticks threshold test in a large, heterogenous sample, testing whether established associations generalise outside the lab. Method A total of 798 museum visitors aged 18–88 years completed the threshold test and rated their o …

07.09.2026journal-article

ANZ Journal of Surgery

Pulmonary Embolism—A Century of Progress

D. A. Watters

ABSTRACT Introduction This narrative review covers a century of progress in the diagnosis, prevention, and treatment of pulmonary embolism (PE). Diagnosis Although the classic clinical presentation of PE was already well described, in the first half of the 20th century additional diagnostic support was limited to signs on a chest radiograph and evidence of right heart strain on ECG. From the 1960's, imaging accuracy improved through the introduction of pulmonary angiography (1963), ventilation perfusion scans (1964 …

07.09.2026journal-article

The American Journal of Sports Medicine

Absolute Risk of Anterior Cruciate Ligament Graft Reruptures From the Posterior Tibial Slope Falls With Increasing Age: A Risk Stratification Analysis

Tomas Pineda, David Mazy, José Ramos-Rojas, Nicolas Cance, Michael J. Dan, Guillaume Demey, David H. Dejour

Background: Posterior tibial slope (PTS) and young age are well-established independent predictors of an anterior cruciate ligament (ACL) graft rerupture. Although both factors have been studied individually, whether age changes the relative effect of PTS, its absolute clinical impact, or both has not been formally examined across the full age range of patients undergoing ACL reconstruction (ACLR). Purpose: To determine whether age modifies the relative or absolute rerupture risk associated with PTS after ACLR, and …

07.09.2026journal-article

Frontiers in Cardiovascular Medicine

Long-term efficacy and impact on rehospitalization of Qishen granules in patients with hypertension and heart failure with reduced ejection fraction: a multicenter, randomized, double-blind, placebo-controlled trial protocol

Fuyuan Zhang, Zhaorui Cui, Zirui Wang, Yonghao Li, Tiantian Xue, Ruikang Liu, Jun Li

Background Heart failure with reduced ejection fraction (HFrEF) represents a severe manifestation or terminal stage of various cardiac diseases. Long-term hypertension frequently leads to pathological changes such as ventricular remodeling, resulting in HFrEF. Despite continuous advancements in medications targeting hypertension complicated by HFrEF, the five-year survival rate for patients remains below 50%. Chinese Medicine (CM) demonstrates favorable long-term efficacy in managing HFrEF and reducing readmission …

07.09.2026journal-article

Clinical and Translational Discovery

SGLT2i in heart failure: Cardiorenal mechanisms, clinical evidence and translational perspectives

Jelica Grujic‐Milanovic, Jovana Rajkovic, Radmila Novakovic, Javad Sharifi‐Rad, Daniela Calina

Abstract Background Heart failure (HF) remains a major clinical and public health challenge despite advances in guideline‐directed therapy. Sodium–glucose cotransporter 2 inhibitors (SGLT2i) have transformed HF management by reducing worsening HF events across the spectrum of left ventricular ejection fraction, irrespective of diabetes status. Methods This narrative review critically examines the mechanisms, clinical evidence, safety, limitations, and translational perspectives of SGLT2i in HF. MEDLINE/PubMed, EMBA …

07.09.2026journal-article

Pharmaceuticals

Long-Term Monitoring of Everolimus Concentrations in Routine Clinical Practice: Evaluation of Patient Percentiles as Quality Indicator and Impact of Analytical Method Change

Anders O. Larsson, Anna-Karin Hamberg, Mats B. Eriksson

Background: Everolimus, an mTOR inhibitor used in oncology and organ transplantation, requires therapeutic drug monitoring due to the narrow therapeutic range of everolimus and substantial pharmacokinetic variation. Patient-derived data can function as a supplementary quality indicator for laboratory methods by providing real-world information on analytical performance. Methods: All routine whole-blood everolimus measurements performed at Akademiska University Hospital, Uppsala, Sweden, 2012 to 2025 were retrospect …

07.09.2026journal-article

Geriatrics

Views on Ageing and Loneliness in Older Patients Undergoing Geriatric Treatment

Luise Umfermann, Aline Schönenberg, Tino Prell

Background/Objectives: Loneliness is a clinically relevant psychosocial factor in later life and has been associated with adverse mental, cognitive, and physical health outcomes. Views on ageing may shape social engagement, coping, and perceived belonging, but evidence from geriatric patient populations remains limited. This study examined whether views on ageing are associated with loneliness in geriatric patients. Secondary analyses explored subjective age, including felt age and the perceived onset of old age. M …

07.09.2026journal-article

Russian Journal of Transplantology and Artificial Organs

The role of anti-HLA antibodies in the prevention, diagnosis, and management of antibody-mediated rejection after kidney transplant

A. G. Balkarov, N. V. Borovkova, Yu. A. Anisimov, N. A. Mushta, N. V. Shmarina, N. V. Doronina, V. V. Smirnova, I. V. Dmitriev

Background . The available literature contains relatively few studies investigating the role of anti-human leukocyte antigen (anti-HLA) antibodies – including pre-existing antibodies, de novo synthesized antibodies, and donor-specific antibodies (DSAs) – in the prevention, diagnosis, and treatment of acute kidney transplant (KT) rejection. Materials and methods . We evaluated the prevalence and specificity of pre-existing anti-HLA antibodies, the incidence and specificity of de novo anti-HLA antibody synthesis (inc …

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Aktuelle Forschung nach Fachgebiet

Single or multiple nutritional hormone receptor modulators for chronic kidney disease

Focused Ultrasound Therapies for Brain, Liver, Prostate, and Breast Cancer Applications: Clinical Evidence and Future Directions

Re-Epithelialization of Donor Sites and Meshed Skin Grafts Using Cryopreserved Cultured Cutaneous Allograft (Epifast®): Experience in Patients with Extensive Burns

An Intelligent Bearing Fault Diagnosis Model with Physics-Information Fusion: Design and Interpretability Mechanism Research

A Shorter Surgical Interval May be Associated with Improved Patient-reported Outcomes in Hip-spine Syndrome

Algorithmic Convergence Across Machine Learning Models Identifies Robust Strategic Priorities for Improving Patient Experience

Real-Time SpO2 Estimation from Chest Reflectance Photoplethysmography: Algorithm Development and Clinical Validation Against Arterial SaO2

Neuroticism, extraversion, and self‐compassion as mediators of therapeutic outcomes: Long‐term effectiveness of a brief group adaptation of the Unified Protocol in a clinical sample of university students

Addiction Consult Service Associated With Improved Rates of 30-day Treatment Engagement After Emergency Department and Hospital Discharge: A Propensity-weighted Analysis

A Self‐Adjuvant Photothermal Carbon Dot‐Based Nanovaccine for Multimodal Nasopharyngeal Cancer Treatment and Prophylaxis

Splicing modulation as an emerging therapeutic strategy in cancer: molecular mechanisms, clinical development, and future perspectives

Prevalence and Determinants of Multidrug-Resistant Tuberculosis among People Living with HIV: A Systematic Review and Meta-Analysis

QUANTITATIVE CORONARY ANGIOGRAPHIC ASSESSMENT OF SEGMENT-SPECIFIC CORONARY ARTERY MORPHOMETRY IN CORONARY ARTERY DISEASE: A HOSPITAL-BASED CASE–CONTROL STUDY

Learning-enhanced hybrid planar-SPECT dosimetry for voxel-level Monte Carlo dose estimation in radionuclide therapy

High‐Resolution Ultrasound for Diagnosing Severity of Traumatic Peripheral Nerve Injuries‐in‐Continuity: A Systematic Review, Meta‐Analysis of Individual Participants' Data, and Illustrative Patient Series

Routine Metabolic and Inflammatory Biomarkers as Predictors of Renal Recovery Following Outpatient Treatment of Urinary Tract Infection

Olfactory Threshold Can Be Reliably Tested With Sniffin' Sticks in Non‐Clinical Settings: Associations Shown in a Diverse, General Population

Pulmonary Embolism—A Century of Progress

Absolute Risk of Anterior Cruciate Ligament Graft Reruptures From the Posterior Tibial Slope Falls With Increasing Age: A Risk Stratification Analysis

Long-term efficacy and impact on rehospitalization of Qishen granules in patients with hypertension and heart failure with reduced ejection fraction: a multicenter, randomized, double-blind, placebo-controlled trial protocol

SGLT2i in heart failure: Cardiorenal mechanisms, clinical evidence and translational perspectives

Long-Term Monitoring of Everolimus Concentrations in Routine Clinical Practice: Evaluation of Patient Percentiles as Quality Indicator and Impact of Analytical Method Change

Views on Ageing and Loneliness in Older Patients Undergoing Geriatric Treatment

The role of anti-HLA antibodies in the prevention, diagnosis, and management of antibody-mediated rejection after kidney transplant