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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
14.08.2026journal-article

Gynecology and Minimally Invasive Therapy

Misdiagnosed Scar Ectopic Pregnancy: From Suction Evacuation to Laparoscopic Excision – A Case Report

Ipsita Mohapatra, Saubhagya Kumar Jena, Laveti Sai Sarvazna, Subha Ranjan Samantaray

Abstract Scar ectopic pregnancy, a rare form of ectopic pregnancy, is implanted in the myometrium at the site of a previous cesarean section scar. With the increasing rate of cesarean deliveries, the incidence of cesarean scar ectopic pregnancies has been increasing. It is the implantation of blastocyst in the uterine scar of previous cesarean delivery. Scar ectopic pregnancies are challenging to diagnose, especially in the early stages. On ultrasound, they may appear similar to normal intrauterine pregnancies or o …

14.08.2026journal-article

Frontiers in Pharmacology

Investigation of complex miRNA-mRNA interaction networks during JAK inhibitor therapy in rheumatoid arthritis

János Rózsa, Dóra Csige, Monika Bodoki, Zsófia Hagymási-Szabó, Ferenc Tóth, Szilvia Szamosi, Ágnes Horváth, Nóra Bodnár, Edit Végh, Sándor Szántó, Gabriella Szűcs, Zsófia Pethő, Zsuzsanna Gyetkó, Levente Bodoki, János Kádas, Zoltán Szekanecz, Szilárd Póliska

Background MicroRNAs (miRNAs) are small molecules that contribute to the regulation of gene expression by binding to messenger RNAs (mRNAs), controlling the amount of proteins being produced. In the past few decades, biologic and targeted synthetic therapies (e.g., Janus kinase (JAK) inhibitors) have emerged for the treatment of rheumatoid arthritis (RA), which have promised new possibilities for treating the disease. By inhibiting the inflammatory cascade, these drugs are able to moderate further mRNA expression o …

14.08.2026journal-article

Small

In Situ Self‐Assembled Nanoparticles for Cascade‐Instructed Photodynamic Therapy and Real‐Time Treatment Feedback Imaging

Taoli Sun, Wenbin Liu, Minghui Yu, Beibei Wang, Zhengjie Liu, Zijuan Hai

ABSTRACT Although the cancer treatment efficacy has significantly improved, delayed and isolated evaluation methods are difficult to prevent excessive or insufficient treatment. Therefore, the single molecule for simultaneous therapy and feedback has become a promising tool. Herein, we develop an in situ self‐assembled probe (HPO‐CYFF‐TPP) for cascade‐instructed therapy and feedback imaging. Under the dephosphorylation of alkaline phosphatase, HPO‐CYFF‐TPP converts to HO‐CYFF‐TPP and self‐assembles into nanoparticl …

14.08.2026journal-article

American Journal of Speech-Language Pathology

Comparing Traditional Motor Speech Practice to Contextualized Speech Practice in Preschoolers With Childhood Apraxia of Speech

Kerry A. McNamara, Nicole F. Caballero, Jonathan L. Preston

Purpose: The aim of this study was to compare retention of real-word targets across practice conditions (contextualized vs. motor-only) within a modified integral stimulation treatment for preschoolers with childhood apraxia of speech (CAS). Method: A single-subject experimental design with alternating treatments was used with matched target sets randomly assigned to contextualized practice, motor-only practice, or no treatment. Three preschoolers with CAS completed 18 therapy sessions, each consisting of two 25-mi …

14.08.2026journal-article

BJU International

Evaluation of triplet therapy combined with robot‐assisted cytoreductive prostatectomy for high‐volume metastatic prostate cancer: a multicentre randomised controlled trial protocol

Xiangwei Yang, Zhuobin He, Jian Chen, Hanqi Lei, Binyuan Yan, Linze Chen, Hong Liu, Jun Pang

Background Prostate cancer (PCa) is the second most common cancer in men. For patients with high‐volume metastatic PCa (mPCa) who are fit for docetaxel, a triplet therapy regimen consisting of androgen deprivation therapy (ADT), chemotherapy, and an androgen receptor pathway inhibitor (ARPI) is recommended. Adding local radiotherapy to triplet therapy has been shown to alleviate symptoms and reduce disease progression. However, the benefit of combining triplet therapy with local surgery remains unclear and warrants …

14.08.2026journal-article

Medicine

Prophylactic negative pressure wound therapy reduces surgical site infection in gastrointestinal, hepatobiliary, and pancreatic laparotomy

Yanyun Long, Xiaohui Gu, Xin Wang, Kelei Wang, Yong Guan, Shaocong Wang, Chao Liu

Background: Surgical site infections (SSIs) remain a major complication following gastrointestinal, hepatobiliary-pancreatic, and pancreatic surgery. This systematic review and meta-analysis aimed to assess the efficacy of prophylactic negative pressure wound therapy (NPWT) in reducing SSIs following closed abdominal incisions. Methods: A systematic search was conducted in PubMed, Embase, the Web of Science, and the Cochrane Library for studies published from January 2016 to December 2025; all databases were last s …

14.08.2026journal-article

Children

Combined Letrozole and Growth Hormone Therapy in Late-Pubertal Males with Advanced Bone Age and Open Knee Physes

Hui Zhang, Pengxiang Zhou, Yunpu Cui, Xuemei Wang, Huiqiang Liu, Jinfang Yuan, Hua Zhang, Rongsheng Zhao, Tongyan Han, Xinli Wang

Background/Objectives: The therapeutic window for growth hormone (GH) therapy in late-pubertal males with advanced bone age (BA ≥ 15 years) is generally considered closed. Yet, open knee physes may indicate residual growth potential. This single-arm retrospective study evaluated the efficacy and safety of letrozole combined with GH in Chinese males with short stature, advanced BA (15 –< 18 years), and open knee physes. Methods: We included 139 male adolescents stratified by baseline BA: 15 ≤ BA < 16 (n = 24), 16 ≤ …

14.08.2026journal-article

Pediatria. Journal named after G.N. Speransky

EVOLUTION OF THERAPY FOR ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN: FROM FIRST REMISSIONS TO MOLECULARLY TARGETED IMMUNOTHERAPY (ON THE CENTENARY OF THE BIRTH OF N.S. KISLYAK)

A.I. Karachunsky, Yu.V. Rumyantseva, E.G. Mansurova, A.G. Rumyantsev

The centenary of the birth of Academician Natalia Sergeevna Kislyak (1926–2008) — the founder of pediatric hematology in Russia — provides an occasion to reflect on one of the most significant medical achievements of the 20th–21st centuries: the transformation of acute lymphoblastic leukemia (ALL) from a fatal disease into one that is curable in the majority of children. This article traces the logic of that evolution — from the first remission induced by S. Farber in 1948 and D. Pinkel's «total therapy» to the met …

14.08.2026journal-article

Muscles, Ligaments and Tendons Journal

Manual therapy for temporomandibular myofascial pain: a phenotype-guided narrative review

Tuba Yerlikaya, Melis Bagkur, Nima Jabri

Background: Manual therapy for temporomandibular myofascial pain is commonly used within conservative care for muscle-related temporomandibular disorders, which involve masticatory muscle pain, trigger-point sensitivity, impaired mandibular mobility, and functional limitation. Conservative and reversible interventions are preferred as first-line management. Objective: This narrative review summarizes the rationale, clinical application, evidence limitations, and safety considerations of manual therapy for temporoma …

14.08.2026journal-article

Baltic Journal of Sport and Health Sciences

Implementation Challenges and Enablers of Wearable Health Technologies in Physiotherapy Among English-Speaking Participants in India: A Qualitative Study

Divya Sharma, Franz Hessel, Vaibhavi Dargude

Introduction: Wearable medical devices are increasingly integrated in physiotherapy to enable exercise optimisation, remote monitoring of therapy progress, and tailoring of treatment plans based on individual needs. However, their current utilisation in clinical practice in India remains limited and at an early stage, as physiotherapy largely remains a manual skill-based profession in which hands-on techniques often supersede wearable devices. This study aimed to identify the potential facilitators and barriers to …

14.08.2026journal-article

Biology

Combinatorial Therapy with Long-Acting Tenofovir and Tizoxanide Controls Viral Replication and Liver Inflammation in a Murine AAV-HBV Model of Chronic Hepatitis B

Mojisola O. Ogunnaike, Ashrafi Sultana, Samiksha Raut, Weimin Wang, Grace Bybee, Howard E. Gendelman, Benson J. Edagwa, Natalia A. Osna, Larisa Y. Poluektova

Chronic hepatitis B (CHB) infection is a major risk factor for progressive cirrhosis and hepatocellular carcinoma. Persistent virus-induced inflammation alters liver function, leading to accelerated disease and increased mortality. Although lifelong treatment with nucleos(t)ide analogs (NAs) is highly effective at suppressing viral replication, covalently closed circular DNA (cccDNA) persists in hepatocytes to sustain chronic infection, underscoring the need for better interventions and combination therapies. The d …

14.08.2026journal-article

Machines

Reinforcement Learning-Based Interactive Control of an Omnidirectional Mobile Lower Limb Rehabilitation Robot

Suyang Yu, Yangqing Yu, Changlong Ye

This paper proposes a hierarchical control architecture that is established at both lower limb joint and platform levels based on a simplified admittance model, where compliance is regulated through virtual mass and damping. At the lower limb joint level, admittance control governs lower limb motion tracking, while at the platform level it adjusts the omnidirectional mobile platform velocity in response to human interaction forces. Within this framework, a Sarsa-based reinforcement learning agent dynamically optimi …

14.08.2026journal-article

Journal of Traumatic Stress

Enhancing cognitive processing therapy via stellate ganglion blocks: A pilot randomized trial

Philip Held, Sarah A. Pridgen, Dale L. Smith, Daniel R. Szoke, Asokumar Buvanendran, Robert J. McCarthy

Abstract Although trauma‐focused psychotherapies, such as cognitive processing therapy (CPT), are effective treatments for posttraumatic stress disorder (PTSD), a substantial portion of individuals exhibit a diminished response. Stellate ganglion block (SGB), an anesthetic procedure targeting the sympathetic nervous system, has shown promise for PTSD but has only recently begun to be evaluated as an augmentation to evidence‐based psychotherapy. This randomized, placebo‐controlled, double‐blind pilot trial assessed …

14.08.2026journal-article

Epidemiologia

Work-Related Illnesses and Work Disability in Brazil: A Scoping Review of the Epidemiological Profile and Determinants of Sick Leave and Occupational Accidents

Luciano Garcia Lourenção, Luciano Silveira Pacheco de Medeiros

Background: This scoping review maps and synthesizes the scientific evidence on the epidemiological profile and determinants of sick leave and work-related accidents in Brazil, with an emphasis on studies using data from the Brazilian Federal Medical Expert Service of the Ministry of Social Security. Methods: Following the PRISMA-ScR guidelines and the JBI Manual for Evidence Synthesis, eight databases (SciELO, PubMed/MEDLINE, Scopus, Web of Science, LILACS, CINAHL, PsycINFO, Embase) were searched for quantitative …

14.08.2026journal-article

Open Research Europe

European Network for Optimization of Veterinary Antimicrobial Therapy (ENOVAT) guidelines for antimicrobial and non-steroidal anti-inflammatory drug use in bovine respiratory disease

Karolina Scahill, Sébastien Buczinski, Clair L. Firth, Bart Pardon, Maria Stokstad, Amelia R. Woolums, Ramazan Yildiz, Lise Marie Ånestad, Mickael Cargnel, Luis Pedro Carmo, Pierre-Louis Toutain, Luca Guardabassi

Background Bovine respiratory disease (BRD) is a major cause of morbidity, mortality, impaired welfare, production loss, and antimicrobial use in cattle. These European Network for Optimization of Veterinary Antimicrobial Therapy (ENOVAT) guidelines provide evidence-based recommendations for antimicrobial and non-steroidal anti-inflammatory drug (NSAID) use in cattle with acute, undifferentiated BRD, balancing animal-level outcomes with antimicrobial stewardship. Methods Recommendations were developed using the GRA …

14.08.2026journal-article

JMIR Medical Education

Effects of an Immersive 180° Video–Based Virtual Reality Instructional Module on Learning Satisfaction, Technology Acceptance, Motivation, and Quiz-Based Learning Achievement in Undergraduate Physical Therapy Students: Randomized Controlled Trial

Hyoshil Yoon, Yongwoo Lee

Abstract Background Virtual reality (VR) offers immersive learning opportunities in health professions education, yet its effects on learner experience and short-term learning outcomes in education on execution of musculoskeletal special tests remain underexplored. Objective This randomized controlled trial evaluated the effects of an immersive 180° video–based VR instruction, compared with conventional 2D video–based instruction, on undergraduate physical therapy students’ learning satisfaction, technology accepta …

14.08.2026journal-article

Cell Biochemistry and Biophysics

A Three-Dimensional Hyaluronic Acid-Based Scaffold Model for Electroporation-Enhanced Resveratrol Therapy in Triple-Negative Breast Cancer

Pragatheiswar Giri, Monica Dettin, Annj Zamuner, Maria Teresa Conconi, Ignacio G. Camarillo, Nicolò Martinelli, Luigi Dall’Olmo, Elisabetta Sieni, Raji Sundararajan

Abstract Triple-negative breast cancer (TNBC) is an aggressive malignancy defined by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). These molecular characteristics render targeted therapies less effective and contribute to poor clinical outcomes. Towards this, we studied the electroporation-mediated delivery of resveratrol, a polyphenolic compound with pleiotropic anticancer activities, on MDA-MB-231, human TNBC cell line. Both conventional tw …

14.08.2026journal-article

Cancers

Overcoming Therapy Resistance in Ovarian Cancer: From Molecular Mechanisms to Emerging Therapeutic Strategies

Zofia Pietrasik, Mikołaj Kapała, Joanna Pietrasik, Monika Stefaniak, Sebastian Szubert, Krzysztof Książek, Justyna Mikuła-Pietrasik

Background/Objectives: Epithelial ovarian cancer (EOC) remains a gynecologic malignancy with a poor prognosis, with a 5-year survival of approximately 29% in advanced-stage disease. Despite cytoreductive surgery and platinum- and taxane-based chemotherapy, most patients relapse within 2 years. Major therapeutic barriers include chemoresistance, molecular heterogeneity, and an immunosuppressive peritoneal microenvironment. This review summarizes emerging therapeutic strategies for EOC, their mechanisms of action, an …

14.08.2026journal-article

Journal of Acute Care Physical Therapy

Development of Interprofessional Collaboration and Communication Through Simulation-Based Learning Experiences for Physical Therapy and Speech-Language Pathology Learners

Sheri R. Kiami, Sarah Young-Hong, Wendy C. Georgan, Heidi Cheerman

ABSTRACT Background and Purpose: Literature has shown that interprofessional simulation-based learning experiences (Sim IPE) are effective at preparing future healthcare providers for interprofessional practice and an impactful way to meet health professions’ accreditation standards. However, there is a lack of literature examining outcomes of Sim IPE among entry-level Doctor of Physical Therapy (DPT) and Master of Science Speech-Language Pathology (MS-SLP) learners. The purpose of this study is to examine how part …

14.08.2026journal-article

Veterinary Medicine and Science

Adjunctive Therapy With a Perna canaliculus and Euphausia superba Extract (EAB‐277 TM ) for Clinical Signs of Tracheal Collapse in Dogs: A Prospective, Randomized and Placebo‐Controlled Exploratory Trial

Wasutorn Yangwanitset, Somkiat Huaijantug, Mookmanee Taechikantaphat, Melanie Hezzell, Walasinee Sakcamduang

ABSTRACT Background Tracheal collapse is a common canine respiratory disease characterized by dorsoventral cartilage flattening, airway lumen narrowing and subsequent mucosal inflammation. Objectives To investigate the efficacy of EAB‐277, a marine lipid extract combining Perna canaliculus (30 mg) and Euphausia superba (20 mg) as an adjunctive therapy in the management of tracheal collapse in dogs. Methods Forty‐one dogs with confirmed tracheal collapse were randomly assigned to receive standard conventional medica …

14.08.2026journal-article

American Journal of Speech-Language Pathology

Paired-Comparison Versus Cross-Sectional Approaches for Assessing Longitudinal Speech Change in Parkinson's Disease Following Deep Brain Stimulation of the Subthalamic Nucleus

Jordan L. Manes, Andrea H. Rohl, Mengyang Qiu, Kaila L. Stipancic, Daniel M. Corcos, Charity G. Patterson, Jeremy D. W. Greenlee, Kris Tjaden

Purpose: Longitudinal changes in perceptual speech outcomes are typically derived from independent judgments at each time point rather than side by side within-speaker comparisons. This study evaluated a paired-comparison method for detecting longitudinal speech change in Parkinson's disease (PD) across three perceptual constructs (intelligibility, listener effort, and severity) relative to a cross-sectional method for detecting speech changes in the same cohort. Method: We collected recordings of the Speech Intell …

14.08.2026journal-article

Annals of African Medicine

Clinico-epidemiological Profile and Outcome of Severe Acute Malnutrition Children Admitted to the Nutritional Rehabilitation Center of a Tertiary Care Center in Kalaburagi, Karnataka: A Retrospective Study

K. S. Sreeshyam, N. A. Gururaj, S. Sangita, H. Ramesh, Ajaykumar Gududur

Abstract Introduction: Severe acute malnutrition (SAM) continues to be one of the most important preventable causes of under-five morbidity and mortality in low- and middle-income countries, particularly in South Asia, a significant proportion of which is contributed by India. Nutritional rehabilitation centers (NRCs) deliver standardized care for children with SAM using guidelines derived from the World Health Organization (WHO); however, there is a paucity of data regarding their functioning in Karnataka and Sout …

14.08.2026journal-article

PLOS One

Factors associated with return to pre-admission functional category at hospital discharge among acute inpatients receiving physical therapy and/or occupational therapy: A retrospective cohort study

Yazeed Temraz, Wafa Bin Salamh, Naif Alsayahi, Mohammed Alrehaili, Fahdah Aljamaan, Hend Alqudaimi, Dina Alqueflie

Background Functional decline associated with acute hospitalization may persist at hospital discharge. This study examined associations between routinely documented admission-time characteristics and return to the same pre-admission functional category among acute inpatients receiving physical therapy and/or occupational therapy. Methods This exploratory single-center retrospective cohort study included 444 unique adults who received acute inpatient physical therapy and/or occupational therapy at a tertiary hospita …

14.08.2026journal-article

International Journal For Multidisciplinary Research

Run Smart, Run Strong: Exploring the Role of Physiotherapy in Running Load Management and Injury Prevention Among Recreational Runners

Ruchita Handore, Aditi Davane, Shashwat Joshi, Priyanranjan Chaudhary

Background Running is a widely practiced form of physical activity among recreational runners; however, inappropriate training load and inadequate progression may contribute to running-related injuries. Physiotherapy may play an important role in optimizing running load, improving physical capacity, and preventing running-related injuries through strengthening, flexibility, neuromuscular, and load-management strategies. Therefore, this narrative review aimed to explore the role of physiotherapy in running load mana …