Medizin: neue Gesundheitspublikationen – Seite 150

07.09.2026journal-article

Aesthetic Surgery Journal

Reevaluation of the Medial Temporal Artery: A 3-Dimensional Anatomical Study and Its Clinical Implications for Safe Auricular Filler Injections

Yu-Hao Zhou, Guo-Hao Yuan, Jia-Ying Xu, Hui-Qin Lu, Fang-Wei Li, Xing Wang, Yan-Qun Wu, Hai-Bin Wang

Abstract Background The medial temporal artery (MTA) supplies the auricle and temporal region but remains understudied despite its relevance to filler injection safety. Objective To comprehensively evaluate the MTA using three-dimensional computed tomography angiography (3D-CTA) and gross dissection. Methods: Fifty-three cadaver heads (106 sides) underwent lead oxide perfusion and CT scanning. The origin, course, branching patterns, and anastomoses of the MTA were analyzed, and a vascular distribution heat map was …

07.09.2026journal-article

Sriwijaya Journal of Surgery

Only the Boey Score Discriminates In-Hospital Mortality After Gastric Perforation: A STARD-Compliant Comparison with the Jabalpur Score

Samuel Bertua Halomoan Manurung, Efman E. U Manawan, Erial Bahar

Background: Gastric perforation remains a highly lethal surgical emergency, and competing preoperative mortality scores have not been compared directly in an Indonesian cohort. Objective: To compare the discrimination, calibration, and clinical utility of the Boey and Jabalpur scores for in-hospital mortality after emergency surgery for gastric perforation. Methods: This retrospective diagnostic-accuracy study, reported according to STARD 2015, included 55 consecutive adults who underwent emergency laparotomy for n …

07.09.2026journal-article

BMC Surgery

Heterogeneity in major amputation risk among patients with WIfI (wound, ischemia, foot infection) Stage 4 diabetic foot ulcers

Sheng-Lian Lee, Yi-Chang Lin, Chiung-Wen Chang, Chiehfeng Chen, Hsian-Jenn Wang, Wen-Kuan Chiu

Abstract Background Although the Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification stratifies limb threat, reported 1-year major amputation rates for WIfI Stage 4 vary widely across institutions. Whether patient-level factors provide prognostic information beyond limb severity in advanced disease remains unclear. Methods We conducted a retrospective single-center cohort study of 296 patients with diabetic foot ulcers (DFUs) admitted to a tertiary referral center between 2017 and …

07.09.2026journal-article

Langenbeck's Archives of Surgery

No prophylactic drains in emergency abdominal surgery- a prospective, cohort study

Mai-Britt Tolstrup, Anders Peter Skovsen

Abstract Purpose It is still common practice to routinely place prophylactic intraperitoneal drains after abdominal emergency surgery, even though this practice has been abandoned in most elective abdominal interventions. International guidelines recommend against prophylactic drain placement, and the available evidence is inconclusive. We aimed to report the impact of an interventional, de-implementation strategy for prophylactic drain placement after emergency laparotomy/laparoscopy in Copenhagen University Hospi …

07.09.2026journal-article

Medicine Insights

Intestinal Barrier Dysfunction in Ulcerative Colitis: Mechanisms and Therapeutic Perspectives

Jingdu Yang, Haifa Qiao

Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease characterized by persistent mucosal inflammation of the colon and rectum. Although the exact etiology of UC remains incompletely understood, accumulating evidence suggests that intestinal barrier dysfunction plays a central role in disease initiation, progression, and recurrence. The intestinal barrier is a complex system composed of the epithelial layer, tight junction proteins, mucus layer, immune components, and gut microbiota, which toget …

07.09.2026journal-article

Journal of Clinical Technology and Theory

How does the gut microbiome impact rheumatoid arthritis?

Xiyan Xie

This dissertation investigates how the gut microbiota impacts Rheumatoid Arthritis (RA), a project that spans three core disciplines: rheumatology, microbiology, and immunobiology. It first outlines the key changes in the gut microbiome observed in rheumatoid arthritis. It also examines possible mechanisms linking the gut to joint inflammation, such as impaired intestinal barrier function and ongoing inflammatory processes. In addition, the potential use of the gut microbiome as a diagnostic biomarker is considered …

07.09.2026journal-article

Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery

Management of Preoperative Anemia: Review of Best Practices in Cardiac Surgery

Stephen D. Waterford, Alexander Gregory, Joshua Nicholas, Rawn Salenger

Up to 40% of cardiac surgery patients present with preoperative anemia, which is associated with significant risks and management challenges. This review highlights the increased perioperative risk attributable to preoperative anemia as well as recommended optimization strategies. This includes screening for anemia and iron deficiency as well as the appropriate use of intravenous iron replacement, vitamin B12, folic acid, and erythrocyte stimulating agents. The mechanism of action, optimal dosing, and anticipated t …

07.09.2026journal-article

Journal of Laparoendoscopic & Advanced Surgical Techniques

Clinical Relevance of Preoperative Upper Gastrointestinal Endoscopy before Sleeve Gastrectomy: A Retrospective Cohort Study of 30-Day Outcomes

Hasan Eroğlu, Ahmed Taha, İskender Eren Demirbaş, Özgür İbiş

Background: Routine preoperative upper gastrointestinal endoscopy before sleeve gastrectomy remains debated. This study evaluated whether selected endoscopic and histopathologic findings were associated with 30-day outcomes after sleeve gastrectomy, with specific attention to reflux-related events and severity-stratified staple-line leak. Methods: We retrospectively analyzed 315 adults who underwent laparoscopic sleeve gastrectomy at a tertiary referral center between June 2016 and December 2019. All patients under …

07.09.2026journal-article

The Anatomical Record

Outcomes of hyaluronic acid and dextrose prolotherapy on surgically induced rat osteoarthritis: Single versus combined treatment

Wael Amin Nasr El‐Din, Bhagath Kumar Potu, Raouf Abdelrahman Fadel, Islam Omar Abdel Fattah

Abstract Osteoarthritis (OA) is the most prevalent chronic joint disorder. This study explored therapeutic mechanisms of intra‐articular (i.a.) hyaluronic acid (HA), and/or dextrose prolotherapy (DPT) on surgically induced OA. Rats were divided into five groups ( n = 12): control, OA, HA, DPT, and DPT + HA groups. OA group revealed increase in serum alkaline phosphatase (ALP) level, knee extension angle diameter, and CD44 immuno‐expression, furthermore a decrease in cartilage thickness, chondrocyte density, and gly …

07.09.2026journal-article

Experimental & Molecular Medicine

Immune pathway activation in gastric cancers with LINE-1 retrotransposon overexpression and homologous recombination deficiency

Young Jin Kim, In-Pyo Baek, Bang Wool Eom, Min-Jung Seo, Heeyeon Joo, Yu Ri Choi, Min Kyoung Park, Jihye Oh, Boram Lee, Seung Min Ham, Nak-Hyeon Choi, Seung-Pyo Hong, Jaeyong Choi, Sookyung Kim, Seong-Ho Kong, Hyuk-Joon Lee, Yun-Suhk Suh, Jinhwa Kong, Je-Keun Rhee, Sang-Won Lee, Hong Man Yoon, Hark Kyun Kim, Young-Woo Kim, Jong-Il Kim, Bong-Jo Kim, Han Kwang Yang

Abstract There are only a few whole genome sequencing studies of human gastric cancer (GC) conducted so far. We performed comprehensive whole genome, bulk RNA, and methylation sequencing analyses of 100 samples of GC and adjacent normal tissue. In a smaller non-EBV/non-MSI subset ( n = 23), we also performed proteomic profiling by mass spectrometry. We validated the proteomic findings in an independent dataset. Using this unprecedented dataset of human GC samples, we examined the extent of chromothripsis, homologou …

07.09.2026journal-article

Revista ft

Evolução clínica e desafios terapêuticos na doença de Parkinson em fase avançada: uma revisão sistemática.

Thiago Guzzo, Daniel Cadore Simionatto, Lilian Celina Soares Maria

Parkinson's disease (PD) is a chronic, progressive neurodegenerative disorder predominantly characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta and the resulting dysfunction of basal ganglia circuits. Although traditionally associated with motor manifestations such as bradykinesia, resting tremor, and rigidity, its progression involves a broad spectrum of non-motor symptoms, including cognitive, autonomic, psychiatric, gastrointestinal, and sleep disturbances. In the adva …

07.09.2026journal-article

Medicine & Science in Sports & Exercise

A Comparison of Ground Reaction Forces, Tibial Forces, and Clinician Perspectives on Tibial Bone Load During Common Rehabilitation Exercises

Meredith K. Owen, Katherine M. Rodzak, Tereza Janatova, Lauren N. Erickson, Camille C. Johnson, Karl E. Zelik, Brian Noehren

Purpose: Optimal healing after a tibia fracture depends on appropriate mechanical loading. Ground reaction force is often used as an indicator of expected tibia load, but it does not account for internal forces placed on the tibia from muscle contractions. Objectives of this study were to 1) characterize peak forces on the distal tibia during common exercises used for rehabilitation after lower extremity injury, 2) compare peak tibial force to peak ground reaction forces for each exercise, and 3) compare rank-order …

07.09.2026journal-article

Infectious Disease Reports

The Role of Infrared Thermography in the Diagnosis and Monitoring of Diabetic Foot Infection: A Systematic Review

Carmen Cantarero-Lozano, Aroa Tardáguila-García, Esther García-Morales, Yolanda García-Álvarez, David Navarro-Pérez, José Luis Lázaro-Martínez

Background: Diabetic foot infection (DFI) is one of the most frequent diabetes-related complications requiring hospitalisation and is a major contributor to lower-extremity amputation. Infrared thermography has emerged as a non-invasive diagnostic tool capable of detecting temperature changes associated with inflammatory and infectious processes. This systematic review aimed to evaluate the role of thermography in the diagnosis and monitoring of diabetic foot infection. Methods: The Preferred Reporting Items for Sy …

07.09.2026journal-article

Japanese Journal of Clinical Oncology

PDGFRA amplification could be a poor prognostic factor of advanced undifferentiated pleomorphic sarcoma in a comprehensive genomic profiling cohort

Hiroshi Kobayashi, Masachika Ikegami, Liuzhe Zhang, Koichi Okajima, Toshihiko Ando, Toshihide Hirai, Yusuke Tsuda, Sakae Tanaka

Abstract Background Undifferentiated pleomorphic sarcoma (UPS) is the most common pleomorphic sarcoma, and its genomic landscape has been analysed, albeit in small numbers. This study aimed to clarify the relationship between gene variants and the prognosis of patients with advanced UPS. Methods This retrospective cohort study was conducted to analyse the data of patients with advanced UPS using a registry of the Center for Cancer Genomics and Advanced Therapeutics (C-CAT) database up to Oct 2025 in Japan, analysed …

07.09.2026journal-article

Aging Clinical and Experimental Research

Chronological age and failure to rescue after colorectal cancer surgery: A multicentre cohort study

Tomasz Cwaliński, Michał Kazanowski, Jacek Piątkowski, Maciej Ciesielski, Marcin Januszkiewicz, Zuzanna Bigus, Patryk Kaczor, Bartosz Kapturkiewicz, Paweł Lesiak, Sergii Girnyi, Damian Nowiński, Piotr Kurek, Marek Jackowski, Marek Bębenek, Mateusz Jagielski, Luigi Marano

Abstract Background Whether advancing chronological age is associated more strongly with serious postoperative events or with survival after an event remains uncertain. Aims To compare the association of chronological age with major postoperative events and failure to rescue after colorectal cancer surgery. Methods We analyzed 1,124 adults treated at five Polish centers between January 2022 and August 2025. Major events were Clavien–Dindo ≥grade IIIa; failure to rescue was cumulative 90-day death after such an even …

07.09.2026journal-article

Psychiatry and Clinical Neurosciences

Cognitive heterogeneity in major depressive disorder: Neuroimaging, transcriptomic, and neurotransmitter profiles

Yushun Yan, Jia'ao Yu, Liang Zuo, Min Wang, Jinxue Wei, Yikai Dou, Xiao Yang, Xiaohong Ma

Background Major depressive disorder (MDD) is often accompanied by cognitive impairment; however, the cognitive heterogeneity of MDD and its neurobiological context remain poorly understood. Methods A total of 198 participants with MDD and 275 HCs underwent multi‐domain cognitive assessments and multi‐modal MRI acquisition. A semi‐supervised approach was applied to identify cognitive dimensions of MDD, and individual‐level structural‐enriched functional networks (SFNs) were constructed. Network‐based statistics wer …

07.09.2026journal-article

Asian Journal of Pharmaceutical and Clinical Research

AMELIORATIVE EFFECT OF SOLANUM XANTHOCARPUM AGAINST CHEMICAL-INDUCED DIABETIC NEPHROPATHY IN RATS

AKANKSHA B DANGE, UJWAL VYAS, BHUSHAN GANDHARE, SADHANA GAUTAM

Objective: The objective of the study was to evaluate the renoprotective effect of Solanum xanthocarpum leaf extract (SXLE) in streptozotocin (STZ) induced diabetic nephropathy (DN) in rats. Methods: Male Wistar rats were given a single intraperitoneal injection of STZ (55 mg/kg) to induce diabetes. Rats with fasting blood glucose levels >250 mg/dL (13.9 mmol/L) 7 days after induction were classified as diabetics and added to the study. For 8 weeks, SXLE was administered orally to diabetic rats at doses of 100 and …

07.09.2026journal-article

Clinical Kidney Journal

Single or multiple nutritional hormone receptor modulators for chronic kidney disease

Hiddo J L Heerspink

Abstract The global rise in obesity and type 2 diabetes mellitus (T2DM) has contributed substantially to the increasing burden of chronic kidney disease (CKD), cardiovascular disease, and heart failure, highlighting the need for therapeutic strategies capable of addressing multiple components of the cardio-renal-metabolic axis. Incretin-based therapies have undergone an evolution from glucose-lowering agents to treatments with broad metabolic, cardiovascular, and renal effects. Glucagon-like peptide-1 (GLP-1) recep …

07.09.2026journal-article

Spine

A Shorter Surgical Interval May be Associated with Improved Patient-reported Outcomes in Hip-spine Syndrome

Joshua Mathew, Mitchell K. Ng, Jonathan Dalton, William Green, Gregorio Baek, Yasmine Eichbaum, Yulia Lee, Morgan Hitchner, Andrew Vanichkachorn, Gil Barksdale, Anthony Buzzetta, Torsten Fras, Dipti Venkatesh, Brandon Martinazzi, Ali Farooqi, Alec Giakas, Paul Mastrokostas, Jeffrey A. Rihn, Ian David Kaye, Mark F. Kurd, Jose A. Canseco, Alan S. Hilibrand, Alexander R. Vaccaro, Gregory D. Schroeder, Christopher K. Kepler

Study Design. Retrospective Cohort Study Objective. This study aimed to: (1) identify demographic differences based on the interval between surgeries; (2) compare differences in perioperative outcomes; (3) determine whether the interval between hip/spine surgery influences patient-reported outcomes (PROMs). Summary of Background Data. The presence of concurrent hip and spine disease in hip-spine syndrome creates a unique challenge in surgical decision-making given overlapping disease, with ideal timing between inde …

07.09.2026journal-article

American Journal of Medical Quality

Algorithmic Convergence Across Machine Learning Models Identifies Robust Strategic Priorities for Improving Patient Experience

Richard H. Savel, Payam Benson, Carmen Collins, Jill Fennimore, Dwight McBee, Kwaku Gyekye, Ije Akunyili, Marc Milano, Ruric Andy Anderson

Background: Improved patient experience is associated with enhanced clinical outcomes. The Hospital Consumer Assessment of Healthcare Providers and Systems Overall Rating of the Hospital (ORH) can be considered a quality metric for health systems. We hypothesized that machine learning models could identify actionable predictors of a less-than-top-box ORH score across a multihospital system and sought to determine whether these predictors were consistent across model architectures and hospital size. Methods: We anal …

07.09.2026journal-article

International Journal of Medical Science and Clinical Research Studies

Re-Epithelialization of Donor Sites and Meshed Skin Grafts Using Cryopreserved Cultured Cutaneous Allograft (Epifast®): Experience in Patients with Extensive Burns

Sergio Morales Acosta, Julio Cesar Villicaña Guillen, Arleth Castillo Aguilar, Angel Elian Flota Blanco, Areli Bath-Sheba González Graciano, Ivan Zuñiga Coronel, Natalia Avila Alba, Nancy Andrea Juárez Ferrusquía

Extensive full-thickness burns remain a major challenge in reconstructive surgery because limited donor-site availability frequently delays definitive wound coverage and increases the risk of infection, prolonged hospitalization, and hypertrophic scarring. Cryopreserved cultured cutaneous allografts have emerged as temporary biological dressings capable of promoting wound healing and accelerating re-epithelialization. This study aimed to evaluate the re-epithelialization time of donor sites and meshed split-thickne …

07.09.2026journal-article

Actuators

An Intelligent Bearing Fault Diagnosis Model with Physics-Information Fusion: Design and Interpretability Mechanism Research

Zhenyang Yu, Fei Shao, Qian Xu, Xingkun Xie, Lixiang He, Yinchuan Hou

To address the issue of limited interpretability in current deep learning-based bearing fault diagnosis methods, this study proposes a convolutional neural network model incorporating spectral physical constraints. The model integrates data-driven learning with physical constraints by embedding the spectral features of bearing faults as prior knowledge into the network architecture during training. This guides the model to adaptively learn spectral features closely associated with fault mechanisms. Experimental res …

07.09.2026journal-article

Cancers

Focused Ultrasound Therapies for Brain, Liver, Prostate, and Breast Cancer Applications: Clinical Evidence and Future Directions

Nassib Abou Heidar, Daniel Sheeran, Divine Nwafor, Olivia C. Sears, Shayan Moosa, Lynn T. Dengel, Kirsten Greene, Alan H. Matsumoto

Focused ultrasound (FUS) is an emerging and evolving minimally invasive therapeutic platform that is helping to redefine the management of malignant diseases. Clinical translation is advancing rapidly, with several completed and ongoing clinical trials demonstrating the safety, feasibility, and early efficacy of FUS in the treatment of cancer. This manuscript provides a synthesis of some of the available clinical data and device platforms being used and evaluates the results from completed and active clinical trial …

07.09.2026journal-article

Advanced Healthcare Materials

A Self‐Adjuvant Photothermal Carbon Dot‐Based Nanovaccine for Multimodal Nasopharyngeal Cancer Treatment and Prophylaxis

Ruiqi Ji, Yijun Mei, Zhiqiang Wang, Mingwu Shen, Xiangyang Shi

ABSTRACT Developing a “full‐cycle” strategy that integrates both treatment and prophylaxis remains a central challenge against nasopharyngeal carcinoma (NPC). Here, a biomimetic nanovaccine (CDC/Toy@CCM) is designed by coating toyocamycin (Toy)‐loaded redox‐responsive carbon dot clusters (CDCs) with homologous cancer cell membranes (CCMs). The obtained nanovaccine exhibits an average size of 70.7 nm, a high drug loading capacity (12.3%), and a superior photothermal conversion efficiency of 48.7%. The nanovaccine le …

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Aktuelle Forschung nach Fachgebiet

Reevaluation of the Medial Temporal Artery: A 3-Dimensional Anatomical Study and Its Clinical Implications for Safe Auricular Filler Injections

Only the Boey Score Discriminates In-Hospital Mortality After Gastric Perforation: A STARD-Compliant Comparison with the Jabalpur Score

Heterogeneity in major amputation risk among patients with WIfI (wound, ischemia, foot infection) Stage 4 diabetic foot ulcers

No prophylactic drains in emergency abdominal surgery- a prospective, cohort study

Intestinal Barrier Dysfunction in Ulcerative Colitis: Mechanisms and Therapeutic Perspectives

How does the gut microbiome impact rheumatoid arthritis?

Management of Preoperative Anemia: Review of Best Practices in Cardiac Surgery

Clinical Relevance of Preoperative Upper Gastrointestinal Endoscopy before Sleeve Gastrectomy: A Retrospective Cohort Study of 30-Day Outcomes

Outcomes of hyaluronic acid and dextrose prolotherapy on surgically induced rat osteoarthritis: Single versus combined treatment

Immune pathway activation in gastric cancers with LINE-1 retrotransposon overexpression and homologous recombination deficiency

Evolução clínica e desafios terapêuticos na doença de Parkinson em fase avançada: uma revisão sistemática.

A Comparison of Ground Reaction Forces, Tibial Forces, and Clinician Perspectives on Tibial Bone Load During Common Rehabilitation Exercises

The Role of Infrared Thermography in the Diagnosis and Monitoring of Diabetic Foot Infection: A Systematic Review

PDGFRA amplification could be a poor prognostic factor of advanced undifferentiated pleomorphic sarcoma in a comprehensive genomic profiling cohort

Chronological age and failure to rescue after colorectal cancer surgery: A multicentre cohort study

Cognitive heterogeneity in major depressive disorder: Neuroimaging, transcriptomic, and neurotransmitter profiles

AMELIORATIVE EFFECT OF SOLANUM XANTHOCARPUM AGAINST CHEMICAL-INDUCED DIABETIC NEPHROPATHY IN RATS

Single or multiple nutritional hormone receptor modulators for chronic kidney disease

A Shorter Surgical Interval May be Associated with Improved Patient-reported Outcomes in Hip-spine Syndrome

Algorithmic Convergence Across Machine Learning Models Identifies Robust Strategic Priorities for Improving Patient Experience

Re-Epithelialization of Donor Sites and Meshed Skin Grafts Using Cryopreserved Cultured Cutaneous Allograft (Epifast®): Experience in Patients with Extensive Burns

An Intelligent Bearing Fault Diagnosis Model with Physics-Information Fusion: Design and Interpretability Mechanism Research

Focused Ultrasound Therapies for Brain, Liver, Prostate, and Breast Cancer Applications: Clinical Evidence and Future Directions

A Self‐Adjuvant Photothermal Carbon Dot‐Based Nanovaccine for Multimodal Nasopharyngeal Cancer Treatment and Prophylaxis