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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Quality of Life Research

Capturing quality of life in pouch anal and vaginal fistula: development of PAVF-QoL-14, a patient-reported outcome measure

Lillian Reza, Laith Alrubaiy, Lara Bapir, Nusrat Iqbal, Charlene Sackitey, Easan Anand, Sally Hughes, Mina Babbar, Rali Marinova, Petya Marinova, Pearl Avery, Phillip Lung, Ailsa Hart, Sue Clark, Phil Tozer

Abstract Introduction Perianal pouch fistula can significantly affect quality of life, yet no disease-specific patient reported outcome measure (PROM) exists. We have developed and validated a 14-item PROM—the Pouch Anal and Vaginal Fistula Quality of Life scale (PAVF-QoL-14). Methods COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) guidance for PROM development was used to develop and validate PAVF-QoL-14. A systematic literature review and semi-structured patient interviews ( …

03.09.2026journal-article

Frontiers in Public Health

A comparative evaluation of generative AI chatbots for patient-oriented advice on painful diabetic peripheral neuropathy: safety, accuracy, guideline concordance, actionability, and readability

Lina Gu, Zhaole Gong, Xiaoli Qian, Ling Miao, Zhengfeng Gu

Background Patients with painful diabetic peripheral neuropathy (PDPN) increasingly use generative artificial intelligence chatbots for information on symptoms, treatment, foot care, and when to seek professional help. Their usefulness depends on safety, accuracy, guideline concordance, actionability, and readability. Objective To compare five publicly accessible generative AI chatbots in answering standardized patient-oriented questions about PDPN. Methods: Sixty standardized English-language questions covering ei …

03.09.2026journal-article

AlQalam Journal of Medical and Applied Sciences

Clinical Effects and Safety of Deep Dry Needling for Upper Trapezius Myofascial Pain Syndrome: A Prospective Single-Group Study in Tripoli, Libya

Fatima Gazah

Myofascial pain syndrome (MPS) is a common musculoskeletal condition characterised by myofascial trigger points, pain, and functional limitations. Although dry needling is widely used in physiotherapy for myofascial pain, locally derived clinical evidence from Libya remains limited. This study evaluated the short-term clinical effects and safety of deep dry needling in patients with upper trapezius myofascial pain syndrome. A prospective, quasi-experimental, one-group pretest–posttest case series was conducted in t …

03.09.2026journal-article

Suicide and Life-Threatening Behavior

Nighttime Sensory–Behavioral Activation and Admission Suicidality in Young Inpatients With Major Depressive Disorder: A Retrospective Clinical‐Record Study

Xinqi Huang, Xiaolong Kuang, Hongxing Wang

ABSTRACT Introduction Suicide risk assessment during psychiatric admission may benefit from clinically observable information beyond overall depressive symptom severity. This study examined whether clinician‐documented nighttime sensory–behavioral activation was associated with admission suicidality in young inpatients with major depressive disorder (MDD). Methods This retrospective study included 406 inpatients aged 15–35 years with moderate‐to‐severe MDD. Nighttime sensory–behavioral activation was coded as none, …

03.09.2026journal-article

Experimental & Molecular Medicine

Proteomic analysis of pancreatic endocrine cells by mechanistic single-cell isolation identifies membrane pathways

Lihi Grinberg, Worood Sirhan, Marina Kurtz, Michael Assa, Assaf Malka, Shira Perez, Corine Katina, Yishai Levin, Ron Piran

Abstract To better understand diabetes and normoglycemia, pancreatic islet biology requires a precise molecular understanding of islet cell types at both the transcriptomic and proteomic levels. While transcriptomic analyses are well established, comprehensive proteomic characterization has been lacking, limiting our knowledge of islet molecular complexity. Here we introduce a nonenzymatic, mechanistic single-cell isolation technology using laser microdissection (LMD7), facilitating proteomic and transcriptomic ana …

03.09.2026journal-article

Frontiers in Medicine

The impact of maternal hepatitis B virus infection on IVF/ICSI-assisted pregnancy outcomes: a propensity score-matched cohort study

Wenwen Jiang, Suqin Zhu, Rongshan Li, Yan Sun, Xiaojing Chen, Beihong Zheng

Background Hepatitis B virus (HBV) infection is highly prevalent among women of reproductive age in China, yet whether maternal HBV carrier status affects the outcomes of assisted reproduction remains unclear. Published studies have yielded conflicting results, most were underpowered or inadequately controlled for confounders, and few have tracked outcomes beyond early pregnancy. This study used propensity score matching to evaluate the impact of maternal HBV infection on laboratory, clinical pregnancy, obstetric, …

03.09.2026journal-article

Frontiers in Oncology

Performance evaluation of large language models in bladder cancer patient education Q&A: a cross-sectional study

Dian Wan, Youwen Li, Zheng Dong, Chen Dai, Jinghe Ye, Song Li, Sunlu Jiang

Background Bladder cancer ranks among the most prevalent urological tumors worldwide, with its global incidence continuing to rise steadily. Although patient education materials (PEMs) play a crucial role in enhancing disease comprehension and supporting joint clinical decision-making, current online resources frequently surpass the readability thresholds recommended for the general public. Large language models (LLMs) hold promise for health communication, yet no systematic assessment has been conducted regarding …

03.09.2026journal-article

Frontiers in Medicine

Safety profiles of cyclosporine and tacrolimus in pregnancy: a pharmacovigilance analysis using the FDA Adverse Event Reporting System

Yanhong Deng, Senling Feng, Shengying Shi, Zhongwen Yuan, Zhengrong Mei, Jinjin Yin, Dongdong Jing, Shaozhi Liu

Background The increasing use of calcineurin inhibitors (CNIs) among pregnant women highlights the importance of continuous safety surveillance. This study aimed to characterize the real-world safety signals of cyclosporine (CsA) and tacrolimus (TAC) during pregnancy using data from the FDA Adverse Event Reporting System (FAERS) database. Methods We applied four disproportionality data-mining algorithms (reporting odds ratio, proportional reporting ratio, Bayesian confidence propagation neural network, and empirica …

03.09.2026journal-article

Clinical Research in Cardiology

Routine versus selective use of a femoral protection wire in transfemoral TAVI: a single-centre analysis of vascular complications

Marc Adrian Rogmann, Victor Klingemann, Max Meertens, Majid Ahoopai, Karl-Philipp Rommel, Philipp Lurz, Ralph S. von Bardeleben, Martin Geyer

Abstract Background Transfemoral transcatheter aortic valve implantation (TAVI) is the treatment of choice for severe aortic stenosis in patients with elevated surgical risk. However, vascular complications remain a major source of morbidity and mortality. The protection wire technique was introduced to prevent major access-related complications, but its role in contemporary TAVI practice is uncertain. Aims To evaluate whether routine protection wire use reduces vascular complications in contemporary transfemoral T …

03.09.2026journal-article

Frontiers in Cell and Developmental Biology

Antibacterial polyphenols for osteomyelitis treatment: from antibacterial mechanisms to biomaterial-based delivery

Xuemei Cao, Yuanmin He, Yamin Zhu, Ping Gu, Ting Dai, Yuyu Zheng

Osteomyelitis is a refractory infection caused by bacterial invasion of bone tissue. Biofilms, small-colony variants (SCVs), and intracellular persistence enable bacteria to evade immune clearance and antibiotic killing, while sequestra and implant surfaces may act as long-term infection reservoirs. Some pathogens can also invade the osteocyte lacuno-canalicular network, further hindering complete eradication. Meanwhile, persistent inflammation, oxidative stress, and impaired local blood supply aggravate bone destr …

03.09.2026journal-article

Frontiers in Immunology

Clinical remission trajectories and histopathological associations in patients with IgA nephropathy treated with targeted-release budesonide: a real-world cohort study

Dafeng He, Jun Xu, Bo Gao, Mingzhu Jiang, Wenjin Liu, Chuanyan Zhao, Xinrui Li, Chunlei Lu, Mengyue Zhu, Hongbin Mou, Guangyu Bi

Background Targeted-release (TR) budesonide provides upstream mucosal immunomodulation in IgA nephropathy (IgAN) by targeting the gut-associated lymphoid tissue. However, the extent to which distinct downstream immune-inflammatory phenotypes and established structural chronicity shape real-world remission trajectories remains insufficiently characterized. Methods We retrospectively analyzed 57 adults with biopsy-proven primary IgAN treated with TR-budesonide. Prespecified milestones were Very Early Response (VER) a …

03.09.2026journal-article

Measurement Science and Technology

Prior-enhanced cross-modal vibration and acoustic fusion network based on directed attention for machine fault diagnosis

Qibo Wang, Tianci Zhang

Abstract Existing intelligent fault diagnosis methods based on multimodal fusion face the problem of significant differences in the representation capabilities of different modal data for machine faults, making it difficult to achieve optimal cross-modal data fusion and accurate fault identification. This study proposes a prior-enhanced cross-modal vibration and acoustic data fusion network based on directed attention mechanisms to address the aforementioned issue. First, through preliminary experiments in fault di …

03.09.2026journal-article

Journal of Advances in Medicine and Medical Research

Age-related BAX and Ki-67 Expression in Regional Lymph Nodes of Infants who Died from Measles: A Retrospective Immunohistochemical Study

Doniyor Saidovich Turdimatov

Background: Measles can produce substantial lymphoid tissue injury and immunosuppression, but age-related patterns of apoptotic and proliferative activity in regional lymph nodes during fatal measles in infancy remain insufficiently characterised. Aims: To evaluate age-related changes in BAX and Ki-67 immunohistochemical expression in regional lymph nodes of infants who died from measles. Study Design: A retrospective morphological and immunohistochemical study of archived autopsy specimens. Methodology: Regional l …

03.09.2026journal-article

Journal of Clinical Medicine

Preoperative Alanine Aminotransferase and Postoperative ALT Elevation: A Retrospective Cohort Study

Jisun Choi, Hyun Young Lim, Jeayoun Kim, Seungwon Lee, MiHye Park

Background: Modestly elevated serum alanine aminotransferase (ALT) levels are associated with increased morbidity and mortality in the general population; however, the perioperative significance of mildly elevated preoperative ALT levels in surgical patients remains unclear. Methods: This retrospective cohort study included adults undergoing non-hepatic, non-cardiac surgery at Samsung Medical Center. Patients with preoperative ALT measured within 3 months and <2 times the upper limit of normal (ULN) were eligible. …

03.09.2026journal-article

Jurnal Sehat Indonesia (JUSINDO)

Advanced-Stage Retinoblastoma with Systemic Manifestations Due to Delayed Diagnosis of Congenital Leukocoria: A Case Report

Alyaa Nabiila, Faliqul Bahar Muhammad, Basuki Rokhmad

Background: Retinoblastoma is the most common primary intraocular malignancy in children, with leukocoria as its hallmark clinical sign. Delayed diagnosis may lead to advanced disease, extraocular extension, and a poor prognosis. Case Presentation: A 2-year-4-month-old girl presented to the emergency department with recurrent vomiting, weakness, and decreased activity. Leukocoria of the left eye had been noted since birth but had never been medically evaluated. Ophthalmologic examination revealed no light perceptio …

03.09.2026journal-article

Annals of Surgery

Expanding Indications of Nonvascularized Rectus Fascia as a Cross-Disciplinary Allograft: A Prospective Single-Center Study

Laurens J. Ceulemans, Ewout Muylle, Gert De Hertogh, Andrea Zajacova, Marina G.M.C. Mori da Cunha, Steffi De Pelsmaeker, Ina Benoy, Antoine Dubois, Thomas Douchy, Daphne Hompes, Albert Wolthuis, Diethard Monbaliu, Philippe Nafteux, Paul De Leyn, André D´Hoore, Jacques Pirenne, Nele Van De Winkel

Objective: To report the expanding application of nonvascularized rectus fascia allotransplantation (NVRF-alloTx) in solid organ transplant (SOT) and non-SOT patients and evaluate its effectiveness, integration, and immunologic response in complex abdominal and thoracic reconstruction. Summary Background Data: Synthetic and biological meshes are limited by infection risk, long-term failure, donor-site morbidity, and high cost. NVRF-alloTx, first applied in intestinal/multivisceral-Tx with a 5.9% herniation rate, of …

03.09.2026journal-article

Applied Sciences

Deep Learning in Multimodal Breast Cancer Imaging: From Image Reconstruction and Segmentation to Diagnosis and Treatment Response Prediction

Dorota Bartusik-Aebisher, Sara Czech, Jakub Szpara, Avijit Paul, Marvin Xavierselvan, David Aebisher

Breast cancer imaging is central to screening, diagnosis, staging, treatment monitoring, and post-treatment surveillance, but image interpretation remains limited by variable image quality, interobserver variability, false-positive findings and heterogeneous tumor biology. This narrative review summarizes current applications of deep learning in multimodal breast cancer imaging, with emphasis on image reconstruction, image enhancement, lesion detection, segmentation, classification, biomarker prediction, treatment …

03.09.2026journal-article

Neurocritical Care

Time-Stamped Annotations in High-Frequency Physiological Data: Evaluating an Approach for Assessing Annotation Plausibility in the CENTER-TBI Dataset

Sara Turella, Erta Beqiri, Stefan Yu Bögli, Bogdan Ianosi, Ihsane Olakorede, Tommaso Zoerle, Jeanette Tas, Raimund Helbok, Peter Smielewski, the Smart Neuromonitoring to Support Precision Medicine in Acute Central Nervous Injury (SOPRANI) collaborators and the CENTER-TBI High-Resolution Sub-Study Participants and Investigators, Audny Anke, Ronny Beer, Bo-Michael Bellander, David Nelson, Andras Buki, Giorgio Chevallard, Arturo Chieregato, Giuseppe Citerio, Endre Czeiter, Bart Depreitere, George Eapen, Shirin Frisvold, Stefan Jankowski, Daniel Kondziella, Lars-Owe Koskinen, Geert Meyfroidt, Kirsten Moeller, Anna Piippo-Karjalainen, Rahul Raj, Andreea Radoi, Juan Sahuquillo, Arminas Ragauskas, Saulius Rocka, Jonathan Rhodes, Rolf Rossaint, Ana Stevanovic, Oliver Sakowitz, Nina Sundström, Riikka Takala, Tomas Tamosuitis

Abstract Background/Objective High-resolution neuromonitoring data with time-stamped clinical annotations offer valuable insights into treatment responses, though reliability is limited by manual documentation. This study aims to develop and demonstrate a three-step methodological framework to evaluate the plausibility of time-stamped clinical annotations using a high-frequency dataset. The framework integrates visual inspection of reference annotations and automated classification based on predefined physiological …

03.09.2026journal-article

Frontiers in Pediatrics

Clinical utility of renal and urinary tract point-of-care ultrasound in the neonatal intensive care unit: insights from a case series

Gayatri Morajkar, Sujata Deshpande, Sachin Verma, Vivek Goyal, Jayanta Hazarika, Prasoon Bansal, Yogen Singh, Pradeep Suryawanshi

Background Clinical decision-making in acutely ill neonates often depends on the timely identification of the underlying pathology. Bedside point-of-care ultrasound (POCUS), performed by the treating clinician, allows immediate correlation of imaging findings with evolving clinical status. However, its role in evaluating renal and urinary tract abnormalities in neonates remains relatively underexplored and is not yet widely integrated into routine practice. Methods This multicenter case series included data from fo …

03.09.2026journal-article

Journal of Palliative Medicine

Liminal Personhood and Continuity of Moral Identity in Clinical Care

Harvey Max Chochinov, Marianne Sofronas, Joseph J. Fins

Capacity-based frameworks of personhood risk marginalizing individuals whose agency, cognition, or consciousness are diminished by illness, brain injury, or proximity to death. This article introduces the concept of liminal personhood , which describes the persistence of moral and relational identity even as conventional markers of personhood fade. Drawing on ethical, philosophical, and neuroethical scholarship, the paper argues that failing to recognize enduring personhood can fracture patient identity and erode c …

03.09.2026journal-article

Frontiers in Pharmacology

Pharmaco-multiomics in major depressive disorder: a narrative review and proposed translational framework for difficult-to-treat and treatment-resistant depression

Bernhard T. Baune

Background Antidepressant prescribing in major depressive disorder (MDD) remains dominated by sequential trial and error, particularly when illness becomes difficult to treat (DTD) or meets conventional treatment-resistant depression (TRD) criteria. Objective This narrative review evaluates pharmacogenomics (PGx), therapeutic drug monitoring (TDM), metabolomics/lipidomics, immune-inflammatory markers, proteomics, transcriptomics, epigenomics, microbiomics, and multi-omics machine learning according to their capacit …

03.09.2026journal-article

Diabetic Medicine

A novel deep intronic EIF2AK3 variant disrupts splicing and causes Wolcott–Rallison syndrome

Alaa Al Assi, Georgia Bonfield, James Russ‐Silsby, Suhel Ahmed, Thomas W. Laver, Kadri Karaer, Bayram Özhan, Ayca Altincik, Kashyap A. Patel, Jayne A. L. Houghton, Sarah E. Flanagan, Matthew B. Johnson, Elisa De Franco

Abstract Aim Deep intronic variants can disrupt splicing and cause monogenic disease but are missed by routine genetic testing. This study assessed the contribution of deep intronic variants to Wolcott–Rallison syndrome (WRS), a recessive disorder characterized by early‐onset diabetes and progressive multisystem disease caused by loss‐of‐function EIF2AK3 variants. Methods We investigated a cohort of 116 individuals referred to the Exeter Genomics Laboratory for genetic testing who had diabetes diagnosed at ≤2 years …

03.09.2026journal-article

Indian Journal of Nuclear Medicine

18 F FDG PET/CT in a Rare Case of CIC::NUTM1 Sarcoma

Yamini Dharmashaktu, Sameer Rastogi, Adarsh Barwad, Ritwik Nitin Wakankar, Shamim A Shamim

Capicua transcriptional repressor ( CIC )-rearranged sarcomas are exceedingly rare and highly aggressive malignancies affecting young individuals predominantly, and CIC::NUTM1 is thought to be a molecular variant of CIC-rearranged sarcoma. It has a poor prognosis and a rapid progression. Here, we present a case of a 3-year-old male with CIC::NUTM1 sarcoma of the pelvis who presented with complaints of constipation associated with severe pain for which 18 F fluorodeoxyglucose positron emission tomography/computed to …

03.09.2026journal-article

Eastern Mediterranean Health Journal

Assessing the predictors of treatment-seeking and health care access barriers among transgender individuals in Pakistan

Athar Memon, Sameena Ourangzaib, Benjamin R. Bates, Shiraz Shaikh

Background: Transgender individuals in Pakistan face barriers to health care access, increasing the risk of serious disease transmission. Aim: To identify the predictors of treatment-seeking intention and health care access delays among transgender individuals in Karachi, Pakistan. Methods: Between December 2024 and April 2025 we interviewed 360 individuals, aged ≥18 years, who identified as transgender and had accessed health care within the past 12 months. We analysed the data using SPSS version 20 and conducted …