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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
14.08.2026journal-article

Nutrients

Medical Nutrition Therapy with Meal Sequence and Divided Carbohydrate Intake: Associations with Ketonuria Resolution and Neonatal Outcomes in Gestational Diabetes Mellitus

Saeko Imai, Shizuo Kajiyama, Yuki Higuchi, Shintaro Kajiyama, Yoshitaka Hashimoto, Michiaki Fukui

Background/Objectives: Ketonuria is frequently observed in women with gestational diabetes mellitus (GDM), particularly when energy and carbohydrate intake is inadequate. This retrospective study evaluated nutritional status and neonatal outcomes following dietitian-led medical nutrition therapy (MNT) in 517 Japanese women with GDM with and without ketonuria. Methods: Dietary counseling emphasized a meal sequence in which vegetables were consumed before protein-rich foods and carbohydrates were consumed last, toget …

14.08.2026journal-article

RSV

Care Management for Neurological Sequelae in Brazil's Unified Health System: Strategies for Comprehensive Rehabilitation

Juliana Aparecida Pereira Ribeiro, Gabriela Eiras Ortoni, Mônica Rodrigues da Silva, Wenderson Gonçalves Andrade, Janayna de Oliveira Silva, Mônica Alessandra Dias Rocha, Regina Gabriela Caldas de Moraes, Oldair Donizete Galeni

Neurological sequelae resulting from stroke, traumatic brain injury, spinal cord injury, neurodegenerative disorders, and other neurological conditions have become a major challenge for healthcare systems due to their long-term impact on functionality, autonomy, and quality of life. In Brazil's Unified Health System (SUS), comprehensive rehabilitation requires coordinated care management capable of integrating different levels of healthcare while ensuring continuity, equity, and patient-centered interventions. This …

14.08.2026journal-article

Journal of Clinical Medicine

Hematological Toxicities in the Modern Era of Melanoma Therapy

Rodica Anghel, Ana-Maria Zamfirescu-Deryder, Vlad-Luca Moga, Antonia-Ruxandra Folea, Radu-Valeriu Toma, Andreea-Iren Șerban, Liviu Bîlteanu

Background/Objectives: The advent of immune checkpoint inhibitors (ICIs) and targeted therapies has revolutionized advanced melanoma treatment but introduced unique immune-related adverse events (irAEs). Hematological irAEs (Hem-irAEs) are rare but carry disproportionately high morbidity and mortality. This review systematically synthesizes current literature to comprehensively understand the incidence, pathophysiology, clinical presentation, and management of Hem-irAEs in modern melanoma therapy. Methods: A compre …

14.08.2026journal-article

Traumatology and Orthopedics of Russia

EFFICACY AND SAFETY OF VARIOUS ORAL ANTIBACTERIAL THERAPY REGIMENS FOR IMPLANT-ASSOCIATED INFECTION CAUSED BY LEADING GRAM-NEGATIVE PATHOGENS

Olga S. Tufanova, Svetlana A. Bozhkova, Ekaterina M. Gordina, Alexander P. Antipov

Background. The high level of antibacterial resistance of the leading gram-negative pathogens of orthopedic infection leads to difficulties in selecting antibacterial drugs at both in patient and out patient treatment stages. Does the antibiotic resistance of Gram(-) bacteria isolated from patients to oral antibiotics affect the effectiveness of treatment? Is it necessary to prescribe oral AB drugs to patients who have isolated a pathogen resistant to them? Are there differences in the efficacy and safety of using …

14.08.2026journal-article

Pharmaceutics

Machine Learning for Valproic Acid Therapy: A Scoping Review of Pharmacokinetic-Prediction Models and Pharmacokinetic-Informed Clinical Outcome Models

Janthima Methaneethorn, Supavadee Aramvith, Wanaporn Charoenchokthavee, Sohaib Habiballah, Khanita Duangchaemkarn, Brad Reisfeld

Background/Objectives: Population pharmacokinetics (PopPK) has been used to aid valproic acid (VPA) dose individualization. However, this approach faces limitations owing to the complexity and high dimensionality of datasets. Machine learning (ML) can handle these challenges. However, the comparative evaluation of these ML algorithms and their practical application in optimizing VPA therapy have not yet been established. This review aims to summarize the current evidence, identify research gaps, and outline ML appl …

14.08.2026journal-article

Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology

Quality of Life Outcomes in Patients with Pulmonary Hypertension Receiving Prostacyclin Therapy: Impact of Anxiety, Depression, Sociodemographic Characteristics, and Treatment-Related Factors

Fatma Yıldırım, Elif Ok, Vesile Ünver, Dilek Sezgin, Halil Ataş, Betül Şentürk Saraç

Objective: Despite advances in prostacyclin therapy, pulmonary hypertension (PH) continues to impair patients' quality of life (QoL). This study aimed to identify the clinical and psychological factors associated with QoL in patients receiving prostacyclin therapy. Method: This cross-sectional study was conducted between July 2023 and September 2024 and included 58 patients with PH receiving prostacyclin therapy. Data were collected using a structured questionnaire assessing sociodemographic and disease-related cha …

14.08.2026journal-article

Pilot and Feasibility Studies

Protocol for a feasibility study of a self-help resource based on the principles of cognitive behavioural therapy to reduce needle fear in young people aged 11- to 16 years

Fiona Sotir, David White, Gemma Wheeler, Helen Rodd, Zoe Marshman

Abstract Background Needle fear affects up to half of all young people, with the potential to impede their accessing and acceptance of healthcare interventions. There is presently a lack of accessible self-help resources available to support young people in managing needle-based procedures. This feasibility study aims to create a trial protocol for future definitive assessment of a self-help tool co-designed with young people, to manage their fear of needles. Methods This article presents the protocol for a study t …

14.08.2026journal-article

physioscience

Group therapy in physiotherapy

Marwin Weber, Lea Gorenflo, Lukas Horstmeier, Nicole Wimmesberger, Franziska Killinger, Julia Allekotte, Joerg J. Meerpohl, Sebastian Voigt-Radloff, Angelika Eisele-Metzger

Abstract Group therapy is rarely used in outpatient physiotherapy in Germany, although it is permitted according to the “Heilmittelrichtlinie” and would be preferable to individual therapy if equally suitable. Group therapy could help expand treatment capacities, reduce costs, and promote factors such as motivation and adherence. Whether it is similarly effective to individual therapy for diagnoses that are frequently prescribed, however, remains unclear. To provide an overview of the current evidence on group-base …

14.08.2026journal-article

Discover Artificial Intelligence

Wearable art therapy as a novel multisensory intervention for alleviating depressive symptoms

Jin Xue, Herdian

Abstract Depression is a main global cause of emotional disability, impacting cognitive function, social interactions, and quality of life. Traditional assessment methods depend on subjective, time-consuming self-reported surveys and clinical interviews, and challenging for continuous monitoring and intervention. To address these limitations, this research-proposed system integrates wearable sensing technologies, multisensory art therapy, and deep learning (DL) techniques to provide personalized and continuous ment …

14.08.2026journal-article

Gynecology and Minimally Invasive Therapy

Ovarian Cystectomy by Vaginal Natural Orifice Transluminal Endoscopic Surgery at 12 Weeks of Pregnancy: A Case Report

Kotone Suzuki, Mai Shimura, Ayaka Yukimori, Hana Ueda, Rena Maeda, Satomi Arakawa, Mari Ishizaka, Riho Sato, Asumi Mishina, Yoshiko Arata, Tatsuya Matsunaga, Yuka Oi

Abstract We report a rare case of bilateral ovarian tumor resection using vaginal natural orifice transluminal endoscopic surgery (vNOTES) at 12 weeks of gestation. A 33-year-old primigravida presented with two cystic ovarian masses, wherein bilateral mature teratomas were suggested based on magnetic resonance imaging. Given the risks associated with the masses during pregnancy, vNOTES was the preferred surgical approach. The tumors were extracorporeally resected after aspiration through the posterior vaginal forni …

14.08.2026journal-article

Chronic Diseases and Translational Medicine

Rehabilitation After Stroke in a Transition From Hospital to Municipality—Impact of Amount of Rehabilitation

Gabriel Tafdrup Notkin, Dorthe Gaby Bove, Lisbet Lind, Michael Broksgaard Jensen, Stig Molsted

ABSTRACT Background Stroke is a leading cause of long‐term disability that impairs physical function and health‐related quality of life (HRQoL). Rehabilitation during and after hospitalization is essential for promoting neurological recovery and functional independence. This study aims to investigate (1) changes in physical function, balance, and HRQoL from hospital admission to completion of rehabilitation after stroke; (2) associations between rehabilitation amount and changes in physical function and balance; an …

14.08.2026journal-article

Frontiers in Medicine

Early dynamic immune-inflammatory and nutritional recovery signature is associated with durable benefit and early progression in advanced non-small cell lung cancer receiving first-line PD-1/PD-L1 inhibitor-based therapy: a real-world retrospective cohort study

Tingting Zhan, Hang Cao

Background Durable benefit from first-line PD-1/PD-L1 inhibitor-based therapy remains heterogeneous in advanced non-small cell lung cancer (NSCLC). Baseline biomarkers, including PD-L1 tumor proportion score, tumor mutational burden, and static inflammatory indices, only partly capture this heterogeneity and may not reflect host response. We evaluated whether a cycle 2 immune-inflammatory and nutritional recovery signature from blood markers was associated with durable clinical benefit (DCB), early progression, and …

14.08.2026journal-article

Medicina

Clinical Outcomes Following Transition from ICS/LABA to Single-Inhaler Triple Therapy in Patients with Uncontrolled Asthma: A Real-World Cohort Study

Melis Yağdıran, Kurtuluş Aksu

Background and Objectives: A considerable proportion of patients with asthma remain inadequately controlled despite treatment with inhaled corticosteroid/long-acting β2-agonist (ICS/LABA) therapy. Single-inhaler triple therapy comprising an inhaled corticosteroid, a long-acting β2-agonist, and a long-acting muscarinic antagonist (ICS/LABA/LAMA) has emerged as an effective step-up treatment; however, real-world evidence remains limited. This study aimed to evaluate the effects of transitioning from high-dose ICS/LAB …

14.08.2026journal-article

Machine Learning and Knowledge Extraction

Persona-ASR: Bilingual Target-Speaker Speech Recognition for Kazakh–English Overlapping Speech

Rakhat Meiramov, Tomiris Rakhimzhanova, Adil Taibassarov, Zhanat Makhataeva, Huseyin Atakan Varol

Target-speaker automatic speech recognition (TS-ASR) enables transcription of a specific speaker in multi-talker environments, yet remains largely unexplored for multilingual, low-resource languages. Existing TS-ASR systems predominantly target monolingual English using diarization-based or speaker-embedding approaches, leaving a critical gap for languages such as Kazakh, where code-switching with Russian and English is commonplace. We propose Persona-ASR, a modular two-stage architecture. The first stage is an exp …

14.08.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Effects of plyometric training on explosive power and swimming performance in adolescent swimmers: a systematic review and meta-analysis with dose-response analysis

Rangxi Jin, Mitchell James Finlay, Francisco Cuenca-Fernández, Wei Huang

Abstract Adolescent swimmers depend heavily on lower-limb power during critical phases such as the block start, wall turn, and sprints, with the circa-peak height velocity (PHV) period representing a sensitive window for neuromuscular development. Plyometric training (PT), utilizing the stretch-shortening cycle, is a key component of long-term athletic development, yet evidence stratified by maturation stage is lacking. This systematic review and meta-analysis searched PubMed, Web of Science, Embase, EBSCO, Cochran …

14.08.2026journal-article

Endocrine Connections

Impact of GAD-65 antibody detection on antihyperglycemic therapy in T2D

Sharon Halliburton, Eric Herber, Kevin M Pantalone, Marcie Parker, Amanda Soric

Abstract Guidelines recommend that latent autoimmune diabetes in adults be managed similarly to type 1 diabetes, emphasizing early insulin initiation, while other guidance suggests incorporating non-insulin antihyperglycemic therapies based on comorbidities and C-peptide levels. The objective of this study was to explore whether glutamic acid decarboxylase-65 autoantibody detection in individuals diagnosed with type 2 diabetes impacts antihyperglycemic treatment. This retrospective, observational cohort study at an …

14.08.2026journal-article

INTERNATIONAL JOURNAL OF ENGLISH LANGUAGE AND COMMUNICATION STUDIES

Metaphors of Hope and Despair in President Bola Ahmed Tinubu’s May 29, 2023 Inaugural Speech

Ehuiken-Ayetin Marvellous

Studies on metaphor in political speeches have gained prominence in recent years. These studies are often interested in the versatile discourse functions of metaphors and how political leaders deploy them as powerful weapons in their armoury of political oratory. However, not much research has focused on the use of metaphors by politicians to conceptualize hope and despair. This study examined the metaphors of hope and despair in president Bola Ahmed Tinubu’s inaugural speech of May 29, 2023. The study sought to fi …

14.08.2026journal-article

Diseases of the Colon & Rectum

SHORT- VERSUS LONG-COURSE RADIATION IN TOTAL NEOADJUVANT THERAPY FOR LOCALLY ADVANCED RECTAL CANCER: A PROPENSITY-MATCHED NATIONAL CANCER DATABASE ANALYSIS

Bryan Szeglin, Michael Consul, Megan Breckheimer, James J. Whitbread, Miloslawa Stem, Alodia Gabre-Kidan, Andrea Bafford, John Migaly

BACKGROUND: Locally advanced rectal cancer is treated with total neoadjuvant therapy which consists of neoadjuvant chemotherapy, radiation, and surgery. The comparative efficacy of long and short course radiotherapy within total neoadjuvant therapy remains uncertain. OBJECTIVE: Compare overall survival and pathological outcomes between patients treated with long or short course radiation as components of total neoadjuvant therapy. DESIGN: Retrospective cohort study. SETTINGS: National Cancer Database, 2018 to 2023. …

14.08.2026journal-article

JAMA Network Open

Internet-Based Cognitive Behavioral Therapy and Telephone Coaching for Anxiety in Children

Andre Sourander, Katri Kaajalaakso, Tarja Korpilahti-Leino, Terja Ristkari, Tiia Ståhlberg, Susanna Hinkka-Yli-Salomäki, Yuko Mori, Terhi Luntamo

Importance Limited data are available on the long-term effectiveness of internet-based cognitive–behavioral therapy (iCBT) for anxiety among children. Objective To evaluate the association of an iCBT intervention with anxiety in children compared with a psychoeducation control group over 12 and 24 months. Design, Setting, and Participants This cohort study is based on 2-year follow-up data of the randomized clinical trial Master Your Worries, which was conducted between August 2017 and January 2020. Participants we …

14.08.2026journal-article

Gynecology and Minimally Invasive Therapy

Misdiagnosed Scar Ectopic Pregnancy: From Suction Evacuation to Laparoscopic Excision – A Case Report

Ipsita Mohapatra, Saubhagya Kumar Jena, Laveti Sai Sarvazna, Subha Ranjan Samantaray

Abstract Scar ectopic pregnancy, a rare form of ectopic pregnancy, is implanted in the myometrium at the site of a previous cesarean section scar. With the increasing rate of cesarean deliveries, the incidence of cesarean scar ectopic pregnancies has been increasing. It is the implantation of blastocyst in the uterine scar of previous cesarean delivery. Scar ectopic pregnancies are challenging to diagnose, especially in the early stages. On ultrasound, they may appear similar to normal intrauterine pregnancies or o …

14.08.2026journal-article

Frontiers in Pharmacology

Investigation of complex miRNA-mRNA interaction networks during JAK inhibitor therapy in rheumatoid arthritis

János Rózsa, Dóra Csige, Monika Bodoki, Zsófia Hagymási-Szabó, Ferenc Tóth, Szilvia Szamosi, Ágnes Horváth, Nóra Bodnár, Edit Végh, Sándor Szántó, Gabriella Szűcs, Zsófia Pethő, Zsuzsanna Gyetkó, Levente Bodoki, János Kádas, Zoltán Szekanecz, Szilárd Póliska

Background MicroRNAs (miRNAs) are small molecules that contribute to the regulation of gene expression by binding to messenger RNAs (mRNAs), controlling the amount of proteins being produced. In the past few decades, biologic and targeted synthetic therapies (e.g., Janus kinase (JAK) inhibitors) have emerged for the treatment of rheumatoid arthritis (RA), which have promised new possibilities for treating the disease. By inhibiting the inflammatory cascade, these drugs are able to moderate further mRNA expression o …

14.08.2026journal-article

Small

In Situ Self‐Assembled Nanoparticles for Cascade‐Instructed Photodynamic Therapy and Real‐Time Treatment Feedback Imaging

Taoli Sun, Wenbin Liu, Minghui Yu, Beibei Wang, Zhengjie Liu, Zijuan Hai

ABSTRACT Although the cancer treatment efficacy has significantly improved, delayed and isolated evaluation methods are difficult to prevent excessive or insufficient treatment. Therefore, the single molecule for simultaneous therapy and feedback has become a promising tool. Herein, we develop an in situ self‐assembled probe (HPO‐CYFF‐TPP) for cascade‐instructed therapy and feedback imaging. Under the dephosphorylation of alkaline phosphatase, HPO‐CYFF‐TPP converts to HO‐CYFF‐TPP and self‐assembles into nanoparticl …

14.08.2026journal-article

American Journal of Speech-Language Pathology

Comparing Traditional Motor Speech Practice to Contextualized Speech Practice in Preschoolers With Childhood Apraxia of Speech

Kerry A. McNamara, Nicole F. Caballero, Jonathan L. Preston

Purpose: The aim of this study was to compare retention of real-word targets across practice conditions (contextualized vs. motor-only) within a modified integral stimulation treatment for preschoolers with childhood apraxia of speech (CAS). Method: A single-subject experimental design with alternating treatments was used with matched target sets randomly assigned to contextualized practice, motor-only practice, or no treatment. Three preschoolers with CAS completed 18 therapy sessions, each consisting of two 25-mi …

14.08.2026journal-article

BJU International

Evaluation of triplet therapy combined with robot‐assisted cytoreductive prostatectomy for high‐volume metastatic prostate cancer: a multicentre randomised controlled trial protocol

Xiangwei Yang, Zhuobin He, Jian Chen, Hanqi Lei, Binyuan Yan, Linze Chen, Hong Liu, Jun Pang

Background Prostate cancer (PCa) is the second most common cancer in men. For patients with high‐volume metastatic PCa (mPCa) who are fit for docetaxel, a triplet therapy regimen consisting of androgen deprivation therapy (ADT), chemotherapy, and an androgen receptor pathway inhibitor (ARPI) is recommended. Adding local radiotherapy to triplet therapy has been shown to alleviate symptoms and reduce disease progression. However, the benefit of combining triplet therapy with local surgery remains unclear and warrants …