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European Health Evidence

The European alternative to PubMed

EUVIMED is the European alternative to PubMed: a central, multilingual research platform for medicine, nursing, life sciences and healthcare. It brings together international and European literature sources, study registries, open-access full texts, citations and retraction notices in one search. Unlike pure bibliographic databases, EUVIMED supports the entire research process – from discovery and appraisal with LIVIA and CLARA to traceable evidence synthesis. European in focus, transparent, interoperable and designed for science and healthcare.

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EUVIMED Themenbrowser · Medizin · Seite 149

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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Aktuelle Forschung nach Fachgebiet

23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
07.09.2026journal-article

Nano Research

CRISPR-Cas9 cleaves DNA microspheres to release drug for efficient thrombosis treatment

Shuai Yang, Ningning Wang, Yihang Huang, Xingang Wang, Qianyun Tang, Guoqing Tang, Jianggui Shan, Peifeng Liu

Abstract The drug delivery nanocarriers are widely employed in thrombolytic therapy. However, the off targeting and ineffective drug release of delivery vehicles make it difficult to targeted accumulation, effective diffusion, and penetration into thrombus tissue. Herein, we reported a biocompatible magnetic microsphere constructed via a programmable DNA rolling circle amplification (RCA) reaction integrated with iron oxide magnetic nanoparticles (Fe3O4 NPs). By combining ultrasound and photoacoustic imaging for di …

07.09.2026journal-article

Asian Journal of Pharmaceutical and Clinical Research

ANALYTICAL QUALITY BY DESIGN-ASSISTED DEVELOPMENT AND VALIDATION OF A RAPID STABILITY-INDICATING GRADIENT ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR SIMULTANEOUS ESTIMATION OF EMPAGLIFLOZIN, SACUBITRIL, AND VALSARTAN IN PHARMACEUTICAL DOSAGE FORMS

BADRI SIREESHA, SARAVANAN RAVINDRAN

Objectives: Simultaneous estimation of empagliflozin, sacubitril, and valsartan in combined pharmaceutical formulations is analytically challenging due to their differing polarity, physicochemical properties, and chromatographic retention behavior. Conventional high-performance liquid chromatography methods often require longer analysis times and greater solvent consumption. To develop, optimize, and validate a rapid, robust, and stability-indicating gradient ultra-performance liquid chromatography (UPLC) method fo …

07.09.2026journal-article

Clinical Pharmacology & Therapeutics

Constructing an External Control Arm Using the French REALYSA Cohort to Replicate Outcomes of a Randomized Trial Arm in Advanced Hodgkin Lymphoma

Olivia Febvey‐Combes, Cédric Rossi, Behrouz Kassai, Tesla Murairi Mirimo, Loïc Chartier, Fanny Cherblanc, Emeline Cugnod, Hervé Ghesquières, Aurélien Belot

External control (EC) arms using routine data can be used as comparators in clinical trials under certain conditions. The objective of this study was to assess the ability of an EC arm to replicate outcomes of a randomized controlled trial (RCT) arm receiving the same treatment strategy in advanced stage classical Hodgkin lymphoma and serve as comparator in future trials. Using the prospective real‐world data in lymphoma and survival in adults (REALYSA) cohort, we constructed an EC arm by applying eligibility crite …

07.09.2026journal-article

Journal of Law, Medicine & Ethics

Industry Exposure in Medical Training: The Case for a Conflict-Free Learning Environment

Joshua D. Hauser, Aaron Seth Kesselheim, Rita Redberg

Abstract Conflicts of interest (COI) between physicians and for-profit companies have existed for centuries, but the last decade has dramatically increased their visibility through the Centers for Medicare and Medicaid Services’ Open Payments database. Despite growing documentation of COI in academic medical environments — where financial relationships are prevalent and industry payments to trainees exceed millions of dollars annually — formal COI policies and curriculum in US medical schools have stagnated or weak …

07.09.2026journal-article

Medicine, Science and the Law

Application of the pleural effusion ratio in diagnosing freshwater drowning: A comparative study

Nirmal Nagar, Binaya Kumar Bastia

Drowning is a leading cause of unintentional death globally, with diagnosis remaining challenging due to the non-specific nature of postmortem findings. This prospective study aimed to evaluate the diagnostic utility of the pleural effusion (PE) ratio in differentiating freshwater drowning from other causes of death. A total of 179 medico-legal autopsies conducted between July 2022 and April 2023 at a tertiary centre in Northern India were analysed, comprising 75 cases of freshwater drowning, 64 sudden cardiac deat …

07.09.2026journal-article

Journal of Pediatric Gastroenterology and Nutrition

Race and neighborhood factors influence clinical outcomes in children hospitalized with acute pancreatitis

Amy Fan, Elizabeth Baker, Chinenye R. Dike

Abstract Objectives Disparities impacting acute pancreatitis (AP) outcomes have been reported. Although racial/ethnic disparities are known in AP, geospatial disparities have been unexplored in pediatric AP. We aimed to investigate area level social determinant of health (SDOH) factors on pediatric AP outcomes. Methods This is a retrospective study of children hospitalized with AP over 5 years. Data including home addresses and zip codes were geocoded to determine area level factors for SDOH. Descriptive statistics …

07.09.2026journal-article

Revista Chilena de Reumatología

Paquidermodactilia: a raíz de un caso clínico con sospecha de artritis idiopática juvenil

Erasmo Benavente O., Martín Valderrama W., Antonia Morales M., Camila Rivera C., Luis Muse R., Alejandro Badilla P.

Se presenta un caso de paquidermodactilia (PDD). La PDD es una entidad rara y benigna, caracterizada por el engrasamiento de partes blandas periarticulares de predominio lateral en los dedos, con compromiso más frecuente de las articulaciones interfalángicas proximales (IFP), y que afecta principalmente a hombres adoles­centes. En este paciente, el cuadro se desarrolló en el contexto de microtrauma periarticular repetitivo, tics persistentes de golpeteo digital y estiramiento de manos, conductas típicamente asociad …

07.09.2026journal-article

Journal of Internal Medicine

AA amyloidosis in the four historical monogenic autoinflammatory diseases: Clinical burden and insights from a retrospective referral‐centre study

Majdouline El Moussaoui, Léa Savey, Hassina Sofia Aloui‐Belhocine, Jean‐Jacques Boffa, Marion Delplanque, Catherine Grandpeix‐Guyodo, Irina Giurgea, Laurence Cuisset, Guilaine Boursier, Gilles Grateau, David Buob, Sophie Georgin‐Lavialle

Abstract Background AA amyloidosis (AAA) remains a life‐threatening yet largely preventable complication of monogenic autoinflammatory diseases (AIDs). Methods We retrospectively described patients with AAA secondary to one of the four historical monogenic AIDs (familial Mediterranean fever [FMF], cryopyrin‐associated periodic syndrome [CAPS], mevalonate kinase deficiency [MKD] and tumour necrosis factor receptor–associated periodic syndrome [TRAPS]) followed at the French National Referral Centre for Monogenic AID …

26.12.2026journal-article

Journal of Chemical Engineering Research Progress

Optimization Studies of The Treatment of Laundry Wastewater Using Activated Carbon Derived from HDPE Chars

David Emoefe Rockson-Itiveh, Cyril Oghenekome Anakpoha, Mabel Keke, Marcel Ajogri, Ulakpa Wisdom, Fabian Chidiebere Ozioko, Samson Onoriode Okpo

Growing plastic waste and industrial wastewater necessitate sustainable treatment solutions. This study optimized industrial wastewater treatment using activated carbon derived from high-density polyethylene (HDPE) pyrolysis char via thermal activation, eliminating the need for aggressive chemical agents. Characterization via FTIR, BET, and SEM-EDX revealed a micro-mesoporous structure with a BET surface area of 287.3 m²/g, a 90.05 atomic percent carbon content, and dominant pore sizes of 2.1 to 2.6 nm. The adsorbe …

07.09.2026journal-article

Frontiers in Endocrinology

Impaired bone health after pediatric acute lymphoblastic leukemia treatment despite normal DXA: insights from high-resolution peripheral quantitative computed tomography

Nina Dominique Stahel, Nicole Bodmer, Aziz Chaouch, Etienne Sochett, Flavia M. Wehrle, Marianne Rohrbach, Camilla Saladin, HansJörg Häuselmann, Daniel Konrad, Nina Lenherr-Taube

Introduction Acute lymphoblastic leukemia (ALL) is the most common cancer in childhood. With improved survival rates, more attention has turned to long-term outcomes such as bone health. High-resolution peripheral quantitative computed tomography (HR-pQCT) allows a three-dimensional assessment of cortical and trabecular bone and may have advantages over standard dual-energy X-ray absorptiometry (DXA). The aim of this study was to evaluate whether HR-pQCT can detect early bone health impairment in children following …

07.09.2026journal-article

Frontiers in Public Health

The success-failure inversion in modern medicine

Madhur Mangalam, Jessica Fabianiak, Barry Cense

Twentieth-century medicine was most successful against diseases sharing a particular causal architecture: a discrete lesion standing in a relation of approximate necessity and sufficiency to a clinical syndrome, amenable to specific perturbation. Mortality from acute myocardial infarction has fallen by nearly 90 percent in the United States since 1970; pediatric leukemia has become survivable; HIV has become chronic. That success has shifted the residual burden toward conditions with a different architecture—late-l …

07.09.2026journal-article

Frontiers in Immunology

A truncating ELF4 variant in a pediatric patient with autoinflammatory disease and cell type-specific immune alterations

Qianlu Zhang, Yatang Lei, Lina Zhou, Zhiyong Zhang, Xuemei Tang, Yunfei An, Xiaodong Zhao, Hongqiang Du

Introduction ELF4 is an ETS family transcription factor involved in immune regulation, including antiviral responses and inflammatory signaling. Germline loss-of-function variants in ELF4 cause deficiency in ELF4, X-linked (DEX), a disorder characterized by recurrent mucocutaneous inflammation and variable immune abnormalities. To date, ELF4-related disease has been reported only in association with germline mutations. Here, we report a pediatric patient with autoinflammatory disease harboring a truncating ELF4 var …

07.09.2026journal-article

Russian Journal of Transplantology and Artificial Organs

Principles Of developing predictive models in medicine and Their application in liver transplantation

A. R. Monakhov

Prognostic models have become an integral part of clinical practice in liver transplantation (LT), supporting decision-making throughout the patient’s clinical pathway – from assessment of the severity of underlying disease to postoperative monitoring of graft function. This review aims to systematize the principles of development, validation, and quality assessment of clinical prognostic models, with a particular focus on the scales used in LT. The review is based on an analysis of key publications on the methodol …

07.09.2026journal-article

The American Surgeon™

Vitamin C Deficiency: A Nutritional Blind Spot in Colorectal Surgery

Eli Mlaver, Luke Galloway, Virginia O. Shaffer, Courtney L. Devin

Background While colorectal surgery quality improvement efforts and ERAS pathways emphasize operative sterility, glycemic control, and fluid optimization, perioperative micronutrient status is rarely assessed. Vitamin C is essential for collagen crosslinking, immune function, and antioxidant activity, and deficiency may plausibly impair anastomotic and wound healing. Patients undergoing colorectal surgery may be at particular risk due to baseline malnutrition, disease related malabsorption, postoperative ileus, and …

07.09.2026journal-article

Frontiers in Medicine

Medical imaging in immunotherapy response evaluation: from RECIST to AI-driven longitudinal models, and the distinction between risk prediction and kinetic diagnosis

Huzhe Cui, Zhengri Piao, Songnan Zhang

Immune checkpoint inhibitors have reshaped cancer treatment, but the response patterns they produce—pseudoprogression, dissociated responses, and hyperprogressive disease (HPD)—fit awkwardly into the size-based logic of RECIST 1.1. This narrative review, prepared with reference to the SANRA criteria, follows the evolution of response assessment from RECIST 1.1 through immune-adapted criteria such as iRECIST to functional and molecular imaging and, most recently, artificial intelligence (AI) models trained on longit …

07.09.2026journal-article

Journal of Pediatric Orthopaedics

Publication Volume and Fellowship Characteristics Are Associated With Future Academic Faculty Appointments in Pediatric Orthopaedic Surgery

Jason Silvestre, Prudhvi Kodali, Pooya Hosseinzadeh, Wudbhav N. Sankar, John M. Flynn

Background: Factors associated with future academic faculty appointments after pediatric orthopaedic surgery fellowship training remain unknown. This study determines fellow and training program factors associated with future academic faculty appointments in pediatric orthopaedic surgery. Methods: This was a case-control study of pediatric orthopaedic surgery fellows from 2017 to 2023. Cases consisted of academic faculty, and controls were in a nonacademic practice setting. Demographic, bibliometric, and training v …

07.09.2026journal-article

Medicine & Science in Sports & Exercise

A Comparison of Ground Reaction Forces, Tibial Forces, and Clinician Perspectives on Tibial Bone Load During Common Rehabilitation Exercises

Meredith K. Owen, Katherine M. Rodzak, Tereza Janatova, Lauren N. Erickson, Camille C. Johnson, Karl E. Zelik, Brian Noehren

Purpose: Optimal healing after a tibia fracture depends on appropriate mechanical loading. Ground reaction force is often used as an indicator of expected tibia load, but it does not account for internal forces placed on the tibia from muscle contractions. Objectives of this study were to 1) characterize peak forces on the distal tibia during common exercises used for rehabilitation after lower extremity injury, 2) compare peak tibial force to peak ground reaction forces for each exercise, and 3) compare rank-order …

07.09.2026journal-article

BMC Surgery

Heterogeneity in major amputation risk among patients with WIfI (wound, ischemia, foot infection) Stage 4 diabetic foot ulcers

Sheng-Lian Lee, Yi-Chang Lin, Chiung-Wen Chang, Chiehfeng Chen, Hsian-Jenn Wang, Wen-Kuan Chiu

Abstract Background Although the Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification stratifies limb threat, reported 1-year major amputation rates for WIfI Stage 4 vary widely across institutions. Whether patient-level factors provide prognostic information beyond limb severity in advanced disease remains unclear. Methods We conducted a retrospective single-center cohort study of 296 patients with diabetic foot ulcers (DFUs) admitted to a tertiary referral center between 2017 and …

07.09.2026journal-article

Emergency Medicine Australasia

Acid–Base Phenotypes in Sedative Toxidrome: Characterisation, Agent‐Specific Patterns and Clinical Associations

Pramod Chandru, Naren Gunja

ABSTRACT Objective Acid–base patterns and their association with clinical outcomes have not been characterised using venous‐specific reference ranges in a sedative‐specific cohort. We aimed to characterise acid–base phenotypes in sedative toxidrome using venous‐specific thresholds, examine agent‐specific associations and evaluate relationships to adverse outcomes. Methods Retrospective cohort study of 374 consecutive patients referred to a toxicology service with sedative poisoning between November 2022 and Novembe …

07.09.2026journal-article

Medicine Insights

Intestinal Barrier Dysfunction in Ulcerative Colitis: Mechanisms and Therapeutic Perspectives

Jingdu Yang, Haifa Qiao

Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease characterized by persistent mucosal inflammation of the colon and rectum. Although the exact etiology of UC remains incompletely understood, accumulating evidence suggests that intestinal barrier dysfunction plays a central role in disease initiation, progression, and recurrence. The intestinal barrier is a complex system composed of the epithelial layer, tight junction proteins, mucus layer, immune components, and gut microbiota, which toget …

07.09.2026journal-article

The Anatomical Record

Outcomes of hyaluronic acid and dextrose prolotherapy on surgically induced rat osteoarthritis: Single versus combined treatment

Wael Amin Nasr El‐Din, Bhagath Kumar Potu, Raouf Abdelrahman Fadel, Islam Omar Abdel Fattah

Abstract Osteoarthritis (OA) is the most prevalent chronic joint disorder. This study explored therapeutic mechanisms of intra‐articular (i.a.) hyaluronic acid (HA), and/or dextrose prolotherapy (DPT) on surgically induced OA. Rats were divided into five groups ( n = 12): control, OA, HA, DPT, and DPT + HA groups. OA group revealed increase in serum alkaline phosphatase (ALP) level, knee extension angle diameter, and CD44 immuno‐expression, furthermore a decrease in cartilage thickness, chondrocyte density, and gly …

07.09.2026journal-article

Experimental & Molecular Medicine

Immune pathway activation in gastric cancers with LINE-1 retrotransposon overexpression and homologous recombination deficiency

Young Jin Kim, In-Pyo Baek, Bang Wool Eom, Min-Jung Seo, Heeyeon Joo, Yu Ri Choi, Min Kyoung Park, Jihye Oh, Boram Lee, Seung Min Ham, Nak-Hyeon Choi, Seung-Pyo Hong, Jaeyong Choi, Sookyung Kim, Seong-Ho Kong, Hyuk-Joon Lee, Yun-Suhk Suh, Jinhwa Kong, Je-Keun Rhee, Sang-Won Lee, Hong Man Yoon, Hark Kyun Kim, Young-Woo Kim, Jong-Il Kim, Bong-Jo Kim, Han Kwang Yang

Abstract There are only a few whole genome sequencing studies of human gastric cancer (GC) conducted so far. We performed comprehensive whole genome, bulk RNA, and methylation sequencing analyses of 100 samples of GC and adjacent normal tissue. In a smaller non-EBV/non-MSI subset ( n = 23), we also performed proteomic profiling by mass spectrometry. We validated the proteomic findings in an independent dataset. Using this unprecedented dataset of human GC samples, we examined the extent of chromothripsis, homologou …

07.09.2026journal-article

Sriwijaya Journal of Surgery

Only the Boey Score Discriminates In-Hospital Mortality After Gastric Perforation: A STARD-Compliant Comparison with the Jabalpur Score

Samuel Bertua Halomoan Manurung, Efman E. U Manawan, Erial Bahar

Background: Gastric perforation remains a highly lethal surgical emergency, and competing preoperative mortality scores have not been compared directly in an Indonesian cohort. Objective: To compare the discrimination, calibration, and clinical utility of the Boey and Jabalpur scores for in-hospital mortality after emergency surgery for gastric perforation. Methods: This retrospective diagnostic-accuracy study, reported according to STARD 2015, included 55 consecutive adults who underwent emergency laparotomy for n …