Onkologie: neue Gesundheitspublikationen – Seite 144

30.08.2026journal-article

HEALTH SCIENCES AND DISEASE

Sexualité et Cancer en Côte d'Ivoire : Évaluation de l'Impact du Diagnostic et des Traitements chez les Patients au CHU de Treichville

Petiori G Laurence Touré, Odo Bitti Adde, Kouassi Konan Kouamé Yvon, Emmanuelle Esther De, Ibrahima Kalil Condé, Madiou Mohamed Kassir, Odidi Femi Perez, Mebiala Prosper Malan N’Guessan, Ismael Kamara, Fleur Audrey Sessegnon, Nogbou Akissi Marie Barbara Yvonne, Yenabahan Lazare Touré, Traoré-Kouassi Danielle, Etobo Innocent Ahounou, Aka Rita, Moctar Touré, Innocent Adoubi

RÉSUMÉIntroduction. Le cancer et ses traitements peuvent altérer la sexualité, dimension essentielle de la qualité de vie souvent négligée en pratique clinique. En Afrique subsaharienne, les données sur l'impact du cancer sur la fonction sexuelle restent limitées. Cette étude avait pour but de décrire les troubles de la sexualité et leur évolution avant et après le diagnostic de cancer chez des patients suivis à Abidjan. Méthodes. Nous avons mené une étude transversale descriptive à recueil comparatif intra-individ …

30.08.2026journal-article

Journal of Artificial Intelligence and Information

From Diagnosis to Treatment: Advances in Clinical Research on Severe Pneumonia

Sheng Wang, Xiaoli Wu, Xiaoshuai Wu

Severe pneumonia is a life-threatening infectious disease associated with high mortality and is frequently complicated by acute respiratory distress syndrome, septic shock, and multiple organ dysfunction. The current diagnostic and therapeutic paradigm is shifting from empirical broad-spectrum treatment toward individualized management based on precise pathogen identification and assessment of the host response. The pathogenesis of severe pneumonia involves a broad range of bacterial, viral, and fungal pathogens, t …

30.08.2026journal-article

Japanese Journal of Radiology

Malignant potential of intraductal papillary mucinous neoplasm (IPMN) of the pancreas: imaging assessment of IPMN-derived cancer and concomitant pancreatic ductal adenocarcinoma

Fumihito Toshima, Dai Inoue, Kazuto Kozaka, Norihide Yoneda, Takahiro Komori, Atsushi Takamatsu, Yuichi Chujo, Satoshi Kobayashi

Abstract The detection of pancreatic cystic lesions (PCLs) has increased markedly with the widespread use of cross-sectional imaging. Although the true proportion of intraductal papillary mucinous neoplasms (IPMNs) among PCLs remains uncertain, IPMN is considered to account for most PCLs and is a representative precursor lesion of pancreatic ductal adenocarcinoma (PDAC). However, not all PCLs should be assumed to represent IPMN, because this assumption may lead to unnecessary surveillance or overtreatment. Therefor …

30.08.2026journal-article

Journal of Surgical Oncology

Prognostic Value of the Preoperative Tumor‐to‐Blood Pool Standardized Uptake Value Ratio Derived From FDG‐PET/CT in Distal Bile Duct and Ampullary Cancers

Hiroyuki Matsukawa, Hironobu Suto, Yasuhisa Ando, Minoru Oshima, Takuro Fuke, Yoshio Shimizu, Mina Nagao, Kenichi Tanaka, Kensuke Kumamoto, Keiichi Okano

ABSTRACT Purpose This study investigated the prognostic value of the preoperative tumor‐to‐blood pool standardized uptake value ratio (TBR) on 18 F‐fluorodeoxyglucose positron emission tomography/computed tomography (FDG‐PET/CT) in patients undergoing pancreatoduodenectomy (PD) for distal bile duct and ampullary cancers. Methods We retrospectively reviewed 100 patients who underwent PD between January 2011 and December 2024. TBR was calculated as tumor SUVmax divided by the SUV of the descending aorta. The optimal …

30.08.2026journal-article

ChemistrySelect

From Resistance to Renewal: Design Strategies and Structure–Activity Relationships of Novel EGFR Inhibitors in Breast Cancer: Mini Review

Neelima Shrivastava, Chanda Ranjan

ABSTRACT Breast cancer continues to be one of the top causes of cancer death globally, with triple‐negative breast cancer (TNBC) being the most aggressive variety as it has a much poorer prognosis, strong propensity for metastases, and fewer effective targeted therapies available. The increased expression of the epidermal growth factor receptor (EGFR) is essential for cancer cell growth, survival, migration, and drug resistance making EGFR a good target for therapy. However, the effectiveness of EGFR inhibitors has …

30.08.2026journal-article

Pharmacoepidemiology and Drug Safety

Postpartum Psychotropic Treatment Patterns and Breastfeeding: Nationwide Clustering Study

Anders Hviid, Anna Laksafoss, Elisabeth O'Regan, Poul Videbech, Ingrid Bech Svalgaard

ABSTRACT Introduction Postpartum psychotropic medication use is heterogeneous, comprising continuation of prenatal treatment, initiation, transient use and complex polypharmacy. Prior studies have reported the prevalence of potential infant exposure to psychotropics via breast milk, but characterisations better capturing the heterogeneity of this exposure are lacking. We aimed to identify distinct postpartum psychotropic treatment patterns using hierarchical clustering accounting for medication type, timing and pol …

30.08.2026journal-article

Journal of Artificial Intelligence and Information

Clinical Study on Qinghuo Qibi Decoction Combined with Rehabilitation Training in the Treatment of Autism Spectrum Disorder of Heart-liver Fire Hyperactivity Pattern

Jiangwei Yang, Yaxiong Guo

Objective: To observe the clinical efficacy of Qinghuo Qibi Decoction combined with rehabilitation training in the treatment of autism spectrum disorder (ASD) of heart-liver fire hyperactivity pattern and its effects on inflammatory cytokines. Methods: A randomized controlled trial (RCT) was conducted. A total of 140 children with ASD of heart-liver fire hyperactivity pattern who attended our hospital and the Affiliated Hospital of Shaanxi University of Chinese Medicine between February 2022 and February 2025 were …

30.08.2026journal-article

Clinical Medicine (Russian Journal)

The results of surgical treatment of arteriovenous fistula thrombosis of local intravenous catheter thrombolysis

Umut M. Muratbekova, Viacheslav N. Kravchuk, Andrey N. Shishkevich, Shamil M. Asadulaev, Valerii S. Ermakov,, Artem S. Fedorov, Evgeniy I. Umantsev, Vadim V. Dalinin,, Daria P. Vereshchak

The aim of the study is to assess the short and medium-term outcomes of surgical treatment for arteriovenous fistula (AVF) thrombosis, using the novel method of local intravenous thrombolysis that we have developed. Material and methods. The study analyzed the clinical data from 158 patients who experienced arteriovenous fistula thrombosis between 2021 and 2024. Two groups of patients were formed: 1) the study group consisted of 77 patients who underwent the first stage of the “local intravenous catheter thrombolys …

30.08.2026journal-article

CNS Neuroscience & Therapeutics

PPARγ ‐Dependent Pioglitazone Treatment Suppresses Neuroinflammation and Improves Cognition in Sepsis‐Associated Encephalopathy in Mice

Jing Zhang, Peng Wang, Nan Li, Yan Gao

ABSTRACT Objective To assess whether pioglitazone (Pio) protects against sepsis‐associated encephalopathy (SAE) and to probe underlying mechanisms. Methods Sepsis was induced in male C57BL/6 mice by caecal ligation and puncture (CLP). At 24 h post‐CLP, mice received Pio and/or the PPAR‐γ antagonist GW9662 and were followed for 14‐day survival. Cognitive and affective behaviors were evaluated using a behavioral battery. Blood–brain barrier (BBB) permeability was assessed by Evans blue extravasation, and hippocampal …

30.08.2026journal-article

Clinical and Translational Medicine

CDO1 as a prognostic biomarker and therapeutic target in gastric cancer: Mechanistic insights into the PI3K/AKT‐THBS1 axis and epigenetic reactivation by decitabine

Fazhi Wang, Runkai Zhou, Jinfeng Cai, Jiazhe Wen, Abudushalamu Yalikun, Yang Yu, Yugang Wen

Abstract Background As a pivotal metabolic enzyme, cysteine dioxygenase type 1 (CDO1) exerts tumour‐suppressive effects across diverse tumour types, and its expression is strongly correlated with clinical prognosis. However, the molecular mechanisms underlying CDO1‐mediated tumour suppression in gastric cancer (GC), its relationship with the tumour‐associated immune microenvironment, and pharmacological strategies to restore its expression remain poorly understood. Methods CDO1 expression and prognosis were evaluat …

30.08.2026journal-article

Revista ft

Hipertensão arterial e doença renal crônica em idosos: revisão das evidências sobre evolução clínica e tratamento

Beatriz Aguiar Medeiros, Julia Gauer Gomides Tavares, Nicolly Cristine Nobre Bredun, Michel Hosananh Vasconcelos

Systemic arterial hypertension (SAH) and chronic kidney disease (CKD) are among the most prevalent chronic conditions in the elderly, frequently coexisting and mutually exacerbating their outcomes. This interaction compromises quality of life and increases the risk of cardiovascular and renal complications, making its management a significant challenge. This study analyzed the influence of hypertension on the progression of kidney disease in the elderly and evaluated the effectiveness of available therapeutic strat …

30.08.2026journal-article

International Journal of Sexual Science

Treatment Options in Erectile Dysfunction

Arda Tongal, Hakan Türk

Erectile dysfunction is a common and important health problem that affects the quality of life of individuals and their partners. Although its etiology includes various factors, the majority of cases have organic causes. In cases of organic ED, lifestyle modification remains the main approach, and oral phosphodiesterase type 5 (PDE5) inhibitors make up the main part of non-invasive management. Additionally, intraurethral suppositories, extracorporeal shock wave therapy (ESWT), and vacuum erection devices are also e …

30.08.2026journal-article

Scientific Reports

Regional disparities in osteosarcoma and soft tissue sarcoma treatment across Northwest China: a cross-sectional multicenter survey

Wenpeng Yang, Junshen Wu, Maierdanjiang Maihemuti, Suzhi Ji, Renbing Jiang

Abstract Osteosarcoma and soft tissue sarcoma are rare but aggressive malignancies requiring multidisciplinary care. Despite consensus guidelines, real-world treatment patterns across Northwest China remain poorly characterized. We conducted a cross-sectional, questionnaire-based multicenter survey of 67 hospitals treating osteosarcoma and 60 treating soft tissue sarcoma across three regional clusters in Northwest China (Xinjiang-Qinghai, Gansu-Ningxia, Shaanxi-Shanxi). The survey instrument, developed through lite …

30.08.2026journal-article

Diagnostics

Few-Shot Learning for Cytological Classification of Primary Lung Cancer and Pulmonary Metastases During Endobronchial Ultrasound

Ching-Kai Lin, Di-Chun Wei, Hsin-Hung Chou, I-Shiow Jan, Yun-Chien Cheng

Background: Endobronchial ultrasound (EBUS) is widely used for the diagnosis of pulmonary lesions. When combined with rapid on-site cytologic evaluation (ROSE), it can improve diagnostic accuracy and facilitate early identification of malignancy origin. However, differentiating primary lung cancer from metastatic tumors (e.g., breast or colorectal origin) during ROSE remains challenging due to limited cytopathology support and morphological similarities between tumor cells. This study aimed to develop a computer-ai …

30.08.2026journal-article

Biomedicines

Mechanistic Links Between Natural Bioactive Molecules and Tumor Immune Microenvironment States in PD-1/PD-L1 Resistance

Huiya Cheng, Meilun Chen, Min Xiao, Heteng Zhang, Zitong Zhang, Dongyue Jiang, Arabella H. Wan, Qiaoping Wang, Guohui Wan

Programmed cell death protein 1/programmed death ligand 1 (PD-1/PD-L1) blockade can produce durable responses, but primary and acquired resistance are common. Treatment outcome is influenced by antigen presentation, T-cell localization, suppressive myeloid populations, metabolic stress, and the gut microbiome, all of which shape the tumor immune microenvironment (TIME). This review examines natural bioactive molecules in relation to these resistance features rather than grouping them by chemical class. Castalagin/c …

30.08.2026journal-article

Archiv Euromedica

CANNABINOIDS AND THE ENDOCANNABINOID SYSTEM IN ONCOLOGY: FROM SUPPORTIVE CARE TO EMERGING ANTICANCER STRATEGIES

Magdalena Korba, Aleksandra Piętak, Izabela Staszczyk, Roksana Hashemi

Background The endocannabinoid system (ECS) regulates key physiological processes involved in pain, appetite, mood, immune function, and tumor biology, supporting growing interest in cannabinoids in supportive oncology and experimental anticancer research. Aim This narrative review critically evaluates current clinical, preclinical, and translational evidence on cannabinoids and the ECS in oncology, with a clear distinction between clinically supported applications in supportive cancer care and experimental data on …

30.08.2026journal-article

Advanced Science

Space Jam‐Ming: Generating Interstitial Space Using Fragmented Granular GelMA to Investigate Novel Paradigms of Cancer Metastasis

Danielle Vahala, Zhuang Min Lee, Sebastian E. Amos, Dong Woo Son, Jong Hwa Byun, Farzan Navaeipour, Jiayue Li, Kai L. Metzner, Ji Hoon Jeong, Juyeon Kim, Yongsung Hwang, Brendan F. Kennedy, Khoon S. Lim, Hee Seung Lee, Hyun Woo Park, Yu Suk Choi

ABSTRACT The tumor microenvironment undergoes extensive remodeling during cancer progression, resulting in increased collagen, altered tissue mechanics, and the formation of collagen tracks that permit migration. However, how the extracellular matrix (ECM) regulates cellular plasticity remains less known. Cellular plasticity is essential for successful metastasis, as cells undergo epithelial‐to‐mesenchymal transition and adherent‐to‐suspension transition (AST). Studies have begun to use 3D photo‐crosslinkable hydro …

30.08.2026journal-article

Veterinary Record Case Reports

Treatment of separation anxiety and fear of noises, confinement and unfamiliar people in a dog using escitalopram and clonidine

Erica Grier

Abstract A 3‐year‐old, 8.9 kg, neutered male dachshund was presented for fear and anxiety that significantly affected his daily quality of life. Distressing situations included being separated from his owner, confined in crates, exposed to noises and introduced to unfamiliar people. Clinical signs frequently included trembling, barking, hypersalivation, urination and attempts to escape or hide, with a recovery time of 20–40 minutes. Previous treatment with fluoxetine, a cannabidiol supplement and trazodone, alongsi …

30.08.2026journal-article

International Journal of Research in Ayurveda and Pharmacy

A CASE STUDY ON THE EFFECTIVE TREATMENT OF LYMPHATIC FILARIASIS WITH PANCHAKARMA THERAPY

Anagha Sudhir, Aashu Rana, Aswathy YS, Prasanth Dharmarajan

Background: This study evaluates the efficacy and outcomes of effective Panchakarma treatment in Lymphatic Filariasis. While antiparasitic drugs help prevent disease transmission and treat early-stage infections, they have limited ability to reverse chronic disease-related damage. Method: The successful management of a 67-year-old female patient with lymphatic filariasis was considered significant enough to be documented. Lymphatic filariasis affects an estimated 14 million people worldwide, and evidence on Ayurved …

29.08.2026journal-article

BMC Gastroenterology

Stromal THY1 expression is associated with improved survival in low-stroma colorectal cancer: an integrated multi-platform analysis

Kemal Kayaşlı, Aynur Işık, Ali Utku Turhan, Seçil Demirkol Canlı, Güneş Güner, Aytekin Akyol

Abstract Background Colorectal cancer (CRC) remains a global health challenge. The tumor microenvironment (TME) plays an important role in CRC progression, yet the cellular distribution and prognostic significance of stromal THY1 (CD90) remain incompletely understood. Methods We investigated THY1 expression in the CRC microenvironment using a multi-platform approach integrating publicly available bulk and single-cell transcriptomic datasets, a transgenic mouse model with ex vivo tissue imaging and histological asse …

29.08.2026journal-article

International Forum of Allergy & Rhinology

Rhinosinusitis in Adults Receiving Tumor Necrosis Factor Alpha Inhibitors and Anti‐CD20 Therapy: A Scoping Review

Obadah Tolaymat, John Dewey, Kushal Modi, Omar G. Ahmed, Antoine Azar, Fuad M. Baroody, Regan W. Bergmark, Peter Filip, Kent Lam, Jivianne T. Lee, Sandra Y. Lin, Amber U. Luong, Daniel O'Brien, Hassan H. Ramadan, Lindsey Ryan, Elina Toskala, Chadi A. Makary

ABSTRACT Introduction Immunomodulatory therapies, including tumor necrosis factor alpha (TNF‐α) inhibitors and anti‐CD20 agents, are often used for autoimmune, inflammatory, and neoplastic disorders. While infection risk is well recognized, their association with rhinosinusitis remains poorly characterized. Goal To map the existing literature on TNF‐α and anti‐CD20 agents and rhinosinusitis and to identify emerging clinical patterns. Methods A scoping review was conducted according to the Preferred Reporting Items …

29.08.2026journal-article

The Nursing Scope

Effect of a Genetic Counselling Educational Intervention on Nurses' Knowledge and Self-Reported Skills for Breast Cancer Risk Assessment in Ekiti State, Nigeria

Oluwabunmi Adeniji

Background: Breast cancer remains one of the leading causes of cancer-related morbidity and mortality among women worldwide, and genetic predisposition is an important contributor to susceptibility. As frontline healthcare professionals, nurses play a critical role in identifying individuals at risk and providing genetic information and referrals. However, deficiencies in nurses' knowledge and skills regarding genetic assessment and counselling continue to limit the effective integration of genomics into routine nu …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Time to Antibiotics and Clinical Outcomes in Pediatric Cancer Patients with Fever: Evaluating the "Golden Hour" Concept

Medalit Luna Vilchez, Grisell Leonor Portilla Uribe, Mitsi Lorraine Santiago Abal, Victoria Angélica Godoy Vila, Alicia Janeth Mafaldo Rengifo, Gloria Francia Oscanoa

Abstract Background In low- andmiddle-income countries, infections remain the leading cause of treatment-related mortality in pediatric patients with cancer. The "Golden Hour" concept advocates antibiotic administration within 60 minutes of emergency department (ED) triage to reduce sepsis and ICU admission. We evaluated whether time to antibiotic administration (TTA) >60 min versus ≤60 min impacts adverse clinical outcomes in children with cancer and fever. Methods We conducted a prospective longitudinal at the In …

29.08.2026journal-article

Current Issues in Molecular Biology

Comparative In Vitro Cytotoxicity of Piper betle Leaf Extracts in KRAS G12D-Mutant Pancreatic Cancer Cell Lines

Nur Syahirah Haidah Zahid, Aziemah Azizi, Aklimah Mustapa, Syahirah Shahlehi, Masayoshi Arai, Siti Nur Idayu Matusin

Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers worldwide, with limited treatment options and a high prevalence of oncogenic KRAS mutations. Piper betle contains numerous bioactive phytochemicals with reported anticancer activities, although its activity against pancreatic cancer remains incompletely characterized. This study evaluated the phytochemical composition of P. betle leaf extracts and the cell viability effects of ethanolic extracts against human KRAS G12D-mutant pancreatic cancer …

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Was ist neu im Gesundheitswesen?

Aktuelle Forschung nach Fachgebiet

Sexualité et Cancer en Côte d'Ivoire : Évaluation de l'Impact du Diagnostic et des Traitements chez les Patients au CHU de Treichville

From Diagnosis to Treatment: Advances in Clinical Research on Severe Pneumonia

Malignant potential of intraductal papillary mucinous neoplasm (IPMN) of the pancreas: imaging assessment of IPMN-derived cancer and concomitant pancreatic ductal adenocarcinoma

Prognostic Value of the Preoperative Tumor‐to‐Blood Pool Standardized Uptake Value Ratio Derived From FDG‐PET/CT in Distal Bile Duct and Ampullary Cancers

From Resistance to Renewal: Design Strategies and Structure–Activity Relationships of Novel EGFR Inhibitors in Breast Cancer: Mini Review

Postpartum Psychotropic Treatment Patterns and Breastfeeding: Nationwide Clustering Study

Clinical Study on Qinghuo Qibi Decoction Combined with Rehabilitation Training in the Treatment of Autism Spectrum Disorder of Heart-liver Fire Hyperactivity Pattern

The results of surgical treatment of arteriovenous fistula thrombosis of local intravenous catheter thrombolysis

PPARγ ‐Dependent Pioglitazone Treatment Suppresses Neuroinflammation and Improves Cognition in Sepsis‐Associated Encephalopathy in Mice

CDO1 as a prognostic biomarker and therapeutic target in gastric cancer: Mechanistic insights into the PI3K/AKT‐THBS1 axis and epigenetic reactivation by decitabine

Hipertensão arterial e doença renal crônica em idosos: revisão das evidências sobre evolução clínica e tratamento

Treatment Options in Erectile Dysfunction

Regional disparities in osteosarcoma and soft tissue sarcoma treatment across Northwest China: a cross-sectional multicenter survey

Few-Shot Learning for Cytological Classification of Primary Lung Cancer and Pulmonary Metastases During Endobronchial Ultrasound

Mechanistic Links Between Natural Bioactive Molecules and Tumor Immune Microenvironment States in PD-1/PD-L1 Resistance

CANNABINOIDS AND THE ENDOCANNABINOID SYSTEM IN ONCOLOGY: FROM SUPPORTIVE CARE TO EMERGING ANTICANCER STRATEGIES

Space Jam‐Ming: Generating Interstitial Space Using Fragmented Granular GelMA to Investigate Novel Paradigms of Cancer Metastasis

Treatment of separation anxiety and fear of noises, confinement and unfamiliar people in a dog using escitalopram and clonidine

A CASE STUDY ON THE EFFECTIVE TREATMENT OF LYMPHATIC FILARIASIS WITH PANCHAKARMA THERAPY

Stromal THY1 expression is associated with improved survival in low-stroma colorectal cancer: an integrated multi-platform analysis

Rhinosinusitis in Adults Receiving Tumor Necrosis Factor Alpha Inhibitors and Anti‐CD20 Therapy: A Scoping Review

Effect of a Genetic Counselling Educational Intervention on Nurses' Knowledge and Self-Reported Skills for Breast Cancer Risk Assessment in Ekiti State, Nigeria

Time to Antibiotics and Clinical Outcomes in Pediatric Cancer Patients with Fever: Evaluating the "Golden Hour" Concept

Comparative In Vitro Cytotoxicity of Piper betle Leaf Extracts in KRAS G12D-Mutant Pancreatic Cancer Cell Lines