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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
16.08.2026journal-article

Annals of General Psychiatry

Bidirectional association between thyroid dysfunction and depressive symptoms: the role of levothyroxine therapy and shared molecular mechanisms

Han-xin Fu, Jia-xin Wang, Bin Qian, Xin Zhang, Lin-lin Hu

Abstract Background The association between thyroid dysfunction, thyroid hormone replacement therapy, and depression remains inconsistent. This study investigated the bidirectional risk association between thyroid dysfunction and depressive symptoms, focusing on the effect of thyroid hormone therapy on depressive symptoms, and exploring the shared molecular basis between hypothyroidism treated with levothyroxine and depression at the genetic level. Methods Part one utilized 2007–2012 National Health and Nutrition E …

16.08.2026journal-article

Lupus

Disseminated Nocardia pseudobrasiliensis infection in a case of juvenile systemic lupus erythematosus on immunosuppressive therapy

Kaustav Bhowmick, Angan Karmakar, Dipendranath Ghosh, Geetabali Sircar, Parasar Ghosh

Nocardiosis is an uncommon infection that presents as a chronic, debilitating illness with radiographic manifestations simulating lung cancer or tuberculosis. Immunocompromised hosts may develop a fulminant disease resembling acute bacterial pneumonia or disseminated disease. We report a case of a juvenile lupus who developed disseminated Nocardia pseudobrasilienisis infection in form of necrotizing pneumonia, subcutaneous nodules and central nervous system (CNS) lesion in the right parietal lobe, following inadver …

16.08.2026journal-article

Journal of Clinical Medicine

Patient-Reported Health-Related Quality of Life in Romanian Patients with Cystic Fibrosis in the Era of Highly Effective CFTR Modulator Therapy: A National Cross-Sectional Mixed-Methods Survey

Cristian Phillip Marinău, Cristian Sava, Alin Iuhas, Ioana Mihaiela Ciucă, Liviu Laurențiu Pop, Mihai Craiu, Zsolt Futaki, Ariana Szilagyi, Alexandru Jurca, Claudia Maria Jurca

Background/Objectives: Highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy has changed cystic fibrosis (CF) care, but Romanian patient-reported health-related quality of life (HRQoL) data remain limited. This national cross-sectional mixed-methods survey aimed to describe patient- and parent-reported HRQoL in Romanian people with CF (pwCF) aged ≥6 years using age-appropriate Cystic Fibrosis Questionnaire-Revised (CFQ-R) versions, with the respiratory domain as the primary o …

16.08.2026journal-article

International Journal of Education and Humanities

Research on Data Augmentation and Deep Learning Algorithms for Speech Emotion Computing

Kaiyu Guo, Yungang Wei

Speech is the most natural human interaction medium, which contains both linguistic semantic information and numerous non-semantic linguistic characteristics such as emotion, attitude and mood, making it a core research object in the fields of computational linguistics and human-computer interaction. Speech emotion computing aims to explore emotional features embedded in speech signals through computer algorithms to realize automatic recognition and classification of human emotions. It is an interdisciplinary resea …

16.08.2026journal-article

Journal of Medical Rehabilitation

Early postoperative complications after extensive surgery for pelvic malignant neoplasms: prevention and nonsurgical correction

V. А. Korotkov, L. S. Mkrtchian, I. N. Kuleshov, М. R. Kasymov, Е. А. Volicheva, G. Kh. Grigorian, Zh. V. Khailova, А. А. Nevolskikh, S. А. Ivanov, А. D. Kaprin

Contemporary surgical procedures are increasingly becoming more complicated and extensive, often requiring the removal of large volumes of tissue and resulting in significant changes to the patient's internal anatomy. Due to the advancements in anesthesia care, these operations can be performed successfully with a low risk of severe intraoperative complications. However, the postoperative period can pose some risks, including seromas, gastrointestinal motility disorders, wound suppuration and dehiscence. While not …

16.08.2026journal-article

Indonesian Journal of Health Science

Physiotherapy management and therapeutic exercise in drop hand due to radial nerve palsy after orif of humeral fracture: A case report

Yunita Andita Putri, Aleyda Asy Syifa, Ardhia Pramesti Amalia

Background: Postoperative radial nerve palsy after Open Reduction Internal Fixation (ORIF) of a humeral shaft fracture may cause wrist drop, sensory disturbance, weakness of the wrist extensors, and limitations in upper-extremity activities. Physiotherapy is intended to reduce secondary impairments, maintain joint mobility, and support function during nerve recovery. Objective: This case report aimed to evaluate clinical changes following physiotherapy management in a patient with wrist drop due to postoperative ra …

16.08.2026journal-article

Journal of Medical Rehabilitation

Сonceptual model and system of performance indicators for medical rehabilitation in the Russian Federation

D. V. Blinov, A. G. Solopova, E. V. Gameeva, A. M. Stepanova, O. A. Obukhova, B. E. Gornyy

Background. Although regulatory requirements for assessing the efficiency of medical rehabilitation have been established in the Russian Federation, a unified, conceptually structured system of indicators consistent with international frameworks still needs to be developed. Due to the disparity of indicators across departments, regional data become difficult to compare and further integrate into international monitoring. Objective: To develop a conceptual model and matrix of basic indicators that evaluate the perfo …

16.08.2026journal-article

Psychogeriatrics

Efficacy and Safety of Electroconvulsive Therapy for Dementia With Lewy Bodies, Its Prodromal Phase, and Parkinson's Disease Dementia: Eight Cases Encountered at Our Institution

Takahide Fukatsu, Kouhei Fujita, Taro Yoshida, Mihoko Kawai, Jun Miyata

ABSTRACT Purpose This study aimed to assess the efficacy and safety of electroconvulsive therapy (ECT) for treating psychiatric symptoms and parkinsonism in patients affected by dementia with Lewy bodies (DLB), its prodromal phase, and Parkinson's disease dementia (PDD). Methods We retrospectively reviewed eight patients (four males, four females; mean age 71.5 ± 8.9 years) diagnosed with probable DLB or its prodromal phase, based on diagnostic criteria, who underwent ECT between January 2020 and December 2025. The …

16.08.2026journal-article

The International Journal of Medical Science and Health Research

A Comprehensive Systematic Review of the Role of Semaglutide Anti-Obesity Therapy in Multiple Metabolic Diseases: A Systematic Review of Randomized Controlled Trials and Primary Studies

Jeffy Marta

Introduction: Obesity constitutes the pathophysiological hub of interconnected metabolic diseases including type 2 diabetes mellitus (T2DM), atherosclerotic cardiovascular disease (ASCVD), heart failure with preserved ejection fraction (HFpEF), chronic kidney disease (CKD), metabolic dysfunction-associated steatohepatitis (MASH) and peripheral artery disease (PAD). Semaglutide, a long-acting glucagon-like peptide-1 receptor agonist (GLP-1 RA), has been evaluated across all these domains. This systematic review synt …

16.08.2026journal-article

Journal Of Babylon Center for Humanities Studies

خطاب الكراهية في الفضاء الرقمي وأثره في السلم المجتمعي

رقيب محمد جاسم, فنار طارق ياسين

يَحمل خطاب الكراهية مدلولاتٍ سلبية، تمخّضت عنه رسائل محرّضة على العنف وبث التفرقة، والتمييز ضد عرقٍ معين أو مجموعةٍ ثقافية أو دينية. وقد تصاعدت لهجة هذا الخطاب في الفضاء الرقمي، من خلال ما تبثّه بعض الجهات والأفراد عبر المنصّات الرقمية من مضامين قائمة على التحّريض والتميّز. لقد أضحى خطاب الكراهية في الفضاء الرقمي ظاهرة تستدعي الدراسة، لأنها خلقت ثقافة تقبّل الكراهية والتشهير والتنمّر الذي يتطلب تضافر كل الجهود لمواجهتها، فضلاً عن عدم وجود تعريفٍ دولي موحّد لها، مما أدى الى ظهور تناقضاتٍ عدة في التطبيق القانوني له ن …

16.08.2026journal-article

Current Issues in Molecular Biology

Antiseizure Medications in Development: Novel Mechanisms, Precision Therapy, and the Move Towards Disease Modification

William Alves Martins

Background: Despite more than 30 licenced antiseizure medications (ASMs), approximately one third of people with epilepsy remain drug-resistant, and developmental and epileptic encephalopathies represent one of the greatest unmet needs in epilepsy therapeutics. The past decade has produced a substantial reorientation of ASM discovery, driven by epilepsy genetics, new disease models, advances in drug screening, and innovative therapeutic modalities. Objective: The objective of this study was to review the contempora …

16.08.2026journal-article

Journal of Drug Delivery and Therapeutics

An Observational and Comparative Study of Cardiovascular Drug: Chlorthalidone and Hydrochlorothiazide the First Line Drug Therapy of Hypertension

Ishika Roy, Abhishek Prasad

Background: Hypertension is when the pressure in blood pressure vessels is too high. The heart has to work harder to pump blood. Hypertension also known as silent killer. There are 2 types of hypertensions each has a different cause. It causes complications such as heart attack or stroke heart failure, kidney problems, metabolic syndrome, etc. The risk of hypertension increases with age. Smoking and alcohol consumption also raises blood pressure. Objective: The present investigation to observe and compare cardiovas …

16.08.2026journal-article

Advanced Healthcare Materials

A Novel Drug‐Loaded Porous Parylene Electrode for Targeted Anti‐Inflammatory Therapy and Hearing Preservation in Cochlear Implantation

Chi‐Chieh Chang, Ying‐Chang Lu, Yu‐Ming Chang, Yen‐Hui Chan, Hong‐Yu Yan, Yi‐Shan Lee, Pei‐Hsuan Lin, Cheng‐Yu Hsieh, Chuan‐Jen Hsu, Tien‐Chen Liu, Hsien‐Yeh Chen, Chen‐Chi Wu

ABSTRACT This study investigates the feasibility and therapeutic effectiveness of a novel drug‑loaded parylene electrode prototype (PEP) designed to reduce inflammation and hearing loss associated with cochlear implantation (CI). The porous PEP was fabricated using vapor‑phase sublimation and deposition, producing an interconnected structure with 20–30 µm pores and mechanical flexibility suitable for intracochlear placement. Dexamethasone was incorporated into the device (Dex/PEP), and in vitro characterization usi …

16.08.2026journal-article

Physiotherapy Research International

Responsiveness, Smallest Detectable Change, and Minimal Important Change of the Turkish Pelvic Floor Distress Inventory‐20 Following Pelvic Floor Muscle Training

Seyda Toprak Celenay, Erhan Secer, Yasemin Karaaslan, Zehra Korkut, Derya Ozer Kaya

ABSTRACT Background and Purpose The Pelvic Floor Distress Inventory‐20 (PFDI‐20) is a widely recognized clinical tool designed to assess the severity of distress caused by pelvic floor symptoms. Within the context of conservative physiotherapy and pelvic floor rehabilitation, this study aimed to determine the responsiveness, smallest detectable change (SDC), and minimal important change (MIC) of the Turkish PFDI‐20 in women with pelvic floor dysfunction (PFD). Methods This multicenter, retrospective study consisted …

16.08.2026journal-article

Brazilian Journal of Science

Functional imaging beyond anatomy: The emerging role of magnetic resonance spectroscopy and metabolic biomarkers in monitoring targeted cancer therapy

Hao Sun, Xiaojun Dong, Jinze Yu, Yuanyin Teng, Gaoyang Guo, Liangyu Li, Wei Wang, Bing Liu, Yuquan Li, Keyang Xu

Anatomical imaging — measurements of tumour size on computed tomography or conventional magnetic resonance imaging (MRI) — remains the backbone of oncologic response assessment, yet it is structurally blind to the earliest events of treatment action. Targeted anticancer agents, by definition, act on specific molecular pathways whose blockade alters tumour metabolism within hours to days, long before any measurable change in tumour dimensions. Magnetic resonance spectroscopy (MRS) and spectroscopic imaging (MRSI) ar …

16.08.2026journal-article

Pharmaceutics

Mechanistic Artificial Intelligence for Personalized Drug Therapy: Integrating Pharmacokinetics, Pharmacodynamics, Therapeutic Drug Monitoring, and Multiomic Systems Biology

Ian Jenkins, Krista Casazza, Waldemar Lernhardt, Valentina Savich, Jayson Uffens, Vaishnavi Narayan, Jonathan R. T. Lakey

Interindividual variability in drug response remains a major challenge in clinical pharmacology despite substantial advances in therapeutic drug monitoring (TDM), pharmacogenomics, pharmacokinetics/pharmacodynamics (PK/PD), and model-informed precision dosing (MIPD). Although these approaches have improved individualized therapy, clinically important variability in efficacy and toxicity persists because drug response is determined not only by systemic exposure but also by target engagement, disease biology, compens …

16.08.2026journal-article

Advanced Healthcare Materials

Engineered Exosome‐Mediated FIH‐1 Delivery for Targeted Therapy of Hyperuricemic Nephropathy by Inhibiting NF‐κB/NLRP3 Inflammasome Signaling and Restoring Autophagic Homeostasis

Ting Xiao, Yu Liu, Zhe He, Ailing Yang, Jing Li, Li Zhou, Qingxiang Yang, Dunquan Xu, Lijia Yuan, Ming Chen, Sha Yang

ABSTRACT Renal tubular epithelial fibrosis is a key pathological process in the progression of hyperuricemia (HUA), and hyperuricemic nephropathy (HN). Targeted inhibition of renal tubular epithelial cell (RTEC) fibrosis represents a promising therapeutic strategy for HN. Extracellular vesicles derived from induced pluripotent stem cell‐derived mesenchymal stem cells (iPSC‐MSCs) were engineered as nanostructured delivery vehicles incorporating two functional modules: a kidney‐targeting module and a functional prote …

16.08.2026journal-article

Exploration of Targeted Anti-tumor Therapy

Response-adaptive breast cancer care in the grey zones: integrating ER and HER2 targeted PET, FDG PET/CT under immunotherapy, and ctDNA kinetics

Jovana Zivanovic, Jules Zhang-Yin

Breast cancer management increasingly hinges on decisions made in “grey zones” where tissue sampling is scarce, and tumour biology evolves under therapeutic pressure. This narrative review synthesises evidence on how whole-body imaging biomarkers and circulating tumour DNA (ctDNA) can support response-adaptive pathways at the interface of surgical and systemic care. Four clinically actionable domains are discussed. (a) 16α-[18F]fluoro-17β-estradiol ([18F]FES) positron emission tomography/computed tomography (PET/CT …

15.08.2026journal-article

Russian Journal of Cardiology

Potential for using speech patterns in cardiovascular disease diagnosis: a systematic review

A. A. Garanin, A. R. Khumorova, A. O. Rubanenko, O. Yu. Aidumova, A. V. Kolsanov

Aim . To determine the potential of using acoustic speech signal analysis parameters and speech biomarkers in the diagnosis and monitoring of cardiovascular diseases. Material and methods . A search was conducted in accordance with the requirements and guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) in the PubMed, Google Scholar, ClinicalTrials, CyberLeninka, and eLibrary databases. The review included 14 original studies that analyzed the voice parameters of patients with …

15.08.2026journal-article

International Journal of Pharmaceutical and Bio Medical Science

Yoga Prana Vidya Healing as Alternative Therapy in the Resolution of Hemorrhoids And Dysmenorrhea: A Case Study

Venkata Satyanarayana Nanduri, Leelavathi Nayak

Background: Hemorrhoids and dysmenorrhea are common conditions that impair quality of life. Conventional treatments often provide partial relief and carry risks of recurrence. Yoga Prana Vidya (YPV), an integrative energy-based healing system, has shown promise in managing chronic conditions. Case Presentation: A 39-year-old female presented with chronic hemorrhoids, dysmenorrhea, headaches, and disturbed sleep. Symptoms persisted despite dietary modifications and self-practice of pranayama. She consulted a certifi …

15.08.2026journal-article

Medicine and ecology

Role of training classes for students in creating an individual human functioning profile and evaluating the effectiveness of rehabilitation

M. T. Koichumanova, I. A. Pekur, Sh. M. Gazalieva, O. V. Kazimirova

In the presented article, the role of the International Classification of Functioning, Limitations of Life and Health of a person is considered, which allows young specialists and interns to practice independently from the first days: 1) to conduct a comprehensive analysis of the patient’s existing life limitations; 2) to change the level and vector of building programs not only medical, but also social and environmental rehabilitation; 3) clarify the sequence of the complex of rehabilitation measures for supervise …

15.08.2026journal-article

Actas Españolas de Psiquiatría

Research Progress on Light Therapy to Improve Depressive Symptoms of Bipolar Depression

Yutong Cui

Bipolar depression is the predominant and most disabling phase of bipolar disorder, featured by recurrent depressive episodes that impair psychosocial function and quality of life. Conventional pharmacotherapy has limited efficacy and carries a risk of mood destabilization (e.g., affective switch). Light therapy, a nonpharmacological chronotherapeutic intervention, has shown potential to improve bipolar depression symptoms by regulating circadian rhythms and mood regulating neural circuits. This review synthesized …

15.08.2026journal-article

Advanced Healthcare Materials

Algae‐Integrated Optoelectronic Nanoplatform for Tumor Hypoxia Relief and Enhanced Photodynamic Therapy

Gongcheng Ma, Nan Zhang, Hongrong Shi, Yaoqiang Li, Haoran Wang, Chaoyang Tang, Shengmei Wang, Hongli Chen, Qingzhi Wang, Zhaohui Wang, Guogang Liu, Ben Zhong Tang, Qihang Ding

ABSTRACT The clinical efficacy of photodynamic therapy (PDT) is fundamentally limited by the scarcity of efficient photosensitizers (PSs) and the oxygen dependence of singlet‐oxygen–mediated cytotoxicity. Here we report pentaperylene decaimide selenide (PPD‐Se), a nanographene‐derived photoelectronic material that functions as a high‐performance Type‐II photosensitizer. PPD‐Se exhibits broadband absorption (300–650 nm), enhanced intersystem crossing enabled by a selenium‐induced heavy‐atom effect, a small ΔE ST (0. …

15.08.2026journal-article

Journal of Dementia and Alzheimer's Disease

Fluid and Imaging Biomarkers in Lecanemab Therapy for Early Alzheimer’s Disease: Current Evidence, ARIA Risk Prediction, and Treatment Monitoring

Pan-Woo Ko

Background/Objectives: Lecanemab, a humanized anti-amyloid-β protofibril antibody, achieves substantial amyloid clearance and modest slowing of clinical decline in early Alzheimer’s disease (AD). Amyloid-related imaging abnormalities (ARIA) represent the most clinically important safety concern, yet no fluid biomarker has been prospectively validated for ARIA prediction in lecanemab-treated patients. This review critically synthesizes current evidence on fluid and imaging biomarkers for ARIA risk stratification and …