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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
17.08.2026journal-article

Adolescência e Saúde

Methodological Confidence And Reported Certainty Of Evidence For Virtual Rehabilitation And Mirror Therapy In Post-Stroke Upper-Extremity Function: An Umbrella-Review Audit Using AMSTAR 2 And GRADE

Tumuluri S S Chandra Sekharendra Swamy, Dr. Payal Sharma, PT, Dr. Dipika Balala, PT, Dr. Deepak Lohar, PT, Dr. Jafar Khan, PT, K. M. Annamalai, Shradha Hariom Tiwari, Sneha Thakur Lund, Parul Sharma, Payal Padole

Background. Systematic reviews of virtual rehabilitation and mirror therapy for post-stroke upper-extremity function have expanded rapidly, but the methodological confidence and reporting practices of these reviews remain unclear. Objective. To audit the methodological confidence and reporting practices of systematic reviews examining virtual rehabilitation and mirror therapy for post-stroke upper-extremity function using AMSTAR 2. Methods. An umbrella-review audit of review methods was conducted. PubMed, Europe PM …

17.08.2026journal-article

Frontiers in Immunology

URAT1 inhibition in hyperuricemia and gout: from transporter biology to clinical precision therapy

Guangtao Li, Yu Wang, Zhuoli Zhang

Impaired renal urate excretion is a major mechanism underlying hyperuricemia and gout, with urate transporter 1 (URAT1), encoded by SLC22A12, playing a central role in proximal tubular urate reabsorption. This review summarizes the biological relevance of URAT1, the pharmacological evolution of URAT1 inhibitors, and their clinical implications in urate-lowering therapy. Evidence from transporter biology, structural pharmacology, pharmacokinetic and pharmacodynamic studies, and clinical trials was narratively synthe …

17.08.2026journal-article

BMEMat

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang

Abstract The dynamic interplay between intratumoral bacteria and cancer progression has unveiled new avenues for precision oncology, positioning bacteria as versatile, programmable platforms for targeted therapy. This review systematically explores the dual roles of tumor‐associated microbiota‐both promoting and suppressing malignancy‐and highlights the transformative potential of engineered bacterial systems in cancer treatment. Capitalizing on their innate tropism for hypoxic tumor cores, bacteria serve as self‐p …

17.08.2026journal-article

Small

Potentiating In Vivo Precision Cancer Therapy With Modularized Aptamer‐Chemotherapeutics Conjugates Based on DNA Tiling‐Mediated Structural Nanotechnology

Weijun Wang, Jingting Wu, Yuxi Yang, Xinru Yu, Wenhao Pan, Wenqing Lin, Zai‐Sheng Wu

ABSTRACT While DNA origami nanotubes have been often used in the biomedical field, the technical challenges in the assembly at large scale and the susceptibility to degradation limit their exploration for clinical application. In the current contribution, we propose a structural DNA nanotechnology (TMM) for the construction of a degradation‐resistant DNA nanotube (DNT) via periodically tiling two structural modules (M) into a modularized (M) tubular DNA nano‐architecture. The tube circumference is 118.6 nm, the tub …

17.08.2026journal-article

Clinical and Experimental Dermatology

Refractory livedoid vasculopathy successfully treated with CHAP therapy and punch grafts: two case reports

María del Señor Gómez Marín, Miguel Juan Cencerrado, Irene Suárez Vergne

Abstract Livedoid vasculopathy (LV) is a chronic thrombotic microangiopathy characterized by painful ulcerations that significantly impair quality of life. Management of refractory LV remains challenging as conventional therapies have limited efficacy. We report two female patients with chronic, painful ulcers unresponsive to multiple intravenous immunoglobulin cycles who achieved complete ulcer healing and rapid pain resolution following a combined regimen of CHAP therapy, comprising nifedipine, hydroxychloroquine …

17.08.2026journal-article

Human Systems: Therapy, Culture and Attachments

The we-dentity daisy approach for creating antidotes to life diminishing stories of identity; a CMM informed systemic narrative approach

Rachel Ames, Glenda Fredman

We share our personal and professional journeys through different identity discourses that have shaped our practice as clinical psychologists and systemic psychotherapists working with children, adults and older people within public physical and mental health services. Through examples of our work with children affected by illness and disability, we track the development of our understandings of identity from ‘internal states of self’ to understandings that are relational, distributed, performed, and fluid. Integra …

17.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

How digital leadership fosters employee proactive behavior: A dual-pathway model based on job demands and resources

Mingqi Huang, Wei Shao

Background Digital leadership is increasingly recognized as critical to organizational digital transformation. How digital leadership fosters employee proactive behavior through job characteristics remains insufficiently understood. Objective Drawing on Job Demands-Resources theory, this study develops and tests a dual-pathway model examining how digital leadership influences employee proactive behavior through digital job demands and digital job resources, with employee digital literacy as a boundary condition. Me …

17.08.2026journal-article

Adolescência e Saúde

Patient-Reported Barriers To Routine Dental Care And Postoperative Maxillofacial Prosthetic Rehabilitation In Head And Neck Cancer Patients: A Cross-Sectional Study

Sudhakar Vundavalli, Koya Srikanth, Radhika Doppalapudi, Aravind Muthukrishnan, Kaleswara Rao Atluri, MeignanaArumugham Indiran, Rakhi Issrani, Ravikanth Manyam

Background: Survivors of head and neck cancer require sustained oral healthcare after cancer therapy; few cases may additionally need specialized maxillofacial prosthetic rehabilitation. Objective: To assess patient-reported barriers to routine dental care among post-treatment head and neck cancer patients and, among those requiring a maxillofacial prosthesis, to characterize barriers to postoperative prosthetic rehabilitation. Methods: A cross-sectional survey was conducted among 194 post-treatment head and neck c …

17.08.2026journal-article

Adolescência e Saúde

Psychological Stress And Occupational Performance Among Seafarers: A Systematic Review Of Verified Empirical Evidence

Rashmi Sharma, Dr. Anurag Shakya

Background: Seafaring brings together several demanding features of work within a single occupation - long absences from family, cramped and shared living conditions, irregular sleep, mixed-nationality crews, and heavy workloads carried out with little outside support. A substantial body of research has examined how these conditions give rise to psychological stress, and how that stress in turn shapes seafarers' mental health, wellbeing, and ability to carry out their duties. Objectives: This review has two aims: f …

17.08.2026journal-article

Revista Árvore

Effect of the rehabilitation of bauxite mining areas on the infiltration and repellency of the soil to water

Henrique de Andrade Cenachi, Herly Carlos Teixeira Dias, Bernardo Fontes Grossi Lino, Bruna Queiroz de Souza, Paulo Cesar Marques Cordeiro, Juliana Marcela de Paiva, Rodolfo Soares de Almeida, Mônica de Abreu Azevedo, Hélio Garcia Leite

Brazil, the fourth-largest holder of bauxite reserves worldwide, plays a prominent role in global mineral production. However, open-pit mining can alter soil hydrological attributes due to vegetation removal and intensive soil disturbance. This study evaluated the effects of rehabilitation practices implemented by Companhia Brasileira de Alumínio (CBA) on water infiltration, unsaturated hydraulic conductivity, and soil water repellency. Six study areas were selected in the municipality of São Sebastião da Vargem Al …

17.08.2026journal-article

Revista de Geopolítica

A GAMETERAPIA ASSOCIADA À FISIOTERAPIA NO TRATAMENTO DE CRIANÇAS COM PARALISIA CEREBRAL: UMA REVISÃO INTEGRATIVA

Elane Tereza Oliveira Bandeira, Emanoel Pereira da Silva Neto, Gustavo Coringa de Lemos, Joelma Gomes da Silva Rocha, Rebeca Graziely Gomes de Melo, Frederico da Silva Jales, Andréa Raquel Fernandes Carlos da Costa, Lidiane Pinto de Mendonça Ferreira, Sirlene Batista Cavalcante, Natália Jéssica Barra Silva

Nos últimos anos o uso de recursos tecnológicos na área da saúde vem sendo utilizado como uma estratégia terapêutica, sendo esta reconhecida como Gameterapia. Dentre esses recursos destaca-se a Realidade Virtual (RV), a qual possibilita ao paciente se sentir inserido em uma realidade artificial criada digitalmente. Assim, no tratamento de crianças com Paralisia Cerebral (PC), a Fisioterapia e a Gameterapia podem estar associadas na tentativa de potencializar os resultados e proporcionar momentos de ludicidade. Dian …

17.08.2026journal-article

Artefactum - revista de estudos interdisciplinares

THE INTEGRATION OF NEUROPSYCHOPEDAGOGY, MUSIC THERAPY, AND PSYCHOMOTOR THERAPY IN THE DEVELOPMENT OF CHILDREN WITH AUTISM SPECTRUM DISORDER: AN INTEGRATIVE LITERATURE REVIEW

Kevin Barbosa de Moraes Feitosa

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by persistent differences in communication and social interaction, associated with restricted and repetitive patterns of behavior and interests. Given the heterogeneity present within the autism spectrum, it is essential to adopt individualized intervention strategies based on each child’s needs, potential, and characteristics. In this context, the integration of neuropsychopedagogy, music therapy, and psychomotor therapy offers an inter …

17.08.2026journal-article

Frontiers in Medicine

Efficacy of ozone with steroid injection therapy in lumbar disc herniation: meta-analysis

Yi Zhou, Hongyu Yu

Background The efficacy of ozone combined with steroid injection for lumbar disc herniation remains uncertain. This systematic review and meta-analysis aimed to investigate the efficacy of Ozone with steroid injection therapy in the treatment of lumbar disc herniation. Methods PubMed, Embase, Web of Science, and Wanfang were searched from database inception to July 20, 2026. Comparative studies evaluating ozone combined with steroid injection in patients with lumbar disc herniation were included. Mean differences ( …

17.08.2026journal-article

International Journal of Molecular Sciences

Clinical Impact of a Common PDCD1 Germline Variant in DLBCL Patients Treated with CAR-T Cell Therapy

Katja Seipel, Marta Gonçalves Fonseca, Inna Shaforostova, Seok-Yun Lee, Ulrike Bacher, Thomas Pabst

Chimeric antigen receptor CAR T-cells are effective immunotherapies for patients with relapsed or refractory diffuse large B-cell lymphoma (r/r DLBCL) with overall response rates of 63–84% and complete response rates of 43–54%. Programmed cell death protein 1 (PD-1) is a cell surface receptor with immune check-point function. There are several common germline variants of the PDCD1 gene, including the linked single nucleotide polymorphisms (SNP) rs6710479 and rs2227981. Genetic variants of the immune-checkpoint regu …

17.08.2026journal-article

The Journal of ECT

Klazomania Refractory to Electroconvulsive Therapy

Vishwa Thakkar, Sagar Karia, Nilesh Shah

Klazomania is a rare phenomenon characterized by compulsive, uncontrollable shouting or yelling without an emotional trigger or reason. It has been reported to be associated with various psychiatric and neurological conditions. No specific treatment has been recommended as the etiology is not known. Trials of antipsychotics, antidepressants, and antiepileptic drugs have been used. Hereby, we report a case of Klazomania in a patient with Obsessive Compulsive Disorder who initially responded to Electroconvulsive Ther …

17.08.2026journal-article

Adolescência e Saúde

Freedom Of Speech And Expression In The Digital Age: A Critical Analysis Of Constitutional Rights, Social Media Regulation, And Emerging Technologies

Dr. Mamta Rani, Dr. Jitendra Yadav

Freedom of speech and expression constitutes one of the fundamental pillars of a democratic society. In India, Article 19(1)(a) of the Constitution guarantees every citizen the right to freedom of speech and expression, while Article 19(2) permits reasonable restrictions in the interests of sovereignty, security, public order, decency, morality, contempt of court, defamation, and incitement to an offence. The emergence of digital technologies, social media platforms, artificial intelligence (AI), algorithmic govern …

17.08.2026journal-article

Clinical Rehabilitation

A systematic review of early neuroimaging and neurophysiological biomarkers for post-stroke mobility prognostication

Cristina Levy, Emily J Dalton, Jennifer K Ferris, Bruce CV Campbell, Amy Brodtmann, Sandra Brauer, Leonid Churilov, Kathryn S Hayward

Objective Prognostication may help guide mobility rehabilitation planning and goal setting post-stroke. This systematic review aimed to examine the prognostic capacity of early neuroimaging and neurophysiological biomarkers of mobility outcomes up to 24 months post-stroke. Data sources MEDLINE/EMBASE was searched from inception to May 2026. Cohort studies that reported neuroimaging or neurophysiological biomarkers measured 14 days but ≤24 months post-stroke were included. Review methods Biomarker analyses were clas …

16.08.2026journal-article

Journal of Intensive Care

Prognostic associations of urine output in AKI and dialysis vintage in ESKD at continuous kidney replacement therapy initiation in ICU patients

Keisuke Okamoto, Naoki Ozu, Hidetada Fukushima, Masahiko Kawaguchi, Kazuhiko Tsuruya

Abstract Background Prognostic assessment at continuous kidney replacement therapy (CKRT) initiation remains challenging in ICU practice. CKRT recipients are heterogeneous; most have acute kidney injury (AKI), whereas a clinically important subset has end-stage kidney disease (ESKD). We evaluated whether pre-CKRT urine output in AKI and dialysis vintage in ESKD were associated with short-term prognosis after CKRT initiation. Methods We conducted a single-center retrospective cohort study of consecutive adults who s …

16.08.2026journal-article

Internal Medicine Journal

Adjunctive metformin therapy in type 1 diabetes in pregnancy: insights from an Australian cohort

Mauli Govinna, Joanna Gong, Jessica Triay, Dev Kevat

Abstract Metformin has gained attention as a potential adjunct therapy in pregnant women with type 1 diabetes mellitus (T1DM), although evidence is limited. We present the first reported experience of metformin use in pregnant women living with T1DM who used continuous glucose monitoring to monitor glycaemic outcomes. In our multicentre case series, metformin use was associated with an increased time in range and reduced glycaemic variability, supporting potential use in pregnant women with T1DM.

16.08.2026journal-article

Journal of Medical Rehabilitation

Medical rehabilitation and health resort treatment in patients with cardiovascular diseases

V. V. Shipulin

Background. Cardiovascular diseases (CVD) remain among the leading causes of mortality and disability, thereby underscoring the clinical and socioeconomic relevance of medical rehabilitation and secondary prevention. Cardiac rehabilitation uses a multidisciplinary approach that includes exercise training, modifying risk factors, educating patients, providing psychosocial support, and improving adherence. Objective: To summarize recent data on effective methods of medical rehabilitation and health resort treatment f …

16.08.2026journal-article

Bali Medical and Wellness Journal

Nutritional Therapy Based on ESPEN Guidelines in a Patient with Ascending Colon Non-Hodgkin Lymphoma Undergoing Chemotherapy with Decreased Oral Intake and Infectious Complications: A Case Report

Ni Komang Saraswita Laksmi

Background: Malnutrition is a frequent complication in patients with cancer undergoing chemotherapy due to increased metabolic requirements, treatment-related adverse effects, and infectious complications. Gastrointestinal disturbances such as nausea, dysphagia, and opportunistic infections may worsen food intake and increase the risk of malnutrition. Case Description: A 66-year-old woman with ascending colon non-Hodgkin lymphoma undergoing the fourth cycle of R-CHOP chemotherapy was hospitalized with pneumonia, or …

16.08.2026journal-article

Acta Medica Alanya

The Prognostic Significance of the NOLUS Score in Patients with Metastatic Breast Cancer Receiving CDK 4/6 Inhibitor Therapy

Ece Ulukal Karancı, Halil Göksel Güzel, Mustafa Özgür Arıcı, Mehmet Acun

Aim: Breast cancer is the most common cancer, and in the metastatic hormone-positive group, CDK-4-6 inhibitors are used. We aimed to examine the prognostic value of the “NOLUS” score, calculated from the estrogen receptor (ER), progesterone receptor (PR), and Ki-67 index, in patients with breast cancer receiving CDK 4/6 inhibitors.Materials and Methods: This retrospective single-center study included 76 patients with HR+/HER2- metastatic breast cancer who were treated with CDK 4/6 inhibitors (ribociclib or palbocic …

16.08.2026journal-article

Journal of Sustainable Research in Applied Sciences

Knowledge, Attitudes, and Barriers to Vital Pulp Therapy among Dental Practitioners in Zliten, Libya: A Cross-Sectional Study

Abdalmagid Rajab Alhammaly, Mustafa Ahmed Ben Hkoma

خلفية الدراسة: شهد مجال طب الأسنان التحفظي تحولاً جذرياً نحو الفلسفة الأساسية المتمثلة في التدبير العلاجي طفيف التوغل لطب اللب. وبدلاً من اللجوء التلقائي إلى علاجات الجذور التقليدية العنيفة وغير العكسية، تولي الأطر السريرية الحديثة الأولوية لعلاج اللب الحيوي (VPT) لإنقاذ الأنسجة اللبية المتضررة من النخر العميق أو الصدمات الميكانيكية. تقيم هذه الدراسة المسحية المقطعية مستوى المعرفة، والمواقف، والعوائق التشغيلية المتعلقة ببتر اللب الجزئي والكلي بين ممارسي طب الأسنان في مدينة زليتن، ليبيا. الأهداف: يتمثل الهدف الرئيسي …

16.08.2026journal-article

Healthcare

Procedural Optimization of Capsaicin 8% Patch Therapy Using Ultrasound-Guided Bilateral Ankle Nerve Block in Painful Diabetic Peripheral Neuropathy: A Retrospective Comparative Cohort Study

Hassan Moria

Background: Application of the capsaicin 8% patch is commonly associated with treatment-related burning pain, which may necessitate rescue analgesia, compromise completion of the standardized 60 min application, and reduce acceptance of repeat treatment. Although capsaicin is an established therapy for painful diabetic peripheral neuropathy (PDPN), evidence supporting strategies to improve procedural tolerability remains limited. This study evaluated whether ultrasound-guided bilateral ankle nerve block (UGBANB) wa …