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European Health Evidence

The European alternative to PubMed

EUVIMED is the European alternative to PubMed: a central, multilingual research platform for medicine, nursing, life sciences and healthcare. It brings together international and European literature sources, study registries, open-access full texts, citations and retraction notices in one search. Unlike pure bibliographic databases, EUVIMED supports the entire research process – from discovery and appraisal with LIVIA and CLARA to traceable evidence synthesis. European in focus, transparent, interoperable and designed for science and healthcare.

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EUVIMED Themenbrowser · Onkologie · Seite 141

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
30.08.2026journal-article

Libyan Journal of Medical Research

Study on Ginger as a Treatment for Stress and Anxiety Comparing With Diazepam

Ashraf Alzalitini, Naima El-Kakalli, Wafa Issadiq

Background: The psychological anxiety is considered one of the most significant animals of the modern era. The most common causes natural indictors that lead to tension, severe stress and un-desirable mental problems or disease are stress Anxiety problems or disease that considered as most frequently appearing as disorders. Anxiety disease is diagnosing as condition that showed or indicate to serious and severe or pathological case as the essential disturbance emotional tone. Aim: In this study, ginger was tested i …

30.08.2026journal-article

AI in Precision Oncology

Governing What We Cannot yet Verify: The Verification Paradox and Responsible AI Implementation in Precision Oncology

Yan Leyfman, Arturo Loaiza-Bonilla

Artificial intelligence (AI) is increasingly embedded in precision oncology, shaping molecular classification, biomarker interpretation, treatment selection, toxicity prediction, trial matching, and disease monitoring—yet institutional governance has not kept pace with clinical adoption. An original cross-sectional survey of U.S. oncology clinicians ( N = 52) reveals a structural governance gap: 83% use AI independently on personal platforms, 71% report no institutional governance policy, and 77% operate without in …

30.08.2026journal-article

Advanced Science

GSTM4 Suppresses Prostate Cancer Progression by Targeting TRIM27‐mediated ACLY Ubiquitination and Lipid Metabolism

Kang‐Ping Xiong, Fei Liu, Wang Wang, Gang Wang, Kai‐Yu Qian, Sheng Tu, Si‐Ming Chen, Hui‐Min Xu, Shan‐Shan Zhang, Yong Li, Xing‐Huan Wang, Hong Weng

ABSTRACT Prostate cancer (PCa) is a prevalent malignancy in men, and lipid metabolic reprogramming contributes to its progression and therapeutic resistance. However, the drivers of lipid metabolic dysregulation in PCa remain incompletely defined. Through transcriptomic sequencing of PCa patient tissues, we identified glutathione S‐transferase mu 4 (GSTM4) as a novel regulator of lipid metabolism. GSTM4 was significantly downregulated in PCa tissues and negatively correlated with triglyceride content. Functionally, …

30.08.2026journal-article

International Journal of Molecular Sciences

Metformin Suppresses Metastatic Potential and Sensitizes Ovarian Cancer Cells to Chemotherapeutics

Megha J. Pandya, Ayokunnumi Ogunsanya, Adedoyin Ajibade, Achuth Padmanabhan

The failure of current therapeutics to elicit a durable response in metastatic ovarian cancer patients highlights the urgent need to develop more effective treatment strategies. In this study, we demonstrate that the anti-diabetic drug metformin exerts cytotoxic effects across a broad panel of ovarian cancer cell lines. Transcriptomic analyses revealed that, in addition to reducing cell viability and proliferation, metformin modulates pathways associated with metastatic progression, including cell migration, extrac …

30.08.2026journal-article

Small

Poly (Lipoic Acid) Nanoparticles With High Blood‐Brain Barrier Permeability and Enhanced Anti‐Ferroptotic Activity for Ischemic Stroke Treatment

Qing‐Zhang Tuo, Juan Tan, Hong‐Fa Yan, Xueying Zhou, Peng Lei, Shiyong Zhang

ABSTRACT Lipoic acid (LA) scavenges free radicals and was clinically tested for ischemic stroke. However, the short half‐life and weak efficacy in penetrating the blood‐brain barrier (BBB) limit its use in the brain. Here, we developed poly (lipoic acid) nanoparticles (pLANs) with a half‐life of more than 15 h and a high efficiency to penetrate the BBB for ischemic stroke treatment. With intraperitoneal injection, imaging studies using fluorescently labelled pLANs of different sizes revealed that 30 nm pLANs entere …

30.08.2026journal-article

Health Science Reports

Temporal Trends in Colorectal Cancer Associated With Type 2 Diabetes Mellitus in U.S. Adults, 1999–2023: A CDC Wonder Database Analysis—A Population‐Based Cross‐Sectional Study

Waleed Tariq, Neha Waseem, Mehreen Maka, Bushra Ubaid, Sheetal Verma, Yusra Ejaz, Maryam Owais, Awais Tariq, Soha Waseem, Iftikhar Khan, Ehsanullah Alokozay, Muhammad Hassan Tariq, Shahzaib Ahmed, Shoaib Ahmad

ABSTRACT Background and Aims Colorectal cancer (CRC) and type 2 diabetes mellitus (T2DM) are significant contributors to global morbidity and mortality, with growing evidence suggesting a synergistic impact on disease outcomes. This research focused on analyzing trends in CRC‐related deaths among individuals with coexisting T2DM in the United States from 1999 to 2023, as well as exploring disparities among different demographic and geographic groups. Methods Data were obtained from the CDC WONDER database for death …

30.08.2026journal-article

Molecular Carcinogenesis

Multi‐Omic Analysis of Putative Cellular Senescence‐Associated Genes on the Risk of Pan‐Cancer

Bin Liu, Weidong Wu, Chang Liu, Pengya Feng, Simeng Liu, Shanshan Gong, Yingying Li, Ya Li, Jun Mi, Pengyuan Zheng, Hongtao Wen, Xia Xue, Yang Mi

ABSTRACT Cellular senescence plays a critical role in physiological and pathological processes. This study aims to elucidate the contribution of cellular senescence‐related genes to disease etiology. We investigated a cohort study of 439,501 individuals, which included 22 cancers and 9 non‐cancer diseases. We found that HLA‐E and HLA‐G ‐associated senescence in epithelial and immune cells were specific oncogenic factors for prostate and lung cancers. MAP2K4 was implicated as a risk factor for breast cancer, while Z …

30.08.2026journal-article

MedComm

Migraine: Epidemiology, Risk Factors, Pathophysiology, and Treatment

Weiwei Lu, Yuan Zhang, Chen Shi, Yu Tao, Shaoxin Li, Yufang Sun, Fuhai Ji, Dongsheng Jiang, Terrance P. Snutch, Jin Tao

ABSTRACT Migraine is a common, disabling brain disorder that affects about 1 billion people worldwide and disproportionately burdens women and working‐age adults. Once viewed mainly as a vascular headache, migraine is now understood as a heterogeneous neurobiological syndrome arising from interactions among genetic susceptibility, hormonal influences, environmental exposures, and cortical, brainstem, trigeminovascular, and neuroinflammatory networks. Although calcitonin gene‐related peptide (CGRP)‐pathway therapies …

30.08.2026journal-article

Cancer Medicine

Target‐Specific Dermatological Adverse Event Reporting With T‐Cell–Engaging Bispecific Antibodies: A Pharmacovigilance Analysis of FAERS and Canada Vigilance, 2016–2026

Saikat Mandal, Manideepa Maji, Arkadeep Dhali

ABSTRACT Background T‐cell–engaging bispecific antibodies are increasingly utilised in haematological malignancies and are beginning to be adopted in solid‐tumour treatment protocols. Cytokine release syndrome and neurotoxicity are well recognised, but target‐specific dermatological adverse event reporting patterns remain poorly defined. Methods We analysed 12,333,305 deduplicated FAERS reports from 2016Q1 to 2026Q1, including 23,386 reports exposed to ten T‐cell–engaging bispecific antibodies grouped by target: CD …

30.08.2026journal-article

Cancer Medicine

The Molecular and Immunological Landscape in Nasopharyngeal Carcinoma ( NPC ) Differs by Somatostatin Receptor 2 ( SSTR2 ) Expression

Dara Bracken‐Clarke, Elisabetta Xue, Harris Krause, Tolulope Adeyelu, Mark G. Evans, Dilara Akbulut, Martha Quezado, Nishant Gandhi, Alex Farrell, Heloisa P. Soares, Emil Lou, Minh Phan, Rusha Patel, Ari M. Vanderwalde, Andrew Elliott, Conor E. Steuer, Nabil F. Saba, Daniel J. Lubin, Nyall R. London, James L. Gulley, Charalampos S. Floudas

ABSTRACT Somatostatin receptor 2 is expressed in nasopharyngeal carcinoma (NPC). We report genomic and transcriptomic analysis results of 163 NPC cases, demonstrating that somatostatin receptor 2 ( SSTR2 ) gene expression in EBV‐positive and in EBV‐negative NPC correlated with genomic alterations and an inflamed microenvironment. Median SSTR2 expression was 6.52 transcripts per million (TPM), ranging from 0.59 TPM (Quartile 1 [Q1], 18.2% EBV‐positive) to 35.79 TPM (Q4, 82.9% EBV‐positive). PIK3CA (20.51%) and CYLD …

30.08.2026journal-article

Journal of Artificial Intelligence and Information

Research Progress of Xuefu Zhuyu Decoction and Its Single Herbs in the Treatment of Coronary Heart Disease

Huan Zhang, Junru Zhang, Yiman Zhang, Danlei Mao

Coronary atherosclerotic heart disease, abbreviated as coronary heart disease (CHD), is a chronic cardiovascular disease and one of the major diseases threatening the life and health of populations worldwide. Its morbidity and mortality rates are on the rise. In recent years, CHD has also shown a trend of affecting younger individuals, making long-term treatment and management critically important. In traditional Chinese medicine (TCM), CHD falls under the category of “chest stuffiness and heart pain” (xiongbi xint …

30.08.2026journal-article

Mini-Reviews in Medicinal Chemistry

Regulation of PI3K Signaling by lncRNAs in Breast Cancer: A Mini-Review

Azita Asadi, Mehran Molavand, Bahman Yousefi

Despite remarkable advancements, the treatment of breast cancer remains a serious challenge. In recent decades, extensive studies have been conducted to identify new therapeutic targets for the treatment of breast cancer. Among these therapeutic targets that have gained attention in recent years are lncRNAs. These molecules appear to affect proliferation, metastasis, and drug resistance in cancer cells by regulating multiple signaling pathways. Among the signaling pathways implicated in breast cancer, the PI3K/AKT/ …

30.08.2026journal-article

Precision Radiation Oncology

Precise delineation of radiation targets for thoracic tumors in the immunotherapy era: from immune mechanisms to clinical practice

Xiaoying Chen, Minxiao Yi, Yu Deng, Qian Shen

Abstract As a core modality for local control of thoracic tumors, including lung and esophageal cancers, radiotherapy (RT) shows synergistic effects with immunotherapy, fundamentally reshaping the landscape of cancer treatment. Given the rapid advancements in immunotherapy, this review explores the critical role of precise delineation of radiotherapy targets in achieving synergistic effects between RT and immunotherapy. It elucidates the dual‐edged nature of RT, which can both activate antitumor immune responses an …

30.08.2026journal-article

HEALTH SCIENCES AND DISEASE

Sexualité et Cancer en Côte d'Ivoire : Évaluation de l'Impact du Diagnostic et des Traitements chez les Patients au CHU de Treichville

Petiori G Laurence Touré, Odo Bitti Adde, Kouassi Konan Kouamé Yvon, Emmanuelle Esther De, Ibrahima Kalil Condé, Madiou Mohamed Kassir, Odidi Femi Perez, Mebiala Prosper Malan N’Guessan, Ismael Kamara, Fleur Audrey Sessegnon, Nogbou Akissi Marie Barbara Yvonne, Yenabahan Lazare Touré, Traoré-Kouassi Danielle, Etobo Innocent Ahounou, Aka Rita, Moctar Touré, Innocent Adoubi

RÉSUMÉIntroduction. Le cancer et ses traitements peuvent altérer la sexualité, dimension essentielle de la qualité de vie souvent négligée en pratique clinique. En Afrique subsaharienne, les données sur l'impact du cancer sur la fonction sexuelle restent limitées. Cette étude avait pour but de décrire les troubles de la sexualité et leur évolution avant et après le diagnostic de cancer chez des patients suivis à Abidjan. Méthodes. Nous avons mené une étude transversale descriptive à recueil comparatif intra-individ …

30.08.2026journal-article

ChemistrySelect

From Resistance to Renewal: Design Strategies and Structure–Activity Relationships of Novel EGFR Inhibitors in Breast Cancer: Mini Review

Neelima Shrivastava, Chanda Ranjan

ABSTRACT Breast cancer continues to be one of the top causes of cancer death globally, with triple‐negative breast cancer (TNBC) being the most aggressive variety as it has a much poorer prognosis, strong propensity for metastases, and fewer effective targeted therapies available. The increased expression of the epidermal growth factor receptor (EGFR) is essential for cancer cell growth, survival, migration, and drug resistance making EGFR a good target for therapy. However, the effectiveness of EGFR inhibitors has …

30.08.2026journal-article

Journal of Artificial Intelligence and Information

From Diagnosis to Treatment: Advances in Clinical Research on Severe Pneumonia

Sheng Wang, Xiaoli Wu, Xiaoshuai Wu

Severe pneumonia is a life-threatening infectious disease associated with high mortality and is frequently complicated by acute respiratory distress syndrome, septic shock, and multiple organ dysfunction. The current diagnostic and therapeutic paradigm is shifting from empirical broad-spectrum treatment toward individualized management based on precise pathogen identification and assessment of the host response. The pathogenesis of severe pneumonia involves a broad range of bacterial, viral, and fungal pathogens, t …

30.08.2026journal-article

Journal of Surgical Oncology

Prognostic Value of the Preoperative Tumor‐to‐Blood Pool Standardized Uptake Value Ratio Derived From FDG‐PET/CT in Distal Bile Duct and Ampullary Cancers

Hiroyuki Matsukawa, Hironobu Suto, Yasuhisa Ando, Minoru Oshima, Takuro Fuke, Yoshio Shimizu, Mina Nagao, Kenichi Tanaka, Kensuke Kumamoto, Keiichi Okano

ABSTRACT Purpose This study investigated the prognostic value of the preoperative tumor‐to‐blood pool standardized uptake value ratio (TBR) on 18 F‐fluorodeoxyglucose positron emission tomography/computed tomography (FDG‐PET/CT) in patients undergoing pancreatoduodenectomy (PD) for distal bile duct and ampullary cancers. Methods We retrospectively reviewed 100 patients who underwent PD between January 2011 and December 2024. TBR was calculated as tumor SUVmax divided by the SUV of the descending aorta. The optimal …

30.08.2026journal-article

Japanese Journal of Radiology

Malignant potential of intraductal papillary mucinous neoplasm (IPMN) of the pancreas: imaging assessment of IPMN-derived cancer and concomitant pancreatic ductal adenocarcinoma

Fumihito Toshima, Dai Inoue, Kazuto Kozaka, Norihide Yoneda, Takahiro Komori, Atsushi Takamatsu, Yuichi Chujo, Satoshi Kobayashi

Abstract The detection of pancreatic cystic lesions (PCLs) has increased markedly with the widespread use of cross-sectional imaging. Although the true proportion of intraductal papillary mucinous neoplasms (IPMNs) among PCLs remains uncertain, IPMN is considered to account for most PCLs and is a representative precursor lesion of pancreatic ductal adenocarcinoma (PDAC). However, not all PCLs should be assumed to represent IPMN, because this assumption may lead to unnecessary surveillance or overtreatment. Therefor …

30.08.2026journal-article

Pharmacoepidemiology and Drug Safety

Postpartum Psychotropic Treatment Patterns and Breastfeeding: Nationwide Clustering Study

Anders Hviid, Anna Laksafoss, Elisabeth O'Regan, Poul Videbech, Ingrid Bech Svalgaard

ABSTRACT Introduction Postpartum psychotropic medication use is heterogeneous, comprising continuation of prenatal treatment, initiation, transient use and complex polypharmacy. Prior studies have reported the prevalence of potential infant exposure to psychotropics via breast milk, but characterisations better capturing the heterogeneity of this exposure are lacking. We aimed to identify distinct postpartum psychotropic treatment patterns using hierarchical clustering accounting for medication type, timing and pol …

30.08.2026journal-article

Journal of Artificial Intelligence and Information

Clinical Study on Qinghuo Qibi Decoction Combined with Rehabilitation Training in the Treatment of Autism Spectrum Disorder of Heart-liver Fire Hyperactivity Pattern

Jiangwei Yang, Yaxiong Guo

Objective: To observe the clinical efficacy of Qinghuo Qibi Decoction combined with rehabilitation training in the treatment of autism spectrum disorder (ASD) of heart-liver fire hyperactivity pattern and its effects on inflammatory cytokines. Methods: A randomized controlled trial (RCT) was conducted. A total of 140 children with ASD of heart-liver fire hyperactivity pattern who attended our hospital and the Affiliated Hospital of Shaanxi University of Chinese Medicine between February 2022 and February 2025 were …

30.08.2026journal-article

Clinical Medicine (Russian Journal)

The results of surgical treatment of arteriovenous fistula thrombosis of local intravenous catheter thrombolysis

Umut M. Muratbekova, Viacheslav N. Kravchuk, Andrey N. Shishkevich, Shamil M. Asadulaev, Valerii S. Ermakov,, Artem S. Fedorov, Evgeniy I. Umantsev, Vadim V. Dalinin,, Daria P. Vereshchak

The aim of the study is to assess the short and medium-term outcomes of surgical treatment for arteriovenous fistula (AVF) thrombosis, using the novel method of local intravenous thrombolysis that we have developed. Material and methods. The study analyzed the clinical data from 158 patients who experienced arteriovenous fistula thrombosis between 2021 and 2024. Two groups of patients were formed: 1) the study group consisted of 77 patients who underwent the first stage of the “local intravenous catheter thrombolys …

30.08.2026journal-article

CNS Neuroscience & Therapeutics

PPARγ ‐Dependent Pioglitazone Treatment Suppresses Neuroinflammation and Improves Cognition in Sepsis‐Associated Encephalopathy in Mice

Jing Zhang, Peng Wang, Nan Li, Yan Gao

ABSTRACT Objective To assess whether pioglitazone (Pio) protects against sepsis‐associated encephalopathy (SAE) and to probe underlying mechanisms. Methods Sepsis was induced in male C57BL/6 mice by caecal ligation and puncture (CLP). At 24 h post‐CLP, mice received Pio and/or the PPAR‐γ antagonist GW9662 and were followed for 14‐day survival. Cognitive and affective behaviors were evaluated using a behavioral battery. Blood–brain barrier (BBB) permeability was assessed by Evans blue extravasation, and hippocampal …

30.08.2026journal-article

Clinical and Translational Medicine

CDO1 as a prognostic biomarker and therapeutic target in gastric cancer: Mechanistic insights into the PI3K/AKT‐THBS1 axis and epigenetic reactivation by decitabine

Fazhi Wang, Runkai Zhou, Jinfeng Cai, Jiazhe Wen, Abudushalamu Yalikun, Yang Yu, Yugang Wen

Abstract Background As a pivotal metabolic enzyme, cysteine dioxygenase type 1 (CDO1) exerts tumour‐suppressive effects across diverse tumour types, and its expression is strongly correlated with clinical prognosis. However, the molecular mechanisms underlying CDO1‐mediated tumour suppression in gastric cancer (GC), its relationship with the tumour‐associated immune microenvironment, and pharmacological strategies to restore its expression remain poorly understood. Methods CDO1 expression and prognosis were evaluat …

30.08.2026journal-article

Revista ft

Hipertensão arterial e doença renal crônica em idosos: revisão das evidências sobre evolução clínica e tratamento

Beatriz Aguiar Medeiros, Julia Gauer Gomides Tavares, Nicolly Cristine Nobre Bredun, Michel Hosananh Vasconcelos

Systemic arterial hypertension (SAH) and chronic kidney disease (CKD) are among the most prevalent chronic conditions in the elderly, frequently coexisting and mutually exacerbating their outcomes. This interaction compromises quality of life and increases the risk of cardiovascular and renal complications, making its management a significant challenge. This study analyzed the influence of hypertension on the progression of kidney disease in the elderly and evaluated the effectiveness of available therapeutic strat …