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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
17.08.2026journal-article

Occupational and Environmental Medicine

Increased risk of occupational falls among cancer survivors: Japanese nationwide cohort

Kazuhiko Watanabe, Ichiro Kawachi, Takahiro Tabuchi, Masayoshi Zaitsu

Objectives Despite declining incidence rates for some cancers, the ageing workforce and improved survival have increased the number of workers with a history of cancer. Cancer treatment can affect strength, balance and bone health, thereby increasing fall risk among cancer survivors. However, an association between a history of cancer and occupational falls has not been reported. We aimed to investigate whether a history of cancer was associated with occupational falls and fall-related fractures among workers in Ja …

17.08.2026journal-article

ACS Biomaterials Science & Engineering

ROS-Responsive, Water–Oil Biphasic Hydrogel-Based Separable Microneedle System for Intra-Articular Delivery in Osteoarthritis Therapy

Xian Zhang, Na Li, ChengRong Zhang, XiaoQing Zhang, Yanhong Ma, Huan Ye, Xin Wang, Guoqing Yan

Abstract Osteoarthritis (OA) is characterized by a chronic inflammatory microenvironment with excessive reactive oxygen species (ROS) and progressive cartilage degeneration. To address these challenges, we developed a ROS-responsive, water–oil biphasic separable microneedle patch (CKCA MN) for transdermal therapy. This microneedle utilizes hyaluronic acid (HA) as a rapidly dissolving substrate, and its needle tip comprises a coordination-crosslinked hydrogel formed by Ce3+ and alendronate (Aln), loaded with cinnama …

17.08.2026journal-article

JAIDS Journal of Acquired Immune Deficiency Syndromes

Use of Long-acting Injectable Antiretroviral Therapy in Kidney and Liver Transplant Recipients with HIV

Christine Durand, Sarah Hussain, Sabrina Kopf, Shikha Mehta, Navya Eleti, Meenakashi Rana, Valentina Stosor, Sander Florman, Jonathan Hand, Nathaniel Erdmann

Background: The 2013 HIV Organ Policy Equity Act facilitated HIV-to-HIV organ transplants, enabling people with HIV to receive transplants more quickly. However, managing drug interactions between ART and immunosuppressive regimens remains a challenge. Objective: This study assesses the safety and effectiveness of cabotegravir/rilpivirine (CAB/RPV), an injectable ART, in maintaining HIV virologic suppression in kidney and liver transplant recipients. Methods: A retrospective review of three clinical studies evaluat …

17.08.2026journal-article

Applied Sciences

Telemonitoring Technologies for Breast Cancer Rehabilitation: A Narrative Review of Digital Health Solutions

Lorenzo Lippi, Alessio Turco, Matilde Rosalia Picco, Stefano Moalli, Mauro Nascimben, Lia Rimondini, Alessandro de Sire, Marco Invernizzi

Long-term functional impairments, including deficits in upper limb mobility, cancer-related fatigue, and reduced physical performance, are often reported by breast cancer survivors, underlining the need for sustainable and easily accessible rehabilitation techniques. Telemonitoring technologies have shown promising results in extending rehabilitation outside of clinical settings. However, the increasing number of technological solutions make it difficult to outline the optimal approach in the comprehensive manageme …

17.08.2026journal-article

NeuroRehabilitation

Beyond the Diagnosis: An Integrated Perspective on Strategic Dosing in Neurologic Motor Rehabilitation. A Scoping Review and Collaborative Viewpoint

Ahmad Rifai Sarraj, Jihan Allaw, Fadi Zein El Abidin, Antonio Pinti

Background Current neurorehabilitation often relies on static, diagnosis-driven protocols or generic exercise administration, contributing to suboptimal long-term outcomes. There is a clinical need for a cohesive, mechanism-based framework to guide therapeutic reasoning, dosing, and longitudinal adaptation. Methods A scoping review of neurorehabilitation literature was conducted according to PRISMA-ScR guidelines to map evidence on dosing, intensity, and longitudinal management. From 9,373 records, 42 studies were …

17.08.2026journal-article

International Journal of Innovative Science and Research Technology

Parental Satisfaction with Occupational Therapy Services at Niepmd

Kurinji Chelvan S., Dukhu Aman Murmu

Background: Parental satisfaction with occupational therapy services is a key indicator of service quality and effectiveness, especially in institutions catering to individuals with disabilities. The National Institute for Empowerment of Persons with Multiple Disabilities (NIEPMD) plays a pivotal role in providing specialised therapeutic services. Understanding parents' perspectives on these services can help identify strengths and areas for improvement, ultimately enhancing therapeutic outcomes.  Aim: To assess p …

17.08.2026journal-article

Adolescência e Saúde

Exercise Rehabilitation and Football Shoe Modification For Patellofemoral Pain in Female Soccer Players: A Narrative Review

Mohamed Abdelrahman Mohamed, Amel Mohamed Yousef, Dalia Mohamed Kamel

Background: Patellofemoral pain syndrome (PFPS) is one of the most prevalent overuse knee disorders among female soccer players and is associated with pain, functional limitations, impaired athletic performance, and reduced participation in sport. Both intrinsic biomechanical deficits and extrinsic factors such as footwear characteristics have been implicated in the development and persistence of PFPS. Objective: This review critically examines current evidence regarding exercise-based rehabilitation and football s …

17.08.2026journal-article

Occupational and Environmental Medicine

Occupational noise exposure and risk of myocardial infarction: results from a prospective Swedish cohort

Claudia Lissåker, Mattias Sjöström, Theo Bodin, Maria Albin, Jenny Selander

Objectives To explore the association between occupational noise exposure the preceding year and myocardial infarction (MI) and cumulatively. Methods Data came from the Swedish National Cohort on Work and Health, a cohort of all Swedish individuals born between 1930 and 1990. We included individuals with at least one occupational code between 1985 and 2013, which was matched to a job-exposure matrix for occupational noise in five categories (LAeq8h):

17.08.2026journal-article

International Journal of Computer Information Systems and Industrial Management Applications

IMPACT OF KEY DIMENSIONS OF OCCUPATIONAL STRESS ON JOB SATISFACTION AMONG TRAFFIC POLICE IN TELANGANA AND ANDHRA PRADESH

K. Nagaraju, P. Saritha

Traffic police personnel operate under demanding conditions involving prolonged duty hours, technological requirements, financial concerns, environmental exposure, public interaction, and operational challenges. This study examines the influence of occupational stress on job satisfaction among traffic police personnel in Telangana and Andhra Pradesh using a multidimensional framework. The study considers Job-Related Stress (JRS), Technology-Related Stress (TRS), Financial-Related Stress (FRS), Environmental and Phy …

17.08.2026journal-article

Revista de Geopolítica

AVALIAÇÃO DO DESENVOLVIMENTO NEUROPSICOMOTOR DE CRIANÇAS PRATICANTES DE EQUOTERAPIA

Fabiola Freire Candido Santos, Jasmim Crislayne Costa Martins, Gustavo Coringa de Lemos, Joelma Gomes da Silva Rocha, Rebeca Graziely Gomes de Melo, Frederico da Silva Jales, Andréa Raquel Fernandes Carlos da Costa, Lidiane Pinto de Mendonça Ferreira, Sirlene Batista Cavalcante, Natália Jéssica Barra Silva

O presente estudo teve como objetivo avaliar o impacto da equoterapia no desenvolvimento neuropsicomotor de crianças entre 3 e 17 anos atendidas no município de Mossoró/RN. A equoterapia, abordagem terapêutica interdisciplinar, utiliza o cavalo como agente terapêutico, promovendo estímulos motores, sensoriais e emocionais que contribuem para o desenvolvimento biopsicossocial. Trata-se de pesquisa descritiva e transversal, de abordagem quantiqualitativa, realizada de agosto a outubro de 2024. Foram avaliadas criança …

17.08.2026journal-article

Adolescência e Saúde

Dealing And Resisting Verbal Aggression In (Husband-Wife) Abusive Relationships Through Cognitive Behavioral Therapy: Reading Meena Kandasamy And Krishna Sobti’s Fiction

Rufus Ruth Livingston Jakki, Boddu Chandrashekar

Verbal aggression within marriage remains one of the least visible forms of domestic abuse despite its severe psychological consequences for women. In patriarchal societies, emotional humiliation, coercive communication, and linguistic domination frequently become normalized within marital relationships. This study examines the representation of verbal aggression and emotional resistance in When I Hit You: Or, A Portrait of the Writer as a Young Wife by Meena Kandasamy and Mitro Marjani by Krishna Sobti through the …

17.08.2026journal-article

Modern Rheumatology Journal

Successful experience with divozilimab therapy for systemic sclerosis

M. N. Starovoitova, O. V. Desinova

Systemic sclerosis (SSc) is a severe rheumatic disease characterized by high mortality and reduced quality of life. Over the past 10–15 years, the treatment paradigm for SSc has changed dramatically owing to a better understanding of its pathogenesis, the accumulation of evidence supporting the efficacy of immunosuppressants, and the emergence of targeted therapies. B lymphocytes are considered to play a key role in disease development through their effects on fibroblast activation and autoantibody production, maki …

17.08.2026journal-article

Journal of Medicinal Chemistry

Structure-Based Design of First Ndc80 Loop-Targeting Peptide Disrupting Ndc80–Nuf2 Interaction for Hepatocellular Carcinoma Therapy

Xing Jin, Miao-Miao Niu, Yifei Geng, Liqiao Han, Yuting Wang, Xianzhang Huang, Qiaoxuan Zhang

Abstract Ndc80 is essential for kinetochore–microtubule attachment, but its broad protein–protein interaction interface remains difficult to target. Here, we used structure-guided peptide optimization to develop Peptide-4, a loop-directed peptide designed to modulate the Ndc80–Nuf2 interaction. In contrast to reported Ndc80-directed compounds acting through the Hec1–Nek2 axis or the calponin homology domain, Peptide-4 addresses an underexplored loop region. Peptide-4 bound Ndc80 with a Kd of 0.45 ± 0.01 nM and inhi …

17.08.2026journal-article

International Journal of Innovative Science and Research Technology

Physiotherapy Management of Chronic Temporomandibular Joint Dysfunction in a Cricket Player: A Case Report

Anoli Gupta, Sneha Ganu

Background: Temporomandibular dysfunction (TMJ) is a commonly seen maxillofacial disorder in athletes, with a predominance in females. Contact sports are a contributing factor to TMJ dysfunction, such as blows to the jaw. In recent years, physiotherapy has had excellent outcomes.  Case Presentation: A 19-year-old male cricket player came in with a complaint of limited jaw opening and a click on jaw movements after suffering a blow to the jaw. Based on clinical examination, he was diagnosed with Internal derangemen …

17.08.2026journal-article

PHAGE: Therapy, Applications, and Research

Prevalence of Biofilm-Forming Pseudomonas aeruginosa from Clinical Samples in Africa: A Systematic Review and Meta-Analysis

Assefa Sisay, Zelalem Asmare, Ermias Getachew, Birhanu Kassanew, Ephrem Tamrat, Yalewayker Gashaw, Melese Abate Reta

Background: Biofilms help Pseudomonas aeruginosa adhere to surfaces and form an extracellular polymeric matrix. P. aeruginosa infections are increasingly difficult to treat due to biofilm formation. This study seeks to ascertain the overall prevalence of biofilm-forming P. aeruginosa clinical isolates in Africa. Methods: All studies published from January 1, 2010, to December 30, 2024, were systematically obtained from electronic databases, including PubMed, ScienceDirect, and Scopus, as well as via the Google Scho …

17.08.2026journal-article

Small

A Dual GSH/ROS‐Functional NIR Fluorescent Platform for Synergistic Photodynamic Therapy and Radiosensitization in Nasopharyngeal Carcinoma

Fan Zheng, Yan Mo, Jin Zhou, Chengmin Li, Min Lin, Yingqi Zhao, Jingmei Zhou, Hui Zou, Zhikang Chen, Runsha Xiao, Xueping Feng, Wenbin Zeng

ABSTRACT High‐precision tumor theranostic systems capable of real time monitoring are imperatively required for optimizing the spatial targeting accuracy during radiotherapy and surgical resection across clinical management of nasopharyngeal carcinoma (NPC). However, the clinical application of photodynamic therapy (PDT) is impeded by the suboptimal reactive oxygen species (ROS) generation efficiency and inadequate visualization of redox procedure. In this study, we developed a theranostic platform HSF , featuring …

17.08.2026journal-article

Journal of Clinical Medicine

Theranostics in Radiation Medicine: Integrating Radiopharmaceutical Therapy and External-Beam Radiotherapy

Senthamizhchelvan Srinivasan, Joseph A. Moore, Sarah Han-Oh

Theranostics has transformed nuclear medicine from an imaging-focused discipline into a data-rich radiation medicine platform in which target expression, pharmacokinetics, tumor dose, and response can be measured in the same patient. This critical narrative review evaluates patient-specific integration of radiopharmaceutical therapy (RPT) with external-beam radiotherapy (EBRT), with emphasis on quantitative imaging, absorbed-dose estimation, spatial registration, biological interpretation, adaptation thresholds, an …

17.08.2026journal-article

Adolescência e Saúde

Eosinophil-Guided Therapy In Chronic Obstructive Pulmonary Disease: Evaluating Blood Eosinophils As Predictors Of Inhaled-Corticosteroids Response

Dr Selva Nandha Kumaran K K, Dr Suresh A, Dr Veena Charishma RP, Dr Ghanshyam Verma

Background-Aim:Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide and is characterized by persistent airflow limitation and recurrent exacerbations. Although inhaled corticosteroids (ICS) are recommended for patients with frequent exacerbations, the response to therapy varies. Blood eosinophil count has emerged as a potential biomarker for identifying patients who may benefit from ICS-containing regimens. This study evaluated the role of baseline blood eosinophil coun …

17.08.2026journal-article

Viruses

Virological Failure and Mortality Among People Living with HIV Transitioned to Second- or Third-Line Antiretroviral Therapy in Rwanda: A Competing-Risks Survival Analysis of National Case-Based Surveillance Data, 2019–2025

Gallican N. Rwibasira, Jean Claude Kwizera, Tafadzwa Dzinamarira, Steven Karera, Gatete Gaetan, Albert Tuyishime, Eric Remera, Daniel Henry Paris, Tracy R. Glass

Background: Despite Rwanda’s achievement of the UNAIDS 95–95–95 targets, national evidence on virological failure (VF) and mortality after transition to second- or third-line antiretroviral therapy (ART) remains limited. We estimated the incidence of these outcomes and examined associated factors among people living with HIV (PLWH) transitioned to second- or third-line ART in Rwanda between 2019 and 2025. Methods: We conducted a retrospective cohort study using Rwanda’s national HIV case-based surveillance (CBS) sy …

17.08.2026journal-article

Current Neuropharmacology

Differential Serum NGF and BDNF Levels in People Living with HIV According to Antiretroviral Therapy, Historical and Current Viroimmunological Condition: A Pilot Study

Luca Maddaloni, Pamela Rosso, Elena Fico, Letizia Santinelli, Carmen Falvino, Marco Ridolfi, Giampiero Ferraguti, Giancarlo Ceccarelli, Claudio Maria Mastroianni, Guido Antonelli, Carolina Scagnolari, Gabriella d'Ettorre, Marco Fiore

Introduction: Although HIV infection can now be kept under control in almost all people living with HIV (PLWH), these individuals are prone to developing several non-AIDS complications due to chronic immune impairments, such as HIV-associated neurocognitive disorders (HAND). Unfortunately, no marker has been identified to predict these conditions, but there is growing interest in neurotrophins, such as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). Methods: In this pilot study, we evaluated …

17.08.2026journal-article

Adolescência e Saúde

Methodological Confidence And Reported Certainty Of Evidence For Virtual Rehabilitation And Mirror Therapy In Post-Stroke Upper-Extremity Function: An Umbrella-Review Audit Using AMSTAR 2 And GRADE

Tumuluri S S Chandra Sekharendra Swamy, Dr. Payal Sharma, PT, Dr. Dipika Balala, PT, Dr. Deepak Lohar, PT, Dr. Jafar Khan, PT, K. M. Annamalai, Shradha Hariom Tiwari, Sneha Thakur Lund, Parul Sharma, Payal Padole

Background. Systematic reviews of virtual rehabilitation and mirror therapy for post-stroke upper-extremity function have expanded rapidly, but the methodological confidence and reporting practices of these reviews remain unclear. Objective. To audit the methodological confidence and reporting practices of systematic reviews examining virtual rehabilitation and mirror therapy for post-stroke upper-extremity function using AMSTAR 2. Methods. An umbrella-review audit of review methods was conducted. PubMed, Europe PM …

17.08.2026journal-article

Frontiers in Immunology

URAT1 inhibition in hyperuricemia and gout: from transporter biology to clinical precision therapy

Guangtao Li, Yu Wang, Zhuoli Zhang

Impaired renal urate excretion is a major mechanism underlying hyperuricemia and gout, with urate transporter 1 (URAT1), encoded by SLC22A12, playing a central role in proximal tubular urate reabsorption. This review summarizes the biological relevance of URAT1, the pharmacological evolution of URAT1 inhibitors, and their clinical implications in urate-lowering therapy. Evidence from transporter biology, structural pharmacology, pharmacokinetic and pharmacodynamic studies, and clinical trials was narratively synthe …

17.08.2026journal-article

Journal of Clinical Oncology

Therapy for Stage IV Non-Small Cell Lung Cancer With Driver Alterations: ASCO Living Guideline, Version 2026.3.3

Paul Wheatley Price, Nofisat Ismaila, Antonio Calles Blanco, Jeremy Cetnar, Terri Conneran, Parth A. Desai, Greg Durm, Hidehito Horinouchi, Humera Khurshid, Swati Kulkarni, Kristen Ashley Marrone, Kirstin Perdrizet, Lyudmila Bazhenova

This guideline has been updated. This ASCO Living Guideline is reviewed on an eight-week cycle. Please see the online dynamic version for the latest updates. Living guidelines are developed for selected topic areas with rapidly evolving evidence that drives frequent change in recommended clinical practice. Living guidelines are updated on a regular schedule by a standing expert panel that systematically reviews the health literature on a continuous basis, as described in the ASCO Guidelines Methodology Manual . ASC …