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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Head and Neck Pathology

Pattern-Anchored Diagnosis of Oral Epithelial Dysplasia: A Position Paper From COST Action INTERCEPTOR Working Group 2

Syed Ali Khurram, Keith D. Hunter, Edward W. Odell, Merva Soluk Tekkeşin, Mark Lingen, Pablo Agustín Vargas, Omar Kujan, Daniela Elena Costea, Paolo Bossi, Pierre Saintigny, Senada Koljenović

Abstract Purpose Oral epithelial dysplasia (OED) is the principal histopathological marker for malignant risk stratification in oral potentially malignant disorders (OPMDs). Current World Health Organisation (WHO) three-tier and other binary grading systems are limited by modest inter-observer reproducibility and suboptimal prognostic discrimination, particularly for architecture-predominant lesions where cytological atypia is inconspicuous. The most clinically consequential failure of current practice is not mis-g …

03.09.2026journal-article

European Journal of Nuclear Medicine and Molecular Imaging

CEA-targeted fluorescence endoscopy for the detection of high-grade dysplasia and early invasive rectal cancer: A proof-of-concept trial

M. I. Warmerdam, T. H. Dijkhuis, D. J. G. Linders, C. M. W. Pesch, A. S. L. P. Crobach, A. Matoshi, K. Basiliya, S. H. van den Berg, F. Cailler, K. C. M. J. Peeters, F. A. Holman, J. S. D. Mieog, A. L. Vahrmeijer, D. E. Hilling, J. J. Boonstra

Abstract Purpose Accurate recognition of high-grade dysplasia (HGD) and early invasive carcinoma (IC) within colorectal polyps is essential for selecting the preferred local resection technique. However, optical endoscopic diagnosis can be challenging, particularly in large and advanced polyps. This study investigates whether carcinoembryonic antigen (CEA)-targeted near-infrared fluorescence (NIRF) imaging can distinguish polyps containing HGD/IC from polyps solely containing low-grade dysplasia (LGD), given prior …

03.09.2026journal-article

Frontiers in Oncology

Risk factors, severity-related factors, and clinical outcomes of immune checkpoint inhibitor-associated pneumonitis in elderly patients with lung cancer

Ying Hu, Shuhua Chen, Yingying Lu, Lingjuan Yang

Objective This study aimed to investigate the clinical characteristics, risk factors, severity-related factors, and clinical outcomes of immune checkpoint inhibitor-associated pneumonitis (CIP) after immune checkpoint inhibitor (ICI) treatment in elderly patients with lung cancer, providing evidence for risk identification and nursing management during ICI therapy. Methods Clinical data from 206 elderly patients with lung cancer who received ICI therapy at the Second Affiliated Hospital of Naval Medical University …

03.09.2026journal-article

Frontiers in Cellular and Infection Microbiology

Multidisciplinary management of severe odontogenic maxillofacial multi-space infection in a patient with HIV–syphilis coinfection and advanced immunosuppression: a case report

Jieying Li, Yuanyong Feng, Xueqiang Guo, Wei Shang, Kai Zhou

Background HIV–syphilis coinfection poses a substantial challenge in the management of severe odontogenic infections, with few reports addressing maxillofacial multi-space infections in this setting. Case presentation A 50-year-old man developed severe left maxillofacial multi-space infection one week after molar extraction, presenting with respiratory distress, trismus, elevated C-reactive protein (235.20 mg/L), computed tomography evidence of gas-forming abscesses, reactive HIV antibody, positive syphilis serolog …

03.09.2026journal-article

Journal of Clinical Medicine

Reference Estimates of Mean Tear Film Lipid Layer Thickness Measured with LipiView® and LipiView II® in Healthy Adults: A Systematic Review and Meta-Analysis

Maria Sobol, Jacek Pniewski

Background/Objectives: Tear film lipid layer thickness (LLT) is an important parameter of ocular surface function and can be objectively measured using LipiView ocular surface interferometry. However, reference LLT estimates in clinically healthy populations remain inconsistent. This systematic review and meta-analysis aimed to estimate pooled reference LLT values and explore potential sources of variability. Methods: A systematic search of PubMed, Scopus, and Web of Science was performed according to PRISMA 2020 g …

03.09.2026journal-article

Indian Journal of Nuclear Medicine

A Resource-Efficient End-to-End Multimodal AI Framework for Automated PET-CT Report Generation and TNM Staging in Breast Cancer

Dibya Prakash, Venkatesh Rangarajan, Manoj Kumar

Objectives: Positron Emission Tomography-Computed Tomography (PET-CT) is integral to breast cancer staging. However, manual interpretation is time-consuming and subject to inter-observer variability. While artificial intelligence has shown promise in lesion detection and standardised uptake value (SUVmax) quantification, existing approaches are fragmented and do not generate complete TNM-aligned structured reports. Consequently, there remains a need for an integrated framework capable of translating PET-CT data int …

03.09.2026journal-article

Frontiers in Surgery

Early outcomes following Duramesh™ implantation for abdominal wall closure: the Croydon experience

Lawrence Nip, Sarah Zhao, Sajid Malik, Reif Hwang, Jessica Quimpo, Eslam Ghazy, Matt Dunstan, Rhys Thomas, Samuel G. Parker

Introduction Mesh suture, or Duramesh™, is gaining traction for abdominal wall closure and ventral hernia repair. However, published data are limited to US case series and institutional registries. Use in UK and European cohorts remains undocumented. This is the first UK series describing indications and outcomes following Duramesh implantation. Methods This is a retrospective case series from a medium-sized tertiary abdominal wall unit in the UK. Institutional implant logs of consecutive patients from 1st Sep 2023 …

03.09.2026journal-article

The Indonesian Journal of International Clinical Legal Education

Legal Education and Child-Responsive Digital Reporting Systems for School Bullying Victims

Anis Widyawati, Diyah Satya Retnani

School bullying remains a significant challenge in educational institutions, affecting children's psychological well-being, academic performance, and access to justice. Despite the existence of legal protection frameworks and anti-bullying policies, many cases remain unreported due to fear of retaliation, limited legal awareness, social stigma, and the absence of child-friendly reporting mechanisms. This study aims to examine the role of legal education as the foundation for developing child-responsive digital repo …

03.09.2026journal-article

Frontiers in Oncology

Factors associated with clinical research participation among Medicare beneficiaries with prostate cancer in the United States

Ryan A. Hankins, Alysha M. McGovern, Abimbola O. Williams, Virgil H. Simons, Sean P. Collins, Deepak Kumar

Introduction Clinical research participation among patients with prostate cancer remains limited, and demographic, clinical, and contextual factors may influence opportunities for participation. Although disparities in prostate cancer diagnosis and treatment are well documented, less is known about the factors associated with clinical research participation in this population. This study examined patient-level and contextual factors associated with clinical research participation among older Medicare beneficiaries …

03.09.2026journal-article

Frontiers in Immunology

The transformative impact of ultra-rapid nanopore sequencing in precision medicine

Sarah Grasedieck, Brendan J. Keating, Stephen Yip, James Lan, Karen R. Sherwood, Paul A. Keown

Nanopore sequencing has emerged as a transformative technology, offering unprecedented speed, ultra-long reads, and portability at a comparatively low cost. These attributes are fundamentally reshaping clinical diagnostics and personalized medicine. This review synthesizes the technological advancements driving nanopore sequencing and elucidates its pivotal applications in time-sensitive areas such as HLA matching in transplantation, infectious disease management, pharmacogenomics, and oncology. Nanopore sequencing …

03.09.2026journal-article

Endodontics Today

Evaluation of post-operative pain following the use of different concentrations of sodium hypochlorite during endodontic treatment: An in vivo study

E.P.M. Pinto, R. A. Pelegrine, A. S. Martin, D.G.P. Rocha, C. P. Stringheta, W. M. Nascimento, A. G. Limoeiro, T.M.C. Coutinho, V. Ronquete, M.A.L.R. Pitzschk, M.F.V. Marceliano-Alves, C.E.S. Bueno

INTRODUCTION. One of the causes of the post-operative pain could be the irrigation solution used during the endodontic treatment. AIM. The aim of this study was to evaluate the pain symptoms after endodontic treatment of teeth with necrotic pulp, using two different concentrations of NaOCl during root canal instrumentation, as well as the necessity of using analgesics. MATERIALS AND METHODS. Fifty single-rooted upper incisors or canines were randomly divided into two groups ( n = 25) according to the concentration …

03.09.2026journal-article

American Journal of Audiology

Clinical Prevalence and Impact of False Air–Bone Gaps in Clinical Audiometry: A Study of 1,000 Ears

Shai Chordekar, Liron Kariv, Nir Fink

Purpose: Accurate hearing loss classification depends on air–bone relationships; however, “false” air–bone gaps (ABGs) in sensorineural hearing loss (SNHL) frequently compromise diagnostic clarity. By shifting the focus from ABG magnitude to clinical prevalence, this study uses the prevalence of clinical ABGs (≥ 15 dB) as a primary metric to quantify diagnostic ambiguity in routine practice and to evaluate the efficacy of bone-conduction (BC) testing at frequencies where frequent false ABGs occur. Method: We retros …

03.09.2026journal-article

Journal of Imaging Informatics in Medicine

Less Is More: Radiologists Prefer Brief Narratives in LLM-Generated Clinical History Summaries

Shawn Lyo, Satvik Tripathi, Ali Tejani, David Vu, Siddhant Dogra, Hamza Alizai, Tessa Cook

Abstract Clinical histories are essential for accurate radiologic interpretation but are often lengthy and time-consuming to review amid increasing radiologist workloads. Large language models (LLMs) offer a potential solution by generating concise, clinically focused summaries from existing documentation; however, the optimal presentation format for radiologists remains unclear. This retrospective reader study evaluated the readability, efficiency, and radiologist preference for a two-stage LLM-based summarization …

03.09.2026journal-article

Journal of Intensive Care Medicine

Pan Immune Inflammation Value in Identifying Sepsis High-Inflammatory and Immunosuppressive Phenotype

Xiao Zhu, Qing Lu, Xin Liu, Xianxiang Zeng

Background The Pan-Immune Inflammation Value (PIV) is a potential indicator of immune phenotypes in sepsis. Objective To explore the association between PIV and clinically defined high-inflammatory and immunosuppressive phenotypes in sepsis and to evaluate its potential predictive value. Methods Clinical data from 156 patients with sepsis were retrospectively analyzed. Patients were divided into high inflammatory (n = 82) and immunosuppressive (n = 74) groups based on their immune status. The clinical data and labo …

03.09.2026journal-article

EMBO Molecular Medicine

FFAR2 activation induces IL-22-dependent intestinal immune responses to suppress CNS autoimmunity

Bojan Jevtić, Milica Lazarević, Goran Stegnjaić, Suzana Stanisavljević, Ivan Pilipović, Neda Nikolovski, Zorana Milosavljević, Miljana Momčilović, Ivan Koprivica, Natalija Jonić, Dragica Mićanović, Nataša Radulović, Maša Marković, Ksenija Mirković, Danijela Mišić, Uroš Gašić, Filip Nikolić, Nikola Veselinović, Henrike Körner, Lukas Grimm, Dmitri Lodygin, Alexander Flügel, Graeme Fraser, Tamara Saksida, Mirjana Dimitrijević, Ivana Stojanović, Đorđe Miljković

Abstract Short-chain fatty acids (SCFA) protect against central nervous system (CNS) autoimmunity, but the receptor-mediated mechanisms underlying these effects remain poorly understood, limiting their therapeutic exploitation. Here, we show that selective oral activation of free fatty acid receptor 2 (FFAR2) with the synthetic agonist Cpd1 effectively ameliorates established experimental autoimmune encephalomyelitis (EAE), demonstrating therapeutic efficacy after the onset of the autoimmune response. Cpd1 treatmen …

03.09.2026journal-article

Quality of Life Research

Capturing quality of life in pouch anal and vaginal fistula: development of PAVF-QoL-14, a patient-reported outcome measure

Lillian Reza, Laith Alrubaiy, Lara Bapir, Nusrat Iqbal, Charlene Sackitey, Easan Anand, Sally Hughes, Mina Babbar, Rali Marinova, Petya Marinova, Pearl Avery, Phillip Lung, Ailsa Hart, Sue Clark, Phil Tozer

Abstract Introduction Perianal pouch fistula can significantly affect quality of life, yet no disease-specific patient reported outcome measure (PROM) exists. We have developed and validated a 14-item PROM—the Pouch Anal and Vaginal Fistula Quality of Life scale (PAVF-QoL-14). Methods COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) guidance for PROM development was used to develop and validate PAVF-QoL-14. A systematic literature review and semi-structured patient interviews ( …

03.09.2026journal-article

Frontiers in Public Health

A comparative evaluation of generative AI chatbots for patient-oriented advice on painful diabetic peripheral neuropathy: safety, accuracy, guideline concordance, actionability, and readability

Lina Gu, Zhaole Gong, Xiaoli Qian, Ling Miao, Zhengfeng Gu

Background Patients with painful diabetic peripheral neuropathy (PDPN) increasingly use generative artificial intelligence chatbots for information on symptoms, treatment, foot care, and when to seek professional help. Their usefulness depends on safety, accuracy, guideline concordance, actionability, and readability. Objective To compare five publicly accessible generative AI chatbots in answering standardized patient-oriented questions about PDPN. Methods: Sixty standardized English-language questions covering ei …

03.09.2026journal-article

AlQalam Journal of Medical and Applied Sciences

Clinical Effects and Safety of Deep Dry Needling for Upper Trapezius Myofascial Pain Syndrome: A Prospective Single-Group Study in Tripoli, Libya

Fatima Gazah

Myofascial pain syndrome (MPS) is a common musculoskeletal condition characterised by myofascial trigger points, pain, and functional limitations. Although dry needling is widely used in physiotherapy for myofascial pain, locally derived clinical evidence from Libya remains limited. This study evaluated the short-term clinical effects and safety of deep dry needling in patients with upper trapezius myofascial pain syndrome. A prospective, quasi-experimental, one-group pretest–posttest case series was conducted in t …

03.09.2026journal-article

Suicide and Life-Threatening Behavior

Nighttime Sensory–Behavioral Activation and Admission Suicidality in Young Inpatients With Major Depressive Disorder: A Retrospective Clinical‐Record Study

Xinqi Huang, Xiaolong Kuang, Hongxing Wang

ABSTRACT Introduction Suicide risk assessment during psychiatric admission may benefit from clinically observable information beyond overall depressive symptom severity. This study examined whether clinician‐documented nighttime sensory–behavioral activation was associated with admission suicidality in young inpatients with major depressive disorder (MDD). Methods This retrospective study included 406 inpatients aged 15–35 years with moderate‐to‐severe MDD. Nighttime sensory–behavioral activation was coded as none, …

03.09.2026journal-article

Experimental & Molecular Medicine

Proteomic analysis of pancreatic endocrine cells by mechanistic single-cell isolation identifies membrane pathways

Lihi Grinberg, Worood Sirhan, Marina Kurtz, Michael Assa, Assaf Malka, Shira Perez, Corine Katina, Yishai Levin, Ron Piran

Abstract To better understand diabetes and normoglycemia, pancreatic islet biology requires a precise molecular understanding of islet cell types at both the transcriptomic and proteomic levels. While transcriptomic analyses are well established, comprehensive proteomic characterization has been lacking, limiting our knowledge of islet molecular complexity. Here we introduce a nonenzymatic, mechanistic single-cell isolation technology using laser microdissection (LMD7), facilitating proteomic and transcriptomic ana …

03.09.2026journal-article

Frontiers in Medicine

The impact of maternal hepatitis B virus infection on IVF/ICSI-assisted pregnancy outcomes: a propensity score-matched cohort study

Wenwen Jiang, Suqin Zhu, Rongshan Li, Yan Sun, Xiaojing Chen, Beihong Zheng

Background Hepatitis B virus (HBV) infection is highly prevalent among women of reproductive age in China, yet whether maternal HBV carrier status affects the outcomes of assisted reproduction remains unclear. Published studies have yielded conflicting results, most were underpowered or inadequately controlled for confounders, and few have tracked outcomes beyond early pregnancy. This study used propensity score matching to evaluate the impact of maternal HBV infection on laboratory, clinical pregnancy, obstetric, …

03.09.2026journal-article

Frontiers in Oncology

Performance evaluation of large language models in bladder cancer patient education Q&A: a cross-sectional study

Dian Wan, Youwen Li, Zheng Dong, Chen Dai, Jinghe Ye, Song Li, Sunlu Jiang

Background Bladder cancer ranks among the most prevalent urological tumors worldwide, with its global incidence continuing to rise steadily. Although patient education materials (PEMs) play a crucial role in enhancing disease comprehension and supporting joint clinical decision-making, current online resources frequently surpass the readability thresholds recommended for the general public. Large language models (LLMs) hold promise for health communication, yet no systematic assessment has been conducted regarding …

03.09.2026journal-article

Frontiers in Medicine

Safety profiles of cyclosporine and tacrolimus in pregnancy: a pharmacovigilance analysis using the FDA Adverse Event Reporting System

Yanhong Deng, Senling Feng, Shengying Shi, Zhongwen Yuan, Zhengrong Mei, Jinjin Yin, Dongdong Jing, Shaozhi Liu

Background The increasing use of calcineurin inhibitors (CNIs) among pregnant women highlights the importance of continuous safety surveillance. This study aimed to characterize the real-world safety signals of cyclosporine (CsA) and tacrolimus (TAC) during pregnancy using data from the FDA Adverse Event Reporting System (FAERS) database. Methods We applied four disproportionality data-mining algorithms (reporting odds ratio, proportional reporting ratio, Bayesian confidence propagation neural network, and empirica …

03.09.2026journal-article

Clinical Research in Cardiology

Routine versus selective use of a femoral protection wire in transfemoral TAVI: a single-centre analysis of vascular complications

Marc Adrian Rogmann, Victor Klingemann, Max Meertens, Majid Ahoopai, Karl-Philipp Rommel, Philipp Lurz, Ralph S. von Bardeleben, Martin Geyer

Abstract Background Transfemoral transcatheter aortic valve implantation (TAVI) is the treatment of choice for severe aortic stenosis in patients with elevated surgical risk. However, vascular complications remain a major source of morbidity and mortality. The protection wire technique was introduced to prevent major access-related complications, but its role in contemporary TAVI practice is uncertain. Aims To evaluate whether routine protection wire use reduces vascular complications in contemporary transfemoral T …