Onkologie: neue Gesundheitspublikationen – Seite 139

30.08.2026journal-article

npj Breast Cancer

Genomic characterization of ER-positive primary tumors and corresponding relapses identifies potentially targetable alterations

Caroline Schagerholm Stanev, Stephanie Robertson, Hosein Toosi, Emmanouil G. Sifakis, Jens Lagergren, Johan Hartman

Abstract The majority of breast cancer patients have tumors expressing estrogen receptor α (ER) and receive endocrine therapy. However, around one-third relapse in their disease, predominantly with retained ER expression. Molecular alterations are proposed to be contributors to the resistance mechanisms. Patients with ER-positive, human epidermal growth factor receptor 2 (HER2)-negative primary breast cancer with an ER-positive relapse

30.08.2026journal-article

HEALTH RESEARCH IN AFRICA

Effectiveness of the Ponseti Method for Clubfoot Treatment in Children in Chad : A 77‑Case Study

Salhadine Yacoub Ahmat, Bembo Lamega, Mahamat Nour Abakar Djibrine, Ngaringuem Olivier, Moyalbaye Yireta, Dezoumbet Olivier, Sobdjolbo Olivier, Souad Abakar, Choua Oucheimi

RÉSUMÉIntroduction. Le pied bot varus équin (PBVE) est une déformation congénitale tridimensionnelle du pied, associant un équin du talon, un varus de l'arrière-pied et une rotation interne du bloc calcanéo-pédieux. En Afrique subsaharienne, son traitement reste un défi en raison du coût des approches chirurgicales et de l'accès limité aux soins spécialisés. La méthode de Ponseti, non invasive et peu coûteuse, pourrait offrir une solution adaptée à notre contexte, mais ses résultats dans les pays en développement s …

30.08.2026journal-article

Catalysts

Machine Learning-Enabled Photocatalytic Wastewater Treatment: Recent Advances in Catalyst Design, Performance Prediction, and Process Optimization

Mai M. A. Hassan Shanab, Taoheed Abiodun Yusuf, Abdullah M. Aldawsari, Amani M. Alansi, Musaad Aleid, Idris K. Popoola, Alya M. Alotaibi, Talal F. Qahtan

Photocatalytic wastewater treatment is a promising technology for degrading persistent organic pollutants; however, its optimization remains challenging because photocatalytic performance depends on complex interactions among catalyst properties, operating conditions, and wastewater composition. Machine learning (ML) has emerged as a powerful tool for accelerating catalyst development, predicting photocatalytic performance, and optimizing process parameters. This review critically analyzes recent studies on ML-assi …

30.08.2026journal-article

Brain and Behavior

Could Subjective Cognitive Complaints Give the Facts of Objective Cognitive Impairments in Non‐Central Nervous System Cancer? A Systematic Review

Chieh‐Ning Li, Nai‐Wen Guo, Bei‐Yi Su

ABSTRACT Introduction Non‐central nervous system (non‐CNS) cancer patients experienced cognitive impairment, both subjectively and objectively. However, they are only weakly correlated. Previous studies indicated that subjective cognitive complaints (SCCs) could be a distinct neural phenotype from objective neuropsychological function. To explore what underlies SCCs, we examined the relationship between SCCs and objective neuropsychological assessment in this systematic review. Methods Following the PRISMA guidelin …

30.08.2026journal-article

ChemistrySelect

Molecular Optimization of Benzimidazole Scaffolds for Targeted Protein Kinase Inhibition in Oncology

Heba T. Abdel‐Mohsen

ABSTRACT Benzimidazole is one of the most prestigious heterocyclic motifs, with a variety of biological applications. Over the years, diverse benzimidazole hybrids have proved single or multi‐protein kinase inhibitory activity. Some examples were approved by the Food and Drug Administration (FDA) for use in the treatment regimens of certain types of cancers, other benzimidazole‐based protein kinase inhibitors are still in clinical trials. Additionally, different research groups have employed different approaches fo …

30.08.2026journal-article

SJ Pediatrics and Child Health Africa

Depression, Associated Factors, and Coping Mechanisms among Caregivers of Children with Cancer at Mobile Hospice Mbarara, Uganda: A Cross-Sectional Study

Ninyikiriza Jackline, Tweheyo Otwiine, Jordan Amanyire

Background: Caregivers of children with cancer experience substantial psychological, emotional, and socioeconomic challenges that increase their risk of depression. Despite the growing burden of pediatric cancer in Uganda, evidence on the prevalence of depression, its associated factors, and coping mechanisms among caregivers in palliative care settings remains limited. This study assessed the prevalence of depression, factors associated with depression, and coping mechanisms among caregivers of children with cance …

30.08.2026journal-article

Clinical and Experimental Dental Research

Machine Learning Prediction of Anterior Open‐Bite Development After Stabilization Splint Treatment in Temporomandibular Disorder

Jae Joon Hwang, Hye‐Mi Jeon, Hye‐Min Ju, Sung‐Hee Jeong, Yong‐Woo Ahn, Soo‐Min Ok

ABSTRACT Objectives To develop interpretable machine learning (ML) models for risk stratification of clinically meaningful anterior overbite decrease after stabilization splint therapy in temporomandibular disorder (TMD) patients, and to compare ML performance with conventional logistic regression. Materials and Methods This retrospective cohort included 87 TMD patients treated with stabilization splints, physical therapy, and pharmacologic therapy. Thirty‐five pre‐treatment cephalometric and demographic features w …

30.08.2026journal-article

Archiv Euromedica

THE ROLE OF DIET AND LIFESTYLE IN THE TREATMENT OF ATTENTION DEFICIT HYPERACTIVITY DISORDER: A NARRATIVE REVIEW

Aleksandra Katarzyna Kłosowicz, Aleksandra Olga Pakulska, Natalia Rządzińska, Aleksandra Maria Błoch, Maria Anna Miller, Kornelia Julia Fimiarz, Aleksandra Jolanta Kamińska

Background Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder characterized by impaired concentration, impulsivity, and excessive motor activity. Although conventional therapy is effective in many patients, it may be associated with high costs, adverse effects, and incomplete symptom control. Therefore, complementary methods, such as dietary modifications and lifestyle factors, are gaining increasing importance in the management of ADHD. Aims The aim of this narrative review was to cri …

30.08.2026journal-article

Advanced Science

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu

ABSTRACT Recurrence and progression remain major clinical challenges in bladder cancer (BC), yet the mechanisms linking glycolysis to persistent malignant states remain incompletely defined. Here, we identify alanyl tRNA synthetase 1 (AARS1) as a clinically relevant driver of aggressive and recurrent BC. AARS1 is upregulated in BC tissues, enriched in muscle invasive and recurrent tumors, and associated with unfavorable survival. Functionally, AARS1 promotes proliferation, epithelial mesenchymal transition, invasio …

30.08.2026journal-article

Journal of Clinical Medicine

Association of PI-RADS Score with Clinically Significant Prostate Cancer and Histopathological Upgrading in Patients Undergoing Radical Prostatectomy: A Retrospective Single-Centre Study

Hubert Andrzej Krzepkowski, Tomasz Ząbkowski, Andrzej Wieczorek, Maciej Walędziak, Tomasz Waldemar Kamiński, Hubert Dąbrowski, Tomasz Syryło

Background and Objectives: Multiparametric magnetic resonance imaging (mpMRI) is widely used in prostate cancer diagnosis, but biopsy findings may still underestimate tumor aggressiveness. This study evaluated the association of Prostate Imaging Reporting and Data System (PI-RADS) assessment with clinically significant prostate cancer (csPCa) and histopathological upgrading after radical prostatectomy. Methods: The retrospective analysis comprised 564 patients who underwent mpMRI–transrectal ultrasound fusion-guide …

30.08.2026journal-article

International Journal of Stroke

Clinical Outcomes among Patients with Active Cancer and Acute Ischemic Stroke Treated with Antiplatelet versus Anticoagulant Therapy.

Gianluca Costamagna, Andreas Hottinger, Francoise Livio, Babak Benjamin Navi, Davide Strambo, Patrik Michel

Background: Patients with acute ischemic stroke (AIS) and active cancer (AC) face high risks of recurrent stroke and death. Evidence guiding antithrombotic selection remains limited. Aims: To investigate post-AIS prescribing patterns of antiplatelet versus anticoagulant therapy in AIS patients with AC and their associated clinical characteristics and outcomes. Methods: We retrospectively analyzed 2003–2024 data from the Acute-Stroke-Registry-and-Analysis-of-Lausanne (ASTRAL). We included patients with AC discharged …

30.08.2026journal-article

Open Access Indonesian Journal of Medical Reviews

Preoperative Sarcopenia and Major Postoperative Complications After Gastrectomy for Gastric Cancer: Does Adding Muscle Function to Muscle Mass Improve Risk Prediction? A Systematic Review and Meta-Analysis

I Putu Oktayana, Gregorius Iwan Budiman Bomba, Nugroho Sofian Aji

Background: Consensus bodies define sarcopenia by low muscle mass plus impaired function, yet most gastrectomy studies use computed-tomography muscle mass alone. Whether adding function improves prediction of major postoperative complications remains uncertain. Objective: To quantify the association between preoperative sarcopenia and major complications after gastrectomy for gastric cancer and compare function-inclusive with imaging-mass-only definitions. Case presentation: This systematic review and meta-analysis …

30.08.2026journal-article

Advanced Science

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou

ABSTRACT Chimeric antigen receptor (CAR)‐engineered cell therapies are being extended from hematological malignancies to autoimmune, inflammatory, and fibrotic diseases, although the maturity of evidence differs markedly among platforms and indications. Early clinical evidence from case reports, small case series, and early‐phase trials suggests that CD19‐ or BCMA‐directed CAR‐T cells can induce deep B‐cell or plasma‐cell depletion and sustained remission in selected patients with refractory autoimmune diseases; ho …

30.08.2026journal-article

Health Science Reports

Sexual Silence in Breast Cancer Survivorship: A Secondary Qualitative Study of Healthcare Practices and Sexual Concerns

Mina Esmkhani, Charrlotte Seib, Armin Ariana

ABSTRACT Background and Aims In routine breast cancer follow‐up care, sexual concerns are rarely discussed, shaping how women understand and respond to post‐treatment changes. This study examined how survivorship care practices influence the expression and recognition of sexual concerns among women after breast cancer treatment. Methods This study employed a qualitative secondary analysis of semi‐structured interview data from 31 women aged 32–72 years who had completed primary treatment for breast cancer in Austra …

30.08.2026journal-article

Genes

The Inhibition of Histone Lysine Demethylases Affects Head and Neck Cancer Cell Growth and Response to Cisplatin

Dawid Dorna, Robert Kleszcz, Violetta Krajka-Kuźniak, Jarosław Paluszczak

Background/Objectives: Head and neck squamous cell carcinomas (HNSCC) are a heterogenous group of tumors, which are usually treated with surgery and radiotherapy, while chemotherapy (e.g., cisplatin), anti-EGFR, or immune checkpoint inhibitors are used to treat locoregionally advanced and recurrent cases. However, survival outcomes are still unsatisfactory, and novel augmenting treatments are required. Recently, histone lysine demethylases (KDMs) emerged as promising anti-cancer targets. In order to further charact …

30.08.2026journal-article

International Journal of Computer Information Systems and Industrial Management Applications

ADVANCED DEEP LEARNING TECHNIQUES FOR BRAIN TUMOR SEGMENTATION AND CLASSIFICATION

Akash Dudhe, Prakash G. Burade

Problems with uncontrolled cell growth in the human body are a major cause of cancer, like brain cancer, which occurs in the brain or the nervous system. Tumours are categorised as benign or malignant and are defined by cellular activity and structure. Cancerous tumours are invasive and might require surgical removal, so early and accurate diagnosis is crucial. A radiologist-based diagnosis manually is time-consuming and error-prone, especially in denseness regions. This work aims to solve this problem through the …

30.08.2026journal-article

Сибирский научный медицинский журнал

CRISPR/Cas9 technology in oncology: mechanisms, applications, and future perspectives

M. A. Omarov, E. I. Karacheva, M. M. Arapieva, K. S. Ulyumdzhiev, V. A. Deiko, I. M. Batyrshin

The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology is a cutting-edge genome editing tool based on the adaptive immune mechanism of prokaryotes. This system, which operates through three key stages‒adaptation, expression, and interference‒offers high precision and efficiency in genetic modification. This article explores the mechanisms of CRISPR/Cas action and its applications in hematologic malignancies, breast cancer, colorectal cancer, gastric cancer, and lung cancer. Genome editing …

30.08.2026journal-article

Dermatitis®

Reasons for Upadacitinib Discontinuation and Risk of Recurrence in the Treatment of Atopic Dermatitis

Yuxin Luo, Ziyi Zhang, Shu Ding, Li Lei, Jing Chen

Background: Treatment discontinuation is common with Janus kinase inhibitors, such as upadacitinib, in moderate-to-severe atopic dermatitis (AD), and this often results in disease relapse and an increased patient burden. Objective: To explore reasons for discontinuation, risk factors, and willingness to reuse upadacitinib. Methods: This retrospective study enrolled 104 patients with AD (50 in the discontinuation, 54 in the non-discontinuation) from Xiangya Third Hospital (Feb–Mar 2026). Data on DLQI, pruritus NRS, …

30.08.2026journal-article

Journal of Medicine and Health

Cognitive Behavioural Therapy as an Adjunct to Pharmacotherapy in Bipolar Disorder: A Systematic Review of Treatment Outcomes and Relapse Prevention

Adeline C Phelps, Hendsun Hendsun, Ernawati Ernawati

Bipolar disorder is a chronic psychiatric condition characterized by recurrent mood episodes and significant functional impairment. Although pharmacotherapy remains the primary treatment, relapse rates remain high, highlighting the need for effective adjunctive interventions. This study aimed to synthesize evidence on the effectiveness of Cognitive Behavioural Therapy (CBT) as an adjunct to pharmacotherapy in improving treatment outcomes and preventing relapse in bipolar disorder. A literature review was conducted …

30.08.2026journal-article

Molecular Carcinogenesis

Spatial Genetic Mapping of Normal Human Prostate Tissue Identifies Epithelial Compartments Enriched for Prostate Cancer Association

Shuai Liu, Owen T. M. Chan, Hua Zhong, Ali Shahabi, Lang Wu, Jingjing Zhu

ABSTRACT Previous genome‐wide association studies have identified more than 400 prostate cancer (PCa) susceptibility loci. However, the tissue and spatial epithelial contexts through which inherited PCa risk may operate in the normal prostate remain incompletely understood. We analyzed normal human prostate spatial transcriptomic data using a gsMap‐based framework to localize PCa association signals across spatially resolved prostate compartments. Spatial spots were clustered using SpaGCN and then manually curated …

30.08.2026journal-article

VIEW

Biopolymer‐Based Polyelectrolyte Nanoplatforms for Targeted Photodynamic Therapy of Breast Cancer

Athira Narayanan, Benedetta di Chiara Stanca, Daniela Pinheiro, Laura Giannotti, Fabrizio Damiano, André Ferreira Moreira, Sónia Miguel, Leonardo Lamanna, Eleonora Stanca, Maria Grazia Raucci, Gianpiero Colangelo, Luisa Siculella, Alessandro Sannino, Paula Coutinho, Christian Demitri

Abstract Nanomedicine has reshaped healthcare, especially in targeted drug delivery systems (DDSs) and diagnostics, addressing the limitations of traditional cancer therapies. Integration of photodynamic therapy (PDT) with nanoparticle‐based DDSs has significantly improved the targeted accumulation and pharmacokinetic properties of photosensitizers within tumor cells, enabling selective tumor cell death while sparing healthy tissues. This study developed chitosan‐sericin polyelectrolyte nanoparticles (CSSN NPs) via …

30.08.2026journal-article

Iraqi Journal of Science

Classifying High-Dimensional Lung Cancer Data Using an Improved Deep Learning Model

Sarab M. Hameed, Dhuha Abdulhadi Abduljabbar

Anomalous cell growth, known as cancer, can cause tumors, weaken the immune system, and cause fatal complications. Early detection of cancer makes treatment easier and contributes to lower mortality rates. Gene expression data contributes crucially to the classification of cancer in its early stages. Accurately classifying cancer is a complex problem because gene expression data is high-dimensional compared to the limited number of samples. This research proposes an improved Deep Learning model that integrates both …

30.08.2026journal-article

Jurnal Kejuruteraan

Effect of Hot Water Treatment on Physical and Mechanical Properties of Oil Palm Empty Fruit Bunch Fibre Cement Boards

Nurul Huda Azmi, Mohammad Soffi Md Noh, Nik Mohd Zaini Nik Soh

The growing demand for sustainable construction materials has increased interest in fibre–cement composites reinforced with natural fibres. Oil palm empty fruit bunch (OPEFB) is an abundant agricultural by-product with strong potential for fibre cement boards. However, its hydrophilic nature and weak fibre–matrix adhesion limit dimensional stability and mechanical performance. While hot water treatment has been shown to improve fibre compatibility, most studies have focused only on untreated, 60°C, and 100°C condit …

30.08.2026journal-article

Cancers

A Logistic Regression Model Integrating Flow Cytometry−Derived Immune Cell Profiles and Hematological Parameters for Preoperative Prediction of Peritoneal Metastasis in Gastric Cancer

Ruihu Zhao, Yuming Ju, Zhichao Yu, Yingwei Xue, Hongjiang Song

Background: Peritoneal metastasis (PM) is a lethal and often occult event in advanced gastric cancer (GC), and its preoperative detection remains difficult. The role of peripheral NK and NKT−like cells in predicting PM has not been well defined. Methods: We retrospectively analyzed 433 patients who underwent surgery for GC from 2016 to 2020. Patients were stratified by PM status and randomly assigned to training and held−out internal validation cohorts. Flow cytometry−derived lymphocyte subset percentages were trea …

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Aktuelle Forschung nach Fachgebiet

Genomic characterization of ER-positive primary tumors and corresponding relapses identifies potentially targetable alterations

Effectiveness of the Ponseti Method for Clubfoot Treatment in Children in Chad : A 77‑Case Study

Machine Learning-Enabled Photocatalytic Wastewater Treatment: Recent Advances in Catalyst Design, Performance Prediction, and Process Optimization

Could Subjective Cognitive Complaints Give the Facts of Objective Cognitive Impairments in Non‐Central Nervous System Cancer? A Systematic Review

Molecular Optimization of Benzimidazole Scaffolds for Targeted Protein Kinase Inhibition in Oncology

Depression, Associated Factors, and Coping Mechanisms among Caregivers of Children with Cancer at Mobile Hospice Mbarara, Uganda: A Cross-Sectional Study

Machine Learning Prediction of Anterior Open‐Bite Development After Stabilization Splint Treatment in Temporomandibular Disorder

THE ROLE OF DIET AND LIFESTYLE IN THE TREATMENT OF ATTENTION DEFICIT HYPERACTIVITY DISORDER: A NARRATIVE REVIEW

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Association of PI-RADS Score with Clinically Significant Prostate Cancer and Histopathological Upgrading in Patients Undergoing Radical Prostatectomy: A Retrospective Single-Centre Study

Clinical Outcomes among Patients with Active Cancer and Acute Ischemic Stroke Treated with Antiplatelet versus Anticoagulant Therapy.

Preoperative Sarcopenia and Major Postoperative Complications After Gastrectomy for Gastric Cancer: Does Adding Muscle Function to Muscle Mass Improve Risk Prediction? A Systematic Review and Meta-Analysis

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Sexual Silence in Breast Cancer Survivorship: A Secondary Qualitative Study of Healthcare Practices and Sexual Concerns

The Inhibition of Histone Lysine Demethylases Affects Head and Neck Cancer Cell Growth and Response to Cisplatin

ADVANCED DEEP LEARNING TECHNIQUES FOR BRAIN TUMOR SEGMENTATION AND CLASSIFICATION

CRISPR/Cas9 technology in oncology: mechanisms, applications, and future perspectives

Reasons for Upadacitinib Discontinuation and Risk of Recurrence in the Treatment of Atopic Dermatitis

Cognitive Behavioural Therapy as an Adjunct to Pharmacotherapy in Bipolar Disorder: A Systematic Review of Treatment Outcomes and Relapse Prevention

Spatial Genetic Mapping of Normal Human Prostate Tissue Identifies Epithelial Compartments Enriched for Prostate Cancer Association

Biopolymer‐Based Polyelectrolyte Nanoplatforms for Targeted Photodynamic Therapy of Breast Cancer

Classifying High-Dimensional Lung Cancer Data Using an Improved Deep Learning Model

Effect of Hot Water Treatment on Physical and Mechanical Properties of Oil Palm Empty Fruit Bunch Fibre Cement Boards

A Logistic Regression Model Integrating Flow Cytometry−Derived Immune Cell Profiles and Hematological Parameters for Preoperative Prediction of Peritoneal Metastasis in Gastric Cancer