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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
17.08.2026journal-article

National Science Review

Muco-infiltrating prodrug coacervates with prolonged colonic retention enhance IBD-associated depression therapy

Fengming Tan, Bo Yi, Lizhi Wang, Kaixin Guan, Jinhong Qin, Mingxin Lin, Weitong Huang, Sirong Chen, Xiayi Xu, Pengchao Zhao, Liming Bian

Abstract Oral delivery of small-molecule drugs to the distal intestine is often hindered by short colonic retention, a key requirement for ensuring sustained colonic drug availability. Herein, we developed a library of minimalist, muco-infiltrating prodrug coacervates by exploiting the interfacial physics of liquid–liquid phase separation (LLPS). By systematically tuning the length of poly(ethylene glycol) (PEG) spacer and the hydrophobicity of drug stickers in PEG–drug conjugates, we precisely modulated the molecu …

17.08.2026journal-article

Teaching and Learning in Communication Sciences & Disorders

Targeted Interprofessional Education (IPE) Curriculum for First-Year Speech-Language Pathology (SLP) Graduate Students

Cody Marie Busch

ASHA requires that SLP graduate programs facilitate opportunities for interprofessional collaborative practice (IPCP). Research suggests that IPCP initiatives should be integrated throughout the curriculum, rather than isolated interprofessional education (IPE) experiences. 15 first-year SLP graduate students participated in a year-long IPE curriculum focused on the IPEC Core Competencies. Quantitative and qualitative data revealed improved perception of IPCP and appreciation of opportunities to interact with other …

17.08.2026journal-article

Journal of Civil, Construction and Environmental Engineering

Comparison of Field Tests and Methods of Rehabilitation for Flexible and Rigid Pavement Infrastructures in Egypt and Saudi Arabia: A Comprehensive Review

Mostafa Hassan

Roads are a vital infrastructure that links cities and countries and facilitates trade between countries. The impact of severe climate change is increasing significantly all over the world and influences its effect on vital roads with respect to changes in temperature that induce significant thermal stresses, relative humidity, and extreme floods these days. Different mix designs, field tests, and materials utilized for flexible (Asphalt) and rigid pavement (Concrete) in Egypt and Saudi Arabia will be discussed in …

17.08.2026journal-article

Journal of Applied Microbiology

Evaluation of Sequential Phage-Antibiotic Therapy Reveals Enhanced Biofilm Control with Meropenem and Colistin in Clinical MDR Hypervirulent Klebsiella pneumoniae Strain

Ramya Juliet, Madhumathi Irulappan, Balaji Veeraraghavan, Ramesh Nachimuthu

Abstract Aims The convergence of multidrug resistance and hypervirulence in Klebsiella pneumoniae (MDR-HvKp) has narrowed treatment options. Despite growing interest in phage-antibiotic synergy (PAS), this study evaluates the underexplored combinatorial effects of phage and antibiotics, including drug-specific interactions and sequence dependency, against the biofilm-forming MDR-HvKp clinical strain. Methods and Results A T5-like Klebsiella bacteriophage, Round, within the genus Webervirus, was therapeutically and …

17.08.2026journal-article

Journal of Oral Rehabilitation

Eccentric Occlusal Loads Remodel the Dentoalveolar and Temporomandibular Biomechanical Unit in Rats

Haochen Ci, Umama Ali, Zhiyuan Yang, Ayush Bakandi, Nhu Huynh, Christine Nguyen, Brandon Lee, Youngho Seo, Robert Flavell, Alireza Hatamifar, Rishi J. Gupta, Rebeka Silva, Yongmei Wang, Bo Wang, Sunita P. Ho

ABSTRACT Background Altered occlusal mechanics are critical regulators of the structure and function of the dentoalveolar and temporomandibular joints (DAJ, TMJ); however, the multiscale biological and mechanical consequences of sustained occlusal rise on the TMJ are not understood. Objective This study establishes a proof‐of‐concept for using an occlusal rise (OR) to investigate how the resulting chronic eccentric loading influences the DAJ and TMJ across mechanical, structural, and metabolic domains. Methods Rats …

17.08.2026journal-article

PLOS One

Occupational safety and health risks among plumbers: A qualitative study of workplace hazards, safety practices, and system-level gaps in Texas

Mary Conger, Avishek Choudhury

Background The plumbing trade exposes workers to ongoing workplace hazards that pose significant health risks. This issue is well known but remains unresolved. A key question remains: why have current safety measures, such as training programs, regulatory standards, and personal protective equipment (PPE) requirements, failed to reduce injury rates or significantly improve safety in the plumbing field. Objectives Despite well-documented hazards in plumbing work, qualitative research examining why existing safety me …

17.08.2026journal-article

Frontiers in Psychology

Psychometric refinement and validation of the Entrepreneurial Personality Inventory across distinct occupational groups

Mariela Pavalache-Ilie, Ana-Maria Cazan, Camelia Truța, Denisa Elena Tomulescu, Marcela Rodica Luca

Introduction Entrepreneurial personality is associated with entrepreneurial intention and business-related behavior, yet existing measures remain fragmented and insufficiently validated across occupational groups. The present study aimed to psychometrically refine and validate the Entrepreneurial Personality Inventory (EPI) across distinct occupational groups. Methods The study included 897 Romanian participants distributed across four groups: students enrolled in entrepreneurial education programs, matched student …

17.08.2026journal-article

Hong Kong Physiotherapy Journal

Effects of robotic glove-assisted task-oriented mirror therapy on hand motor function in sub-acute stroke patients: Randomised controlled trial

Abdul Rehman, Furqan Ahmed Siddiqi, Saman Shaukat

Background: The incidence of stroke has increased globally, leading to mortality and disability. Approximately 30–66% of stroke survivors are unable to regain motor functions in the affected hand throughout their lives, which significantly impacts their functionality and daily activities. Objective: This study aimed to determine the effects of robotic glove-assisted task-oriented mirror therapy in comparison with task-oriented mirror therapy on the motor functions of the hand in sub-acute stroke. Methods: This was …

17.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Factors affecting job stress among health workers and support staff: A case study of an affiliated private hospital in Thailand

Sanpatchaya Sirisawasd, Darika Wortong, Chakrapan Wisedsammapan, Chalobon Treesak, Paiboon Eksaengsri, Dhanoo Lawbundis, Rachata Lumkul

Background Managing an affiliated private hospital through various hospital groups in Thailand may increase job stress among health workers and support staff. Objectives To determine the prevalence and identify the factors affecting job stress among 2242 health workers and support staff in an affiliated private hospital in Thailand. Methods This cross-sectional analytical study included, via convenience sampling, health workers and support staff who worked at seven hospitals of an affiliated private hospital locate …

17.08.2026journal-article

Per Musi

Análisis del impacto de técnicas musicoterapéuticas en el bienestar emocional, calidad de vida y ansiedad de alumnos de un Conservatorio Profesional de Música

Mayte Sancho Herreros, Manuel Sequera Martín, Vicente Alejandro March Luján

La ansiedad escénica constituye una problemática prevalente entre estudiantes de conservatorios profesionales de música, afectando significativamente su rendimiento y bienestar emocional. El presente estudio analiza el impacto de técnicas musicoterapéuticas en el bienestar emocional, calidad de vida y ansiedad de 39 alumnos de un Conservatorio Profesional de Música mediante un diseño cuasi experimental. Los participantes se distribuyeron en grupo experimental (19 estudiantes) que recibió intervención musicoterapéut …

17.08.2026journal-article

Journal of Rational-Emotive & Cognitive-Behavior Therapy

Appraisals and Positive Irrational Beliefs in Dysfunctional Positive Feelings: Appraisal Vulnerabilities for Positive Emotion Disturbance

Marius Drugaș, Alexandru Tiba, Simona Trip, Bogdan Vlad

Abstract Positive emotion disturbance (PED) - high-arousal, high-intensity dysfunctional positive emotions - is thought to play a key role in bipolar disorder (BD). Yet its underlying cognitive processes remain poorly understood. In two samples, we explore whether rigid and extreme positive appraisals such as positive irrational beliefs (PIBs) function as emotion-specific appraisals associated with dysfunctional positive emotions beyond domain-general appraisals. In Study 1 ( N = 120), we demonstrate that domain-ge …

17.08.2026journal-article

Physiotherapy Research International

Acute Foot Warming Enhances Plantar Tactile Sensitivity With Limited Postural Control Effects in Obese Older Adults

Mathias Sosa Machado, Lissandra dos Santos Gonçalves, Amanda Carolina Paim Camponogara, Marieli Miranda Paz, Álvaro Sosa Machado, Felipe P. Carpes

ABSTRACT Background and Purpose Interventions to enhance tactile sensitivity, such as warming the feet, positively affect skin sensitivity with varying influence on postural control. Here, we hypothesize that foot warming may benefit tactile sensitivity and postural control in older adults, particularly those with obesity. Methods Fifty participants divided into 16 middle‐aged adults (14 women, mean ± standard deviation: age 40.29 ± 3.73 years, body mass index, BMI, 24.51 ± 1.70 kg/m 2 ), 17 non‐obese older adults …

17.08.2026journal-article

Adolescência e Saúde

Shifting the Paradigm in GDM Care: A Randomized Controlled Trial of Midwifery-Led Versus Standard Care on Birth and Emergency Complication Preparedness Performance

Debajani Nayak, Pravati Tripathy, Prasant Kumar Nayak

Background: Gestational Diabetes Mellitus (GDM) is a high-risk illness linked to poor maternal and newborn outcomes. Adequate birth preparedness and complication readiness (BPCR) are critical components of safe motherhood, especially for women with GDM. Midwifery-led forms of care have demonstrated the ability to improve maternal outcomes via ongoing support, education, and empowerment. Objective: The objective is to assess the impact of a midwifery-led care paradigm on birth preparedness and complication readiness …

17.08.2026journal-article

Research, Society and Development

Fisioterapia após Acidente Vascular Cerebral: Recuperação da marcha, independência funcional e prevenção de incapacidade

Matheus Antônio dos Santos Araújo, Thelkia de Araujo Oliveira, Renan Soares e Silva, Ana Carolina Gazzola Braga, Sara Saba Faria

O Acidente Vascular Cerebral (AVC) constitui uma das principais causas de incapacidade adquirida em adultos e representa um importante problema de saúde pública devido ao seu impacto na funcionalidade, na qualidade de vida e nos custos dos sistemas de saúde. A fisioterapia desempenha papel essencial na recuperação motora e na promoção da reintegração social dos indivíduos acometidos. Esta revisão objetivou analisar as evidências científicas sobre a eficácia da fisioterapia na recuperação da marcha, no ganho de inde …

17.08.2026journal-article

Arthritis & Rheumatology

Risk of Cancer according to Duration of Targeted Therapy Exposure in Spondyloarthritis: A Nationwide Cohort Study from the French Health Insurance Database

Karine Tankovic, Pascal Claudepierre, Tat Thang Vo, Tran Trong Khoi Le, Siham Iggui, Laetitia Penso, Emilie Sbidian, Laura Pina Vegas

Objective To assess the association between duration of targeted therapy exposure and cancer risk in patients with spondyloarthritis (SpA), including those with psoriatic arthritis, axial SpA, and other subtypes. Methods This nationwide cohort study used the French health insurance database to identify adults with SpA initiating a targeted therapy (TNFi, IL17i, IL12/23i, IL23i, JAKi) from January 2014 to September 2022. Patients with prior cancer, HIV infection, or organ transplantation were excluded. Follow‐up beg …

17.08.2026journal-article

Adolescência e Saúde

Sign Voice: Real-Time Sign Language Recognition and Speech Translation System

Dr. R. Salini, Jeswin Ebenezer P, Karthik R, Jason Jacinth Moses A, Dr.Jainish G R, Dr.P. Deepa

Communication between deaf or hearing-impaired people and the rest of society is still quite a social and technological challenge. The main reason for this is the fact that a very small number of people understand sign language. Although sign language is a very good and expressive way of communicating, the lack of sign language translation tools in real-time is one of the main barriers for inclusive communication in everyday environments. To solve this problem, we have developed SignVoice, a system that recognizes …

17.08.2026journal-article

Prenatal Diagnosis

Maternal Sirolimus Therapy for Fetal Extensive Lymphatic Cystic Malformation: Selection Criteria, Management, and Outcomes in a Series of Six Cases

L. Guibaud, M. Bordas‐Fournel, S. Cabet, C. Le Vaillant, A. Bruel, T. Lefrançois, C. Megier, A. Benachi, M. Sohier, Y. Gallois, T. Simon, J.‐M. Jouannic, G. Canaud, A. Guilhem, A. Atallah, A. Fraissenon

ABSTRACT Objective Maternal sirolimus therapy has emerged as a potential prenatal treatment for extensive fetal lymphatic malformations, particularly when associated with the risk of neonatal airway compromise. Data on prenatal indications, pharmacokinetics, and outcomes remain limited. We aimed to describe patient selection, treatment management, maternal and fetal safety, and early outcomes. Methods Between December 2023 and May 2025, 15 fetuses with extensive cystic or mixed vascular anomalies suggestive of lymp …

17.08.2026journal-article

Frontiers in Neuroscience

Stem cell and stem cell-derived extracellular vesicle therapy for traumatic brain injury: mechanisms, engineering and translation

Shijun Bi, Dandan Gao, Kunyuan Zhu, Sanchuan Liu, Ligang Chen, Wei Jiang, Guobiao Liang

Traumatic brain injury (TBI) remains a major unmet clinical challenge owing to its complex pathophysiology, profound heterogeneity, and limited regenerative capacity of the adult central nervous system (CNS). Existing therapeutic interventions are largely restricted to supportive management and fail to adequately address the secondary injury cascade characterized by persistent neuroinflammation, oxidative stress, vascular dysfunction, and progressive neurodegeneration. Against this backdrop, stem cell-based therapi …

17.08.2026journal-article

Gels

Dual−Network PVA/PAM Hydrogel Strain Sensor for Machine−Learning−Assisted Rehabilitation−Oriented Hand Motion Monitoring

Wendi Liu, Jintao Wang, Yuanduo Wang, Zhangqi Xia, Ruixin Liu, Yixuan Li, Xinyang He, Hailou Wang

Wearable rehabilitation monitoring requires soft strain sensors with mechanical robustness, stable electromechanical responses, and intelligent motion recognition capability. Here, we report a poly(vinyl alcohol)/polyacrylamide (PVA/PAM) double−network hydrogel strain sensor for rehabilitation−oriented wearable monitoring. The hydrogel was prepared by ultraviolet ray (UV)−initiated acrylamide polymerization followed by freeze−thaw−induced PVA crystallization, forming a covalent PAM network interpenetrated with a ph …

17.08.2026journal-article

Revista ft

Atuação da terapia ocupacional no desenvolvimento das atividades de vida diária em crianças com transtorno do espectro autista

Peterson Pereira de Carvalho

Objective: To analyze the role of Occupational Therapy in the development of Activities of Daily Living (ADLs) in children with Autism Spectrum Disorder (ASD), identifying the main interventions used and their impacts on autonomy, functional independence, and occupational participation. Method: This is an integrative literature review with a qualitative and descriptive approach, conducted through scientific articles published between 2020 and 2026, selected from the SciELO, LILACS, PubMed, and PEDro databases. Desc …

17.08.2026journal-article

International Journal of Language & Communication Disorders

Building Knowledge and Confidence: Student Speech Pathologists' Perspectives on Learning About Cognitive‐Communication Disorders and the Potential of Implementing Convers‐ABI‐lity on Placement

Ashna Nadan, Petra Avramović, Leanne Togher, Annie Chan, Rachael Rietdijk

ABSTRACT Background Cognitive‐communication disorders (CCDs) are common after acquired brain injury (ABI). People with CCD experience communication breakdowns, significantly impacting long‐term social, familial, and vocational outcomes. Convers‐ABI‐lity, a web‐based communication partner training intervention, was co‐designed with key stakeholders, including people with ABI, their family members, speech pathologists, and other allied health professionals, to address communication breakdowns in everyday interactions …

17.08.2026journal-article

Proceedings of the National Academy of Sciences

CXCR4-targeted dual softener for inducing senescence therapy in hepatic fibrosis

Junmei Mu, Jingwen Dong, Jiahui Chen, Panle Sima, Yinuo Fan, Xunyi Gong, Junjie Zhou, Xue Yang, Zhanwei Zhou, Minjie Sun

Hepatic fibrosis is a central pathological driver of chronic liver diseases, including metabolic dysfunction-associated steatotic liver disease and alcohol-related liver disease, which collectively impose a growing global health burden. Fibrosis is primarily mediated by persistent activation of hepatic stellate cells (aHSCs) and excessive deposition of stiff extracellular matrix (ECM). The dense and rigid ECM-aHSCs network severely hinders drug delivery and penetration, posing a major challenge for effective antifi …

17.08.2026journal-article

Frontiers in Neurology

Application of musculoskeletal ultrasound in quantitative assessment and rehabilitation of lower leg muscles in stroke patients

Chengrui Ma, Liansong Liu, Rongxing Yang, Ping Yao

Objective To investigate the application of musculoskeletal ultrasound in the quantitative assessment of lower leg muscles and its value in stratifying rehabilitation outcomes in patients with stroke. Methods A single-center retrospective study was conducted, including 152 patients with stroke. Based on predefined composite functional criteria at 6 months after rehabilitation, patients were classified into favorable outcome ( n = 105) and poor outcome ( n = 47) groups. Baseline clinical characteristics (FMAS, Barth …

17.08.2026journal-article

MedComm

Abscopal Effect in Radiation Therapy: The Immune Mechanisms and Clinical Advances

Yihong Dong, Moran Chen, Xupeng Hou, Xiaoya Tang, Xiaoli Yu, Jing Liu

ABSTRACT The abscopal effect is a systemic antitumor response to localized radiotherapy (RT) that has emerged as a central focus in the era of immunotherapy. Clinical evidence demonstrates that local RT can induce regression of distant, nonirradiated metastases, including cases of complete remission. However, the effect remains unpredictable, with marked variation in clinical outcomes ranging from complete regression to paradoxical progression. The mechanistic basis for this heterogeneity and optimal strategies to …