Onkologie: neue Gesundheitspublikationen – Seite 137

30.08.2026journal-article

HEALTH SCIENCES AND DISEASE

Évaluation de l'Effet Néphroprotecteur du Sulfate de Magnésium chez les Patients Traités par Cisplatine à l'Institut de Cancérologie d'Akanda

Nziengui Tirogo C, Nzamba Bisselou Pl, Okourimakima Nguia M, Edzang Nkoulou N, Filankembo Kava A, Ndengue Tsana JJ, Igabouyi Moussadji C, Tsitsi Nding P, Belembaogo E

RÉSUMÉIntroduction. La chimiothérapie à base de cisplatine, pierre angulaire du traitement de nombreux cancers, expose à une néphrotoxicité dose-dépendante dont l'insuffisance rénale aiguë (IRA) est la complication la plus redoutable. L'hyperhydratation, méthode standard de prévention, réduit l'incidence de l'IRA sans la supprimer, justifiant la recherche de stratégies adjuvantes. Cette étude visait à évaluer l'efficacité du sulfate de magnésium associé à l'hyperhydratation dans la prévention de l'IRA induite par l …

30.08.2026journal-article

Applied System Innovation

Spatial Heterogeneity in Cancer Incidence: Assessing Behavioral and Environmental Associations Using Machine Learning and Multiscale Geographically Weighted Regression

Yuhang Xie, Zhe Zhang, Chanam Lee, Marcia G. Ory, Ipek Nese Sener, Bahar Dadashova, Gisou Salkhi Khasraghi, Jinsil Hwaryoung Seo, Galen Newman, Chunwu Zhu, Wenjin Wang, Xuemei Zhu

Cancer incidence exhibits substantial spatial disparities associated with environmental, behavioral, built-environment, healthcare access, and socioeconomic conditions, yet the extent to which these county-level associations vary geographically and across spatial scales remains insufficiently understood. This study evaluates an explainable spatial epidemiology workflow that integrates Random Forest (RF), SHapley Additive exPlanations (SHAP), permutation importance, Ordinary Least Squares (OLS), Geographically Weigh …

30.08.2026journal-article

Current Oncology

Impact of Decision Aids for Shared Decision-Making for Patients with Early Stage Breast Cancer: A Systematic Review

Serena Sdinami, Lorenzo Conti, Benedetta Capetti, Valeria Sebri, Paola Zagami, Roberto Grasso, Carmen Criscitiello, Giuseppe Curigliano, Gabriella Pravettoni

Objectives: To systematically review the evidence on the effectiveness of patient decision aids (PDAs) for women with early stage breast cancer, focusing on decision-making outcomes, psychological variables, and quality of life. Methods: A systematic review was conducted in accordance with PRISMA guidelines. PUBMED, EMBASE and SCOPUS databases were searched to identify quantitative, qualitative and mixed-methods studies evaluating PDAs designed to support treatment decision-making in women with early stage breast c …

30.08.2026journal-article

Gümüşhane Üniversitesi Fen Bilimleri Enstitüsü Dergisi

An ablation analysis of feature selection strategies for machine learning–based breast cancer recurrence prediction

Şeyma Aymaz

Breast cancer recurrence after treatment remains a critical clinical problem that directly affects patient management and survival outcomes. In this study, a machine learning–based classification framework is proposed to predict breast cancer recurrence risk. Experiments were conducted on the Wisconsin Prognostic Breast Cancer and Recurrent Breast Cancer datasets. During the data preprocessing stage, missing values were imputed, categorical variables were transformed into numerical representations, and all features …

30.08.2026journal-article

Basic & Clinical Pharmacology & Toxicology

Regional Variation in ADHD Treatment and Diagnosis Among Children and Adolescents in Denmark

Heidi Sonne, Anton Pottegård, Anna Sofie Kjærgaard Hansen, Mickael Bech, Helene Kildegaard

ABSTRACT Geographic variation in ADHD treatment and diagnosis among children and adolescents is well documented, yet the system‐level factors driving such differences remain poorly understood. We examined nationwide patterns of ADHD medication use and diagnoses in Denmark in 2024 and assessed whether municipal socioeconomy, regional hospital waiting times or private child psychiatrist capacity contributed to geographic variation. In this register‐based cross‐sectional study, we included all Danish residents aged 4– …

30.08.2026journal-article

Pharmaceutics

Aerosolized Quercetin-Loaded Chia Seed Polysaccharide Nanoparticles: Design of Experiments and Machine-Learning-Guided Optimization for Enhanced Lung Cancer Cell Delivery

Sara Hasan, Seyedeh Negin Kassaee, Derek J. Richard, Nazrul Islam, Emad L. Izake

Background/Objectives: The recent advances in pulmonary delivery have shifted the paradigm to the development of inhalable drug-loaded polysaccharide particles that can be positioned at the respiratory interface while reducing the systemic exposure. Quercetin has broad anticancer activity but remains difficult to translate because of its poor aqueous solubility, limited bioavailability and rapid metabolic loss. Here, we report quercetin-loaded chitosan/Salvia hispanica polysaccharide nanoparticles as a natural poly …

30.08.2026journal-article

physica status solidi (a)

Multilayer WS 2 /Borophene/Au/MXene/Cu Metasurface Terahertz Biosensor With Machine Learning‐Augmented Prediction for Label‐Free Brain Tumor Detection

Hassan Nasiri, Amuthakkannan Rajakannu

High‐performance terahertz metasurface biosensor is numerically developed for label‐free brain tumor detection. The sensor employs six multilayer elliptical resonators integrating WS 2 , borophene, Au, MXene, and Cu on a graphene‐coated SiO 2 substrate. Three material configurations are compared, with the hybrid WS 2 /borophene/MXene/Cu structure (Case 3) enabling plasmon–exciton (plexcitonic) coupling and delivering the best performance. Full‐wave FEM simulations in COMSOL incorporate dispersive material models, g …

30.08.2026journal-article

HEALTH SCIENCES AND DISEASE

Infection à Papillomavirus Humain et Lésions Précancéreuses du Col Chez les Travailleuses de Sexe à Parakou (Bénin) en 2025 : Prévalence et Acceptabilité du Traitement

Atade Sèdjro Raoul, Sidi Imorou Rachidi, Vodouhe Mahublo Vinadou, Yessoufou Junior Abd’ousmane, Klikpezo Roger, Bakary Samiath, Doha Valdes, Salifou Kabibou

RÉSUMÉIntroduction. Les travailleuses de sexe constituent une population à haut risque d'infection à Papillomavirus humain (HPV) et de lésions précancéreuses du col de l'utérus. Au Bénin, les données sur le dépistage et le traitement dans ce groupe vulnérable sont rares. Cette étude visait à déterminer la prévalence des lésions précancéreuses et à évaluer l'acceptabilité du traitement chez les travailleuses de sexe à Parakou en 2025. Méthodes. Nous avons mené une étude transversale descriptive du 3 août au 20 septe …

30.08.2026journal-article

International Journal of Research in Ayurveda and Pharmacy

FORMULATION AND EVALUATION OF MUCOADHESIVE HERBAL ORAL GEL CONTAINING SCUTELLARIA BAICALENSIS EXTRACT FOR THE TREATMENT OF ORAL INFLAMMATORY CONDITIONS

Aditya Uttam Waghmare, Pratik Sanjeev Gunale, Kiran C. Rodage, Sameer Shafi, Dharashive VM, Kavita Shivkumar Sirgire

The present study aimed to formulate and evaluate a mucoadhesive herbal oral gel containing Scutellaria baicalensis extract for the treatment of oral inflammatory conditions. The plant extract, rich in flavonoids such as baicalin and baicalein, exhibits significant anti-inflammatory, antimicrobial, and antioxidant properties. Herbal gel formulations (F1-F6) were prepared using Carbopol 940 as a gelling agent with varying concentrations to optimise physicochemical and release characteristics. The formulations were e …

30.08.2026journal-article

Advanced Science

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo

ABSTRACT Developing effective therapies for triple‐negative breast cancer (TNBC) requires the identification of key molecular regulators. Here, among the major m6A modulators, we find that only the reader YTHDC1 is specifically overexpressed in TNBC and correlates to unfavorable prognosis. Mechanistically, YTHDC1 orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress in TNBC cells. It not only stabilizes GLUT3 mRNA to sustain glucose uptake …

30.08.2026journal-article

Ukrainian Heart Journal

Ізольована дисекція верхньої брижової артерії: ендоваскулярне лікування. Клінічний випадок

S. M. Furkalo, Yu. H. Vahis, A. O. Danylets

The aim – to describe a case of elective endovascular treatment of asymptomatic spontaneous isolated dissection of the superior mesenteric artery with a self-expanding covered stent via right transbrachial access and to justify the indication for intervention based on morphological risk criteria.Materials and methods. The follow-up of a 67-year-old man with coronary artery disease, compensated type 2 diabetes mellitus, arterial hypertension, dyslipidaemia and previous left total hip arthroplasty is presented. The d …

30.08.2026journal-article

Eskisehir Medical Journal, Eskisehir City Hospital

TREATMENT STRATEGY AND INTERVENTION TIMING IN ELDERLY PATIENTS WITH ACUTE MESENTERIC ISCHEMIA: A MULTICENTER RETROSPECTIVE COHORT STUDY

Mehmet Emin Gonullu, Ahmet Tugrul Zeytin, Gurkan Guneri, Kadir Corbaci, Mucahit Unal, Fatih Gursoy, Erman Yekenkurul

Introduction: This study aimed to evaluate the association between treatment modality, intervention timing, and clinical outcomes in patients aged 65 years or older with acute mesenteric ischemia (AMI). Methods: This multicenter retrospective cohort study included 126 patients aged 65 years or older who were diagnosed with AMI between January 2015 and December 2025. Patients were classified according to treatment modality as endovascular treatment, open surgery, or conservative management. The primary outcome was 3 …

30.08.2026journal-article

Anatolian Journal of Health Research

The relationship between infertility stress, coping, and quality of life among women undergoing infertility treatment

Büşra Çark, Seyhan Çankaya, Ümmügülsüm Esenkaya

Aim: This study aimed to examine the relationships between infertility-related stress, coping strategies, and quality of life among women undergoing infertility treatment. Methods: This descriptive, cross-sectional study was conducted between April-November 2025 with 200 women attending an infertility outpatient clinic at a city hospital in Central Anatolia, Türkiye. Data were collected using a Personal Information Form, the COMPI Fertility Problem Stress Scales, the COMPI Coping Strategy Scales, and the Fertility …

30.08.2026journal-article

MedComm

Artificial Intelligence Integration With Nanotechnology for Cancer Therapy

Shengbin Liu, Zhi Liu, Haixing Shi, Chengyi Wei, Ruijie Zhang, Xiangrong Song

ABSTRACT Cancer nanomedicine offers a versatile platform for improving therapeutic index, but its clinical translation remains limited by unpredictable in vivo behavior, heterogeneous biological contexts, and inefficient design paradigms. Artificial intelligence (AI) is emerging as an integrative framework that links data‐driven modeling with nanomedicine design, biological transport, and clinical decision‐making. In this review, we discuss AI‐guided strategies for material design, targeting, payload optimization, …

30.08.2026journal-article

European Heart Journal

Safety of withdrawal of pharmacological treatment after recovery from HER2 therapy-related cardiac dysfunction: the HER-SAFE trial

B Dowsing, H-M Dehbi, M S Andres, R Chung, A Oashou, J M Wilson, I Hussein, B Meredith, I Pierce, S Ahmed, J Pedra, O Worn, M Howe, S Assadullah, P Schmid, R Roylance, T Crake, M Westwood, A K Ghosh, D Auger, C M Plymen, J Baksi, M S Nazir, J C Moon, D Chen, A R Lyon, J M Walker, C H Manisty

Abstract Background Heart failure therapy (HFT) is routinely continued in breast cancer survivors after recovery from anti-HER2 cancer therapy-related cardiac dysfunction (CTRCD), despite limited evidence. HER-SAFE is the first randomised trial to assess HFT withdrawal in this population. Methods In this open-label, multicentre, randomised controlled trial, breast cancer survivors with recovered anti-HER2 CTRCD (asymptomatic, left ventricular ejection fraction [LVEF] ≥50%, normalised biomarkers) were randomised to …

30.08.2026journal-article

Phlebology: The Journal of Venous Disease

Clinical treatment strategies and perioperative management of restenosis or secondary deep venous thrombosis after iliac vein balloon angioplasty

Zi-shuo Yang, Shuang-jie Tang

Objective To explore the surgical selection of iliac vein balloon angioplasty, as well as the treatment and management of postoperative complications including restenosis and secondary deep venous thrombosis. Methods All 55 enrolled patients received routine telephone follow-up, and imaging reexamination and statistical analysis were only performed on 10 patients complicated with restenosis or secondary thrombosis after balloon angioplasty. Conclusion This study provides reference basis for the selection of clinica …

30.08.2026journal-article

Medicina

Radiotherapy Modality and Primary Tumor Type as Determinants of Outcomes in Brain Metastases: A Retrospective Study of 734 Patients

Lucie Hnidakova, Andrea Pagacova, Sarka Kristkova, Jan Svancara, Ludmila Hynkova, Petr Pospisil, Renata Belanova, Jana Maistryszinova, Radek Lakomy, Tomas Prochazka, Miroslav Vrzal, Jiri Sana, Radim Jancalek, Martin Smrcka, Ivana Kolouskova, Lukas Moran, Katerina Prochazkova, Vera Andraskova, Jan Garcic, Pavel Slampa, Pavel Fadrus, Tomas Kazda

Background and Objectives: Radiotherapy (RT) is a standard component of palliative treatment for brain metastases. The aim of this retrospective analysis of consecutive patients treated between 2017 and 2023 is to analyze overall survival after brain radiotherapy depending on the type of radiotherapy delivered and to monitor the shift from whole-brain radiotherapy (WBRT) to stereotactic radiotherapy (SRS/FSRT) in real-world practice before the era of routinely used modern brain-penetrant targeted therapy. Materials …

30.08.2026journal-article

Cancer Medicine

Chronic Kidney Disease in Children Within Five Years After Ifosfamide Chemotherapy for Childhood Cancer: A Dutch Pediatric Oncology Cohort Study

Lotte Pitlo, Francis S. P. L. Wens, Paulien A. M. A. Raymakers‐Janssen, Lianne M. Haveman, Johannes H. M. Merks, Martine van Grotel, Geert O. Janssens, Marta Fiocco, Marry M. van den Heuvel‐Eibrink, Gerrit van den Berg

ABSTRACT Introduction Children treated with ifosfamide seem to have an increased risk for developing chronic kidney disease (CKD) already within the first years following chemotherapy. However, studies investigating CKD prevalence in this specific phase are scarce. This study aimed to determine the prevalence, course, and determinants of CKD in ifosfamide‐treated children within the first five years after chemotherapy. Methods This cohort study included children treated with ifosfamide at the Princess Máxima Center …

30.08.2026journal-article

Cellular Oncology

The role of hSSB1 and hSSB2 in the DNA damage response: mechanisms and implications

Armin Sharifi, Amila Suraweera, Kenneth J. O’Byrne, Derek J. Richard

Abstract The DNA damage response preserves genome integrity by detecting DNA lesions, activating checkpoint signalling, and coordinating repair with cell-cycle control. Defective or incomplete repair can promote mutation accumulation, chromosomal instability, cancer development, and ageing-associated diseases. In this review, we discuss the human single-stranded DNA-binding proteins hSSB1 and hSSB2, with an emphasis on their roles in ssDNA-rich repair intermediates generated during double-strand break repair, repli …

30.08.2026journal-article

Frontiers on Healthcare Research

What Explains the Survival Gap? Decomposing Cross-National Inequality in Breast Cancer Mortality-to-Incidence Ratios Using Open Global Data Repositories

Graduate Institute of Translational Medicine and New Drug Development, College of Medicine, China Medical University, Taichung, Taiwan, Siti Mardhiah El-Khairah Siti Mardhiah, Department of Epidemiology, Faculty of Public Health, Universitas Andalas, Padang, Indonesia, Melsi Pita Sari Melsi Pita

Background: Women diagnosed with breast cancer in low-resource countries are several times more likely to die from the disease than those in high-income countries, despite lower incidence. The mortality-to-incidence ratio (MIR) captures this survival gap, but previous studies have mainly described its association with national wealth rather than quantified the contribution of specific health-system factors. We aimed to measure inequality in breast cancer MIR across the human development gradient and identify key de …

30.08.2026journal-article

Advanced Science

Hyper‐Intense Tumor Peripheral Accumulation of Antibody‐Conjugated Iron Oxide Nanoparticles can Enable Breast Cancer Detection by Magnetic Particle Imaging

Preethi Korangath, Hayden Carlton, Theresa Wong, Sean Healy, Toby Sanders, Mason Song, Patrick W. Goodwill, Cordula Grüttner, Kathleen Gabrielson, Robert Ivkov

ABSTRACT Targeting nanoparticles to cancer cells in vivo remains a challenge for cancer imaging. We assessed nanoparticle distribution after injecting iron oxide nanoparticles conjugated with either a monoclonal anti‐HER2 (human epidermal growth factor 2), or a non‐specific IgG antibody into a human HER2 overexpressing murine breast cancer model. We used Magnetic Particle Imaging (MPI) and histopathology to assess particle localization at 72 h after injection. MPI detects magnetic moments produced by magnetic parti …

30.08.2026journal-article

Biomedicines

Basic Periodontal Treatment Improves Periodontal Inflamed Surface Area Without Adverse Events in Patients Receiving Direct Oral Anticoagulants: A Retrospective Clinical Study with an Animal Model

Ryousuke Fujimori, Yuri Taniguchi, Kazuhisa Ouhara, Shunsuke Miyauchi, Shinji Matsuda, Naoya Kuwahara, Shoya Ueda, Yitong Hou, Masaru Shimizu, Misako Tari, Shoko Kono, Tomoyuki Iwata, Tomoaki Shintani, Mikihito Kajiya, Mutsumi Miyauchi, Yukiko Nakano, Noriyoshi Mizuno

Background/Objectives: The optimal management of periodontal treatment in patients receiving direct oral anticoagulants (DOACs) remains poorly established, and bleeding concerns may lead clinicians to delay or limit treatment. We evaluated the clinical efficacy and safety of nonsurgical periodontal treatment in patients receiving DOAC therapy. Methods: This retrospective study included 67 patients receiving continuous DOAC therapy (edoxaban, apixaban, dabigatran, or rivaroxaban) who underwent nonsurgical periodonta …

30.08.2026journal-article

Journal of Research and Investigation in Education

Development of a Web-Based Expert System for Cancer and GERD Diagnosis

Aprilia Adelina Roring, Gilbert Josua Mangkay, Jean Stella Saragih, Ricat Abetnego Sundari, Jhosua Allesandro Tingon, Paul Aleksander Mundung, Yulisa Aprianti

Cancer and Gastroesophageal Reflux Disease (GERD) are serious health problems whose early detection is often hampered by limited access and awareness. This research aims to develop a website-based expert system as a solution to help the public perform an initial diagnosis of cancer and GERD independently. The system development methodology includes a requirements analysis phase, data flow design using DFD and ERD, and implementation using Visual Studio Code with programming languages such as Python and JavaScript …

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Was ist neu im Gesundheitswesen?

Aktuelle Forschung nach Fachgebiet

Évaluation de l'Effet Néphroprotecteur du Sulfate de Magnésium chez les Patients Traités par Cisplatine à l'Institut de Cancérologie d'Akanda

Spatial Heterogeneity in Cancer Incidence: Assessing Behavioral and Environmental Associations Using Machine Learning and Multiscale Geographically Weighted Regression

Impact of Decision Aids for Shared Decision-Making for Patients with Early Stage Breast Cancer: A Systematic Review

An ablation analysis of feature selection strategies for machine learning–based breast cancer recurrence prediction

Regional Variation in ADHD Treatment and Diagnosis Among Children and Adolescents in Denmark

Aerosolized Quercetin-Loaded Chia Seed Polysaccharide Nanoparticles: Design of Experiments and Machine-Learning-Guided Optimization for Enhanced Lung Cancer Cell Delivery

Multilayer WS 2 /Borophene/Au/MXene/Cu Metasurface Terahertz Biosensor With Machine Learning‐Augmented Prediction for Label‐Free Brain Tumor Detection

Infection à Papillomavirus Humain et Lésions Précancéreuses du Col Chez les Travailleuses de Sexe à Parakou (Bénin) en 2025 : Prévalence et Acceptabilité du Traitement

FORMULATION AND EVALUATION OF MUCOADHESIVE HERBAL ORAL GEL CONTAINING SCUTELLARIA BAICALENSIS EXTRACT FOR THE TREATMENT OF ORAL INFLAMMATORY CONDITIONS

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Ізольована дисекція верхньої брижової артерії: ендоваскулярне лікування. Клінічний випадок

TREATMENT STRATEGY AND INTERVENTION TIMING IN ELDERLY PATIENTS WITH ACUTE MESENTERIC ISCHEMIA: A MULTICENTER RETROSPECTIVE COHORT STUDY

The relationship between infertility stress, coping, and quality of life among women undergoing infertility treatment

Artificial Intelligence Integration With Nanotechnology for Cancer Therapy

Safety of withdrawal of pharmacological treatment after recovery from HER2 therapy-related cardiac dysfunction: the HER-SAFE trial

Clinical treatment strategies and perioperative management of restenosis or secondary deep venous thrombosis after iliac vein balloon angioplasty

Radiotherapy Modality and Primary Tumor Type as Determinants of Outcomes in Brain Metastases: A Retrospective Study of 734 Patients

Chronic Kidney Disease in Children Within Five Years After Ifosfamide Chemotherapy for Childhood Cancer: A Dutch Pediatric Oncology Cohort Study

The role of hSSB1 and hSSB2 in the DNA damage response: mechanisms and implications

What Explains the Survival Gap? Decomposing Cross-National Inequality in Breast Cancer Mortality-to-Incidence Ratios Using Open Global Data Repositories

Hyper‐Intense Tumor Peripheral Accumulation of Antibody‐Conjugated Iron Oxide Nanoparticles can Enable Breast Cancer Detection by Magnetic Particle Imaging

Basic Periodontal Treatment Improves Periodontal Inflamed Surface Area Without Adverse Events in Patients Receiving Direct Oral Anticoagulants: A Retrospective Clinical Study with an Animal Model

Development of a Web-Based Expert System for Cancer and GERD Diagnosis