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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
17.08.2026journal-article

Central European Journal of Communication

Detecting and Categorizing Islamophobic Hate Speech on Spanish Twitter/X

William González-Baquero, Carlos Arcila Calderón, Javier Amores, Rocio Zamora, Pilar Garrido Clemente, Maria del Mar Grandio, Pedro Rojo

Islamophobic hate speech on social media includes overt toxicity and contextual frames that associate Muslims with invasion, criminality, cultural threat, or racialized exclusion. This study examines 21,326 Spanish-language tweets about Islam and Muslims posted in Spain between 2010 and 2022. We combine human annotation, exploratory discursive coding, Perspective API scores, and a multilingual BERT classifier. Human coders classified 28.2% of tweets as Islamophobic hate speech. Explicit hostility was the most frequ …

17.08.2026journal-article

Journal of Pharmaceutical Research and Integrated Medical Sciences

ML in Rare Facial Disorders: Hemifacial Microsomia, Parry-Romberg Syndrome, Moebius Syndrome, Treacher Collins Syndrome, Apert Syndrome, and Crouzon Syndrome-From Etiological Mapping and Pathology to AI-Driven Bio-Computational Gene Therapy

Yash Srivastav, Stuti Verma, Kamini Prajapati, Sandeep Prakash, Rajeev Kumar, Anubha Dhuriya, Anup Kumar Sirbaiya, Shivani Singh

These rare facial diseases, which include hemifacial microsomia, Parry-Romberg syndrome, Moebius syndrome, Treacher Collins syndrome, Apert syndrome, and Crouzon syndrome, among others, pose considerable difficulties in diagnosis and treatment due to their clinical variability, rare occurrence, and complex genetic etiology. This review highlights the increasing potential of artificial intelligence (AI) and machine learning (ML) technologies in the better diagnosis, phenotyping, genotyping, and clinical management o …

17.08.2026journal-article

Life

Stellate Ganglion Block Combined with Hyperbaric Oxygen Therapy for Sudden Sensorineural Hearing Loss: A Retrospective Three-Arm Study

Geng-He Chang, Chung-Hang Wong, An-Ting Lee, Yu-Ching Cheng, Wen-Chun Liu

Sudden sensorineural hearing loss (SSNHL) carries unpredictable recovery, and adjunctive therapies beyond systemic corticosteroids are limited. Stellate ganglion block (SGB) and hyperbaric oxygen therapy (HBOT) have each been proposed as adjuncts, yet their combined effect remains poorly characterized. A retrospective three-arm cohort study (IRB No. 202401644B0) enrolled 75 SSNHL patients: Control (standard corticosteroid, n = 39), SGB (n = 21), and SGB+HBOT (n = 15). PTA4 improvement and Siegel recovery categories …

17.08.2026journal-article

Cancers

Functional Characterization of Myelodysplastic Syndrome by Multiparameter Flow Cytometry: The Clinical Synergy Between Ki-67 and Bcl-2 and Their Potential Role in Diagnostics and Personalized Therapy

Sixuan J. Wang, Rinaldo A. J. N. van Meel, Stefan G. C. Mestrum, Thomas H. P. M. Habets, Anton H. N. Hopman, Frans C. S. Ramaekers, Yvonne M. C. Henskens, Otto Bekers, Mathie P. G. Leers

The diagnosis and clinical management of myelodysplastic neoplasms are increasingly challenged by the disease’s inherent heterogeneity, particularly with respect to the diagnosis of low-grade variants. While standardized flow cytometric protocols traditionally rely on static biomarkers for lineage assignment, these often fail to capture the dynamic biological behavior of the malignant clone. This review synthesizes studies on the integration of functional biomarkers, specifically the nuclear proliferation marker Ki …

17.08.2026journal-article

Annals of the American Thoracic Society

Respiratory Effort–Driven Mandibular Opening as a Mechanism of Air Leak During CPAP Therapy

Jean-Benoît Martinot, Nhat-Nam Le-Dong, Didier Clause, Atul Malhotra, Jean-Louis Pépin

Abstract Rationale Unintentional air leaks are common during continuous positive airway pressure (CPAP) therapy and represent a leading cause of treatment failure. Objective To investigate the temporal association between respiratory effort (RE)-driven mouth opening and the occurrence of mouth leaks in patients with obstructive sleep apnea (OSA) during CPAP therapy. Methods Polysomnography with simultaneous mandibular jaw movements (MJM) and leak-flow monitoring was conducted in 200 OSA patients during CPAP therapy …

17.08.2026journal-article

Journal of Rehabilitation Medicine

Survey on stroke rehabilitation in Europe (SUSTAIN-EU) to evaluate European stroke rehabilitation services

Guna Bērziņa, Katharina S. Sunnerhagen, Ayse A. Küçükdeveci, Mauro Zampolini, Volodymyr Golyk, Yvona Angerova, Marco Franceschini, Daiana Popa, Catarina Aguiar Branco, Markos Sgantzos, Paolo Boldrini, Dominic Perennou, Thierry Lejeune, Xiaolei Hu

Objective: This study aimed to assess the organization and delivery of post-stroke rehabilitation services across Europe, focusing on the role of Physical and Rehabilitation Medicine physicians. Design and Methods: A cross-sectional online survey was conducted by the ESPRM Working Group of Stroke Rehabilitation from 30 European countries. The survey followed the International Classification of Service Organization in Rehabilitation framework and covered stroke care levels, rehabilitation services, registries, and q …

17.08.2026journal-article

Brazilian Journal of Music Therapy

O Timbre como Recurso Mediador na Musicoterapia com Pessoas Autistas:

Paula Ferreira Dantas

A musicoterapia, enquanto prática clínica fundamentada na experiência sonora, oferece recursos que ultrapassam os limites da linguagem verbal, favorecendo modos singulares de expressão e comunicação. Entre esses recursos, o timbre destaca-se por sua potência expressiva e por sua articulação com a constituição subjetiva do sujeito. Este artigo tem como objetivo refletir sobre o timbre como recurso mediador na musicoterapia com pessoas autistas, considerando sua influência na construção da musicalidade individual, na …

17.08.2026journal-article

Current Chemical Biology

Recent Advances in Cancer Therapy (2020–2025): Evolving Therapies, Biomarkers, and Diagnostic Technologies

Keshava Kyatanahalli Shekharappa, Mohammad Ali

Cancer is one of the major causes of morbidity and mortality globally, and treatment resistance and disease heterogeneity are ongoing problems. Over the past five years, cancer treatment has undergone a substantial transformation thanks to precision medicine, molecular profiling, and the application of artificial intelligence (AI) in diagnostics. Next-generation immune checkpoint inhibitors, CAR T-cell treatments targeting solid tumours, and bispecific antibodies are examples of advances in immunotherapy. RNA-based …

17.08.2026journal-article

Journal of Clinical Oncology

Laser Interstitial Thermal Therapy for Brain Tumors: A Prospective Multicenter Analysis of Patients From the LAANTERN Study

Eric C. Leuthardt, Veronica Chiang, Constantinos G. Hadjipanayis, Patrick Landazuri, Dimitris G. Placantonakis, Steven R. Abram, David A. Sun, Kris A. Smith, Alireza M. Mohammadi, Clark C. Chen, Brian J. Williams, David E. Piccioni, Tiffany R. Hodges, Andrew E. Sloan, Bradley Lega, Analiz Rodriguez, Michel Lacroix, Fedor Panov, Hamid Borghei Razavi, James Baumgartner, Taylor J. Abel, Kathleen Bandt, Matthew D. Smyth, Ganesh Rao, Peter E. Fecci, Adrian W. Laxton, Stephen B. Tatter, Albert H. Kim, Sujit S. Prabhu

PURPOSE Laser interstitial thermal therapy is a surgical tool used to ablate brain tumors, radiation necrosis, and epileptic foci. Data from the LAANTERN prospective multicenter registry (ClinicalTrials.gov identifier: NCT02392078 ), containing patients with tumor from 25 US centers between 2015 and 2023, were analyzed to determine clinical outcomes. METHODS All patients with primary or metastatic brain tumors treated with LITT using the Monteris NeuroBlate System were included in this analysis. Demographics, intra …

17.08.2026journal-article

Minerva

Refractory Multisystem Gorham-Stout Syndrome: Robotic Approach, Vascular Microsurgery, and Immunological Therapy

Kerly Lilibeth Cabezas Estrada, Paula Estefania Gaibor Ramos, Diego Freddy Garcia Rivera, Giovanna Estefania Ramos Onate

Gorham-Stout syndrome (GSS) is a rare lymphatic malformation with fewer than 400 documented cases, characterized by progressive osteolysis and multisystem involvement. Its refractory management to conventional therapies represents a significant clinical challenge. This systematic review, following PRISMA 2020, synthesizes current evidence on pathophysiological mechanisms, diagnosis, and emerging therapeutic strategies for refractory multisystem GSS, with emphasis on robotic surgery, vascular microsurgery, and immun …

17.08.2026journal-article

ACS Omega

Targeted Catalytic Anti-Inflammatory and Antioxidant Therapy for Aortic Dissection Using Biomimetic Nanomaterials

Hongwei Ge, Jun Wang, Ziyang Li, Dongmei Di, Weibin Huang, Xin Wang, Yiming Huang, Xiaoying Zhang

Abstract Aortic dissection (AD) is a life-threatening cardiovascular disease with an extremely high mortality rate. Excessive reactive oxygen species (ROS) production and inflammatory responses in diseased vascular regions are central drivers of AD pathogenesis, leading to destruction of the aortic wall structure and fatal hemorrhage. However, conventional clinical therapies for AD cannot effectively eliminate excessive ROS at lesion sites while simultaneously exerting anti-inflammatory effects. To address these li …

17.08.2026journal-article

Clinical Infectious Diseases

The Impact of Isoniazid Preventive Therapy on Tuberculosis Infection and Disease Progression

Oscar E Zazueta, Mercedes C Becerra, Jerome T Galea, Roger I Calderon, Carmen Contreras, Chuan-Chin Huang, Judith Jimenez, Leonid W Lecca, Rosa M Yataco, Zibiao Zhang, Megan B Murray

Abstract Background Tuberculosis (TB) causes major morbidity and mortality among children worldwide. Isoniazid preventive therapy (IPT) protects against progression to TB disease, but its effect on preventing new TB infection remains uncertain. Methods We conducted a longitudinal cohort study in Lima, Peru, enrolling adults with microbiologically confirmed pulmonary TB and their household contacts (HHCs). We assessed HHCs at baseline and 6 months for TB infection using tuberculin skin testing (TST) and for TB disea …

17.08.2026journal-article

ACS Applied Bio Materials

Amplifying Lipid Peroxidation via a Cascade Nanozyme with Lipid Metabolism Reprogramming for Enhanced Chemodynamic Therapy

Yuhang Wang, Hao Zhang, Jingyu Zhou, Zhengze Yu

Abstract The therapeutic efficacy of chemodynamic therapy (CDT) is severely constrained by insufficient endogenous hydrogen peroxide (H2O2), excessive glutathione (GSH)-mediated scavenging of hydroxyl radicals (·OH), and the limited abundance of lipid peroxidation (LPO) substrates due to low membrane unsaturation in tumor cells. To address these challenges, we herein develop a tumor microenvironment (TME)-responsive, multifunctional mesoporous multimetallic nanozyme (CuPtAu, CPA) loaded with the lipid metabolism mo …

17.08.2026journal-article

PLOS One

EMPATH protocol: Randomized, double-blind trial of an Engaging and Mobile Prism Adaptation Treatment for spatial neglect in Home and rehabilitation settings

Catrina MacPhee, Gail Eskes, Sean P. Mackinnon, Anne Sophie Champod

Background Spatial neglect is a common attentional condition post-stroke linked to poor rehabilitation outcomes. Prism adaptation, though a promising intervention, is not yet widely used clinically due to various barriers to its implementation, including limited accessibility, the repetitive nature of the therapy, and the need for specialized equipment. This protocol aims to examine the effectiveness, feasibility, and acceptability of an engaging, mobile, computerized prism adaptation procedure (Peg-the-Mole) for t …

17.08.2026journal-article

Catheterization and Cardiovascular Interventions

A Staged Revascularization Strategy for Chronic Limb‐Threatening Ischemia With GLASS Stage IMP2 Disease: Distal Bypass Following Infrapopliteal/Pedal Endovascular Therapy

Yoshihiko Tsuji, Taku Toyoshima, Osamu Iida, Ikuro Kitano

ABSTRACT Patients with chronic limb‐threatening ischemia (CLTI) and Global Limb Anatomic Staging System (GLASS) stage IMP2 disease often lack suitable inframalleolar target arteries for distal bypass on conventional imaging, rendering them technically ungraftable. We adopted a staged revascularization strategy consisting of initial infrapopliteal/pedal endovascular therapy (EVT) to establish graftable pedal arteries, followed by distal bypass using autologous saphenous vein grafts before restenosis or reocclusion o …

17.08.2026journal-article

Anaesthesiology Intensive Therapy

Comparison of kinemyography and electromyography during onset of and recovery from non-depolarising neuromuscular blockade: prospective observational study

Michal Kalina, Jan Beneš, Olha Litvina, Vladimír Černý

Background Quantitative neuromuscular monitoring is essential for the safe management of neuromuscular blockade. Although electromyography (EMG) is increasingly regarded as a reference technique, kinemyography (KMG) remains widely used in clinical practice; however, clinically relevant differences between these modalities during onset and recovery of neuromuscular blockade are not fully understood. Methods In this prospective observational study, adult patients undergoing general anaesthesia with non-depolarising n …

17.08.2026journal-article

Frontiers in Public Health

Patients’ perspectives on pulmonary rehabilitation for pulmonary hypertension in high-altitude areas: a mixed-methods study

Wenrui Li, Xiangqun Ke, Jinpeng Ma, Rui Jin, Haiyu Zhao, Yu Zheng, Xiaozhou Wang, Yaping Zeng, Mingwei Chen, Tinghua Hu

Background Chronic hypoxia at high altitudes worsens pulmonary hypertension (PH), leading to earlier symptom onset, more frequent exacerbations, and diminished quality of life. While pulmonary rehabilitation (PR) is known to enhance exercise capacity and ease breathlessness, implementing it in high-altitude settings presents a range of multifaceted challenges. Research capturing patients’ firsthand experiences with PR in these settings is largely absent. This study explored how PH patients in high-altitude areas cu …

17.08.2026journal-article

World Journal of Surgery

Effect of Prophylactic Incisional Negative Pressure Wound Therapy on Surgical Site Infection After Emergency Laparotomy: An Updated Meta‐Analysis With Trial Sequential Analysis

Ana Luíza Rocha Soares Menegat, Brenda Luana Rocha Soares Menegat, Sara Bravin, Jacopo Lin, Henrique Wiederkehr

ABSTRACT Introduction Patients undergoing emergency laparotomy are at high risk of surgical site infections (SSI), which contribute substantially to postoperative morbidity. Incisional negative pressure wound therapy (iNPWT) has been shown to reduce the incidence of SSI following elective surgery, however, its effectiveness in the emergency setting remains uncertain. Therefore, we conducted a systematic review and meta‐analysis to evaluate the effectiveness of iNPWT in reducing SSI after emergency laparotomy. Metho …

17.08.2026journal-article

British Journal of Occupational Therapy

Factors influencing the level of creative participation of nursing home residents: An observational cohort study

Nicola Ann Plastow, Elzaan Blaauw, Kayla Burger, Tyla van Schalkwyk, Fatima Moos, Shivani Naidoo, Fiona Smith, Monique de Wit

Introduction: The Vona du Toit Model of Creative Ability (VdT MOCA) is a widely used theoretical framework that has the potential to improve meaningful participation among nursing home residents. No published research evidence supports its use in occupational therapy with older people. Method: We used a quantitative cross-sectional observational cohort study design to identify factors influencing the level of creative participation of 30 nursing home residents ( M age = 87.2, SD = 8.42) in South Africa, using the C …

17.08.2026journal-article

Journal of Computational and Cognitive Engineering

IoT-Controlled EEG Monitoring and Decision Support System for Autism Therapy Using Signal Analysis and Embedded Processing

Melinda Melinda, Nizam Albar, Yuwaldi Away, Karlisa Priandana, Prima Dewi Purnamasari, Muhammad Saifullah Nur, Nurlida Basir, Syahrul Gazali

Autism spectrum disorder (ASD) is associated with irregular neural activity that complicates therapy planning when based solely on behavioral observation. This study introduces an Internet of Things (IoT)-based electroencephalography (EEG) analysis system designed to support real-time therapy recommendations for children with ASD. EEG signals were processed using the fast Fourier transform for noise reduction and evaluated through power spectrum density (PSD) using Welch's method to characterize spectral patterns. …

17.08.2026journal-article

Adolescência e Saúde

Predicting The Outcome Of Comprehensive Occlusal And Temporomandibular Rehabilitation In Adults With Class II Malocclusion: Development And Internal Validation Of A Weighted Four-Domain Compensatory-Reserve Index

Nasimov E. E., Rasulova Sh. R., Kodirova S. U., Sotivoldieva S. Z., Rakhmanova D. R., Sotivoldiev U. T., Khabibova N.N., Turayeva F., Po’latova Z. A.

Objective. Angle’s classification describes the occlusal contact but does not define how much dentoalveolar movement an adult can absorb, nor how the condylar position constrains the mechanics that may be used. The study aimed to identify pre-treatment determinants of a stable occlusal and temporomandibular result in adults with Class II malocclusion and to develop, weight and internally validate an interpretable prognostic index of dentoalveolar compensatory reserve. Materials and Methods. A single-centre observat …

17.08.2026journal-article

World Journal of Urology

Percussion, diuresis, and inversion therapy can facilitate lower renal pole stone passage after extracorporeal shock wave lithotripsy and retrograde intrarenal surgery? A systematic review and meta-analysis of randomized controlled trials

Luiz G. S. Gimenez, Giovanni S. Marchini, Fabio C. M. Torricelli, Alexandre Danilovic, Carlos A. Batagello, Fabio C. Vicentini, William C. Nahas, Eduardo Mazzucchi

Abstract Purpose Patients with lower pole stones (LPS) present a significant challenge for urologists because of the increased likelihood of residual fragments and recurrence following extracorporeal shockwave lithotripsy (ESWL) and retrograde intrarenal surgery (RIRS). Although percussion, diuresis, and inversion (PDI) therapy has demonstrated potential for enhancing the stone-free rate (SFR) in these patients, its application remains a topic of debate. Consequently, our objective was to conduct a systematic revie …

17.08.2026journal-article

Advanced Materials

Thermosensitive Liposome‐Loaded Hydrogels Enable Mechano‐Chemical Cascade Therapy for Promoting Angiogenesis

Meng Lei, Zhaoxinru Liu, Yizhou Xie, Xuewen Chen, Yaohui Wang, Jichang Wang, Feng Xu, Zhao Wei

ABSTRACT Pharmacological activation of selective biophysical or chemical signaling pathways is known to regulate angiogenesis; however, whether these cues can be modulated in a temporally coordinated, cascade‐like manner to generate stable and functional vascular networks remains unclear, particularly in the ischemic microenvironment. Here, we demonstrate a mechanochemical cascade in which TRPV4 (transient receptor potential vanilloid 4)‐mediated mechanosensing initiates endothelial activation, followed by platelet …