Onkologie: neue Gesundheitspublikationen – Seite 135

28.08.2026journal-article

SCRIPTA SCORE Scientific Medical Journal

Dynamic Digestive Health Surveillance System (DDHSS): A Conceptual Framework for Longitudinal Colorectal Cancer Surveillance

Aisyah Aulia Az-Zahra Ikhsan, Akmal Hisyam, Raihansyah Harris Nasution, Muhammad Zain Ardiansyah

Background: Colorectal cancer (CRC) remains a leading cause of cancer-related morbidity and mortality worldwide. Although fecal immunochemical tests (FIT) and colonoscopy effectively detect precancerous lesions and early-stage CRC, current screening strategies remain predominantly age-based and episodic. Such approaches inadequately capture longitudinal changes in individual risk profiles. Recent advances in electronic health records (EHRs), longitudinal healthcare databases, and artificial intelligence (AI) provid …

28.08.2026journal-article

Pharmacoepidemiology and Drug Safety

Dementias in Older Women With Early‐Stage HER2 ‐Negative Breast Cancer Treated With Anthracycline Plus Taxane Versus Taxane‐Based Chemotherapy Regimens

Nguyen Le, Nirupama Anne, Chan Shen, Ratnakishore Pallapothu, Yan Liu, Chanhyun Park

ABSTRACT Background Anthracycline plus taxane (ATAX) regimens are associated with improved survival in HER2‐negative breast cancer (HBC) compared to taxane‐based (TAX) regimens. However, anthracyclines are known for their cardiotoxicity, which could increase the risk of neurocognitive deficits, raising concerns about neurocognitive safety, particularly in older adults. Limited evidence exists comparing neurocognitive outcomes between these two regimens. Objective To compare the incidence of Alzheimer's disease and …

28.08.2026journal-article

Odovtos - International Journal of Dental Sciences

Artificial Intelligence in Endodontic Diagnosis and Treatment: A Bibliometric and Science-Mapping Analysis

María Mihaela Iuga, Tatiana Ramírez-Mora, Fernando Mauricio Espada Salgado

This study aimed to map global research trends, intellectual structure, and emerging themes in artificial intelligence (AI) applications for endodontic diagnosis and treatment using bibliometric and science-mapping approaches. A comprehensive search of the Web of Science Core Collection was performed on July 20, 2025, without time restrictions. Records were independently screened by two reviewers according to predefined inclusion and exclusion criteria. Bibliometric data were analyzed using Microsoft Excel, RStudio …

28.08.2026journal-article

Nutrients

Whole-Blood Fatty Acid Phenotypes and Subsequent Quality-of-Life Changes Among Cancer Survivors

Lin Lv, Juan Xia, Xinyu Zhu, Luxin Wang, Chen Lv, Yanyi Fu, Donghui Yu, Jinming Yu

Background/Objectives: Whole-blood fatty acid composition provides an objective biomarker of fatty acid status, but its relationships with nutritional characteristics and subsequent quality-of-life (QoL) changes among cancer survivors remain incompletely understood. We aimed to identify whole-blood fatty acid phenotypes and examine their associations with nutritional characteristics, cross-sectional QoL profiles, and subsequent QoL changes in an overlapping longitudinal subcohort. Methods: In this cohort study, the …

28.08.2026journal-article

Journal of Neuro-Oncology

CAR-T cell therapy: potential for paediatric brain tumours—an update

Alexandra Zehner, Benjamin Draper, Darren Hargrave, Laura K. Donovan, John Anderson

Abstract Central nervous system (CNS) tumours are the deadliest cancer for children and currently present limited treatment options. Chimeric antigen receptor (CAR)-T cell therapies have emerged as an innovative approach supported by encouraging clinical results. Current clinical trials using CAR-T cells in the treatment of paediatric CNS cancers differ in a number of variables, including the CAR-T cell route of delivery, presence of lymphodepletion, identified target antigen, and CAR engineering features. Consider …

28.08.2026journal-article

Nano

Microneedle-mediated delivery of DNA and mRNA therapeutics for cancer immunotherapy: advances, design strategies and translational challenges

Haowei Liu, Qiong Yi, Ling Mei, Yantao Wang

Nucleic acid therapeutics, particularly DNA and messenger RNA (mRNA), provide programmable platforms for cancer vaccination, local expression of immunomodulatory proteins, and gene regulation. Their therapeutic performance, however, is strongly constrained by extracellular degradation, route-dependent biodistribution, inefficient cellular uptake, and limited delivery to antigen-presenting cells. Microneedle (MN) systems offer a minimally invasive means of depositing nucleic acids in the epidermis and dermis, where …

28.08.2026journal-article

Koloproktologia

Colorectal cancer incidence in Siberia and the Far East

L. D. Zhuikova, O. A. Ananina, G. A. Kononova, L. V. Pikalova

OBJECTIVE: to analyze the incidence of colon cancer in the Siberian (SFD) and Far Eastern Federal Districts (FEFD) for 2019–2024. MATERIALS AND METHODS: a retrospective descriptive study of depersonalized data on the incidence of colorectal cancer (colon (C18), rectosigmoid junction (C19), rectum, anus and anal canal (C20-21) — ICD-10 codebook) was conducted for the period from January 2019 to December 2024 according to absolute data (the number of malignant neoplasms detected for the first time in life (table 2000 …

28.08.2026journal-article

Pakistan Journal of Pharmaceutical Sciences

Development of a biomarker-guided chemotherapy response model using combined CEA and CA19-9 profiles in esophageal cancer: A real-world pharmacotherapeutic study

Orcun Can

Abstract: Background: Esophageal adenocarcinoma is associated with poor survival despite advances in systemic therapy. Readily available serum biomarkers may improve risk stratification; however, their combined role in biomarker-guided treatment decisions remains insufficiently investigated. Objectives: To evaluate the prognostic significance of combined baseline carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) levels and explore their utility for biomarker-based risk stratification in patients …

28.08.2026journal-article

International Journal of Public Health and Medical Research

Research Advances and Future Directions of Biotechnology in the Treatment of Myasthenia Gravis

Jiaqi Lin

Myasthenia gravis (MG) is an autoimmune disease with a core pathological mechanism involving specific attacks by the immune system on proteins at the neuromuscular junction. This study reveals that our understanding of its pathogenesis has expanded beyond mere neuromuscular transmission dysfunction to encompass multiple aspects, including the dysregulation of immune regulatory networks, abnormal activation of the complement system, and damage mediated by specific autoantibodies. While conventional pharmacological t …

28.08.2026journal-article

Molecular Pharmaceutics

A Diazaborine-Based ROS Switch Enables Copper Transfer for Tumor-Specific Prodrug Activation and Therapy

Zeqian Huang, Yaqing Ding, Shengzhi Wang, Zijun Lin, Conghan Wang, Dong Zheng, Tao Zhang, Chunshun Zhao

Abstract Reactive oxygen species (ROS) are significantly elevated in tumor cells, providing an intrinsic trigger for selective drug activation and tumor-specific therapy. However, commonly used ROS-responsive linkers, such as thioketals and boronates, often suffer from limited sensitivity or poor physiological stability, and the development of new ROS-responsive motifs remains scarce. Herein, we develop a hydrazide-derived diazaborine (DAB) scaffold and establish it as a general ROS-responsive linker for small-mole …

28.08.2026journal-article

Belitung Nursing Journal

Corrigendum to “The experiences of Chinese colorectal cancer survivors in marital intimacy after ostomy creation: A qualitative study” [Belitung Nursing Journal, 2024; 10(2): 222-230]

Xixi Du, Suchira Chaiviboontham, Bualuang Sumdaengrit

This corrigendum corrects clerical errors regarding the data collection timeline and interview methodology in the original article (DOI: https://doi.org/10.33546/bnj.3212). The authors confirm that these administrative corrections do not affect the methodology, data analysis, results, or conclusions of the original study and sincerely apologize for any inconvenience caused.

28.08.2026journal-article

Pediatric Infectious Disease Journal

Effectiveness of Bedaquiline-, Delamanid- and Linezolid-Containing Regimens in Improving Treatment Outcomes Among Pediatric and Adolescents With Drug-Resistant Tuberculosis in the Country of Georgia

Tea Madzgharashvili, Nino Lomtadze, Mamuka Chincharauli, Maia Kipiani, Nestani Tukvadze, Zaza Avaliani, Henry M. Blumberg, Russell R. Kempker, Paata Imnadze, Argita D. Salindri, Marcos C. Schechter

Background: Formulating effective regimens to treat children with drug-resistant tuberculosis (TB) remains a great challenge. We aimed to compare treatment outcomes among children treated with regimens containing newer second-line anti-TB drugs to those treated with previously used regimens. Methods: We conducted a retrospective cohort study of individuals ≤18 years old treated for rifampicin-resistantTB in the country of Georgia from 2009 to 2023. We defined “new and repurposed second-line drugs (SLDs)” as regimen …

28.08.2026journal-article

Academia Molecular Biology and Genomics

A multi-layer framework for computational cancer epigenomics

Manyata Srivastava, Pratik Kumar, Ankita Chouhan, Komal Maan, Shishir Singh, Monisha Banerjee, Atar Singh Kushwah

Cancer epigenomics has become central to understanding tumor initiation, progression, heterogeneity, and therapeutic response. High-throughput profiling technologies including bisulfite sequencing, chromatin immunoprecipitation sequencing (ChIP-seq), assay for transposase-accessible chromatin using sequencing (ATAC-seq), and RNA sequencing (RNA-seq) generate complex, multi-dimensional datasets that require robust computational frameworks for meaningful interpretation. This review outlines key bioinformatics workflo …

28.08.2026journal-article

Japanese Journal of Clinical Oncology

Darolutamide-based triplet therapy versus androgen receptor pathway inhibitor-based doublet therapy for metastatic castration-sensitive prostate cancer: a real-world analysis using the TriNetX database

Yoichiro Tohi, Yuri Kitadani, Takuma Kato, Shunsuke Nakamura, Naoya Kani, Iori Matsuda, Kana Kohashiguchi, Yohei Abe, Hirohito Naito, Homare Okazoe, Rikiya Taoka, Fumiaki Mikami, Mikio Sugimoto

Abstract Background Currently, there are no large cohort studies comparing the clinical outcomes of triplet therapy with those of androgen receptor pathway inhibitor (ARPI)-based doublet therapy for patients with metastatic castration-sensitive prostate cancer (mCSPC) representing real-world practice. Therefore, the present study aimed to compare whether triplet or doublet therapy is more effective in patients with mCSPC. Methods This large-scale retrospective cohort study used TriNetX electronic medical record dat …

28.08.2026journal-article

European Thyroid Journal

Approaches to Thyroid Nodules in Paediatric Cancer Predisposition Syndromes

Michaela Kuhlen, Samuele Naviglio, Raphael Hirtz, Calogero Virgone, Ronald R. de Krijger, Sarah Theurer, Nicolas Waespe, Antje Redlich

Abstract Objective To summarise current evidence and practical management considerations for thyroid nodules in children and adolescents with cancer predisposition syndromes (CPS), focusing on follicular cell–derived nodules and non-medullary thyroid carcinoma (NMTC). Methods We synthesised current paediatric guideline recommendations and recent cohort, pathology, and molecular studies addressing CPS-associated nodular thyroid disease including PTEN hamartoma tumour syndrome, DICER1 syndrome, familial adenomatous p …

28.08.2026journal-article

Journal of Experimental & Clinical Cancer Research

Overcoming immune checkpoint inhibitor-mediated T-cell exhaustion with a TCR β chain-directed selective dual T-cell activator

Shantel Angstadt, Lucas A. Horn, Kristen Fousek, Nika Rajabian, Haiyan Qin, Miriam M. Medina-Enriquez, Marcus D. Kelly, Nicole Hsiao-Sanchez, Thomas J. Meyer, Jacques Moisan, Madan Katragadda, Andrew Bayliffe, Zhen Su, Jeffrey Schlom, Claudia Palena

Abstract Background Resistance to immune checkpoint inhibition (ICI) using antibodies against the PD-1/PD-L1 axis remains a significant clinical challenge. Here, we report that combination of anti-PD-1 with a bifunctional fusion molecule, anti-TCRβ-IL-2, comprised of a monovalent Fab that binds and activates the T-cell receptor (TCR) through distinct variable beta (Vβ) chain residues and an IL-2 molecule, mediates robust anti-tumor control in the context of ICI resistance. Methods Syngeneic murine models with varyi …

28.08.2026journal-article

Frontiers in Oncology

Cancer screening utilization among insured beneficiaries in Saudi Arabia, 2023–2024: a national analysis of trends, calendar variation, and distribution across breast, cervical, and colorectal screening programs

Abdurahman Alloghbi

Background Breast, cervical, and colorectal cancer (CRC) screening uptake in Saudi Arabia has been reported as consistently low, but no national longitudinal description of insurance-linked screening utilization has been published. This study examined temporal trends, calendar variation, and demographic distribution of cancer screening among privately insured beneficiaries in Saudi Arabia. Methods We analyzed six publicly available Council of Health Insurance datasets reporting monthly breast, cervical, and colorec …

28.08.2026journal-article

British Journal of Health Psychology

Acceptability, perceived outcomes and underlying mechanisms of a professionally led support group intervention for women with breast cancer using a qualitative method approach

Andreia Soares, Diogo Carreiras, Bruna Veloso, Ana Pereira, Priscyla Costa, Mind Project Team, Helena Moreira, Inês A. Trindade

Abstract Objectives Breast cancer (BC) remains the most diagnosed cancer among women worldwide and its growing survivorship population faces numerous long‐term physical and psychological challenges. Cancer support groups emerge as promising interventions to promote comprehensive management of the disease and survivorship needs, emotional well‐being and social connection. Accordingly, this study aimed to analyse the acceptability and perceived impact of the Mind Support Group (MSG), a professionally led support grou …

28.08.2026journal-article

Journal of the Endocrine Society

Colorectal neuroendocrine neoplasm organoids reveal the potential therapeutic value of targeting BRAF mutations

Yanan Chen, Biao Fan, Yue Zhang, Zhijie Wang

Abstract Background Colorectal neuroendocrine neoplasms (NEN) are a rare entity lacking effective pharmacologic therapies. We aimed to address the paucity of preclinical models for colorectal NEN that facilitate the exploration of novel therapeutic strategies. Methods We used 3-dimensional culture techniques to establish colorectal NEN organoids. These organoids were subjected to pathological examination and sequence analyses to verify their neuroendocrine nature. Subsequently, the organoids were subcutaneously imp …

28.08.2026journal-article

Pathogens

Diagnosis of Rare Cervical Tumors: IECC Classification, HPV Status, and Subtype-Directed Immunohistochemistry, with Treatment Outcomes from a Tertiary Center

Osman Doğan, Mürşide Çevikoğlu Kıllı, Mehmet Sait Bakır, Şahin Yüksek, Duygu Kolukısa, Numan Bilgiç, Hasan Turan

Background/Objectives: Rare histologic subtypes of cervical cancer are uncommon and may be misclassified during initial diagnosis. Their recognition depends on subtype-directed immunohistochemistry, which excludes metastatic mimics, and on high-risk HPV (hrHPV) testing, which establishes HPV status. Published series rarely report how the diagnosis was reached. We therefore documented the full diagnostic work-up, together with treatment and outcomes, in a consecutive single-center series. Methods: This was a retrosp …

28.08.2026journal-article

Wellcome Open Research

Development and External Validation of a Treatment-Adjusted Machine Learning Model to Support Risk-Informed Group-Based Depression Care for People Living with HIV in Uganda

Shakira Babirye, Rongjie Huang, Chengbo Zeng, Jeremiah Mutinye, Barbara Kemigisha, Kizito Wamala, Rosco Kasujja, Kenneth Kalani, Raquel Andres Martinez, Etheldreda Nakimuli-Mpungu

Background Group-based depression care is widely used in HIV services in Uganda, yet some patients remain symptomatic following treatment. We developed and externally validated a treatment-adjusted machine learning model to support risk-informed group-based depression care for people living with HIV (PLWH). Methods We analyzed data from 1,140 adults living with HIV and significant depression symptoms enrolled across 30 HIV clinics in the SEEK-GSP trial (PACTR201608001738234). Participants received either Group Supp …

28.08.2026journal-article

Frontiers in Medicine

Real-time vascular monitoring of PDLs and IPL for vascular treatment: effects of fluence and pulse duration on a rabbit ear model

Tun Tun Aung, Yusang Hu, Xiaohan Liu, Manmei Long, Wanyi Wang, Khin Maung Htwe, Soe Lei May, Yuhao Sun, Yixin Zhang, Zheng Zhang

Background Pulsed dye lasers (PDLs) and intense pulsed light (IPL) are commonly used for treating cutaneous vascular diseases but lack standardized and reproducible treatment protocols. Reliable vascular models are needed to visually assess posttreatment responses. Methods Sixteen male rabbits were divided into two groups, with each ear subdivided into three treatment regions. PDL treatment was applied with pulse durations of 0.45 ms (fluences: 4, 5.5, and 8 J/cm 2 ) and 1.5 ms (fluences: 5.5, 8, and 13 J/cm 2 ). I …

28.08.2026journal-article

Frontiers in Oncology

Advances in understanding the tumor microenvironment of neuroendocrine prostate cancer

Nan Yao, Qixing Yang, Pengkang Chang, Yangcai Wang, Hao Li, Ronghua Wu, Ji Zheng, Weihua Fu

Neuroendocrine prostate cancer (NEPC) is an aggressive, treatment-refractory phenotype of advanced prostate cancer. This narrative review was informed by targeted searches of PubMed, Web of Science through May 2026. We classify evidence as Level A (human NEPC samples or clinical cohorts), Level B (NEPC-specific models), Level C (prostate adenocarcinoma or CRPC without NEPC resolution), or Level D (pan-cancer or non-prostate extrapolation), and apply these levels to central claims and a study-level evidence table. D …

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Aktuelle Forschung nach Fachgebiet

Dynamic Digestive Health Surveillance System (DDHSS): A Conceptual Framework for Longitudinal Colorectal Cancer Surveillance

Dementias in Older Women With Early‐Stage HER2 ‐Negative Breast Cancer Treated With Anthracycline Plus Taxane Versus Taxane‐Based Chemotherapy Regimens

Artificial Intelligence in Endodontic Diagnosis and Treatment: A Bibliometric and Science-Mapping Analysis

Whole-Blood Fatty Acid Phenotypes and Subsequent Quality-of-Life Changes Among Cancer Survivors

CAR-T cell therapy: potential for paediatric brain tumours—an update

Microneedle-mediated delivery of DNA and mRNA therapeutics for cancer immunotherapy: advances, design strategies and translational challenges

Colorectal cancer incidence in Siberia and the Far East

Development of a biomarker-guided chemotherapy response model using combined CEA and CA19-9 profiles in esophageal cancer: A real-world pharmacotherapeutic study

Research Advances and Future Directions of Biotechnology in the Treatment of Myasthenia Gravis

A Diazaborine-Based ROS Switch Enables Copper Transfer for Tumor-Specific Prodrug Activation and Therapy

Corrigendum to “The experiences of Chinese colorectal cancer survivors in marital intimacy after ostomy creation: A qualitative study” [Belitung Nursing Journal, 2024; 10(2): 222-230]

Effectiveness of Bedaquiline-, Delamanid- and Linezolid-Containing Regimens in Improving Treatment Outcomes Among Pediatric and Adolescents With Drug-Resistant Tuberculosis in the Country of Georgia

A multi-layer framework for computational cancer epigenomics

Darolutamide-based triplet therapy versus androgen receptor pathway inhibitor-based doublet therapy for metastatic castration-sensitive prostate cancer: a real-world analysis using the TriNetX database

Approaches to Thyroid Nodules in Paediatric Cancer Predisposition Syndromes

Overcoming immune checkpoint inhibitor-mediated T-cell exhaustion with a TCR β chain-directed selective dual T-cell activator

Cancer screening utilization among insured beneficiaries in Saudi Arabia, 2023–2024: a national analysis of trends, calendar variation, and distribution across breast, cervical, and colorectal screening programs

Acceptability, perceived outcomes and underlying mechanisms of a professionally led support group intervention for women with breast cancer using a qualitative method approach

Colorectal neuroendocrine neoplasm organoids reveal the potential therapeutic value of targeting BRAF mutations

Diagnosis of Rare Cervical Tumors: IECC Classification, HPV Status, and Subtype-Directed Immunohistochemistry, with Treatment Outcomes from a Tertiary Center

Development and External Validation of a Treatment-Adjusted Machine Learning Model to Support Risk-Informed Group-Based Depression Care for People Living with HIV in Uganda

Real-time vascular monitoring of PDLs and IPL for vascular treatment: effects of fluence and pulse duration on a rabbit ear model

Advances in understanding the tumor microenvironment of neuroendocrine prostate cancer