EUVIMEDEuropean Health Evidence
Uhr 10/10Sources Journal Tree
Easy Demo

European Health Evidence

The European alternative to PubMed

EUVIMED is the European alternative to PubMed: a central, multilingual research platform for medicine, nursing, life sciences and healthcare. It brings together international and European literature sources, study registries, open-access full texts, citations and retraction notices in one search. Unlike pure bibliographic databases, EUVIMED supports the entire research process – from discovery and appraisal with LIVIA and CLARA to traceable evidence synthesis. European in focus, transparent, interoperable and designed for science and healthcare.

EuropeanMultilingualInteroperableTraceable

EUVIMED Themenbrowser · Onkologie · Seite 134

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

MicroRNA

In Silico Analysis of Potential miRNAs-EGFR Binding Complex for EGFR-TKI Resistance Lung Cancer Cells

Manisha Ray, Sheikh Naim, Pritinanda Mishra, Mukund Namdev Sable

Introduction: Overexpression of Epidermal Growth Factor Receptor (EGFR) plays a critical role in the progression and high mortality of Non-Small Cell Lung Cancer (NSCLC). Although EGFR tyrosine kinase inhibitors (EGFR-TKIs) demonstrate promising efficacy as first-line therapy, acquired resistance remains a major clinical challenge. Increasing evidence suggests that microRNAs (miRNAs) regulate EGFR signaling pathways and may influence therapeutic response and the development of resistance. Methods: This study aimed …

28.08.2026journal-article

Molecular Pharmaceutics

Novel Covalent FAP-Targeted Radiotherapy Drug Based on DOTA-FAP-2286 for Enhanced Tumor Uptake, Retention, and Therapeutic Efficacy

Shijie Tang, Zhongcai Jin, Tongtong Wu, Yanggang Liu, Yiheng Ai, Qiang Wan, Yang Liu, Shuang Yan, Yue Chen, Jingjing Zhang, Lin Qiu

Abstract Fibroblast activation protein (FAP)-targeted radioligand therapy is often limited by insufficient tumor uptake and retention. We designed and synthesized two novel aryl fluorosulfate-based covalent FAP-targeted radioligands, [177Lu]Lu-DOTA-mFS-FAP-2286 and [177Lu]Lu-DOTA-mFS-KERERG-FAP-2286, to enhance tumor retention and therapeutic efficacy. Two FAP-targeted radioligands were synthesized, radiolabeled with 177Lu, and evaluated for radiochemical stability. Cellular uptake and internalization were assessed …

28.08.2026journal-article

Medicine

Clinical risk factors associated with postoperative malnutrition in patients with laryngeal cancer

Cheng Jin, Yi Zhang

Postoperative malnutrition is a frequent yet variably defined complication after laryngeal cancer surgery and may compromise functional rehabilitation and subsequent oncologic management. This retrospective cohort study consecutively included adult patients (≥ 18 years) with histopathologically confirmed primary laryngeal cancer who underwent curative-intent surgery at our institution between July 1, 2021 and July 31, 2025. The primary endpoint was postoperative malnutrition within 3 months, diagnosed using the Glo …

28.08.2026journal-article

Journal of Biomedical Materials Research Part B: Applied Biomaterials

Metalorganic Titanium Treatment to Change Enamel Optical Properties

Yara Oweis, Amir Elhadad, Sophia Smith, Qiman Gao, Emily Buck, Mohamed‐Amine Mezour, Wenge Jiang, Javier Vargas Balbuena, Sailer S. Dos Santos, Marta Cerruti, Faleh Tamimi

ABSTRACT Observational studies have shown that human teeth with higher concentrations of titanium traces have better optical properties. The aim of this study was to investigate how titanium ion infiltration into tooth enamel affects its optical properties by studying the diffusion and reactivity of titanium compounds in tooth enamel and how this affected enamel optical properties. Tooth enamel specimens were incubated in hydrophobic solutions of titanium isopropoxide. The effect of the treatments on surface compos …

28.08.2026journal-article

European Geriatric Medicine

A survey among geriatricians on geriatric oncology and geriatric surgical oncology models in Europe

Paula Sobrini-Morillo, Isabelle Moens, Alfonso Cruz-Jentoft, Andrea Sebastiano Ciccone, Jugdeep K. Dhesi, Nicolas M. Gonzalez-Senac, Marije Hamaker, Cecilia Lund, Francesco Mattace-Raso, Nina Neuendorff, Siri Rostoft, David Shipway, Giuseppe Dario Testa, Anja Velghe, Harmke A. Polinder-Bos, on behalf of the SIG Perioperative Geriatric Medicine and the SIG Gero-Oncology of the European Geriatric Medicine Society

Abstract Purpose To provide an up-to-date overview of geriatricians’ involvement in oncological and onco-surgical care for older adults across Europe. Methods An anonymous 35-item online survey was distributed via (inter)national societies between 10 April and 23 May 2025. The responses were summarized, and associations between comprehensive geriatric assessment (CGA) outputs, participation in oncological multidisciplinary team (MDT) meetings, and involvement in treatment decision-making were explored. Results A to …

28.08.2026journal-article

Human Reproduction

Monitoring ovarian reserve dynamics via a high-sensitivity anti-Müllerian hormone assay in premenopausal breast cancer patients undergoing chemotherapy

Xiaojun Kuang, Min Ji, Yongzhe Tang, Qian Wang, Shun Pan, Jialiang He, Richard A Anderson, Bing-Shun Wang, Hong Xu, Dongmei Lai

Abstract STUDY QUESTION Does an ultra-sensitive anti-Müllerian hormone (UD-AMH) assay enhance the accuracy of ovarian dysfunction assessment in premenopausal women with breast cancer (PBC) during and after chemotherapy? SUMMARY ANSWER Low AMH levels at pre-treatment and end-of-chemotherapy, measured by the UD-AMH assay, are strong predictors for the development of premature ovarian insufficiency (POI) at 12 months post-chemotherapy. WHAT IS KNOWN ALREADY Anti-Müllerian hormone (AMH) is a recognized biomarker for as …

28.08.2026journal-article

International Journal of Cancer

High‐Risk Human Papillomavirus Prevalence and Detection of Anal Intraepithelial Neoplasia in Women Undergoing Screening Colonoscopy: A Prospective Study

Carlo Vivaldi, Hanna Schmitten, Matthias Schmid, Hartmut Schäfer

ABSTRACT The incidence of anal cancer in older women has risen significantly in recent decades, yet no standard screening strategy exists. Screening aims to detect potentially precancerous lesions, anal intraepithelial neoplasia (AIN), which can be treated to prevent cancer progression. In this prospective study, we assessed the prevalence of high‐risk human papillomavirus (hrHPV), abnormal anal cytology, and AIN confirmed by high‐resolution anoscopy (HRA)‐guided biopsy. Women aged ≥ 40 undergoing routine screening …

28.08.2026journal-article

Farabi Tıp Dergisi

Micronutrient and Lipid Profile in Gestational Diabetes: Zinc, Triglycerides, and Pharmacological Treatment Requirement

Meryem Kececi Oguzhanoglu, Kürşat Oğuzhanoğlu

Objective: To characterize serum zinc and a broader micronutrient panel in gestational diabetes mellitus (GDM) versus normoglycemic controls, and to evaluate associations between serum zinc, pharmacological treatment requirement and triglyceride concentration within GDM.Material and Methods: In this observational study with a one-week prospective follow-up component, 100 women with GDM and 100 frequency-matched controls were studied at a tertiary center. A nine-analyte micronutrient panel was compared with Benjamin …

28.08.2026journal-article

APS Open Science

Conjecture of classical e-h liquid for understanding the FLASH modality of radiation cancer treatment

Diana Shvydka, Victor Karpov, Nilendu Gupta

We consider physics behind the FLASH modality of cancer radiation treatment, where extremely short treatment times are achieved with ultrahigh dose rates maintaining the conventional antitumor effectiveness and yet substantially reducing damage to normal tissues (sparing effect). The difference in responses between normal and tumor tissues is attributed here to the structure transformation rates related to their morphologies: ordered in the normal tissues versus disordered in tumor tissues. Correspondingly differen …

28.08.2026journal-article

ARACÊ

EFEITOS DA MUSICOTERAPIA COMO INTERVENÇÃO COMPLEMENTAR NO TRATAMENTO DE PACIENTES COM DEPRESSÃO: UMA ABORDAGEM CLÍNICA

Janete Maria de Oliveira Praxedes Lira Costa

Contexto: A depressão é um transtorno mental de alta prevalência associado a comprometimentos significativos na qualidade de vida. Perante as limitações dos tratamentos convencionais, a busca por abordagens complementares e não farmacológicas vem se tornado essencial. Objetivo: Analisar os efeitos da musicoterapia como intervenção complementar no tratamento de pacientes com depressão, a partir de uma perspectiva clínica. Metodologia: Trata-se de uma revisão de escopo (scoping review), de abordagem qualitativa e car …

28.08.2026journal-article

Oncologie

Gut microbiota-mediated programmed cell death in colorectal cancer: implications for precision medicine

Wei Liu, Wei Zhang

Abstract Colorectal cancer (CRC) remains a major global health burden, with marked interindividual variability in disease progression and therapeutic response. Emerging evidence suggests that the gut microbiota shapes CRC biology not only through inflammation and metabolism, but also by regulating programmed cell death (PCD) pathways that may influence tumor cell fate and treatment sensitivity. This review summarizes recent advances in microbiota-mediated regulation of major PCD modalities relevant to CRC, includin …

28.08.2026journal-article

Frontiers in Oncology

Combination therapy with Nifuroxazide and Lenvatinib exerts superior anti-hepatocellular carcinoma effect by enhancing the anti-tumor immune response

Jing Yang, Jiaxin Geng, Yue Yin, Kangle Wang, Leyao Tian, Jingyi Wang, Huijie Jia, Lei Wang, Yongxi Zhang, Tiesuo Zhao

Background Lenvatinib is a first-line multi-target tyrosine kinase inhibitor for hepatocellular carcinoma (HCC) that exerts anti-angiogenic effects by blocking VEGF signaling. However, its clinical efficacy is often compromised by adaptive resistance. Nifuroxazide, an anti-diarrheal agent, has been identified by our group as a potent inhibitor of PD-L1 expression in HCC. Objective This study aimed to evaluate the therapeutic potential and underlying molecular mechanisms of nifuroxazide combined with lenvatinib agai …

28.08.2026journal-article

Sustainability

Spent Coffee Grounds and Their Derivatives as Biosorbents in Wastewater Treatment and Gas Purification

Yi Hu, Juan Li, Zhiyong Qi, Yiping Wu, Rui Yang

Spent coffee grounds (SCGs), a ubiquitous and renewable agricultural waste, have emerged as a promising biosorbent for environmental remediation. This review provides a comprehensive overview of the application of SCG-derived materials in wastewater treatment and gas purification. We systematically summarize their physicochemical characteristics, adsorption performance towards diverse contaminants, and underlying mechanisms. Specifically, modification strategies of raw SCGs are discussed in detail, including chemic …

28.08.2026journal-article

Frontiers in Molecular Biosciences

Crucial role of telomere maintenance-related genes in survival prediction and subtype identification in colorectal cancer

Feng Huang, Jung-Yin Fong, Chin Tat Ng, Karthikkumar Venkatachalam, Mohammed Abdullah Alshawsh, Chun-Wai Mai, Yik-Ling Chew, Muralidharan Anbalagan, Ravishankar Ram Mani, Malarvili Selvaraja

Background Telomere maintenance-related genes (TMRGs) are implicated in Colorectal cancer (CRC) development, but their prognostic value and clinical relevance remain insufficiently explored. This study aims to develop a TMRG-based prognostic model and elucidate its clinical utility in CRC management. Methods The Cancer Genome Atlas database was utilized to download RNA-seq data from 638 CRC and 51 control samples. Differential expressed genes were screened and intersected with 2086 TMRGs, resulting in the identific …

28.08.2026journal-article

International Journal of Molecular Sciences

Circulating Tumor DNA and Circulating Tumor Cells in Liquid Biopsy as Post-Treatment Prognostic Biomarkers in Early Breast Cancer: A Systematic Review and Meta-Analysis

Einas M. Yousef, Motaz Talaat Elghnam, Hiba Elhassan, Malak Hassan, Saifeldin Yousef, Hend Aabed, Noha Mitwally

Despite advances in systemic therapy, many early breast cancer patients experience recurrence due to subclinical minimal residual disease (MRD). Circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) have emerged as promising liquid biopsy markers for post-treatment MRD detection. This pre-registered systematic review and meta-analysis (PROSPERO/PRISMA 2020) evaluated their comparative prognostic significance. Seven databases were searched from inception to March 2026. Eligible studies included early brea …

28.08.2026journal-article

Cancer

The burden of male breast cancer (MBC) in the GBD Central, Eastern, and Western Europe Regions from 1990 to 2023: Results from the Global Burden of Disease Study 2023

Roberto Passera, Elisa Fabbro, Giulia Zamagni

ABSTRACT Purpose Male breast cancer (MBC) is underrepresented in cancer statistics: this study aimed to assess the burden of MBC in Central, Eastern, and Western Europe from 1990 to 2023, using data from the Global Burden of Disease (GBD) Study 2023. Methods Estimates from GBD 2023 were analyzed to determine the MBC incidence, mortality, and disability‐adjusted life years, their all‐ages and age‐standardized rates, and the 1990 through 2023 annual percent change. These estimates were compared to those for the GBD S …

28.08.2026journal-article

SCRIPTA SCORE Scientific Medical Journal

Dynamic Digestive Health Surveillance System (DDHSS): A Conceptual Framework for Longitudinal Colorectal Cancer Surveillance

Aisyah Aulia Az-Zahra Ikhsan, Akmal Hisyam, Raihansyah Harris Nasution, Muhammad Zain Ardiansyah

Background: Colorectal cancer (CRC) remains a leading cause of cancer-related morbidity and mortality worldwide. Although fecal immunochemical tests (FIT) and colonoscopy effectively detect precancerous lesions and early-stage CRC, current screening strategies remain predominantly age-based and episodic. Such approaches inadequately capture longitudinal changes in individual risk profiles. Recent advances in electronic health records (EHRs), longitudinal healthcare databases, and artificial intelligence (AI) provid …

28.08.2026journal-article

Pharmacoepidemiology and Drug Safety

Dementias in Older Women With Early‐Stage HER2 ‐Negative Breast Cancer Treated With Anthracycline Plus Taxane Versus Taxane‐Based Chemotherapy Regimens

Nguyen Le, Nirupama Anne, Chan Shen, Ratnakishore Pallapothu, Yan Liu, Chanhyun Park

ABSTRACT Background Anthracycline plus taxane (ATAX) regimens are associated with improved survival in HER2‐negative breast cancer (HBC) compared to taxane‐based (TAX) regimens. However, anthracyclines are known for their cardiotoxicity, which could increase the risk of neurocognitive deficits, raising concerns about neurocognitive safety, particularly in older adults. Limited evidence exists comparing neurocognitive outcomes between these two regimens. Objective To compare the incidence of Alzheimer's disease and …

28.08.2026journal-article

Nano

Microneedle-mediated delivery of DNA and mRNA therapeutics for cancer immunotherapy: advances, design strategies and translational challenges

Haowei Liu, Qiong Yi, Ling Mei, Yantao Wang

Nucleic acid therapeutics, particularly DNA and messenger RNA (mRNA), provide programmable platforms for cancer vaccination, local expression of immunomodulatory proteins, and gene regulation. Their therapeutic performance, however, is strongly constrained by extracellular degradation, route-dependent biodistribution, inefficient cellular uptake, and limited delivery to antigen-presenting cells. Microneedle (MN) systems offer a minimally invasive means of depositing nucleic acids in the epidermis and dermis, where …

28.08.2026journal-article

Pakistan Journal of Pharmaceutical Sciences

Development of a biomarker-guided chemotherapy response model using combined CEA and CA19-9 profiles in esophageal cancer: A real-world pharmacotherapeutic study

Orcun Can

Abstract: Background: Esophageal adenocarcinoma is associated with poor survival despite advances in systemic therapy. Readily available serum biomarkers may improve risk stratification; however, their combined role in biomarker-guided treatment decisions remains insufficiently investigated. Objectives: To evaluate the prognostic significance of combined baseline carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) levels and explore their utility for biomarker-based risk stratification in patients …

28.08.2026journal-article

Koloproktologia

Colorectal cancer incidence in Siberia and the Far East

L. D. Zhuikova, O. A. Ananina, G. A. Kononova, L. V. Pikalova

OBJECTIVE: to analyze the incidence of colon cancer in the Siberian (SFD) and Far Eastern Federal Districts (FEFD) for 2019–2024. MATERIALS AND METHODS: a retrospective descriptive study of depersonalized data on the incidence of colorectal cancer (colon (C18), rectosigmoid junction (C19), rectum, anus and anal canal (C20-21) — ICD-10 codebook) was conducted for the period from January 2019 to December 2024 according to absolute data (the number of malignant neoplasms detected for the first time in life (table 2000 …

28.08.2026journal-article

Journal of Neuro-Oncology

CAR-T cell therapy: potential for paediatric brain tumours—an update

Alexandra Zehner, Benjamin Draper, Darren Hargrave, Laura K. Donovan, John Anderson

Abstract Central nervous system (CNS) tumours are the deadliest cancer for children and currently present limited treatment options. Chimeric antigen receptor (CAR)-T cell therapies have emerged as an innovative approach supported by encouraging clinical results. Current clinical trials using CAR-T cells in the treatment of paediatric CNS cancers differ in a number of variables, including the CAR-T cell route of delivery, presence of lymphodepletion, identified target antigen, and CAR engineering features. Consider …

28.08.2026journal-article

Odovtos - International Journal of Dental Sciences

Artificial Intelligence in Endodontic Diagnosis and Treatment: A Bibliometric and Science-Mapping Analysis

María Mihaela Iuga, Tatiana Ramírez-Mora, Fernando Mauricio Espada Salgado

This study aimed to map global research trends, intellectual structure, and emerging themes in artificial intelligence (AI) applications for endodontic diagnosis and treatment using bibliometric and science-mapping approaches. A comprehensive search of the Web of Science Core Collection was performed on July 20, 2025, without time restrictions. Records were independently screened by two reviewers according to predefined inclusion and exclusion criteria. Bibliometric data were analyzed using Microsoft Excel, RStudio …