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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
17.08.2026journal-article

The Journal of ECT

Living With Electroconvulsive Therapy—A Qualitative Study of the Subjective Experiences of Patients Having Continuation or Maintenance Electroconvulsive Therapy

Prashanth Mayur, Nyan Du, Anthony Harris, Venkat Ramakrishnan, Jagadeesh Andepalli, Beatriz López-Portillo

Objective: To explore the subjective experience of patients receiving continuation/maintenance electroconvulsive therapy (C/M-ECT) for severe, recurrent mental illnesses, addressing a literature gap in this unique cohort whose perspective remains unexplored. Methods: An exploratory qualitative study was conducted on 10 voluntary adult patients (aged 32 to 66 y) from outpatient C/M-ECT services in Western Sydney Local Health District and St John of God Richmond Hospital, Sydney, Australia. Participants, primarily wi …

17.08.2026journal-article

Adolescência e Saúde

Effect Of Intranasal Therapy On Serum Periostin Levels In Allergic Rhinitis: A Comparative Study

Dr. Dhanya Boopathe, Dr Jitesh Kumar Baskaran

Background: Allergic rhinitis (AR) is a chronic inflammatory disease driven by Type 2 immune responses. Periostin, an IL-4/IL-13–induced matricellular protein, has emerged as a biomarker of allergic inflammation. This study evaluated the effect of intranasal therapy on serum periostin levels and correlated these changes with clinical outcomes, comparing TriVital Mix with standard therapy. Methods: Thirty patients with AR were randomized into two groups: standard therapy and TriVital Mix. Clinical scores (SNOT-22, N …

17.08.2026journal-article

Modern Rheumatology Journal

Resolution of the Expert Council “Reproductive health of patients with rheumatic diseases during targeted therapy: from preconception preparation to postpartum follow-up”

E. L. Nasonov, A. M. Lila, T. V. Dubinina, P. A. Shesternya, E. A. Trofimov, G. V. Lukina, A. I. Zagrebneva, N. M. Kosheleva, N. I. Klimenchenko, Yu. A. Koloda, I. P. Nikishina, P. I. Novikov, S. P. Yakupova, L. P. Evstigneeva, I. M. Patrikeeva, L. V. Ivanova, O. N. Anoshenkova, I. A. Cherentsova, A. Yu. Skripkin

On June 19, 2026, a meeting of the Expert Council was held to discuss reproductive health issues in patients with immune-mediated inflammatory rheumatic diseases and the safety of antirheumatic therapy. Rheumatologists, obstetrician-gynecologists, reproductive medicine specialists, and other experts participated in the discussion.

17.08.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

POLÍTICAS PÚBLICAS PARA ENFRENTAMENTO AO DISCURSO DE ÓDIO E PREVENÇÃO DE LITÍGIOS

Camilo Onoda Luiz Caldas

No presente artigo desenvolvemos uma análise do discurso de ódio como fenômeno jurídico e social, examinando os fundamentos normativos — nacionais e internacionais — que o repudiam, bem como as políticas públicas disponíveis para seu enfrentamento e para a consequente prevenção de litígios. A pesquisa parte da premissa de que a resposta estatal ao discurso de ódio não pode ser reduzida à via punitiva, demandando uma arquitetura intersetorial de políticas preventivas, educativas e reparatórias. Do ponto de vista met …

17.08.2026journal-article

Europace

Management of recurrent atrial fibrillation after catheter ablation: 5-year outcomes of repeat catheter ablation vs. antiarrhythmic therapy

Yong Hao Yeo, Hermon Kha Kin Wong, Aravinthan Vignarajah, Min Choon Tan, Nishanthi Vigneswaramoorthy, Justin Lee, Luis Scott, Kamala P Tamirisa, Dan Sorajja, Christopher DeSimone

Abstract Aims Recurrence of symptomatic atrial fibrillation (AF) after catheter ablation (CA) is not uncommon. However, real-world long-term data on clinical outcomes of rhythm control strategies in patients with recurrent AF after CA remain limited. Methods and results Using the TriNetX database, we identified adult patients (≥18 years) with recurrent AF after index CA. A 3-month blanking period was applied, during which no rhythm-control therapy was received. Patients were classified into two groups: repeat CA or …

17.08.2026journal-article

Journal of Medicine and Health Research

Artificial Intelligence in the Optimisation of Glucagon-Like Peptide-1 Receptor agonist Therapy for Obesity and Type 2 Diabetes: A Critical Narrative Review of Treatment Monitoring and Clinical Decision Support

Mirembe Katabaazi Lillian, Anyebe Daniel Ameh, Jacob Miracle Godswill, Nana Ama Aduma Amankwah

Glucagon-like peptide-1 receptor agonists have changed what can be achieved pharmacologically in obesity and type 2 diabetes, yet the average effects reported in registration trials conceal wide interindividual variation in weight and glycaemic response, high rates of early discontinuation, incomplete dose escalation in routine care, and pronounced inequity in who receives treatment. These features have prompted the claim that artificial intelligence, and machine learning in particular, can improve candidate select …

17.08.2026journal-article

Clinical and Experimental Dermatology

Localized bullous pemphigoid arising within sites of radiation in the context of immune checkpoint inhibitor therapy

W Austin Wyant, Lara Drake, Antonio Ji-Xu, Dhruv Singhal, Anupam M Desai, Christopher Iriarte

There is minimal literature on the development of localized bullous pemphigoid exclusively in previously irradiated skin. We report two patients with bullous pemphigoid strikingly localized to areas of previous radiation therapy that occurred in the setting of concomitant immune checkpoint inhibitor therapy.

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17.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Driven or drained? How addiction to work shapes the effects of need satisfaction on well-being at community-based work

Marta P Alves, Vítor Costa, Ana I Cunha, Ludovina Ramos

Background The theoretical framework of the study draws on Self-Determination Theory (SDT), Job Demands–Resources (JD-R) theory, and Conservation of Resources (COR) theory. Objective The study explores the association between the satisfaction of basic psychological needs at work and psychological well-being, and the role of work addiction as a moderator of that relationship, distinguishing between the effects of excessive and compulsive work. Methods Participants were 204 employees involved in community-based work …

17.08.2026journal-article

Child Language Teaching and Therapy

What is a good outcome in speech and language therapy and how can this be achieved? Exploring the views of school-aged children and parents

Caroline Tiong, Jane McCormack, Anna Cronin

Speech and language therapists are guided by standards and frameworks that emphasise client contributions to decision-making and holistic outcomes. Currently, there is little known about the preferences of school-aged children with speech, language and communication needs (SLCN) for speech and language therapy services. This study explored the perspectives of five primary school-aged children with SLCN and their parents about their preferred experiences of speech and language therapy and what they identified as suc …

17.08.2026journal-article

Frontiers in Oncology

Associations between pretreatment composite inflammatory indices and pathological response to neoadjuvant therapy in breast cancer: a retrospective cohort study

Yuhong Zhang, Cailing Tong

Background Pretreatment inflammatory indices may reflect the host immune-inflammatory status in breast cancer. Evidence comparing multiple composite indices across pathological response endpoints after neoadjuvant therapy remains limited. This study evaluated the associations between pretreatment composite inflammatory indices and pathological response in breast cancer. Methods This retrospective study included 280 patients with breast cancer who underwent neoadjuvant therapy followed by surgery. Baseline neutrophi …

17.08.2026journal-article

Journal of Clinical Medicine

Biologic Therapy Is Associated with Reduced Pleural-Line Thickness in Severe Asthma: A Prospective Transthoracic Ultrasound Study

Müge Erbay, Selçuk Akkaya, Funda Öztuna, Hatice Tayar

Background/Objectives: Tissue-level markers of treatment response are lacking in severe asthma. Transthoracic ultrasound (TUS) non-invasively detects pleural-line and subpleural abnormalities that have been linked to small-airway disease, but it has not been evaluated as a marker of response to biologic therapy. The primary objective was to determine whether mean pleural-line thickness in the right and left hemithoraces changed between baseline and week 16 of biologic therapy. The secondary objectives were to descr …

17.08.2026journal-article

Wiener Medizinische Wochenschrift

Extracorporeal shockwave therapy as a key component of interdisciplinary wound management in diabetic foot syndrome

Richard Crevenna, Zoltan Vass, Michael Mickel, Michael Leutner, Shuren Li, Mohammad Keilani

Summary Background A 57-year-old male patient presented with the first manifestation of severe type 2 diabetes mellitus in the setting of diabetic foot syndrome complicated by osteomyelitis. Methods The patient was treated conservatively within a multimodal interdisciplinary approach. In addition, focused extracorporeal shockwave therapy (fESWT) was performed according to International Society for Medical Shockwave Treatment (ISMST)-oriented principles. Results After five sessions of fESWT, local wound management r …

17.08.2026journal-article

Archivos en Medicina Familiar

Calidad de vida en pacientes con nefropatía diabética y terapia sustitutiva renal

Yanet Flores Morales, Itzia I. Corona Candelas, Citlalli Orizaga de la Cruz, Anel Gómez García, María P. Rodríguez Correa

Objetivo: Comparar la calidad de vida en pacientes con nefropatía diabética sometidos a diálisis continúa ambulatoria y hemodiálisis. Métodos: Estudio observacional, transversal y prospectivo realizado en la Unidad Médica de Atención Ambulatoria 254 de Morelia Michoacán, México del Instituto Mexicano del Seguro Social. Se efectuó de diciembre 2023 a abril 2024, fueron incluidos 136 pacientes con nefropatía diabética en diálisis peritoneal continua ambulatoria y hemodiálisis. Para evaluar la calidad de vida se aplic …

17.08.2026journal-article

Biomolecules

Two Faces of the Right Ventricle in Fabry Cardiomyopathy: Septal-Coupled and Atrial-Coupled Strain Patterns and Their Differential Associations with Enzyme Replacement Therapy

Kuo-Tzu Sung, Dau-Ming Niu, Shu-Fen Hsu, Ming-En Liu, Po-Lin Lin, Yau-Huei Lai, Hsiang-Wei Yang, Yung-Hsiu Lu, Cheng-Ting Tsai, Ta-Chuan Hung, Po-Sheng Chen, Chung-Lieh Hung

Right ventricular global longitudinal strain (RVGLS) and right ventricular free-wall longitudinal strain (RVFWLS) are both used to assess right ventricular involvement, but they include different myocardial components. We examined their cross-sectional correlates and longitudinal changes associated with enzyme replacement therapy (ERT) in 100 patients with genetically confirmed Fabry disease, including 69 with serial echocardiography. RVGLS was independently associated with left ventricular global longitudinal stra …

17.08.2026journal-article

International Journal of Molecular Sciences

Recent Advances in Therapy for the Neurodegenerative Disorder Ataxia-Telangiectasia

Sam Nayler, Simon Foster, Martin Lavin, David Coman

At present, there is no cure for the human genetic disorder ataxia-telangiectasia (A-T), which is managed by supportive care. This disorder arises due to mutations in the ATM (ataxia-telangiectasia mutated) gene and is characterised by a defect in the response to DNA damage, oxidative stress, mitochondrial dysfunction and immune deficiency. The ATM protein is activated by DNA damage, reactive oxygen species (ROS), and a variety of other stimuli, which leads to the phosphorylation or altered cellular localisation of …

17.08.2026journal-article

Journal of Clinical Medicine

Occupational Contact Dermatitis in the Post-COVID Era: From Barrier Dysfunction and Microbiome Dysbiosis to Prevention and Precision Management

Laura Maghiar, Andrada Iftode, Teodor-Andrei Maghiar, Raul Chioibas, Titus Grecu, Carmen Neamțu, Sandor Mircea Ioan, Cristina-Adriana Dehelean, Cristina Dumitrescu, Andreea-Adriana Neamțu

Background/Objectives: Occupational contact dermatitis (OCD) is the most common work-related skin disease, accounting for roughly 90–95% of occupational dermatoses and falling predominantly on the hands. It is rarely dangerous yet imposes a substantial burden through impaired quality of life, lost productivity, and premature exit from affected trades. The COVID-19 pandemic intensified this burden among healthcare workers, in whom the pooled one-year prevalence of self-reported hand eczema reaches around 27%; meta-a …

17.08.2026journal-article

Frontiers in Oncology

High dose IFN-α2b as post operative adjuvant therapy for acral melanoma: a multi-center real-world cohort study of 171 Chinese patients

Kaidi Yang, Shiji Lan, Yan Wang, Jin Wu, Xin Cai, Kui Jiang, Zhen Guo, Mei Xiang, Hongfeng Zhou, Jiwei Li, Fang Liu, Jianping Gui, Yuhuan Mao, Hongxue Meng, Xiang Ji, Janan Pang, Xinxin Yang, Lu Feng, Weizhen Zhang, Di Wu

Background This study aimed to investigate recurrence patterns and survival outcomes in Chinese patients with AM who received postoperative adjuvant High-dose interferon (HD-IFN), and to assess how treatment duration and the interval between surgery and therapy initiation relate to recurrence and survival. Methods A multi-center, retrospective cohort study involving 171 patients with AM who received postoperative adjuvant HD-IFN therapy between January 2012 and March 2025 was conducted at five melanoma diagnostic a …

17.08.2026journal-article

Frontiers in Neurology

Dose–response and recovery trajectories of fall prevention rehabilitation in older patients with vertigo: a retrospective cohort study based on vestibular and gait impairment phenotypes

Xiao-Qing Zhang, Jing Qin, Hong-Min Wang, Li Liu, Jie Zhang, Ya-Hui Wang, Wen-Ting Wang, Rui-Ting Zhu, Hong-Lei Guo

Background Vertigo and dizziness are common in older adults and are associated with a significantly increased risk of falls. Fall prevention rehabilitation therapy (FPRT) is recommended, but current prescriptions remain largely empirical and do not account for heterogeneity in baseline vestibular and gait impairments. The dose–response relationship between rehabilitation hours and functional improvement, and how baseline phenotypes are associated with recovery trajectories, are poorly understood. Methods This retro …

17.08.2026journal-article

Journal of Neurosurgery: Case Lessons

Primary denosumab therapy for a three-column pediatric cervical aneurysmal bone cyst: illustrative case

Mohammed Amin, Odette El Ghawi, Aya Mosleh, Louna Ftouni, Mohamad El Houshiemy, Marwan Najjar

BACKGROUND Pediatric spinal aneurysmal bone cysts (ABCs) involving all three columns present significant surgical challenges due to high procedural morbidity and vertebral artery risks. While denosumab is utilized off-label for these aggressive lesions, its efficacy and safety in pediatric spinal cases remain insufficiently characterized. OBSERVATIONS A 12-year-old girl with a C6 ABC and progressive myelopathy (modified Japanese Orthopaedic Association [mJOA] score 14) underwent 12 months of primary denosumab thera …

17.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Psychosocial safety climate and emotional exhaustion among police officers in guangxi, China: The mediating role of surface acting

Mao Xueying, Fonny Dameaty Hutagalung, Rosila Bee Mohd Hussain

Background Emotional exhaustion is a central component of burnout and is highly prevalent among police officers due to the emotionally demanding nature of policing work. Psychosocial safety climate (PSC), as an organizational resource, may influence emotional exhaustion directly and through emotional regulation strategies such as surface acting. Objective This study aimed to examine the relationship between psychosocial safety climate, surface acting, and emotional exhaustion among police officers, and to investiga …

17.08.2026journal-article

Adolescência e Saúde

Efficacy Of High Tone Power Therapy Combined With A Targeted Physical Therapy Program For Overactive Bladder In People With Multiple Sclerosis: A Randomized Controlled Trial

Mohamed H. Hussien, Eman S. Fayez, Salma H. Khalil, Amr M. Sayed, Jasmine M. Mahmoud, Mohamed H. Marzouk

Objective: Overactive bladder (OAB) is a predominant urinary tract disorder in people with multiple sclerosis (PwMS). We sought to assess the therapeutic effects for high tone therapy (HTT) in treatment of OAB symptoms and quality of life (QOL) in PwMS. Methods: A prospective, randomized controlled study included forty remitting relapsing MS patients of both sexes (RRMS) with moderate OAB symptoms were randomly allocated into 2 equal groups: The treatment group (GA) received HTT + targeted physical therapy program. …

17.08.2026journal-article

Contemporary Education and Community Engagement (CECE)

Influence of Rational Emotive Behavior Therapy on Sexual Abuse Education among Sampled Adolescents in Imo State, Nigeria

Mohamed Alusine Mansaray, Gilbert Madubuike

Adolescent sexual abuse remains a pervasive and deeply damaging issue globally, with significant psychological ramifications for its victims. In Nigeria, particularly within states like Imo, the prevalence of such abuse necessitates effective therapeutic interventions. This article explores the potential influence of Rational Emotive Behavior Therapy (REBT) as a therapeutic approach in addressing the psychological trauma experienced by adolescents who have endured sexual abuse in Imo State, Nigeria. Drawing upon ex …

17.08.2026journal-article

Scientific Reports

Immune responses elicited by rMV-SLAMblind oncolytic therapy exert a synergistic effect on cancer therapy

Kanako Moritoh, Tomoko Fujiyuki, Yosuke Amagai, Hiroki Sato, Misako Yoneda, Chieko Kai

Abstract Oncolytic virotherapy has emerged as a promising strategy for cancer therapy. rMV-SLAMblind is a recombinant measles virus that lacks the ability to interact with SLAM and specifically infects and lyses NECTIN4 + cancer cells. We previously reported that rMV-SLAMblind oncolytic virotherapy (rMV-OVT) exerts anti-tumor immunity through the activation of immune cells in virus-treated tumors. It is thought that oncolytic virotherapy promotes anti-tumor effects via two mechanisms: direct tumor cell lysis caused …

17.08.2026journal-article

Circulation: Population Health and Outcomes

Effectiveness of Multidomain Cardiac Rehabilitation After Myocardial Infarction by Patient Frailty: Prespecified Subgroup Analysis of the PIpELINe Trial

Beatrice Dal Passo, Elisabetta Tonet, Andrea Raisi, Silvia Zagnoni, Giorgio Chiaranda, Giovanni Pasanisi, Rita Pavasini, Paolo Cimaglia, Tommaso Piva, Gianni Casella, Serena Caglioni, Valentina Zerbini, Marta Cocco, Erica Menegatti, Simona Mandini, Gianni Mazzoni, Simone Biscaglia, Stefano Volpato, Giovanni Grazzi, Gianluca Campo

BACKGROUND: Frailty is common among older patients surviving myocardial infarction, is associated with adverse outcomes, and is often perceived as a barrier to cardiac rehabilitation (CR). The aim of this study is to determine whether frailty influences prognosis after myocardial infarction, and whether frailty modifies the clinical benefit of multidomain CR. METHODS: We performed a prespecified subgroup analysis of the PIpELINe (Physical Activity Intervention in Elderly Patients With Myocardial Infarction) randomi …