Onkologie: neue Gesundheitspublikationen – Seite 132

28.08.2026journal-article

Clinical Cancer Research

Long-term Results of Multiantigen Stimulated Cell Therapy I, Alone or in Combination with Chemotherapy, as First-line Maintenance Therapy in Advanced Sarcoma: A Multicenter, Phase I Trial

Xing Zhang, Bushu Xu, Qiuzhong Pan, Ruiqing Peng, Desheng Weng, Jingjing Zhao, Xizhi Wen, Qiyan Cai, Wei Li, Hongcheng Hu, Ruihua Xu

Abstract Purpose: Advanced sarcomas lack effective maintenance therapies after first-line chemotherapy. We present long-term phase I results evaluating multiantigen stimulated cell therapy I (MASCT-I), a novel immunotherapy integrating dendritic cell vaccination with adoptive T-cell transfer, as maintenance treatment (NCT03034304). Patients and Methods: Thirty-one patients with disease control after chemotherapy received MASCT-I alone (n = 17) or with ifosfamide (n = 14). The primary endpoint was safety. Secondary …

28.08.2026journal-article

Clinical and Translational Discovery

Computational strategies to address therapeutic resistance in estrogen receptor‐positive breast cancer: A narrative review of molecular docking, molecular dynamics simulations, and emerging therapeutic targets

Emmanuel Ifeanyi Obeagu, Yaregal Asres

Abstract Background Estrogen receptor‐positive (ER+) breast cancer represents the most common molecular subtype of breast cancer and remains highly responsive to endocrine therapy. However, therapeutic efficacy is frequently compromised by acquired or intrinsic endocrine resistance, particularly through ESR1 mutations, altered receptor conformation, co‐regulatory mechanisms, and activation of compensatory signaling pathways such as PI3K/AKT/mTOR. Conventional drug‐discovery approaches are often slow, resource‐inten …

28.08.2026journal-article

Advances in Rheumatology

Socioeconomic inequalities in psoriatic arthritis treatment in Brazil: a nationwide analysis of coverage, use and expenditure

Gabriela Bittencourt Gonzalez Mosegui, Fernando Antoñanzas-Villar, Cid Manso de Mello Vianna, Deison Alencar Lucietto, Alfonso Jesús Gil-López

Abstract Background Psoriatic arthritis (PsA) is a chronic inflammatory immune-mediated disease associated with significant impairment and reduced quality of life. Despite the availability of a clinical protocol within the Brazilian Unified Health System (SUS), the coverage and socioeconomic distribution of pharmacological treatment for PsA across federative units remain uncharacterized. This study analysed territorial and socioeconomic inequalities in PsA treatment coverage, use, and expenditure in Brazil in 2025. …

28.08.2026journal-article

Cancer Prevention Research

Barriers to Diagnostic Colonoscopy After a Positive Stool-Based Screening Test: A Scoping Review

Manali Patel, Paul Gerardo. Yeh, Thomas F. Imperiale, Victoria L. Champion, David R. Lairson

Abstract Non-invasive stool-based colorectal cancer (CRC) screening (e.g., fecal immunochemical test [FIT], guaiac fecal occult blood test [gFOBT], multitarget stool DNA [mt-sDNA]) reduces CRC mortality only when a positive result is followed by timely diagnostic colonoscopy. We synthesized barriers and facilitators to completing diagnostic colonoscopy after a positive stool-based screening test. Guided by Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR), …

28.08.2026journal-article

Molecules

Thermoluminescence-Based Detection of Irradiation in Valerian Root (Valeriana officinalis) Dietary Supplements: A Pilot Study on Undeclared Treatment and Labelling Compliance

Jarosław Chmielewski, Michał Sroka, Barbara Gworek, Ewa Górska, Piotr Szenk, Edyta Hewelke, Monika Kaczoruk

Background/Objectives: Food irradiation is a recognized method for the microbiological decontamination and preservation of plant raw materials; however, in the European Union, its use is subject to strict legal regulation and to a mandatory labelling obligation. For dietary supplements, which are legally classified as foodstuffs, this issue is particularly important for market transparency and the consumer’s right to information. The aim of this pilot study was to assess the presence of post-irradiation characteris …

28.08.2026journal-article

Biosensors

Microfluidic Single-Cell Bioanalysis for Decoding Tumor Heterogeneity

Xingyu Tao, Shuang Feng, Yi Luo, Zhenfei Yu, Ruiheng Wang, Ru-Jia Yu

Tumor heterogeneity drives cancer progression, dissemination, therapeutic adaptation, and relapse, yet many clinically relevant cell states are rare, transient, context-dependent, and obscured by population-averaged analysis. This review examines how microfluidic platforms preserve biologically meaningful linkages among cell identity, molecular state, secreted output, functional phenotype, perturbation history, and microenvironmental context, which are frequently disrupted by conventional workflows. We first define …

28.08.2026journal-article

Ophthalmology

Impact of dupilumab treatment on the ocular surface – a review of current evidence

Mateusz Kubicz, Julia Kucza, Marzena Jargiło, Sebastian Sirek, Ewa Mrukwa-Kominek

Dupilumab is a human monoclonal antibody used in the treatment of diseases associated with type 2 inflammatory responses, such as atopic dermatitis and bronchial asthma. With the increasing use of this therapy, adverse effects are being reported more frequently, including those affecting the visual system, collectively referred to as dupilumab-associated ocular surface disease. Dupilumab acts by blocking IL-4 and IL-13 signaling, which leads to the inhibition of the type 2 inflammatory response. Disruption of the I …

28.08.2026journal-article

Journal of Oncology Pharmacy Practice

Fatal toxic epidermal necrolysis induced by high-dose methotrexate in T-cell acute lymphoblastic leukemia

Wafa Chenbah, Amira Guizani, Haifa Regaieg, Monia Guermazi, Neila Fathallah, Sarra Saad, Yosra Ben Youssef

Introduction High-dose methotrexate (HD-MTX) is a cornerstone in the treatment of acute lymphoblastic leukemia but carries a risk of severe toxicity. Toxic epidermal necrolysis (TEN) is a rare life-threatening adverse reaction. Case report We report the case of a 15-year-old male with high-risk T-cell acute lymphoblastic leukemia who developed fatal TEN following HD-MTX therapy during induction chemotherapy. Ten days after methotrexate administration, the patient developed rapidly progressive epidermal detachment w …

28.08.2026journal-article

Genes

MicroRNAs in Colorectal Cancer Immunotherapy: Biomarkers, Resistance Mechanisms, and Strategies to Convert “Cold” Tumors to “Hot”

Jin Yan, Ruixia Ma, Yaguang Xi

Colorectal cancer (CRC) remains a major cause of cancer morbidity and mortality. Immune checkpoint inhibitors (ICIs) have transformed the treatment of microsatellite instability-high/mismatch repair-deficient (MSI-H/dMMR) CRC, yet most CRCs are microsatellite-stable/mismatch repair-proficient (MSS/pMMR) and remain poorly responsive to immunotherapy. MicroRNAs (miRNAs) are well positioned to influence this biology because individual miRNAs can coordinate multiple tumor-intrinsic and microenvironmental programs that …

28.08.2026journal-article

Medicine

Treatment of elderly patients with advanced (M1) gallbladder cancer – Aggressive or conservative?

Bin He, Ti Zhou, Penghua Weng, Haibin Lan

The optimal treatment strategy for elderly patients with distant metastatic gallbladder cancer (GBC, M1) remains controversial. We extracted data from the Surveillance, Epidemiology, and End Results (SEER) database for 528 elderly patients (aged ≥ 60 years) diagnosed with M1 GBC between 2000 and 2020. Patients were stratified by age (60–69, 70–79, ≥80 years) and treatment received: no surgery or chemotherapy (Group N), surgery alone (Group S), chemotherapy alone (Group C), or surgery combined with chemotherapy (Gro …

28.08.2026journal-article

Medicine

Traditional Chinese medicine treatment in a patient with severe COVID-19

Ming Zhong, Shiqi Sun, Fengjun Zhang, Wei Zhang

Rationale: Elderly patients with severe COVID-19 frequently develop chronic critical illness marked by prolonged ventilation, multidrug-resistant infections, enteral-nutrition (EN) intolerance, and persistent inflammation–immunosuppression–catabolism syndrome, making liberation from the ventilator and recovery difficult. Integrative Chinese and Western medicine (ICWM) is hypothesized to modulate immunity and the gut–lung axis and to stabilize frail physiology during long ICU courses. Patient concerns: An 87-year-ol …

28.08.2026journal-article

Journal of Fish Diseases

Assessment of Salinity Tolerance in Lepeophtheirus salmonis Following Five Generations of Freshwater Treatment Selection

Reza Ghanei‐Motlagh, Shona K. Whyte, Manuel Soto‐Dávila, Eyesun Fajei, Maricruz Guevara, Amber F. Garber, Gro Vee, Preben R. Antonsen, Gordon Ritchie, Mark D. Fast

ABSTRACT Non‐medicinal approaches for controlling sea lice ( Lepeophtheirus salmonis ) infestations, such as freshwater (FW) treatments, have been increasingly implemented to support more sustainable parasite control in aquaculture. This study evaluated the efficacy of FW treatment against sea lice under controlled experimental conditions and assessed the potential development of resistance across multiple generations. Sea lice populations were maintained over five consecutive generations, and FW efficacy was evalu …

28.08.2026journal-article

International Journal of Cancer

Smoking, Solid Fuel Use for Cooking, and Cancer Mortality: A Prospective Cohort Study in Southwestern China

Di Wu, Boke Chen, Xiaofang Chen, Xia Wu, Mingqiang Yuan, Yujin He, Zhuo Wang, Xu Han, Jun Lv, Canqing Yu, Pei Pei, Dianjianyi Sun, Xianping Wu

ABSTRACT Smoking and solid fuel are common exposures among Chinese adults, yet evidence regarding their associations with cancer mortality remains inconsistent, and their joint effects are insufficiently studied. Using data from the Pengzhou site of the China Kadoorie Biobank in Sichuan Province, we applied Cox proportional hazards models to examine associations of smoking, cooking fuel use, and co‐exposure with mortality from overall cancer and major site‐specific cancers. Among 55,404 participants, 61.63% were wo …

28.08.2026journal-article

Psychotherapy and Psychosomatics

Back to gut feelings. Latent class analysis of daily perceived health variations identifies later responses to antidepressant treatment

Laura Di Lodovico, Charles Westphalen, Chloé Tezenas du Montcel, Loïck Le Tertre, Philippe Courtet, Philip Gorwood

Major depressive disorder (MDD) is a prevalent and disabling condition, yet predicting individual response to antidepressants remains difficult. Traditional symptom-based assessments, typically conducted weeks apart, may miss early and dynamic changes. Daily self-reported measures of wellbeing dimensions, particularly via simple tools such as visual analog scales (VAS), could provide ecologically valid and patient-centered markers of early treatment response. This study aimed to identify distinct early trajectories …

28.08.2026journal-article

Frontiers in Pharmacology

Elucidating the role of medicinal plants in melanoma treatment: a review on metastatic progression and phytochemical intervention

Jonathan Lloyd Seaman, Danielle Twilley, Namrita Lall

Metastatic melanoma remains one of the most highly aggressive and treatment-resistant cancers, highlighting the need for enhanced understanding of its progression and novel therapeutic strategies. The metastatic cascade is an intricate, dynamic, and coordinated series of events which initiates with melanoma cell proliferation and the release of regulatory signalling molecules, followed by angiogenesis in response to hypoxia and nutrient deprivation, and extracellular matrix (ECM) degradation and invasion via matrix …

28.08.2026journal-article

Frontiers in Medicine

The impact of preoperative inflammatory indices on retinal vessel density and macular perfusion after anti-VEGF treatment in branch retinal vein occlusion (BRVO) using wide-field SS-OCTA

Rong Hu, Chen Zeng, Hao Cui, Ming Li, Chong Tang, Qi Li

Background This study aimed to comprehensively explore the macular perfusion and topographic distributions of retinal vessel alterations in branch retinal vein occlusion (BRVO)-affected eyes that had been treated with an anti-vascular endothelial growth factor (anti-VEGF) intravitreal injection for 1 month prior, using swept-source optical coherence tomography angiography (SS-OCTA). Methods Thirty BRVO-affected patients with macular edema (ME) who had received anti-VEGF treatment were included in this observational …

28.08.2026journal-article

Discover Oncology

Ketone body metabolism is associated with macrophage heterogeneity and a protumor phenotype in gastric cancer through single cell and bulk transcriptomic analysis

Yanhui Tang, Yuanman Zhang, Chengjian Wu, Xuan Feng

Abstract Background The tumor microenvironment (TME) in gastric cancer (GC) is characterized by significant heterogeneity, particularly among tumor-associated macrophages (TAMs). While metabolic reprogramming is a hallmark of cancer, the role of ketone body metabolism in shaping macrophage heterogeneity and its functional impact in GC remains largely unexplored. Methods We analyzed the single-cell RNA-seq dataset GSE206785 (24 tumor and 24 paired normal tissues from treatment-naïve GC patients). After quality contr …

28.08.2026journal-article

Medicine

Bilateral advancement flaps in the treatment of divided nevus of the eyelid

Yan Yu, Fan Dai, Jie Gao, Tao Liu, Haijuan Sun, Yanrong Li

Divided eyelid nevus can affect facial appearance and is difficult to reconstruct after excision. We conducted a retrospective case series (N = 11) and reported the study according to the STROBE guidelines. Eleven patients aged 1–10 years with congenital divided eyelid nevi underwent single-stage excision followed by bilateral advancement flaps and canthal anchoring. Outcomes were evaluated using the Vancouver Scar Scale (VSS) and parent/guardian satisfaction scores. The median VSS score was 1 (interquartile range, …

28.08.2026journal-article

Frontiers in Immunology

Glycolysis and T cell-associated gene signature predicts prognosis and therapeutic responses in pancreatic cancer

Wancheng Li, Dongao Fan, Yan Du, Lin Li, Wenjia Li, Wence Zhou

Background Pancreatic cancer (PC) is a fatal malignancy, with glycolysis and T cells playing crucial roles in its pathogenesis. This study explored prognosis-related genes in glycolysis and T cells in PC using bioinformatics methods. Methods We first quantified distinct T-cell subsets via immune infiltration analysis of the TCGA-PAAD cohort and extracted T cell-related genes (T-RGs). Differentially expressed genes (DEGs) were obtained from GSE28735 and TCGA-PAAD. Intersecting these DEGs with T-RGs and glycolysis-re …

28.08.2026journal-article

International Journal of Molecular Sciences

Liquid Biopsy for Molecular Residual Disease Detection and Postoperative Surveillance in Gastric Cancer: Current Evidence and Future Directions

Lydia Lazaridou, Kalliopi Vakalou, Alexandra Dimaki, Konstantinos Eleftherios Koumarelas, Konstantinos Zachos, Dimitrios Schizas, Grigorios Christodoulidis

Gastric cancer remains a major cause of cancer mortality worldwide, mainly due to its frequent diagnosis at advanced stages and the high probability of recurrence even after curative treatment. Conventional postoperative follow-up is mainly based on imaging studies, endoscopy and serological tumor markers, such as carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), and carbohydrate antigen 72-4 (CA72-4)This narrative review was based on a structured literature search of PubMed, Scopus, Web of Scienc …

28.08.2026journal-article

Eastern-European Journal of Enterprise Technologies

Defining the design and operating parameters for an energy-efficient unit for continuous microwave treatment of sunflower kernels prior to pressing in order to produce sunflower oil

Akzhol Suleimen, Baurzhan Nurakhmetov, Ardak Askarov, Ilyas Nurakhmetov

This study explores a powdered core strip for arc surfacing of complex doped alloy and composite alloys. The task addressed is to determine conditions for uniform melting of the shell and core. The conditions under which, during surfacing, the uneven heating of the shell and core at powdered core strip extension is reduced have been determined. When surfacing composite alloys, this achieves the dosed mass transfer of refractory metal carbides into the weld pool in their initial state and their required volumetric c …

28.08.2026journal-article

MicroRNA

In Silico Analysis of Potential miRNAs-EGFR Binding Complex for EGFR-TKI Resistance Lung Cancer Cells

Manisha Ray, Sheikh Naim, Pritinanda Mishra, Mukund Namdev Sable

Introduction: Overexpression of Epidermal Growth Factor Receptor (EGFR) plays a critical role in the progression and high mortality of Non-Small Cell Lung Cancer (NSCLC). Although EGFR tyrosine kinase inhibitors (EGFR-TKIs) demonstrate promising efficacy as first-line therapy, acquired resistance remains a major clinical challenge. Increasing evidence suggests that microRNAs (miRNAs) regulate EGFR signaling pathways and may influence therapeutic response and the development of resistance. Methods: This study aimed …

28.08.2026journal-article

Molecular Pharmaceutics

Novel Covalent FAP-Targeted Radiotherapy Drug Based on DOTA-FAP-2286 for Enhanced Tumor Uptake, Retention, and Therapeutic Efficacy

Shijie Tang, Zhongcai Jin, Tongtong Wu, Yanggang Liu, Yiheng Ai, Qiang Wan, Yang Liu, Shuang Yan, Yue Chen, Jingjing Zhang, Lin Qiu

Abstract Fibroblast activation protein (FAP)-targeted radioligand therapy is often limited by insufficient tumor uptake and retention. We designed and synthesized two novel aryl fluorosulfate-based covalent FAP-targeted radioligands, [177Lu]Lu-DOTA-mFS-FAP-2286 and [177Lu]Lu-DOTA-mFS-KERERG-FAP-2286, to enhance tumor retention and therapeutic efficacy. Two FAP-targeted radioligands were synthesized, radiolabeled with 177Lu, and evaluated for radiochemical stability. Cellular uptake and internalization were assessed …

28.08.2026journal-article

Medicine

Clinical risk factors associated with postoperative malnutrition in patients with laryngeal cancer

Cheng Jin, Yi Zhang

Postoperative malnutrition is a frequent yet variably defined complication after laryngeal cancer surgery and may compromise functional rehabilitation and subsequent oncologic management. This retrospective cohort study consecutively included adult patients (≥ 18 years) with histopathologically confirmed primary laryngeal cancer who underwent curative-intent surgery at our institution between July 1, 2021 and July 31, 2025. The primary endpoint was postoperative malnutrition within 3 months, diagnosed using the Glo …

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Aktuelle Forschung nach Fachgebiet

Long-term Results of Multiantigen Stimulated Cell Therapy I, Alone or in Combination with Chemotherapy, as First-line Maintenance Therapy in Advanced Sarcoma: A Multicenter, Phase I Trial

Computational strategies to address therapeutic resistance in estrogen receptor‐positive breast cancer: A narrative review of molecular docking, molecular dynamics simulations, and emerging therapeutic targets

Socioeconomic inequalities in psoriatic arthritis treatment in Brazil: a nationwide analysis of coverage, use and expenditure

Barriers to Diagnostic Colonoscopy After a Positive Stool-Based Screening Test: A Scoping Review

Thermoluminescence-Based Detection of Irradiation in Valerian Root (Valeriana officinalis) Dietary Supplements: A Pilot Study on Undeclared Treatment and Labelling Compliance

Microfluidic Single-Cell Bioanalysis for Decoding Tumor Heterogeneity

Impact of dupilumab treatment on the ocular surface – a review of current evidence

Fatal toxic epidermal necrolysis induced by high-dose methotrexate in T-cell acute lymphoblastic leukemia

MicroRNAs in Colorectal Cancer Immunotherapy: Biomarkers, Resistance Mechanisms, and Strategies to Convert “Cold” Tumors to “Hot”

Treatment of elderly patients with advanced (M1) gallbladder cancer – Aggressive or conservative?

Traditional Chinese medicine treatment in a patient with severe COVID-19

Assessment of Salinity Tolerance in Lepeophtheirus salmonis Following Five Generations of Freshwater Treatment Selection

Smoking, Solid Fuel Use for Cooking, and Cancer Mortality: A Prospective Cohort Study in Southwestern China

Back to gut feelings. Latent class analysis of daily perceived health variations identifies later responses to antidepressant treatment

Elucidating the role of medicinal plants in melanoma treatment: a review on metastatic progression and phytochemical intervention

The impact of preoperative inflammatory indices on retinal vessel density and macular perfusion after anti-VEGF treatment in branch retinal vein occlusion (BRVO) using wide-field SS-OCTA

Ketone body metabolism is associated with macrophage heterogeneity and a protumor phenotype in gastric cancer through single cell and bulk transcriptomic analysis

Bilateral advancement flaps in the treatment of divided nevus of the eyelid

Glycolysis and T cell-associated gene signature predicts prognosis and therapeutic responses in pancreatic cancer

Liquid Biopsy for Molecular Residual Disease Detection and Postoperative Surveillance in Gastric Cancer: Current Evidence and Future Directions

Defining the design and operating parameters for an energy-efficient unit for continuous microwave treatment of sunflower kernels prior to pressing in order to produce sunflower oil

In Silico Analysis of Potential miRNAs-EGFR Binding Complex for EGFR-TKI Resistance Lung Cancer Cells

Novel Covalent FAP-Targeted Radiotherapy Drug Based on DOTA-FAP-2286 for Enhanced Tumor Uptake, Retention, and Therapeutic Efficacy

Clinical risk factors associated with postoperative malnutrition in patients with laryngeal cancer