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European Health Evidence

The European alternative to PubMed

EUVIMED is the European alternative to PubMed: a central, multilingual research platform for medicine, nursing, life sciences and healthcare. It brings together international and European literature sources, study registries, open-access full texts, citations and retraction notices in one search. Unlike pure bibliographic databases, EUVIMED supports the entire research process – from discovery and appraisal with LIVIA and CLARA to traceable evidence synthesis. European in focus, transparent, interoperable and designed for science and healthcare.

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EUVIMED Themenbrowser · Onkologie · Seite 130

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Cancers

Evaluating the Prognostic Relevance of Pre-Treatment Epstein–Barr Virus Levels in Non-Endemic Pediatric Nasopharyngeal Carcinoma

Ahmed Farrag, Yanbo Yang, Jin Piao, Lindsay Younis, Hans-Joachim Wagner, Hans Christiansen, Tristan Römer, Allison Poore, Christopher Szot, Nadia Thibeau, Sue S. Yom, Benjamin A. Pinsky, Quynh-Thu Le, Junne Kamihara, David T. Ting, Theodore W. Laetsch, Kenneth S. Chen, Carlos Rodriguez-Galindo, Randall T. Hayden, Udo Kontny, Robyn D. Gartrell

Background/Objectives: Pediatric nasopharyngeal carcinoma (NPC) is a very rare childhood cancer strongly associated with Epstein–Barr virus (EBV) infection. We investigated the prognostic value of EBV DNA on staging and outcome in pediatric NPC from two large study centers, the Children’s Oncology Group (COG) in North America and the German Society of Pediatric Oncology and Hematology (GPOH) in Europe. Methods: Samples collected from NPC patients treated on the COG study ARAR0331 between 2006 and 2012 and the GPOH …

28.08.2026journal-article

Cancer

Racial differences in multiple myeloma survival: Associations with stem cell transplantation, insurance, and Medicaid expansion

F. Lennie Wong, Scott R. Goldsmith, Kimlin Ashing, Amrita Krishnan, Michael A. Rosenzweig, Saro H. Armenian

ABSTRACT Background At the population level, Black patients with multiple myeloma (MM) may experience worse survival than White patients. The authors examined how autologous stem cell transplantation (ASCT), insurance, and Medicaid expansion relate to racial differences in real‐world overall survival (rwOS). Methods Data from 4932 patients with MM (24% Black) in the Flatiron Health Research Database were analyzed using Cox regression (rwOS), Fine and Gray competing‐risk models (ASCT), and polytomous regression (ins …

28.08.2026journal-article

Frontiers in Medicine

Clinical efficacy of Masquelet technique in the treatment of tibial and fibular bone defects caused by severe gunshot wounds

Qiming Sun, Yingjie Cong, Wei Sun, Xinwei Liu, Baolei Guo, Chunli Zhao, Baoxian Hou, Ye Liu, Dapeng Zhou

Objective To explore the clinical efficacy of the Masquelet technique in the treatment of tibial and fibular bone defects resulting from severe gunshot wounds. Methods A retrospective analysis was conducted on six male patients (mean age, 23 ± 5 years; range, 18 to 33 years) with tibial and fibular bone defects resulting from gunshot wounds, treated with the Masquelet technique between January 2022 and January 2024. In Stage 1, blood transfusions and fluid resuscitation were administered to manage shock. Wound debr …

28.08.2026journal-article

Frontiers in Oncology

Incidence and risk factors for catheter-related thrombosis in elderly patients with malignant tumors: a single-center retrospective cohort study

Yanli Wang, Xiaoli Mei, He Liu, Fuqiu Tang

Background Peripherally inserted central catheters (PICCs) are widely used in hospitalized patients with cancer for chemotherapy, nutritional support, and routine medication infusion. Catheter-related venous thrombosis (CRT) is a severe complication that is associated with poor prognosis, especially among elderly patients with cancer. However, studies on the identification of risk factors for CRT in elderly patients with cancer are limited. Methods From June 2024 to May 2025, clinical data from hospitalized elderly …

28.08.2026journal-article

Koloproktologia

Local excision of a residual tumor after neoadjuvant chemoradiotherapy for rectal cancer (a systematic review and meta-analysis of comparative studies)

V. V. Cherepahina, M. V. Alekseev, E. G. Rybakov, M. A. Ignatenko, Yu. A. Shelygin

B ACKGROUND: the optimal treatment strategy for patients with rectal cancer who achieve a complete or nearcomplete clinical response after neoadjuvant chemoradiotherapy is challenging. AIM: to assess oncological outcomes after neoadjuvant chemoradiotherapy followed by total mesorectumectomy (TME) or local excision of residual rectal tumor (TEM). MA TERIALS AND METHODS: a systematic review and meta-analysis were done according to the PRISMA 2020 guidelines. A literature search included PubMed, MEDLINE, and e-library …

28.08.2026journal-article

Journal of Health Psychology

Lived experiences, adherence, and transformation in patients with treatment-resistant depression undergoing transcranial magnetic stimulation (TMS): An interpretative phenomenological study

Margit Julia Guerra Ayala, Marcelo Pablo Aramayo Zamalloa, María del Rosario Ccahuana Ranilla, Lucero Isabel Vílchez Herencia, Miguel David Sánchez Fernández

Treatment-resistant depression (TRD) poses a critical challenge, particularly where conventional treatments fail. Transcranial magnetic stimulation (TMS) has shown clinical efficacy, yet little is known about how patients in Peruvian contexts perceive this intervention. This study explored patients’ lived experiences of TMS, emphasising how adherence, acceptance, and perceived efficacy were shaped by subjective, relational, and contextual factors. Using Interpretative Phenomenological Analysis (IPA), five women age …

28.08.2026journal-article

Journal of Endovascular Therapy

Endovascular Aspiration Thrombectomy of the Superior Mesenteric Artery for Treatment of Acute Mesenteric Ischemia: Results From the ENDO-SMA2MI Registry

Mario D’Oria, Sandro Lepidi, Paolo Spath, Mauro Gargiulo, Ciro Ferrer, Gioele Simonte, Stefano Gennai, Francesco Giurazza, Anna Maria Ierardi, Diego Visconti, Reinhold Perkmann, Raffaello Bellosta, Nicolò De Manzini, Cristiano Calvagna, Alan Biloslavo

Background/Objective. Acute mesenteric ischaemia (AMI) is a multidisciplinary emergency, requiring the involvement of different medical specialties for successful management. Endovascular aspiration thrombectomy (EAT) has entered the field leading to the possibility of treating acute arterial occlusions with a minimally invasive approach. The aim of the study was to provide contemporary data on results after use of EAT in AMI patients. Methods. The study was a retrospective, observational, multicentre study conduct …

28.08.2026journal-article

International Journal of Cancer

Estimation of Subtype‐Specific Tumour Growth Rate Distributions and Interval Cancer Proportions in Breast Cancer Using Biology‐Inspired Natural History Models

Letizia Orsini, Yuqi Zhang, Kamila Czene, Keith Humphreys

ABSTRACT Breast cancer progression varies across molecular subtypes, influencing detection rates and prognosis. Differences in the proportion of interval cancers (PIC)—cancers detected symptomatically between scheduled screening rounds—have been observed across subtypes, likely reflecting heterogeneity in tumour growth dynamics. We applied a continuous‐growth natural history model to a cohort of 7818 breast cancer patients diagnosed between 2007 and 2020 in Sweden. Using subtype‐specific estimates, we quantified th …

28.08.2026journal-article

Diagnostics

Stratified Analysis of Patients Within the PSA Gray Zone (4–10 ng/mL) and Its Clinical Application Value: Development of a Predictive Model for Clinically Significant Prostate Cancer Using Quantitative Indicators of PSA, ADC, and Relative T2 Value

Pan Hao, Tong Zhu, Ruiqiang Xin, Xiaoyong Lv

Objective: Patients with prostate-specific antigen (PSA) levels in the 4–10 ng/mL gray zone present a diagnostic challenge, as PSA alone cannot reliably distinguish clinically significant prostate cancer (csPCa) from benign conditions or indolent disease, potentially leading to unnecessary biopsies or missed clinically significant disease. This study aimed to develop a risk prediction model for csPCa in this population using clinical indicators and magnetic resonance imaging (MRI) quantitative data, and to evaluate …

28.08.2026journal-article

Medicina

Clinical and Dermoscopic Determinants of Surgical Decision-Making in Skin Cancer Screening: A Retrospective Analysis

Adrian Chwojnicki, Sebastian Makuch, Hanna Adamska, Michalina Świetlicka, Maja Hrynczyszyn, Inga Buława, Paulina Piesch, Jacek Polański, Wojciech Tański

Background and Objectives: Deciding which pigmented or non-pigmented skin lesions require surgical excision, as opposed to continued observation, is a common challenge in everyday dermatologic practice. Although dermoscopy is well established as a tool that improves melanoma detection accuracy compared with naked-eye examination, real-world evidence on how demographic profile, patient history, and dermoscopic impression jointly influence the surgical decision remains limited. This study examined the clinical and de …

28.08.2026journal-article

World Journal of Gastroenterology

Endoscopic follow-up in colorectal cancer: Comparisons and critical issues across different guidelines

Sara Cherri, Daniele Salvi, Edoardo Pezzuto, Elisa Tabbone, Alberto Zaniboni, Paola Cesaro

Endoscopic surveillance plays a fundamental role in the long-term management of patients treated for colorectal cancer. Despite significant advances in surgical techniques, systemic therapies, and molecular diagnostics, recurrence and metachronous neoplasia remain clinically relevant challenges, particularly within the first three years following curative-intent treatment. This review summarizes current evidence and major guideline recommendations on endoscopic follow-up after colorectal resection, endoscopic remov …

28.08.2026journal-article

ACS ES&T Engineering

Exogenous Folate Supplementation Weakens Cross-Feeding and Enriches Marine Anammox Bacteria in Marine Wastewater Treatment

Hui Lv, Weichuan Kong, Yuhui Fang, Xiaocui Wang, Jin Li

Abstract Cross-feeding, defined as the exchange of metabolites within the microbiome, plays a critical role in the promotion of bacterial activity and growth. Marine anammox bacteria (MAB) possess natural advantages for the treatment of marine wastewater (MW). Herein, the folate-mediated cross-feeding mechanism in MAB-based microbiome was first elucidated under salt stress. The total nitrogen removal rate notably reached 5.2 kg/(m3·d) at the optimal exogenous folate concentration (1.1 mg/L). The stoichiometric rati …

28.08.2026journal-article

Clinical Cancer Research

Weight Loss Responses to Pharmacotherapy in Breast Cancer Survivors: Results from the Adaptive Nutrition and Exercise Weight Loss (A-NEW) Study

Jennifer Y. Sheng, Marianna L. Zahurak, Faith Too, Amanda Montanari, Jennifer Trost, Mengyang Lu, Young Lee, Sheetal Parida, Amanda L. Blackford, Dipali Sharma, Marci Laudenslager, Claire Snyder, Janelle W. Coughlin, Vered Stearns

Abstract Purpose: Behavioral weight loss (BWL) interventions consisting of remote coaching and self-monitoring have limited effectiveness in breast cancer survivors. We conducted a single-arm phase II study evaluating the addition of Contrave for <5% weight loss (%WL) after 2 months of BWL. Patients and Methods: Women with prior stage 0 to III breast cancer and a body mass index ≥27 kg/m2 were eligible and initiated BWL. We collected weight, patient-reported outcomes, and labs at baseline, 2 months, and 6 months. A …

28.08.2026journal-article

Journal of Mechanics in Medicine and Biology

ENHANCING RADIOTHERAPY SAFETY IN HEAD AND NECK CANCER TREATMENT: A HYBRID DOUBLE-LAYERED ORTHODONTIC MOUTH GUARD

YOJANA SHARMA, AYUSH AWASTHI, MOHIT PANT, PARNIKA SHRIVASTAVA

Radiotherapy is a widely used method in the treatment of head-and-neck cancers; however, irradiation of surrounding oral structures often results in clinical complications such as dental caries, oral mucositis, osteoradionecrosis, dysphagia, dysgeusia, xerostomia and trismus. To address such issues, a patient-specific hybrid double-layer orthodontic mouthguard has been proposed to simultaneously enhance the radiation shielding and biomechanical comfort in treatments. The customized device integrates radiation-shiel …

28.08.2026journal-article

Frontiers in Bioengineering and Biotechnology

Raman and surface-enhanced Raman spectroscopy for intraoperative cancer diagnostics: sentinel lymph node biopsy, biomarkers and translational challenges

Jiaqi Feng, Chunyan Li, Xiaowei Jiang, Lizhi Zhou, Yifei Jiang, Binge Deng

Sentinel lymph node biopsy (SLNB) serves as the gold standard for staging regional lymph node metastasis of solid tumors, which is crucial for guiding clinical treatment decisions and evaluating prognosis. Conventional intraoperative detection methods for SLN, such as frozen section and touch imprint cytology, have limitations including low sensitivity for micrometastasis, long detection time, and high subjectivity. Raman spectroscopy (RS), as a label-free, non-destructive optical molecular imaging technology, can …

28.08.2026journal-article

Breast Cancer Research

MDM2 inhibition restores p53 function to overcome dual endocrine and CDK4/6 inhibitor resistance in ER+ breast cancer

Leila Eshraghi, Fiona H. Zhou, Sarah Alexandrou, Chan Jae Lee, Chau Lam Miu, Aliza Yong, Ashleigh Wilkinson, Denise Attwater, Man Ting Siu, Kristine Fernandez, Heloisa H. Milioli, Andrew Parker, Davendra Segara, C. Elizabeth Caldon, Neil Portman, Elgene Lim

Abstract Background Approximately 70% of breast cancers are estrogen receptor (ER)-positive, with endocrine therapy (ET) forming the treatment backbone. ET plus CDK4/6 inhibitors is standard-of-care for advanced and high-risk early-stage ER+ breast cancer. Despite improved outcomes, resistance and progression remain major challenges. p53 is wild type in most ER+ cancers and is suppressed by its negative regulator MDM2. We previously showed that MDM2 inhibition is effective in ET-resistant ER+ models, however its ef …

28.08.2026journal-article

Oncology Reviews

Clinical value of combined SHOX2 and RASSF1A methylation in lung cancer diagnosis across tissue and liquid biopsy samples: a systematic review and meta-analysis

Ting Wang, Jianguo Zhang, Jiayang Wang, Xiaoqun Dong, Qiushi Lin, Leiming Guo, Bo Zhang, Yue Cao, Yining Zhai, Mathhew Hadfield, Khan Hina, Abbas E. Abbas, Hong Ge, Liang Cheng, Hang Xing, Yifei Liu

Lung cancer remains the leading cause of cancer-related mortality worldwide, with poor prognosis in advanced stage diseases. Although early diagnosis has the potential to improve patient outcomes, current diagnostic methods remain suboptimal, highlighting the need for accurate molecular biomarkers. We systematically reviewed 49 studies to evaluate the diagnostic performance of SHOX2 methylation, RASSF1A methylation, and their combined panel for lung cancer detection. The combined SHOX2/RASSF1A methylation panel dem …

28.08.2026journal-article

Frontiers in Oncology

Clonal evolution in gastrointestinal cancers: multi-omics insights into tumor heterogeneity, microenvironmental selection, and translational biomarkers

Wenyi Fan, Chunhong Zheng

Clonal evolution in hepatocellular carcinoma (HCC), esophageal squamous cell carcinoma (ESCC), and gastric cancer (GC) reflects the interaction of genetic diversification, cell-state plasticity, and tissue-specific selection. Multi-region and single-cell DNA sequencing resolve truncal and subclonal lineages, whereas single-cell and spatial transcriptomics, proteomics, and serial liquid biopsy characterize cellular states, ecological niches, and temporal dynamics. The three cancers differ in dissemination timing, do …

28.08.2026journal-article

Arthritis & Rheumatology

Cancer in systemic sclerosis: clinical associations and prognostic impact from the EUSTAR registry

Antonio Tonutti, Francesca Motta, Liala Moschetti, Cosimo Bruni, Carina Mihai, Claudia Iannone, Maria Rosa Pellico, Stefano Stano, Stefano Erba, Claudia Barison, Eleonora Pazzi, Andrea Benini, Beatrice Moccaldi, Kurszán Jász Dávid, Ágnes Ágoston‐Szabó, Beatrice Gabrielli, Francesca Nava, Dóra Tari, Francesca Romana Di Ciommo, Yuri Sasaki, Gonçalo Boleto, Radim Bečvář, Alejandro Brigante, Britta Maurer, Massimiliano Limonta, Rahma A. Elziaty, Fabiola Atzeni, Lilian Maria López Núñez, Roberta Foti, Francesco Benvenuti, Brigitte Granel, Elena Rezus, Leila Caillault, Sophie Blaise, Cristiana Sieiro Santos, Fabio Cacciapaglia, Roberto Giacomelli, Rossella De Angelis, Serena Guiducci, Duygu Temiz Karadag

Background Cancer represents a major cause of mortality in systemic sclerosis (SSc). Established risk factors are limited to specific subsets, particularly early diffuse anti‐RNA polymerase III (POLR3)‐positive disease, needing further exploration. Methods We performed a nested case‐control study within EUSTAR: cases were SSc patients developing cancer at any timepoint; controls were cancer‐free SSc matched for age and disease duration. Malignancies were classified as synchronous to SSc onset (±3 years), subsequent …

28.08.2026journal-article

Frontiers in Oncology

Integrating intratumoral and peritumoral radiomics with deep transfer learning from multiparametric MRI for preoperative prediction of HER2 status in breast cancer: a multicenter study

Saisai Zhang, Jing Rong, Tiantian Liu, Xiujuan Yin, Shuqin Xue, Likang Yin, Lei Liu, Yang Ji, Xijun Gong, Xiao Wang

Purpose To develop and validate a combined model integrating intratumoral and peritumoral radiomics features, deep transfer learning features from multiparametric MRI (DCE-MRI, T2WI, and DWI), and clinical indicators, and to evaluate its diagnostic performance and clinical utility for preoperative prediction of HER2 expression status in breast cancer. Methods We collected data from 411 breast cancer patients from three centers retrospectively (training set: 212; internal validation set: 91; external test sets: 50 a …

28.08.2026journal-article

Angewandte Chemie International Edition

ALDH Inhibition‐Primed Photocatalysis Disrupts Cancer Stemness Plasticity

Yujin Kim, Shankun Yao, Ji Hyeon Kim, Rongrong Huang, Hyeonji Rha, Shumeng Li, Kippeum Lee, Yunjie Xu, Xiaogang Liu, Yuncong Chen, Jong Seung Kim

ABSTRACT Light‐driven photoredox catalysis can shift intracellular NADH/NAD + balance by oxidizing NADH, but intracellular NADH pools are dynamically replenished through enzyme‐coupled redox metabolism. We show that ALDH‐mediated restoration of NADH/NAD + balance can buffer photoredox‐induced NADH depletion, providing a design rationale for coupling enzyme inhibition with photoredox catalysis. To counteract this redox‐buffering process, we introduce an enzymatic–photocatalytic strategy, termed E–PC, that integrates …

28.08.2026journal-article

International Journal of Computer Information Systems and Industrial Management Applications

Enhanced Brain Tumor Classification Using Capsule Networks with Hybrid Activation Function

Mamta Sharma, Sunita Beniwal

Detection of life-threatening disease at an early stage is crucial for improving patient survival rates. The advancement in diagnostic technology has made disease identification faster and more accurate. Brain tumors are very critical and require prompt and precise detection for treatment. Deep learning algorithms can aid medical experts in diagnosis and treatment. Capsule Networks, a Deep Learning technique, have shown significant potential in medical diagnosis. The performance of capsule networks is driven mainly …

28.08.2026journal-article

World Journal of Gastroenterology

Helicobacter pylori promotes gastric cancer progression by upregulating EPS8L3 to inhibit ferroptosis

Meng-Di Ma, Wan-Jing Chen, Ke-Xun Yu, Hui-Zhen Wang, Yong-Xiang Li

BACKGROUND Gastric cancer (GC) represents one of the most prevalent malignancies globally and is ranked as the fourth leading cause of cancer-related mortality. Helicobacter pylori (H. pylori ) infection is a major risk factor for GC, however, the molecular mechanisms by which H. pylori promotes gastric carcinogenesis remain unclear. AIM To investigate how H. pylori promotes GC development by activating specific signaling pathways. METHODS Transcriptome sequencing identified epidermal growth factor receptor kinase …