EUVIMEDEuropean Health Evidence
Uhr 7/7Sources Journal Tree
Easy Demo

EUVIMED Themenbrowser · Onkologie · Seite 13

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Laryngoscope Investigative Otolaryngology

Large Language Models Versus Multidisciplinary Tumor Board Decisions in Thyroid Cancer

Bayram Barış Büyük, Arzu Or Koca, Felat Toprak, Aslı Ayan, Tuncay Tunçcan, Ayça Arslan, ArzuBetül Duran, Elif Akyol Şen, Ömer Semih Budak, Alptekin Gürsoy, Caner Kılıç

ABSTRACT Objectives Large language models (LLMs) are increasingly proposed as clinical decision‐support tools; however, their agreement with real‐world multidisciplinary tumor board (MDT) decisions remains insufficiently investigated in thyroid oncology. To evaluate the concordance between treatment recommendations generated by ChatGPT 5.2 and Gemini 3.0 and decisions made by a tertiary multidisciplinary thyroid tumor board. Methods This study included 59 consecutive patients discussed at a tertiary MDT between Aug …

02.09.2026journal-article

British Journal of Healthcare and Medical Research

Associations of Musculoskeletal Pain with Sociodemographic, Health Related, Reproductive Related, Pain Related, Treatment Seeking Pattern and Outcome Among Postmenopausal Women From Dhaka City

Rojina Akter, Abu Sayed Mohammad Giasuddin, Jasim Uddin, Md. Raisul Hassan

Background: The associations (correlations) of Musculoskeletal pain (MSP) with the presenting characteristics in postmenopausal women from Dhaka City are not known; Objectives: To determine the statistical significance of the associations of MSP with the presenting characteristics in postmenopausal women from Dhaka City; Materials & Methods: Statistically further analyses were done for associations of MSP with the presenting features reported in our descriptive cross-sectional study. The SPSS version 22.0 was used …

02.09.2026journal-article

Mycopathologia

Epidemiology and Species Distribution of Candida Bloodstream Infections in a Comprehensive Cancer Center, 2008–2023

Mohammad El-Atoum, George L. Chen, Brahm H. Segal, John P. Bonnewell, Nikolaos G. Almyroudis

Abstract Introduction Candida bloodstream infections remain a significant complication of malignancies and their therapies. Aim To investigate the epidemiology of Candida species causing bloodstream infections in patients with malignancies. Methods We retrospectively reviewed bloodstream infections due to Candida from July 2008 to June 2023 in patients admitted under hematological, solid tumor and surgical services. Common species included C. albicans, Nakaseomyces glabratus (formerly C. glabrata ), Pichia kudriavz …

02.09.2026journal-article

Acta Odontologica Turcica

Evaluation of parents' knowledge and awareness of early orthodontic treatment for their children in Türkiye

Mehmed Taha Alpaydın, Merve Köklü, Tuğçe Alpaydin

ABSTRACT OBJECTIVE: The aim of this study is to evaluate the knowledge and awareness levels of parents in Turkish society regarding early orthodontic treatment and to explain how it is related to various factors. MATERIALS AND METHODS: The survey was distributed to voluntary participants across Türkiye via Google Forms. Sociodemographic data and data measuring the level of knowledge and awareness about early orthodontic treatment were obtained. Data analysis was performed using SPSS (Statistical Package for Social …

02.09.2026journal-article

International Journal of Molecular Sciences

Nutritional Prevention of Oxidative Stress-Induced Cardiotoxicity in Pediatric Cardio-Oncology: Molecular Mechanisms and Translational Perspectives—A Narrative Review

Karmen Stankov, Bojan Stanimirov, Aleksandar Ninković, Maja Đanić, Slavica Lazarević, Dragana Zaklan, Nebojša Pavlović

Cancer therapy-related cardiotoxicity has emerged as a major challenge in contemporary oncology, particularly in long-term survivors of childhood malignancies. Oxidative stress (OS)-induced cardiotoxicity represents a key mechanistic pathway underlying myocardial injury caused by numerous anti-neoplastic drugs, most notably anthracycline-based chemotherapy, while OS also critically contributes to radiotherapy-induced cardiotoxicity. Excessive reactive oxygen and nitrogen species generation promotes mitochondrial dy …

02.09.2026journal-article

Journal of Clinical Medicine

Can Ultrasound Texture Analysis Differentiate Liver Metastases According to the Histopathological Origin of the Primary Tumor?

Seda Nida Karakucuk, Murat Baykara, Mehmet Demir, Ali İsler

Objective: We aimed to investigate whether ultrasound-based texture analysis can differentiate liver metastases according to the histopathological origin of the primary tumor and to evaluate the quantitative texture characteristics of metastases originating from colorectal, pancreatic, and breast cancer. Materials and Methods: This prospective study included 75 patients with biopsy-proven liver metastases, comprising 25 colorectal adenocarcinoma, 25 pancreatic ductal adenocarcinoma, and 25 invasive ductal breast ca …

02.09.2026journal-article

Acta Poloniae Pharmaceutica - Drug Research

Potential Mechanism of Ginsenoside Re in Tumor Progression of Colorectal Cancer Through Affecting MmiR-4516

Zeming Bai, Zhuoran Li, Lifen Mu, Juanjuan Yan, Xinfeng Wang, Limin Chai, Xiaoxia Wang, Zhiying Hao

This study aims to investigate whether G-Re exerts anti-tumor effects in CRC by modulating miR-4516. The anti-proliferative effect of G-Re was evaluated by CCK-8 (IC₅₀ calculation). MiR-4516 expression was detected via qRT-PCR. Functional assays (proliferation, migration, invasion) were performed after transfection with miR-4516 inhibitor/mimic and G-Re treatment. The miR-4516/ETV4 binding relationship was confirmed by dual-luciferase and RIP assays, with ETV4 expression examined. Rescue experiments were conducted …

02.09.2026journal-article

Experimental & Molecular Medicine

The long non-coding RNA-encoded microprotein MKKS3 drives colorectal cancer chemoresistance

Hui-Fang Hu, Qi Zhou, Jia-Zhen Huang, Jia-Ying Fu, Zhi-Ting Zuo, Qing-Yu He

Abstract Although oxaliplatin is widely used in the frontline treatment of colorectal cancer (CRC), CRC recurrence is commonly observed owing to oxaliplatin resistance. The roles of long non-coding RNAs-encoded microproteins in oxaliplatin chemoresistance remain inadequately explored. In this study, a CRISPR/Cas9 library was developed to target previously identified 314 microproteins translated from long non-coding RNAs, followed by functional screening. This strategy identified MKKS3, encoded by NR_072977, as a ke …

02.09.2026journal-article

The Laryngoscope

Treatment of Congenital Cytomegalovirus Beyond the Neonatal Period: A Single‐Arm Meta‐Analysis

Thamiris D. D. Cabral, Marcela Mafra, Jaime Plane, Matheus Sewastjanow‐Silva, Isadora Martins Nascimento, Asitha D. L. Jayawardena, Abby Meyer, Andrew Redmann, Luke Jakubowski

ABSTRACT Objective To evaluate hearing outcomes in postneonatal treatment of congenital cytomegalovirus (cCMV) infection and assess the effect of treatment initiated after the first month of life. Data Sources PubMed, Embase, Web of Science, and Cochrane Library were systematically searched. Review Methods Articles reporting antiviral treatment of cCMV, with Ganciclovir (GCV) or Valganciclovir (VGCV) in the postneonatal period were included. Outcomes of interest included viral load (urine and plasma), neutropenia, …

02.09.2026journal-article

Cancers

Interpretable Machine Learning for Predicting Radiation-Induced Hypothyroidism in Head and Neck Cancer: A Dual-Center Retrospective Study

Wenhui Li, Ying Zhang, Yangyang Ji, Rui Jian, Zequn Jia, Ziyu Wei, Yingjun Liu, Hua Zhou, Hongyang Yu

Background/Objectives: Radiation-induced hypothyroidism (RIHT) is a frequent complication in head and neck cancer (HNC) patients following radiotherapy, significantly impacting quality of life. This study aimed to develop and validate an interpretable machine learning model for predicting RIHT, with a focus on providing individualized risk assessment. Methods: The study included a development cohort (n = 256) from the Second Affiliated Hospital of Harbin Medical University and an independent external validation coh …

02.09.2026journal-article

Molecular Oncology

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane

Various environmental and endogenous stressors, including ultraviolet (UV) radiation, cytotoxins, and dysregulated translation, can induce ribosome stalling and collisions, disrupting protein homeostasis. The ribotoxic stress response (RSR) is a cellular surveillance mechanism that senses translational stress and activates stress signaling via the MAP3 kinase ZAKα and the stress‐activated protein kinases (SAPKs) p38 and JNK. This review outlines the molecular mechanisms behind RSR, distinguishes RSR from other tran …

02.09.2026journal-article

Journal of Clinical Medicine

The Prognostic Value of the Advanced Lung Cancer Inflammation Index on Disease-Free Survival in Patients with Gastric Cancer Receiving Neoadjuvant Chemotherapy

Mahmut Kara, Muslih Ürün, Senar Ebinç, Yasin Sezgin, Yonca Yılmaz Ürün, Mehmet Naci Aldemir

Objectives: The present study investigated whether the pre-treatment Advanced Lung Cancer Inflammation Index (ALI) could serve as a prognostic indicator of disease-free survival (DFS) in patients with locally advanced gastric cancer treated with neoadjuvant chemotherapy followed by curative D2 gastrectomy. Methods: We retrospectively analyzed 157 patients with gastric adenocarcinoma who received treatment between 2016 and 2025. The pre-treatment ALI was derived from body mass index, serum albumin concentration, and …

02.09.2026journal-article

JAMA Dermatology

Delphi Consensus Statement on Treatment of Severe Alopecia Areata in US Adults

Samantha Gregoire, Eliza Dewey, Ursula Biba, Katherine Sanchez, Hanna Englander, Lana Salloum, Sherry Ershadi, Debby Cheng, Basil Alex McIntosh, Nikki Zangenah, Maria Vazquez-Machado, Aneri Parekh, Lisa Kam, Nora Bensellam, Crystal Aguh, Wilma Bergfeld, Valerie D. Callender, Leslie Castelo-Soccio, Brittany Craiglow, Dirk Elston, Ronda Farah, Jennifer Fu, Carolyn Goh, Emma Guttman-Yassky, Kathie P. Huang, Ali Jabbari, Chesahna Kindred, Justin Ko, Mark Lebwohl, Kristen I. Lo Sicco, Amy McMichael, Natasha A. Mesinkovska, Paradi Mirmirani, Melissa Piliang, Maryanne Senna, Jerry Shapiro, Jennifer Soung, Susan Taylor, Antonella Tosti, Benjamin Ungar

Importance Alopecia areata (AA) is an autoimmune hair loss disorder that affects more than 7 million people in the US. Before US Food and Drug Administration–approved trials of Janus kinase inhibitors, numerous treatments had been explored, with variable efficacy and quality of evidence. The absence of standardized treatment guidelines may lead to poor treatment outcomes and payer coverage. Objective To establish a consensus on treatment for adults with severe AA in the US. Evidence Review Systematic literature rev …

02.09.2026journal-article

Mathematics

Optimal Chemotherapy Control and Dynamics of Tumor–Immune Interactions

Saira Batool, Muhammad Imran, Brett McKinney

This study develops and analyzes a nonlinear tumor–immune–chemotherapy model to investigate how chemotherapy influences tumor suppression in the presence of heterogeneous tumor subpopulations and immune responses. The model incorporates two tumor cell populations with different immunogenic characteristics, innate and adaptive immune responses, and a dynamic chemotherapy effect. We analytically identify the equilibrium points and assess the conditions for their stability in the presence of chemotherapy. A bifurcatio …

02.09.2026journal-article

Frontiers in Microbiology

HIV-driven tumor ecosystem: from chronic immune dysfunction to cancer evolution

Guangchao Zhou, Juanyan Liao, Haolin Tang, Xingyu Hou, Qing Li, Xia Li

Although HIV-associated malignancies have been reviewed separately through the lens of individual oncogenic viruses (KSHV, EBV, HPV) or immune dysfunction in isolation, no prior synthesis has integrated these processes into a single, systemic “tumor ecosystem” framework spanning virology, immunology, the tumor microenvironment, and clinical treatment response. Human immunodeficiency virus (HIV) infection profoundly alters the immune landscape, establishing a distinctive tumor ecosystem characterized by chronic immu …

02.09.2026journal-article

Molecular Cancer Research

The PON1–NDUFA4 Axis Maintains Mitochondrial Respiratory Fitness and Drives Lenvatinib Tolerance in Hepatocellular Carcinoma

Shi-Lin Lin, Yue Wang, Yi-min Zheng, Ai-Wu Ke, A-ying Ma, Chao Gao

Abstract Metabolic plasticity driven by mitochondrial oxidative phosphorylation (OXPHOS) is increasingly recognized as a key determinant of therapeutic tolerance in hepatocellular carcinoma (HCC), but the upstream regulators that preserve electron transport chain stability during treatment remain poorly defined. In this study, we identified paraoxonase 1 (PON1) as a clinically relevant regulator of mitochondrial metabolism and lenvatinib response in HCC. PON1 was markedly upregulated in HCC and independently associ …

02.09.2026journal-article

Materials and Structures

Impact of induced rapid surface carbonation (IRS-C) treatment on the steel corrosion in reinforced concrete: a counterintuitive effect

Raquel Ruiz, Julio Ramirez, Mirian Velay-Lizancos

Abstract Corrosion of steel reinforcement in concrete is one of the main issues plaguing aging infrastructure worldwide. While concrete’s carbonation is usually associated with an increased risk of corrosion, this study proposes a counterintuitive method that uses carbonation of hardened elements to reduce corrosion risk: the induced rapid surface carbonation (IRS-C) treatment. Besides, this study analyzes the impact of IRS-C on the corrosion resistance of precast reinforced concrete elements and explains the mecha …

02.09.2026journal-article

Physics in Medicine & Biology

Biologically optimized 3D range modulators for fast conformal carbon ion therapy: in vitro validation, treatment planning, and robustness analysis

Sae Hyun Hailey Ahn, Domenico Ivan Filosa, Peter Lysakovski, Stephan Brons, Amir Abdollahi, Jürgen Debus, Ivana Dokic, Thomas Tessonnier, Andrea Mairani

Abstract Objective. Patient-specific 3D range modulators (RMs) allow rapid and conformal particle therapy with monoenergetic beams and may support motion management and ultra-high dose rate (UHDR) studies. For carbon ions, however, relative biological effectiveness (RBE) varies strongly with depth, so RM geometry should be optimized for biological effect rather than physical dose alone. This work presents a translational pathway for biologically optimized 3D RMs (bio-RMs) for carbon ion therapy, evaluated through d …

02.09.2026journal-article

INTERNATIONAL JOURNAL OF APPLIED SCIENCE AND MATHEMATICAL THEORY

Survival Times of Triple-Negative Breast Cancer Patients Based on Treatment Type: A Comparative Nonparametric Survival Analysis

Hindatu Saidu

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer associated with poor prognosis and limited treatment options. Survival outcomes among TNBC patients are known to vary depending on the type of treatment received, making comparative survival evaluation essential for clinical decision-making. This study aimed to assess and compare the survival times of TNBC patients based on different treatment types, including chemotherapy, radiotherapy, surgery, and combination therapy. Survival data fr …

02.09.2026journal-article

PLOS One

MR-based radiomics of mesorectal fat for improved prediction of perirectal lymph node metastasis and extramural venous invasion in locally advanced rectal cancer

Yaniga Swaengdee, Sararas Khongwirotphan, Jaravee Lasode, Phakakarn Kuecharoen, Phathayphout Phetvilay, Thitithep Limvorapitak, Anapat Sanpavat, Sira Sriswasdi, Piyaporn Boonsirikamchai, Yothin Rakvongthai

Objective Accurately assessing residual disease after neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC) remains challenging. Residual extramural venous invasion (EMVI) and perirectal lymph node (PLN) metastasis indicate adverse outcomes, but treatment-related changes obscure their detection on post-treatment MRI. This study developed MRI-based radiomics models to predict residual EMVI and PLN metastasis using post-nCRT restaging MRI. Materials and methods In this retrospective study, 219 …

02.09.2026journal-article

International Journal of Biology and Life Sciences

Pan-cancer Expression Analysis of CXCL1/8/10 and Their Relationship with Prognosis and Tumor Microenvironment

Peng Xie, Zhuizhui Jiao, Tingting Yin

Objective To analyze the expression characteristics and prognostic value of CXCL family members (CXCL1/8/10) across pan-cancer using bioinformatics approaches. Methods Transcriptomic and clinical data of 33 tumor types were obtained from the TCGA database. Differential expression was evaluated by the Wilcoxon rank-sum test. Prognostic significance was assessed using Kaplan-Meier survival curves and univariate Cox regression. Spearman correlation analysis was applied to examine associations with immune subtypes, tum …

02.09.2026journal-article

Academy for Practical Oncology

Synchronous hodgkin lymphoma in monozygotic twins: a case report of ovarian stimulation with aromatase inhibitors and recombinant follicle-stimulating hormone

I. A. Yagovkina, M. V. Kiseleva

Hodgkin lymphoma (HL) is one of the most common malignancies affecting young adults of reproductive age. Given the high long-term survival rates, fertility preservation has become a critical aspect of comprehensive patient care. Alkylating agents (procarbazine, cyclophosphamide), which are included in standard chemotherapy regimens, exhibit the highest gonadotoxic potential. However, cases of synchronous HL in monozygotic twins followed by controlled ovarian stimulation are extremely rare in the literature.Aim. To …

02.09.2026journal-article

Behavioral Sciences

Beyond Invisible: Confronting the Policy and Practice Void in Eating Disorder Prevention and Treatment for Indigenous Peoples in Canada

Katherine Fredrickson, Amelia Austin, Maureen Plante, Kienan Williams, Gina Dimitropoulos, Carolyn Melro

Indigenous populations internationally experience eating disorders (EDs) at similar or higher rates than colonizing majority populations. In Canada, emerging evidence suggests that this is also true among First Nations, Métis, and Inuit (FNMI) populations. However, most existing recommendations and best practices for ED prevention, early intervention, and treatment do not consider unique contextual and cultural factors that are relevant to FNMI Peoples, such as the effects of historical and ongoing colonialism. Thi …

02.09.2026journal-article

Southern African Journal of HIV Medicine

Adherence thresholds of tenofovir diphosphate in dried blood spots for HIV treatment and pre-exposure prophylaxis: A scoping review

Mohammed K. Alghamdi, Mohammed W. Ali, Anel Schoonees, Tamara Kredo, Eric Decloedt, Roland van Rensburg

Background: Tenofovir (TFV) is a key antiretroviral used in HIV pre-exposure prophylaxis (PrEP) and treatment, with efficacy contingent on adherence. Quantifying TFV concentrations in dried blood spots (DBS) as tenofovir diphosphate (TFV-DP) is a robust method for determining long-term adherence. However, standardised TFV-DP adherence thresholds in DBS have not been established. Objectives: To map the existing literature on TFV-DP concentration thresholds in DBS for assessing adherence to TFV-based HIV prevention a …