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European Health Evidence

The European alternative to PubMed

EUVIMED is the European alternative to PubMed: a central, multilingual research platform for medicine, nursing, life sciences and healthcare. It brings together international and European literature sources, study registries, open-access full texts, citations and retraction notices in one search. Unlike pure bibliographic databases, EUVIMED supports the entire research process – from discovery and appraisal with LIVIA and CLARA to traceable evidence synthesis. European in focus, transparent, interoperable and designed for science and healthcare.

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EUVIMED Themenbrowser · Onkologie · Seite 129

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Journal of Computer Assisted Tomography

Association of Imaging-Defined Deep Invasion and Tumor Volume With Clinical Cervical Lymph Node Metastasis in Hypopharyngeal Carcinoma

Hinano Anaba, Yohei Morishita, Ryo Ishii, Takuma Usuzaki, Tomo Kinoshita, Yoshitaka Toyama, Akira Ohkoshi, Yukio Katori, Kei Takase

Objective: Deep tumor invasion is a recognized pathologic risk factor for cervical lymph node metastasis in patients with hypopharyngeal carcinoma, but the relationship between imaging findings of the primary tumor and clinical lymph node metastasis has not been fully defined. In this study, we assessed whether imaging-defined deep invasion and tumor volume are associated with clinical lymph node metastasis. Methods: This retrospective study included 142 consecutive patients with newly diagnosed hypopharyngeal squa …

28.08.2026journal-article

Medicine

Association between thymidine kinase 1 and clinicopathological high-risk features in breast cancer

Yanze Liu, Jiaqi Liu

Thymidine kinase 1 (TK1) is a cell-cycle-regulated enzyme involved in DNA synthesis and is closely linked to tumor cell proliferation. This study investigated whether serum TK1 concentration is associated with clinicopathological high-risk features in breast cancer (BC) and whether TK1 changes after neoadjuvant chemotherapy (NACT). This retrospective single center cohort included 410 patients with invasive BC. Serum TK1 was analyzed according to age, lymph node metastasis (LNM), histological grade, Ki-67, circulati …

28.08.2026journal-article

International Journal of Health Management Review

COLORECTAL CANCER SCREENING STATUS AND ASSOCIATED FACTORS AMONG ADULTS IN CAN THO CITY, VIETNAM

Nguyen Huu Ky Phuong

Objective: To describe colorectal cancer (CRC) screening status and identify associated factors among adults aged 45-74 years in Can Tho City, Vietnam. Methods: This analytical cross-sectional study included 600 participants from 12 clusters. Frequencies, proportions, and adjusted odds ratios (aORs) were estimated using multivariable logistic regression with cluster-adjusted standard errors. Results: Overall, 159 participants (26.5%) were up to date with CRC screening. Among those screened, 59.1% had undergone colo …

28.08.2026journal-article

Annals of Surgical Oncology

Prospective Clinical Trial on Expanding the Eligibility Criteria for Targeted Axillary Dissection after Neoadjuvant Systemic Therapy in Breast Cancers with Advanced Nodal Disease

A. J. T. Lee, B. H. H. Cheung, D. T. K. Suen, A. Kwong

Abstract Background Targeted axillary dissection (TAD) is an established axillary restaging approach in breast cancer after neoadjuvant chemotherapy (NAC), but evidence to date has focused largely on clinical N1 disease with limited nodal involvement. For higher nodal burden patients, axillary dissection (AD) is still frequently performed despite high axillary pathologic complete response (pCR) rates. We hypothesized that TAD is noninferior to AD for nodal staging in patients with advanced nodal disease. Patients a …

28.08.2026journal-article

Metals

Effects of Lattice Architecture, Nominal Feature Size and Heat Treatment on the Tensile Behavior of L-PBF-Fabricated Inconel 718 Lattice Structures

Melih Canlıdinç

Laser powder bed fusion (L-PBF)-fabricated Inconel 718 lattice structures offer considerable potential for lightweight load-bearing applications, but their mechanical integrity depends on architecture, geometric scale, manufacturing defects, and post-processing condition. This study examined the combined effects of Diamond, Gyroid, and Octet architectures, nominal feature sizes of 1.0, 1.25, and 1.5 mm, and four heat-treatment conditions on tensile behavior and fracture characteristics. The specimens were evaluated …

28.08.2026journal-article

International Journal of Molecular Sciences

Longitudinal In Vivo Imaging at Single-Lesion Resolution Identifies Allele-Associated Response and Resistance Dynamics in EGFR-Mutant Lung Cancer

Eva Cabrera San Millan, Daniele Panetta, Paolo Armanetti, Mauro Quaglierini, Alessandro Zega, Raffaella Mercatelli, Emilia Bramanti, Luca Menichetti, Giorgia Maroni, Elena Levantini

Acquired resistance to targeted therapies is inevitable in EGFR-mutant non-small cell lung cancer (NSCLC), yet the principles governing its emergence in vivo remain incompletely understood. In particular, how lesion-level response patterns vary across distinct EGFR allele contexts during therapy has not been systematically examined at single-lesion resolution. Here, we establish a longitudinal in vivo imaging platform enabling single-lesion resolution tracking of tumor behavior during therapy in genetically enginee …

28.08.2026journal-article

International Journal of Social Sciences and Public Administration

Exploration on Practical Applications of Artificial Intelligence in the Field of Precision Oncology

Xinyu Meng

Precision oncology is a new model for cancer treatment that will no longer use traditional all-or-nothing methods but rather tailor treatments to specific changes in genes and other factors that cause cancer in different people. As the number of dimensions in biomedical data has been rising, more powerful computing facilities are needed to process such a large amount of data. Systematically explore the applications of artificial intelligence in the field of precision oncology in this paper. Research has been conduc …

28.08.2026journal-article

Malignant tumours

Induction chemo-immunotherapy followed by surgery or radiotherapy for locally-advanced III stage non-small cell lung cancer: prospective single center non-randomized study (preliminary results)

Y. S. Esakov, O. A. Kuchevskaya, I. A. Pokataev, M. A. Lyadova, E. S. Kuzmina, V. G. Shatalov, E. A. Kulikova, L. A. Efteev, Z. G. Tukvadze, S. A. Samsonik, V. N. Galkin

Background. The evolving modalities of systemic treatment for non-small cell lung cancer (NSCLC) promotes the need to redefine different strategies for combined treatment in stage III and borderline-resectable lung cancer. Hereby we present the outcomes of a neoadjuvant chemo-immunotherapy regimen with subsequent individualized local control strategy of patients with locally advanced NSCLC. Materials. Prospective, single-center, non-randomized observational study enrolled patients with the following criteria: age > …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Antibacterial resistance in dermatology: a modern perspective on the problem and the place of amoxicillin/clavulanic acid in the treatment of bacterial skin infections

E.V. Svechnikova, S.E. Zhufina

Introduction. The problem of microbial resistance to antibacterial drugs is becoming increasingly pressing each year and poses a global threat to public health. In dermatological practice, systemic antibiotics are widely used for both skin and soft tissue infections and chronic inflammatory dermatoses (acne, rosacea, hidradenitis suppurativa), which increases the risk of resistant strain selection and microbiome disruption. Objective. To analyze current literature data and our own clinical observations, as well as …

28.08.2026journal-article

ULAKES JOURNAL OF MEDICINE

NUTRIÇÃO E CÂNCER: UMA REVISÃO NARRATIVA

Diogo Boreski, Daniela Cardoso Umbelino Cavallini

As alterações nutricionais relacionadas ao câncer abrangem redução da ingestão alimentar, perda involuntária de peso, diminuição da massa e da força muscular, inflamação sistêmica e distúrbios metabólicos. Embora frequentemente coexistam, desnutrição, sarcopenia e caquexia não são termos equivalentes e exigem avaliação própria. O objetivo deste trabalho foi realizar uma revisão narrativa, apresentando as informações mais recentes acerca das definições, mecanismos da deterioração nutricional nos pacientes com câncer …

28.08.2026journal-article

Frontiers in Nutrition

The role of nutritional status and sarcopenia in treatment tolerance and toxicity in head and neck cancer: a narrative review

Ana Cebrián-Vázquez, Agustín Ramos-Prol, Erika Vieira-Maroun, María Argente-Pla, Juan Francisco Merino-Torres

Introduction Malnutrition, sarcopenia, and adverse body-composition phenotypes are highly prevalent in patients with head and neck cancer (HNC) and have been increasingly recognized as clinically relevant predictors of treatment tolerance, treatment-related toxicity, and oncologic outcomes. Morphofunctional assessment has emerged as a comprehensive approach for evaluating nutritional and functional status beyond conventional anthropometric measures. Methods A narrative review was conducted using a structured litera …

28.08.2026journal-article

International Journal of Innovative Technologies in Social Science

IMPACT OF OPIOID DEPRESCRIBING AND TAPERING ON MENTAL HEALTH AND SOCIAL FUNCTIONING IN PATIENTS WITH CHRONIC NON – CANCER PAIN: AN OVERVIEW OF CURRENT EVIDENCE

Mateusz Wnęk, Michał Adam Łebek, Wiktoria Zofia Komornik, Jakub Jan Piec, Damian Grębosz, Wojciech Kukiełka, Bartłomiej Andrzej Sałapski, Dominika Weronika Brożyna, Jarosław Dudek, Jakub Dawid Gałwiaczek

Background. Long-term opioid therapy for chronic non-cancer pain is associated with numerous adverse effects, including psychological distress, dependence, and impaired functioning. In response to growing concerns about opioid-related harms, opioid deprescribing and tapering strategies have gained increasing attention in clinical practice. However, their impact on patients’ mental health and social functioning remains incompletely understood. Aim. This review aimed to evaluate the available evidence on the effects …

28.08.2026journal-article

Health Promotion Practice

Effectiveness of Social Cognitive Theory–Based Oral Cancer Awareness Module Among Adolescents: An Interventional Study

Tejaswini B. Darukaradhya, Shwetha Kanyaloor Mallikarjuna, Pushpanjali Krishnappa, Anju James

Oral cancer remains a significant public health challenge, particularly in India, where it accounts for a substantial global burden. Despite its preventability, awareness levels among adolescents remain low. Schools provide an ideal platform for health education interventions, yet traditional approaches often fail to yield lasting behavioural change. This study aimed to evaluate the effectiveness of a social cognitive theory (SCT)-based oral cancer awareness module in enhancing adolescents’ knowledge and self-effic …

28.08.2026journal-article

Cancers

Evaluating the Prognostic Relevance of Pre-Treatment Epstein–Barr Virus Levels in Non-Endemic Pediatric Nasopharyngeal Carcinoma

Ahmed Farrag, Yanbo Yang, Jin Piao, Lindsay Younis, Hans-Joachim Wagner, Hans Christiansen, Tristan Römer, Allison Poore, Christopher Szot, Nadia Thibeau, Sue S. Yom, Benjamin A. Pinsky, Quynh-Thu Le, Junne Kamihara, David T. Ting, Theodore W. Laetsch, Kenneth S. Chen, Carlos Rodriguez-Galindo, Randall T. Hayden, Udo Kontny, Robyn D. Gartrell

Background/Objectives: Pediatric nasopharyngeal carcinoma (NPC) is a very rare childhood cancer strongly associated with Epstein–Barr virus (EBV) infection. We investigated the prognostic value of EBV DNA on staging and outcome in pediatric NPC from two large study centers, the Children’s Oncology Group (COG) in North America and the German Society of Pediatric Oncology and Hematology (GPOH) in Europe. Methods: Samples collected from NPC patients treated on the COG study ARAR0331 between 2006 and 2012 and the GPOH …

28.08.2026journal-article

Cancer

Racial differences in multiple myeloma survival: Associations with stem cell transplantation, insurance, and Medicaid expansion

F. Lennie Wong, Scott R. Goldsmith, Kimlin Ashing, Amrita Krishnan, Michael A. Rosenzweig, Saro H. Armenian

ABSTRACT Background At the population level, Black patients with multiple myeloma (MM) may experience worse survival than White patients. The authors examined how autologous stem cell transplantation (ASCT), insurance, and Medicaid expansion relate to racial differences in real‐world overall survival (rwOS). Methods Data from 4932 patients with MM (24% Black) in the Flatiron Health Research Database were analyzed using Cox regression (rwOS), Fine and Gray competing‐risk models (ASCT), and polytomous regression (ins …

28.08.2026journal-article

Frontiers in Medicine

Clinical efficacy of Masquelet technique in the treatment of tibial and fibular bone defects caused by severe gunshot wounds

Qiming Sun, Yingjie Cong, Wei Sun, Xinwei Liu, Baolei Guo, Chunli Zhao, Baoxian Hou, Ye Liu, Dapeng Zhou

Objective To explore the clinical efficacy of the Masquelet technique in the treatment of tibial and fibular bone defects resulting from severe gunshot wounds. Methods A retrospective analysis was conducted on six male patients (mean age, 23 ± 5 years; range, 18 to 33 years) with tibial and fibular bone defects resulting from gunshot wounds, treated with the Masquelet technique between January 2022 and January 2024. In Stage 1, blood transfusions and fluid resuscitation were administered to manage shock. Wound debr …

28.08.2026journal-article

Frontiers in Oncology

Incidence and risk factors for catheter-related thrombosis in elderly patients with malignant tumors: a single-center retrospective cohort study

Yanli Wang, Xiaoli Mei, He Liu, Fuqiu Tang

Background Peripherally inserted central catheters (PICCs) are widely used in hospitalized patients with cancer for chemotherapy, nutritional support, and routine medication infusion. Catheter-related venous thrombosis (CRT) is a severe complication that is associated with poor prognosis, especially among elderly patients with cancer. However, studies on the identification of risk factors for CRT in elderly patients with cancer are limited. Methods From June 2024 to May 2025, clinical data from hospitalized elderly …

28.08.2026journal-article

Diagnostics

Stratified Analysis of Patients Within the PSA Gray Zone (4–10 ng/mL) and Its Clinical Application Value: Development of a Predictive Model for Clinically Significant Prostate Cancer Using Quantitative Indicators of PSA, ADC, and Relative T2 Value

Pan Hao, Tong Zhu, Ruiqiang Xin, Xiaoyong Lv

Objective: Patients with prostate-specific antigen (PSA) levels in the 4–10 ng/mL gray zone present a diagnostic challenge, as PSA alone cannot reliably distinguish clinically significant prostate cancer (csPCa) from benign conditions or indolent disease, potentially leading to unnecessary biopsies or missed clinically significant disease. This study aimed to develop a risk prediction model for csPCa in this population using clinical indicators and magnetic resonance imaging (MRI) quantitative data, and to evaluate …

28.08.2026journal-article

Koloproktologia

Local excision of a residual tumor after neoadjuvant chemoradiotherapy for rectal cancer (a systematic review and meta-analysis of comparative studies)

V. V. Cherepahina, M. V. Alekseev, E. G. Rybakov, M. A. Ignatenko, Yu. A. Shelygin

B ACKGROUND: the optimal treatment strategy for patients with rectal cancer who achieve a complete or nearcomplete clinical response after neoadjuvant chemoradiotherapy is challenging. AIM: to assess oncological outcomes after neoadjuvant chemoradiotherapy followed by total mesorectumectomy (TME) or local excision of residual rectal tumor (TEM). MA TERIALS AND METHODS: a systematic review and meta-analysis were done according to the PRISMA 2020 guidelines. A literature search included PubMed, MEDLINE, and e-library …

28.08.2026journal-article

Journal of Endovascular Therapy

Endovascular Aspiration Thrombectomy of the Superior Mesenteric Artery for Treatment of Acute Mesenteric Ischemia: Results From the ENDO-SMA2MI Registry

Mario D’Oria, Sandro Lepidi, Paolo Spath, Mauro Gargiulo, Ciro Ferrer, Gioele Simonte, Stefano Gennai, Francesco Giurazza, Anna Maria Ierardi, Diego Visconti, Reinhold Perkmann, Raffaello Bellosta, Nicolò De Manzini, Cristiano Calvagna, Alan Biloslavo

Background/Objective. Acute mesenteric ischaemia (AMI) is a multidisciplinary emergency, requiring the involvement of different medical specialties for successful management. Endovascular aspiration thrombectomy (EAT) has entered the field leading to the possibility of treating acute arterial occlusions with a minimally invasive approach. The aim of the study was to provide contemporary data on results after use of EAT in AMI patients. Methods. The study was a retrospective, observational, multicentre study conduct …

28.08.2026journal-article

Journal of Health Psychology

Lived experiences, adherence, and transformation in patients with treatment-resistant depression undergoing transcranial magnetic stimulation (TMS): An interpretative phenomenological study

Margit Julia Guerra Ayala, Marcelo Pablo Aramayo Zamalloa, María del Rosario Ccahuana Ranilla, Lucero Isabel Vílchez Herencia, Miguel David Sánchez Fernández

Treatment-resistant depression (TRD) poses a critical challenge, particularly where conventional treatments fail. Transcranial magnetic stimulation (TMS) has shown clinical efficacy, yet little is known about how patients in Peruvian contexts perceive this intervention. This study explored patients’ lived experiences of TMS, emphasising how adherence, acceptance, and perceived efficacy were shaped by subjective, relational, and contextual factors. Using Interpretative Phenomenological Analysis (IPA), five women age …

28.08.2026journal-article

International Journal of Cancer

Estimation of Subtype‐Specific Tumour Growth Rate Distributions and Interval Cancer Proportions in Breast Cancer Using Biology‐Inspired Natural History Models

Letizia Orsini, Yuqi Zhang, Kamila Czene, Keith Humphreys

ABSTRACT Breast cancer progression varies across molecular subtypes, influencing detection rates and prognosis. Differences in the proportion of interval cancers (PIC)—cancers detected symptomatically between scheduled screening rounds—have been observed across subtypes, likely reflecting heterogeneity in tumour growth dynamics. We applied a continuous‐growth natural history model to a cohort of 7818 breast cancer patients diagnosed between 2007 and 2020 in Sweden. Using subtype‐specific estimates, we quantified th …

28.08.2026journal-article

Medicina

Clinical and Dermoscopic Determinants of Surgical Decision-Making in Skin Cancer Screening: A Retrospective Analysis

Adrian Chwojnicki, Sebastian Makuch, Hanna Adamska, Michalina Świetlicka, Maja Hrynczyszyn, Inga Buława, Paulina Piesch, Jacek Polański, Wojciech Tański

Background and Objectives: Deciding which pigmented or non-pigmented skin lesions require surgical excision, as opposed to continued observation, is a common challenge in everyday dermatologic practice. Although dermoscopy is well established as a tool that improves melanoma detection accuracy compared with naked-eye examination, real-world evidence on how demographic profile, patient history, and dermoscopic impression jointly influence the surgical decision remains limited. This study examined the clinical and de …