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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
18.08.2026journal-article

Frontiers in Digital Health

Digitization of rehabilitation evaluation and activity monitoring using thermography: protocol for a mixed-methods randomized multiple baseline study in inpatient rehabilitation

Ravi Shankar, Karen Chua, Rathi Ratha Krishnan, Shuen-Loong Tham, Llewelyn Yi Chang Tan, Aletheia Lai, Megan Si En Lau, Zhi Kai Koh, Ernest Thia, Yating Su, Srinikethan Madapuzi Srinivasan, Poo Lee Ong

Background Patients in inpatient rehabilitation spend significant time of their day in sedentary activities, limiting recovery potential. Current monitoring relies on manual, intermittent nursing observations that are labor-intensive and produce fragmented data. Thermography-based artificial intelligence (AI) monitoring offers a privacy-preserving, continuous alternative; however, its impact on rehabilitation engagement when combined with patient-facing feedback has not been rigorously evaluated. Conventional pre-p …

18.08.2026journal-article

Frontiers in Reproductive Health

Fertility counseling experiences and perceived gaps in provider support among people living with HIV: a qualitative study from an antiretroviral therapy clinic in Ghana

Victor Luckyboy Dzramado, Priscilla Asantewaa Boadi

Introduction Antiretroviral therapy (ART) has made safer childbearing achievable for people living with HIV (PLHIV), and the reproductive health counseling PLHIV receive within HIV care shapes whether they can act safely on their fertility intentions. This study explored, from the perspective of PLHIV themselves, how the reproductive counseling they reported receiving shaped their fertility decision making, and which aspects of counseling support they perceived to be missing. Methods A qualitative descriptive desig …

18.08.2026journal-article

Stem Cells Translational Medicine

Exosome therapy for knee osteoarthritis: a network meta-analysis based on rat models

Yixiang Zhao, Haochuan You, Xiuyuan Wang, Xiping Dou, Jiangying Zhang, Yuzhe He, Lei Chen, Fei Huang, Yayi Xia

Abstract Objective To compare the therapeutic effects of exosomes from different cell sources and doses in rat knee osteoarthritis models using network meta-analysis, and to identify potential optimal strategies for preclinical optimization and clinical hypothesis generation. Methods A systematic search of PubMed, Web of Science, Embase, and Scopus identified 27 eligible randomized controlled trials (456 rats). Traditional random-effects meta-analysis and frequentist network meta-analysis were conducted. Treatments …

18.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Attitudes towards artificial intelligence among students and faculty staff at Kuwait University's Health Science Centre: A cross-sectional study

Hamad AlHamad, Ahmad Alenezi, Musaed Z. Alnaser, Dalal Almutairi, Fatemah AlObaid, Sara AlHarban, Sara AlRasheed

Background Artificial intelligence (AI) is increasingly integrated into healthcare and health-professions education. While it may improve efficiency, decision support, and learning, it also raises concerns about workforce impacts, safety, privacy, and accountability. Gulf-region evidence on how students and faculty perceive AI across disciplines within a single health science center remains limited. Objective To assess attitudes toward AI among health-sciences students and faculty and examine demographic factors as …

18.08.2026journal-article

Theoretical and Natural Science

A Literature Review of Recent Advances in Cell Therapy for Diabetes Mellitus

Ziqi Li

With the rising global prevalence of obesity and population aging, the number of patients with diabetes mellitus, a common chronic metabolic disorder, keeps rising and imposes mounting pressure on clinical medical services. Although current pharmacological interventions and insulin replacement therapy can effectively control blood glucose levels, they cannot fundamentally repair the functional defects of pancreatic islet β-cells, nor can they cure the disease. Under these circumstances, cell-based therapy has gradu …

18.08.2026journal-article

PAIN, JOINTS, SPINE

Assessment of Spirulina Gel Prepared by Different Extraction Methods as an Adjunctive Therapy to Mechanical Debridement in the Treatment of Stage II Periodontitis: A Randomized Clinical Trial

Faisal Mohammed M Alsharif, Nancy Hussein, Noha F. Ghazi, George Bebawy, Nermin Ali Mohamed Alamer, Mohamed Mahmoud Anees

Objective: To evaluate the clinical and biochemical effects of locally delivered spirulina gels prepared by different extraction methods as adjuncts to mechanical debridement in stage II periodontitis.Materials and methods: Seventy-five participants were included: 15 periodontally healthy negative controls and 60 participants with periodontitis who were randomized in a 1:1:1:1 ratio to the positive control, phosphate-buffered saline (PBS), 2% calcium chloride (CaCl₂), or ethanol groups (n=15 each). The clinical out …

18.08.2026journal-article

International Journal of Ophthalmology

Changes of pupil parameters and visual quality after cataract surgery as well as their correlation

Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China; NHC Key Laboratory of Myopia and Related Eye Diseases, Shanghai 200031, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, China, Fan Yang, Pei-Min Lin, Ming-Yang Wang, Department of Ophthalmology, Shanghai Tenth People’s Hospital, Shanghai 200072, China; Visual Rehabilitation Center, Tongji University School of Medicine, Shanghai 200072, China; Tongji Eye Institute, Tongji University School of Medicine, Shanghai 200072, China, Tian-Yu Zheng

AIM: To compare the changes of pupil parameters and visual quality after cataract surgery and explore their potential correlations. METHODS: This retrospective cohort study analyzed clinical data of Han Chinese patients who received cataract surgery from June 2016 to October 2016. Visual acuity, pupil size, pupil shift, wavefront aberrations, point spread function (PSF), and modulation transfer function (MTF) were detected preoperatively, 1d and 1mo postoperatively. Pupil parameters and visual outcomes were compare …

18.08.2026journal-article

Water

Influence of Natural Waters on the Leaching of Sewer Rehabilitation Resins

Konstantin Roman Ahrens, Reiner Gschwendtner, Anya Vollpracht

The leaching behavior of bisphenol A (BPA) remains a significant environmental concern. Despite EU regulatory restrictions and the World Health Organization (WHO) establishing precautionary values for human exposure to this monomer, BPA is still widely used in polymer-based products, including materials for sewer rehabilitation. Standard leaching assessments typically employ deionized water, although natural waters represent actual field conditions. This study investigates the release of BPA and its substitute, bis …

18.08.2026journal-article

Muscles, Ligaments and Tendons Journal

Rehabilitation Approaches After Meniscal Allograft Transplantation: A Systematic Review

Erva Nur Sagirli, Tugce Poyraz Isleyen

Purpose: This study aimed to (i) evaluate long-term outcomes after meniscal allograft transplantation (MAT), and (ii) review current rehabilitation protocols, including immobilization, weight-bearing, range of motion (ROM) progression, and return-to-sport timing. Methods: A systematic search of databases was conducted for articles published between January 2019 and April 2025 using the terms “meniscus transplantation OR meniscus allograft transplant” AND “rehabilitation OR physiotherapy OR physical therapy.” Result …

18.08.2026journal-article

Clinical Rehabilitation

Development and external validation of quality indicators for Neurorehabilitation Units: The REHABest Delphi study

Jacobo Formigo-Couceiro, Clara Pérez-Esteve, José María Climent-Barberá, Carlos Cordero-García, Raquel Cutillas-Ruiz, Esther Duarte, Francisco Javier Juan-García, María Lourdes López De Munaín, Rosa Martín-Mourelle, Antonio Montoto-Marqués, Serafín Rodríguez-Palero, Pedro Ignacio Tejada-Ezquerro, Emilio Ignacio-García, Helena Bascuñana-Ambrós

Objective To develop a consensus-based framework of quality indicators for Neurorehabilitation Units. Design Delphi consensus study with two-phase external validation. Setting Expert consultation and external validation were conducted through online questionnaires. Participants Twelve neurorehabilitation experts participated in the Delphi process. External validation involved 63 independent specialists and a multidisciplinary panel of nine professionals. Intervention Development of quality indicators through a thre …

18.08.2026journal-article

Multimedia Tools and Applications

Efficient speech denoising using CleanUNet optimized with Mamba and hybrid spectral loss

Matheus Vieira da Silva, João Fernando Mari, André Ricardo Backes

Abstract Speech enhancement aims to recover clean speech from signals degraded by noise and adverse acoustic conditions, such as background interference and echo. CleanUNet has emerged as an effective solution for causal speech denoising, but its high computational demands limit deployment on resource-constrained devices. In this work, we propose an optimized version of CleanUNet that significantly reduces model complexity while maintaining competitive performance. We replace the original Transformer bottleneck wit …

18.08.2026journal-article

Frontiers in Public Health

Exploring the occupational protection potential of an intravenous compounding robot across the cytotoxic drug workflow

Jing Sun, Bing Liu, Zhiqing Li, Ruoyu Hu, Shujuan Bai

Objective To evaluate an intravenous compounding robot's occupational protection across the full workflow (compounding, packaging, administration) by measuring cytotoxic drug residues, and to assess its cleaning protocol and cross-contamination risk for subsequent non-cytotoxic drug compounding. Methods (1)Questionnaire survey: Cytotoxic drug handlers at various workflow stages were surveyed for occupational protection and awareness. (2) Experimental study: Cyclophosphamide and fluorouracil were selected for a 3-da …

18.08.2026journal-article

Frontiers in Pharmacology

Case Report: Lorlatinib combined with chemotherapy and anti-angiogenic therapy shows promising efficacy in an ALK gene fusion lung adenocarcinoma patient with iruplinalkib resistance

Mengqing Cao, Shumin Li, Linfeng Cao, Feng Tao, Na Li

Background The Echinoderm microtubule-associated protein-like 4 (EML4) - Anaplastic lymphoma kinase (ALK) gene fusion represents a significant driver mutation in non-small cell lung cancer (NSCLC). Among the over 20 identified EML4-ALK variant subtypes, the V5' variant occurs relatively infrequently, constituting merely 4% of cases. Currently, the clinicopathological features and prognostic implications associated with this particular variant remain poorly characterized in the literature. Case summary We report the …

18.08.2026journal-article

Frontiers in Pharmacology

From toxicity to signal: positioning symptom clusters as pharmacodynamic indicators in ICI therapy

Yufang Ding, ChunWang Hua, Miao Rao, Cailin Ma, Qiuxia Zhong, Ping Gan, Guihua Hang

Immune checkpoint inhibitors (ICIs) have enhanced the treatment of cancer, but their clinical effect is usually limited by immune-related adverse events (irAEs). Currently, it is recognized that these toxicities are not merely common side effects. Rather, they are a set of complicated symptoms caused by different cytokine networks with different occurrences, progress and affected organ systems. Therefore, We propose that symptom assessment should not be limited to safety monitoring. Symptom complexes should be rega …

18.08.2026journal-article

Journal of Complementary and Alternative Medical Research

Massage Therapy in Naturopathic Practice: A Critical Narrative Review of Mechanistic Rationale, Clinical Evidence and Conceptual Coherence

B. V. Bhoomika, Siddappa Naragatti

Massage is among the oldest and most widely recognised components of naturopathic physical medicine, yet its position within the discipline has become unsettled. Naturopathic philosophy justifies manual therapy through claims about circulation, elimination, nervous regulation and the stimulation of self-healing capacity, whereas the contemporary evidence base evaluates massage as an isolated modality tested against pain, anxiety and function in narrowly defined populations. This review examines that divergence. Its …

18.08.2026journal-article

Human Gene Therapy

Perivascular Astrocytic Gliosis Induced by Retinal Gene Therapy

Maram E.A. Abdalla Elsayed, Immanuel Philipp Seitz, M. Dominik Fischer, Robert E. MacLaren

This retrospective follow-on study reviewed 25 consecutive patients with genetically confirmed choroideremia who were treated with subretinal AAV2-CAG-REP1 in dose-escalation gene therapy clinical trials conducted at Oxford University Hospitals NHS Foundation Trust and the University Eye Hospital Tübingen. Six patients in Oxford received 10 10 vector genomes in 100 µL, while a further 19 patients across both centers received 10 11 vector genomes in 100 µL. Although the primary safety outcomes of both investigator-l …

18.08.2026journal-article

ACS Applied Materials & Interfaces

Engineered Long-Acting Mild Hyperthermia Microneedle Patches for Personalized Therapy of Infected Diabetic Wounds

Xinmei Zhang, Miao Zhang, Fangyuan Li, Wenjie Yang, Haoyue Wang, Yuemin Wang, Jie Weng, Jianshu Li, Xingyu Chen

Abstract The clinical treatment of chronically infected wounds faces multiple challenges, including antibiotic resistance, imprecise thermal control, and frequent dressing changes that hinder healing. Herein, we developed a multifunctional mild hyperthermic microneedle patch (GPD-NAS@PDA MN) based on the reversible phase-transition characteristics of lower critical solution temperature (LCST) thermoresponsive polymers, enabling single-application administration and precise long-term temperature regulation. Under ne …

18.08.2026journal-article

Medicina

Impact of COVID-19 Vaccination on Patients with Non-Small Cell Lung Cancer Receiving First-Line Immune Checkpoint Inhibitor Therapy: Real-World Evidence from Romania

Valeriu Gheorghiță, Horia Teodor Cotan, Adriana Pistol, Cristina Maria Orlov-Slavu, Elena Tianu, Alexandra Teodora Lazar, Miruna Stanciu, Indira Radoi, Laura Mitroi, Cornelia Nițipir

Background: The interaction between COVID-19 vaccination and immune checkpoint inhibitor (ICI) therapy in advanced non-small cell lung cancer (NSCLC) remains incompletely characterized. Methods: Retrospective cohort study of 139 patients with stage IV NSCLC treated with first-line ICI-based therapy, stratified by vaccination status and total doses received (0–1 vs. ≥2). Progression-free (PFS) and overall survival (OS) were analyzed by Kaplan–Meier and Cox regression; logistic regression explored factors associated …

18.08.2026journal-article

International Journal of Ophthalmology

Guidelines for visual cognitive rehabilitation of visual information processing disorders (2025)

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai 200080, China, Yi Shao, Chun-Nan Zhang, Southeast Vision and Ophthalmology Institute, Fuzhou Southeast Eye Hospital, Fuzhou 350004, Fujian Province, China

Visual information processing (VIP) is essential for perception and cognition. It enables the brain to acquire and integrate visual stimuli into coherent representations. Visual information processing disorder (VIPD) is characterized by impairments in visuospatial ability, visual analysis, and visuomotor integration. These deficits significantly affect daily activities, learning, and occupational performance. The etiology of these disorders is multifaceted, including developmental anomalies, traumatic brain injurie …

18.08.2026journal-article

International Journal of Ophthalmology

Medium-dose intravenous methylprednisolone pulse therapy for thyroid-associated orbitopathy

Bangladesh Eye Hospital, Zigatola Ltd., Dhaka 1209, Bangladesh, Ashfaque Rahman Khan, Riffat Rashid, Department of Oculoplasty, Ispahani Islamia Eye Institute and Hospital, Dhaka 1215, Bangladesh, Farzana Afzal, Syeed Mehbub Ul Kadir, Department of Oculoplasty, National Institute of Ophthalmology & Hospital, Dhaka 1207, Bangladesh

AIM: To evaluate the efficacy and safety of a medium-dose intravenous methylprednisolone (IVMP) pulse regimen for moderate-to-severe active thyroid-associated orbitopathy (TAO), with change in clinical activity score (CAS) as the primary outcome. METHODS: This prospective interventional study was conducted at a tertiary eye care center in Bangladesh between February and November 2022. Patients with active moderate-to-severe TAO (CAS≥3) received IVMP totaling 4.0 g (500 mg daily for 3 consecutive days, followed by 5 …

18.08.2026journal-article

Frontiers in Medicine

Systematic review and meta-analysis of physical rehabilitation on functional recovery in critically ill patients

Gang Wang, Xinghua Li, Linlin Fan, Li Lin, Zhiguo Yu, Qing Fang, Weihua Lu

Purpose Survivors of critical illness frequently experience persistent physical impairment, particularly ICU-acquired weakness (ICU-AW), which contributes to prolonged disability after intensive care. We conducted a systematic review and meta-analysis to evaluate the effects of physical rehabilitation on muscle strength, physical function, health-related quality of life, and clinical outcomes in critically ill adults. Methods Four electronic databases were searched from inception to March 2026. Randomized controlle …

18.08.2026journal-article

Neurology, Neuropsychiatry, Psychosomatics

The effect of cyclobenzaprine therapy on the recovery of daily activities and work capacity in patients with non-specific back and neck pain in real-world clinical practice

D. O. Rozhkov, P. M. Asadullaeva, O. V. Burenkova, Yu. M. Vorontsova, V. V. Galkin, M. N. Dadasheva, I. A. Zhukova, N. G. Zhukova, K. S. Manko, D. V. Milchakov, E. B. Natarova, D. V. Semenchenko, V. Yu. Sokolova, A. P. Solovyov, V. V. Sharykin

Objective: to assess the impact of cyclobenzaprine therapy in real-world clinical practice on the severity of pain, functional capacity and the time taken to return to work in patients with non-specific back and neck pain, as well as to evaluate the drug's safety profile. Material and methods. The multicentre study included 997 patients (full analysis set, FAS) aged 18 years or older, of whom 976 completed the study according to protocol – per-protocol (PP) population. Patients received Reloprim (cyclobenzaprine) a …

18.08.2026journal-article

Advances in Computer and Materials Scienc Research

Research on the Objective and Subjective Evaluation Methods of Speech Quality Driven by Feature Fusion

Pengzhen Yang, Tao Qi, Xin Lv

Aiming at the problem of inaccurate speech quality evaluation caused by the previous subjective evaluation-dominated and insufficient coverage of objective evaluation indicators in military communication equipment speech testing, this paper proposes a subjective and objective comprehensive evaluation method based on feature fusion. It focuses on extracting feature parameters such as range, variance, skewness, and kurtosis to characterize the transmission characteristics of speech signals. Through the automatic extr …

18.08.2026journal-article

HAND

Self-Management Exercise Regimen Versus Supervised Hand Therapy in Patients With Dorsal Dislocation or Hyperextension Injury With a Volar Plate Avulsion of the Proximal Interphalangeal Joint: The Randomized Controlled PINOT Study

Dorien A. Salentijn, Priscilla Jawahier, Marit van Barreveld, Tosca Vrolijk-van Hengel, Niels Schep, Marcel G. W. Dijkgraaf, Mark van Heijl, Ruben N. van Veen

Background: Supervised hand therapy (SHT) with early mobilization is recommended for patients with a stable, congruent proximal interphalangeal (PIP) joint after dorsal dislocation or hyperextension injury with a volar plate avulsion. Early mobilization uses a dorsal block splint. A self-management exercise regimen (SMER) may offer a valuable alternative that reduces demand on therapists. We hypothesized that SMER is noninferior to SHT. Methods: Noninferiority was assessed in adult patients in a multicenter, open r …