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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
18.08.2026journal-article

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH

Impact of Rational Emotive Behavior Therapy and Cognitive Behavioral Therapy on Drug Abuse Reduction Among NDLEA Rehabilitation Clients in Abuja, Nigeria

Fatima Abiola Popoola

Drug abuse remains a significant public health and psychosocial challenge globally, with Nigeria experiencing an increasing burden, particularly among youths and young adults. The growing prevalence of substance use disorders has necessitated the adoption of evidence-based psychological interventions to enhance rehabilitation outcomes. This study investigated the impact of Rational Emotive Behavior Therapy (REBT) and Cognitive Behavioral Therapy (CBT) on drug abuse reduction among clients in National Drug Law Enfor …

18.08.2026journal-article

Rehabilitation Oncology

Aquatic Exercise for Pain Intensity and Mechanical Pain Sensitivity in Women Surviving Breast Cancer: Systematic Review and Meta-Analysis

Victor Hugo G. Pinheiro, Tania Angelita I. Guesser, Antonio I. Cuesta-Vargas, Cristine L. Alberton

Background: Persistent pain after breast cancer treatment may involve self-reported pain intensity and mechanical pain sensitivity (MPS). Previous reviews of aquatic exercise in women surviving breast cancer mainly synthesized broad rehabilitation outcomes. This review aimed to evaluate the effects of structured aquatic exercise interventions on pain intensity and MPS in this population. Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidance, five databases were searched from …

18.08.2026journal-article

PLOS Computational Biology

Reassessing adult surfactant replacement therapy with mechanics-informed reinforcement learning

Philippe Meliga, Gregor Roncin, Alejandro Yepes Peñaranda, Elie Hachem

Surfactant replacement therapy (SRT) remains clinically limited to neonatal applications, in part because the mechanical feasibility of achieving efficient delivery in adult lungs is poorly understood. Previous computational studies have largely been descriptive or based on parameter sweeps, providing limited guidance on how to design efficient adult protocols under anatomical constraints. Here, we introduce a computational framework that integrates mechanistic modeling of surfactant propagation in anatomically mot …

18.08.2026journal-article

Journal of Back and Musculoskeletal Rehabilitation

Focused shock wave versus radial pressure wave therapy for musculoskeletal disorders: A systematic review and meta-analysis

Mariam Ismail Hassan, Ahmed Ibrahim Abdelhamed, Tasbih Emad, Mariam Hesham Sallam, Haidy Samy, Hadel Hesham Elkhodary, Mazen Mohamed Sayed

Background Focused shock wave therapy (FSWT) and radial pressure wave therapy (RPWT) are commonly used noninvasive modalities for managing musculoskeletal disorders (MSKDs), yet their distinct physical properties and inconsistent evidence make it unclear which modality provides better outcomes. Objective To compare the FSWT with the RPWT in terms of pain, function, strength, and range of motion (ROM) in patients with MSKDs. Methods We searched PubMed, the Cochrane Central Register of Controlled Trials, Web of Scien …

18.08.2026journal-article

International Journal of Sports Medicine

Metabolic and Arterial Stiffness Correlates of Aerobic Capacity in Male Occupational Personnel

Yuhang Liu, Michael J Conner, J Jay Dawes, Steve E Martin, Drew E Gonzalez, Richard B Kreider

To examine associations between body composition, physical performance, and inflammatory/oxidative stress biomarkers with aerobic capacity, indexed by VO₂peak, among tactical personnel, and to develop predictive models for health, performance, and readiness assessment. Complete case data were available for 102 occupational personnel. Variance inflation factors assessed multicollinearity. Linear models tested associations with VO₂peak, while generalized additive models explored nonlinear relationships. A 10-fold cro …

18.08.2026journal-article

Occupational and Environmental Medicine

Sleep disturbances and sleep duration as predictors of working life expectancy among adults aged 50 years and older in Finland

Saana Myllyntausta, Katriina Heikkilä, Jaana Pentti, Holendro Singh Chungkham, Sakari Suominen, Mika Kivimaki, Jussi Vahtera, Paola Zaninotto, Jenni Ervasti, Sari Stenholm

Objectives To examine the associations of sleep disturbances and sleep duration with working life expectancy (WLE; the estimated number of years an individual is expected to be in the workforce) from age 50 to 68. Methods Data of individuals ≥50 years were drawn from two cohort studies: the Finnish Public Sector (FPS) study involving public sector employees in 2000–2016 (n=70 339, 80% women) and the Health and Social Support (HeSSup) study in 1998–2013 initially representing the general working age population in Fi …

18.08.2026journal-article

JMIR Medical Education

Multiagent Large Language Model Framework for Psychotherapy Fidelity Assessment in Motivational Interviewing and Cognitive Behavioral Therapy Training: Cross-Sectional, Simulation-Based Evaluation Study

Mohammad Amin Kamaleddin, Mina Mirjalili, Reza Barzegar, Nghia Trung Le, Zachary Cote, Olga Winkler, Lisa Burback, Yanbo Zhang, Osmar R Zaiane, Candice Monson, Divya Sharma, Sri Krishnan, Andrew J Greenshaw, Richard Zeifman, Peter Selby, Venkat Bhat

Abstract Background Psychotherapy training is difficult to scale because manual rating of motivational interviewing (MI) and cognitive behavioral therapy (CBT) sessions is time-intensive, requires trained raters, and is subject to rater variability. Large language models (LLMs) may support simulation-based training and rubric-guided scoring, but early-stage evidence is needed before such systems can be applied to real learners. Objective This study aimed to conduct a simulation-based evaluation of a multiagent LLM …

18.08.2026journal-article

Proceedings of the National Academy of Sciences

The immunophenotype and proviral landscape of HIV-infected CD4 T cells during antiretroviral therapy

Cyrille L. Delley, Sakshi Shah, Kevin M. Joslin, Yujung P. Park, Benjamin Demaree, Michael P. Busch, Mars Stone, Steven G. Deeks, Eli A. Boritz, Adam R. Abate, Iain C. Clark

In individuals on effective antiretroviral therapy (ART), integrated HIV proviruses persist within CD4 T cells, forming a viral reservoir that rebounds if treatment is stopped. Identifying and targeting these rare, infected cells is critical for advancing therapies, but methods to study reservoir cells are limited, and their unique properties remain largely unknown. We applied DAb-seq, a high-throughput method that combines single-cell DNA and surface protein sequencing, to profile ~527,000 CD4 T cells from the blo …

18.08.2026journal-article

Journal of Pharmacy Practice

Standardized Bone Health Assessment and Treatment Among Prostate Cancer Patients on Androgen Deprivation Therapy in a Large Integrated Managed Care Delivery System

Michael J. Shulman, Brandon H. Horton, Joan C. Lo, Marilyn J. Meganck, Masy K. Miller, Jennifer J. Park-Sigal, Andrew L. Avins

Background: Bone-health risk assessment and treatment among prostate-cancer patients on androgen-deprivation therapy (ADT) is often inadequately completed in clinical practice. Objective: To determine the impact of a population-management program on bone-health risk assessment and bisphosphonate therapy among prostate-cancer patients on ADT. Methods: We used retrospective data from a large integrated healthcare system to identify men aged 41-89 years diagnosed with prostate cancer in 2011-2024 who received ≥1 ADT d …

18.08.2026journal-article

British Journal of Occupational Therapy

Effects of a short-term, low-frequency occupational participation programme on health-related quality of life in community-dwelling older adults: A multicentre quasi-experimental study

Shota Aoyagi, Ryota Izumi, Yohei Kurita, Tetsuya Sano, Kosuke Suzuki, Yuki Satake

Introduction: Promoting health-related quality of life in community-dwelling older adults is central to occupational therapy practice in super-ageing societies. However, evidence for short-term, low-frequency occupational participation programmes remains limited. Methods: A multicentre, non-randomised within-subject longitudinal study was conducted in Japanese community groups. Participants served as their own controls during a usual activity period, followed by a 3-month intervention comprising three monthly sessi …

18.08.2026journal-article

South African Journal of Psychology

Boundaries Between Freedom of Expression and Hate Speech: The Case of Struggle Songs Current Perspectives From the Global South

Joanna Botha, Liz Gunner, Sisanda Nkoala, Ben Winks

This discussion article addresses the historical, political and social context of struggle songs in South Africa and the circumstances in which such songs should be considered prohibited hate speech. The analysis is framed around the decision in AfriForum v Malema , in which the Supreme Court of Appeal held that the singing of the Dubul’ ibhunu ( Kill the boer ) song on the occasions in issue did not amount to hate speech. The article approaches the problem from three main perspectives, namely law, politics and mus …

18.08.2026journal-article

International Journal of Gynecology & Obstetrics

Hormone therapy ( HT ) in women with premature ovarian insufficiency or early menopause: Time to think of a new paradigm for healthy aging. A joint FIGO and IMS position paper

Chiara Benedetto, Suvarna S. Khadilkar, Rossella E. Nappi, Andrea R. Genazzani, Federica Frezet, Laura Cucinella, Hema Divakar, Panagiotis Anagnostis, Nick Panay

Abstract Premature ovarian insufficiency (POI) and early menopause (EM) affect millions of women worldwide. Compared with normal menopause, they confer a longer duration of estrogen deficiency and are associated not only with a shorter lifespan, but with a reduced healthspan, owing to an increased risk of cardiovascular, skeletal, cognitive and psychological morbidity, and sexual health concerns. Therefore, interventions in POI/EM represent some of the most actionable opportunities to reduce long‐term disability an …

18.08.2026journal-article

Physiotherapy Research International

Effects of Dynamic Neck Sensorimotor Biofeedback Training in Individuals With Mechanical Neck Pain: A Pilot Randomized Controlled Trial

Min Hsu, Yen‐Cheng Lee, Chia‐Chi Yang, Pei‐Chi Lin, Lih‐Jiun Liaw, Chen‐Yu Chien, Pei‐Yun Lee, Lan‐Yuen Guo

ABSTRACT Mechanical neck pain (MNP) is commonly accompanied by pain‐related functional limitations, sensorimotor disturbances, and fear of movement, which together may contribute to persistent disability. This preliminary randomized controlled trial study investigated the short‐term effects of dynamic neck sensorimotor‐based biofeedback training in individuals with MNP. 20 MNP patients from outpatient clinics were assigned to a biofeedback training group or a control group. The training group underwent dynamic biof …

18.08.2026journal-article

Frontiers in Oncology

Efficacy and safety of dalpiciclib combined with endocrine therapy in elderly patients with HR+/HER2- advanced breast cancer: a real-world study

Yan Li, Bingyu Li, Xiaoping Ma, Dan Liu, Li Li, Zhenhui Zhao, Xiner Zhang, Bing Zhao

Background Dalpiciclib shows satisfactory efficacy and safety in patients with hormone receptor-positive (HR + )/human epidermal growth factor receptor 2-negative (HER2 - ) advanced breast cancer. Nevertheless, relevant real-world evidence is inadequate, particularly in elderly patients. This real-world study intended to explore the efficacy and safety of dalpiciclib plus endocrine therapy in elderly patients with HR + /HER2 - advanced breast cancer. Methods This single-center retrospective study analyzed the data …

18.08.2026journal-article

Journal of Histochemistry & Cytochemistry

Immunocytochemical Localization of Neuronal Nitric Oxide Synthase (nNOS) in Neutrophils: Hydroxyurea Therapy Induced Nucleo-Cytoplasmic Translocation in Sickle Cell Disease

Rashmi Saini, Shilpy Shakya, Silvio Roberto Consonni

Sickle cell disease (SCD) is an inherited hemoglobinopathy leading to the deformability of red blood cells, enhanced cellular adhesion, and blockage in microcirculation. “Sickle Neutrophils” cause oxidative stress and decreased bioavailability of nitric oxide (NO) due to enhanced generation of reactive oxygen species (ROS). The mechanism of action of the common medication of SCD, hydroxyurea (HU), has not yet been thoroughly examined. This investigation examines the subcellular localization of neuronal nitric oxide …

18.08.2026journal-article

Virtual Communication and Social Networks

Adapting Musical Terminology to Virtual Communication: Musical Commentary as a New Speech Genre

Stepan Oreshkin

Songs, music videos, biographies of musicians, and music forums occupy a lot of virtual space. Internet users have to adapt musical terms to virtual communication, turning online musical commentary into a new speech genre. The author studied music-related texts, users’ comments, and video reviews in the Russian-speaking segment of the Internet to identify the processes of terminological adaptation and the genre specifics of music commentaries. Music-related terms undergo a deep transformation on the Internet. As a …

18.08.2026journal-article

Jurnal Keperawatan Profesional

Impact of Drawing Occupational Therapy on Auditory Hallucinations Among Mental Health Patients

Bunga Yusnanda, Milkhatun Milkhatun, Arief Budiman, Dwi Rahmah Fitriani

Auditory hallucinations are a common positive symptom of schizophrenia that can impair psychosocial functioning and increase the risk of aggressive behavior. Drawing-based occupational therapy has been proposed as a simple nonpharmacological intervention to help patients manage hallucinations. This study evaluated the implementation of drawing-based occupational therapy in reducing the severity of auditory hallucinations in a client with schizophrenia using a psychiatric nursing care approach. A single-case study w …

18.08.2026journal-article

BLACK SEA REGION AT THE CROSSROADS OF CIVILIZATIONS

ღორჯომის ხეობის მეტყველების ზოგიერთი ფონეტიკური თავისებურება

კაკალა ებრალიძე

დიალექტებში მოქმედ ენობრივ პროცესებზე დაკვირვება და მათი შესწავლა ენათმეცნიერებისათვის ყოველთვის საჭირო და სიახლისმომცემია. ხშირად დიალექტებში შემონა­ხუ­ლია ის, რაც სალიტერატურო ქართულში დავიწყებული ჩანს. ამ კუთხით განსაკუთრებული მნიშვნელობა ენიჭება დიალექტის ლოკალურ კვლევას, რომელიც დიალექტის ენობრივ თავი­სე­ბურებათა შედარებით სრულ სურათს წარმოაჩენს. ნაშრომში განხილულია ზემოაჭარული კილოკავის ერთ-ერთი საინტერესო და სახასიათო ხეობის - ღორჯომის მკვიდრთა მეტყველების ფონეტიკური თავისებურებები. კერძოდ, ბგერითი შედგენილო …

18.08.2026journal-article

BLACK SEA REGION AT THE CROSSROADS OF CIVILIZATIONS

ფილერები ფერეიდნელ ქართველთა მეტყველებაში

ეკა დადიანი, გიორგი მულიანი

ფერეიდნული დიალექტი, რომელიც ირანის ისლამურ რესპუბლიკაში, კერძოდ, ფერეიდუნშაჰრის პროვინციაში არის გავრცელებული, ენათმეცნიერთა განსაკუთრებული ინტერე­სის საგანია. ფერეიდნელ ქართველთა მეტყველება საინტერესოა ფილერების გამოყენების მხრივ. მეტყველების პროცესში ხშირად იხმარება სხვადასხვა ენობრივი საშუალებები: ნაცვალსახელები, შორისდებულები, ნაწილაკები, სიტყვები, ფრაზები, ბგერები / მარცვლები, პაუზა...). ფილერების მრავალფეროვნებასა და ინტენსივობას ძირითადად განსაზღვრავს ფერეიდანში არსებული ბი­ლინ­გვური გარემო და, შესაბამისად, …

18.08.2026journal-article

Physiotherapy Research International

Therapeutic Exercise Protocol During Hospitalization in Pediatric Oncohematological Patients: Randomized Clinical Trial

Cintia Freire Carniel, Bruna Cunha de Souza, Henrique Ferreira Leite, Juliana Zangirolami‐Raimundo, Rodrigo Daminello Raimundo

ABSTRACT Background Leukemias, lymphomas, and central nervous system tumors are among the most common pediatric cancers and may lead to motor deficits, impaired balance, reduced muscle strength, fatigue, and decreased functional capacity. Early physiotherapy during hospitalization may help prevent inactivity and support functional preservation in this population. Objective To evaluate the effects of a therapeutic exercise program on quality of life, muscle strength, fatigue, and functional capacity in hospitalized …

18.08.2026journal-article

Periódicos Brasil. Pesquisa Científica

Depression and Work Absence or Job Loss in Organizations

Paulo Henrique Andrade de Oliveira, Carlos Alberto Gonçalves, Luiz Osvaldo Vilar de Almeida De Almeida, Alexandre Dos Reis, Jennifer Michett

Recognized as one of the leading global causes of disability, depression broadly impairs emotional functioning, interpersonal relationships, and occupational performance, making it a phenomenon of increasing relevance within organizational contexts. Despite the growing body of scientific inquiry into the subject, integrative reviews that systematically address its multidimensional effects on working life remain scarce. Against this backdrop, the present study aimed to critically and comprehensively examine the psyc …

18.08.2026journal-article

ACS Applied Materials & Interfaces

Ultrasound-Activated Janus Heterojunction-Mediated Enhanced Cascade Nanozyme for Inflammatory Bowel Disease Therapy

Siyu Zhao, Jing Zhang, Xin Li, Yating Cui, Peng Cheng, Yunxiang Zhang, Xinmiao Hou, Derui Xu, Bolin Du, Qing Song, Ruijie Zhao, Xiaohui Wang, Peter R. Taylor, Xichuan Li, Xinghua Jin

Abstract Inflammatory bowel disease (IBD) is exacerbated by the excessive accumulation of reactive oxygen species (ROS). To overcome the insufficient catalytic activity of conventional cerium-based nanozymes, we designed an ultrasound-activated Bi@BTC heterojunction nanozyme. The ultrasound-activated carriers generated by bismuth core undergo effective electron-hole separation in the Janus Bi@BTC heterojunction. The holes are enriched in the valence band of the BTC shell, catalyzing the oxidation reaction of Ce3+. …

18.08.2026journal-article

Frontiers in Reproductive Health

Fertility counseling experiences and perceived gaps in provider support among people living with HIV: a qualitative study from an antiretroviral therapy clinic in Ghana

Victor Luckyboy Dzramado, Priscilla Asantewaa Boadi

Introduction Antiretroviral therapy (ART) has made safer childbearing achievable for people living with HIV (PLHIV), and the reproductive health counseling PLHIV receive within HIV care shapes whether they can act safely on their fertility intentions. This study explored, from the perspective of PLHIV themselves, how the reproductive counseling they reported receiving shaped their fertility decision making, and which aspects of counseling support they perceived to be missing. Methods A qualitative descriptive desig …