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European Health Evidence

The European alternative to PubMed

EUVIMED is the European alternative to PubMed: a central, multilingual research platform for medicine, nursing, life sciences and healthcare. It brings together international and European literature sources, study registries, open-access full texts, citations and retraction notices in one search. Unlike pure bibliographic databases, EUVIMED supports the entire research process – from discovery and appraisal with LIVIA and CLARA to traceable evidence synthesis. European in focus, transparent, interoperable and designed for science and healthcare.

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EUVIMED Themenbrowser · Medizin · Seite 126

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Current Issues in Sport Science (CISS)

Musculoskeletal Models from Sparse Medical Images – Towards Personalized Load Management in Sports and Medicine

Clara Egner, Willi Koller, Laura Rathmair, Kevin Kitir, Hans Kainz

Introduction & Purpose Internal musculoskeletal loads (e.g. muscle-forces, joint-moments, and joint-contact-forces) are key indicators of locomotor loading, relevant to sports medicine and rehabilitation. Since many such variables cannot be measured directly, they are estimated using musculoskeletal modelling, driven by 3D-gait-analysis (3DGA) (marker trajectories, electromyography, ground reaction forces). Personalization of musculoskeletal models ranges from simple scaling of a generic model to fully personalized …

03.09.2026journal-article

JAMA Ophthalmology

Safety and Effects of Gildeuretinol Acetate on Retinal Atrophic Lesions in Stargardt Disease

Christine N. Kay, Leonide Saad, Gabrielle DeBartolomeo, Neil Bressler, Stephen H. Tsang, Kimberly Stepien, Paul Bernstein, Byron L. Lam, Ilyas Washington, Michael B. Gorin, TEASE-1 Study Group, Arsany Makkar, Hendrik Scholl, Mahmood Seyd Shah, Mandeep Singh, Shazia Khan, Mary Frey, Robert L. Roseman, Kaushik M. Hazariwala, Jing Zhang, Sarah Justus, Sophia Karen Park, Christine Xu, Thomas Connor, Dennis Han, Judy Kim, David Weinberg, William Wirostko, Kurt Pfeifer, Heather Toth, Krissa Packard, Eleanor Dorsey Veh, Vesper Williams, Kaitlin McKenney, Brittany Rego, Patricia Winter, Hannah Sheppard, Stephanie Moebius, Angela Urmanski, Amanda Daubert

Importance Stargardt disease (STGD) is the most common macular dystrophy, resulting in profound loss of vision. There is no approved treatment. Objective To evaluate the safety and effects of oral gildeuretinol acetate on the growth of retinal atrophic lesions in individuals with STGD. Design, Setting, and Participants TEASE-1 was a 2-year, multicenter, double-masked, placebo-controlled randomized clinical trial incorporating a crossover group and additional natural history (NH) cases selected prior to drafting the …

03.09.2026journal-article

Gastroenterology Insights

Barriers and Enablers Influencing Adherence to ERAS Protocols in Gastrointestinal Surgery: A Scoping Review

Suja P. Davis, Jinyu Guo

Background/Objective: Enhanced recovery after surgery (ERAS) is a global surgical quality improvement initiative that aims to improve perioperative care based on evidence-based interventions. Although ERAS protocols in gastrointestinal (GI) surgery result in improved patient outcomes, there are variations in protocol adherence and important gaps in understanding the barriers and enablers influencing this adherence. The objective of this scoping review was to map evidence from the relevant literature to identify the …

03.09.2026journal-article

Frontiers in Nutrition

The role of psychiatric nurses in nutritional care for treatment-resistant depression: a relapse-prevention perspective

Agnieszka Mechlińska, Natalia Sudoł, Dorota Pazda-Juda, Wiesław Jerzy Cubała

Treatment-resistant depression (TRD) is associated with persistent symptoms, impaired functioning, physical comorbidity and a high risk of recurrence, making continuation and maintenance care particularly important. Nutrition may influence several modifiable aspects of recovery, including cardiometabolic health, daily functioning, self-care and treatment adherence, although evidence for a direct effect on depressive recurrence remains limited. This review examines the role of nutritional care within TRD relapse pre …

03.09.2026journal-article

Online Journal of Public Health Informatics

Global Trends in Phenylketonuria Treatment Research, 2000-2025: Bibliometric Analysis

Sitong Yang, Kaichao Song, Qingbo Chen, Jiandong Jiang, Lulu Wang

Abstract Background Phenylketonuria (PKU) is the most common inborn error of amino acid metabolism, and if untreated, leads to severe neurocognitive impairment. Over the past 2 decades, treatment strategies have evolved from strict dietary phenylalanine restriction to include pharmacological therapies such as tetrahydrobiopterin and, more recently, enzyme substitution with pegvaliase. Despite these advances, significant heterogeneity exists in global research priorities, collaboration patterns, and the translation …

03.09.2026journal-article

Bulletin of Pirogov National Medical & Surgical Center

SURGICAL TREATMENT OF A PATIENT WITH ACUTE TYPE A AORTIC DISSECTION COMPLICATED BY CEREBRAL MALPERFUSION USING ADAPTIVE PERFUSION AND THE BRANCH-FIRST TECHNIQUE

V. A. Mironenko, S. V. Garmanov, M-B. T. Mamilov, N. A. Darvish, S. S. Ismailov, N. V. Fedorov

A clinical case of surgical treatment of a 50-year-old patient with acute type A aortic dissection complicated by severe cerebral malperfusion and extension of the dissection into the brachiocephalic arteries is presented. Multislice CT revealed dissection of the brachiocephalic trunk with false lumen thrombosis, stenosis of the right common carotid artery, critical stenosis and false lumen thrombosis of the left common carotid artery, as well as involvement of the left subclavian artery. Given the high risk of per …

03.09.2026journal-article

Frontiers in Pediatrics

Clinical utility and tolerability of ketamine as adjunctive rescue therapy for refractory neonatal status epilepticus: a case report of a late preterm infant with multifocal hemorrhagic brain injury

Chiara Gulisano, Alessia Pepe, Elisabetta Amadori, Samuele Caruggi, Daniele Caratozzolo, Lino Nobili, Pasquale Striano, Luca Antonio Ramenghi, Andrea Calandrino

Background Neonatal status epilepticus (NSE) is a life-threatening neurological emergency associated with high mortality and long-term neurodevelopmental morbidity. Although phenobarbital remains the recommended first-line antiseizure medication (ASM), followed by agents such as phenytoin or levetiracetam, seizure control is not always achieved. Ketamine, a non-competitive N methyl-D-aspartate (NMDA) receptor antagonist, has emerged as a potential rescue therapy for refractory status epilepticus because of its uniq …

03.09.2026journal-article

L'Endocrinologo

Biomarcatori nell’orbitopatia basedowiana: nuove prospettive per diagnosi, prognosi e terapia personalizzata

Silvia Corrias, Marina Porcu, Francesco Boi, Filippo Lixi, Giuseppe Giannaccare, Giulia Lanzolla

Sommario L’identificazione di biomarcatori rappresenta una delle principali sfide irrisolte nell’orbitopatia basedowiana (OB). In assenza di indicatori biologici validati, la valutazione della malattia rimane essenzialmente clinica. Le crescenti evidenze relative a biomarcatori sierologici, lacrimali e tissutali delineano nuove prospettive per la diagnosi precoce, la stratificazione dei pazienti, il monitoraggio terapeutico e l’implementazione di approcci personalizzati.

03.09.2026journal-article

Clinical Chemistry and Laboratory Medicine (CCLM)

Translating analytical performance into clinical misclassification risk: a probabilistic framework for HbA 1c interpretation

Lorenza Fagnani, Rita Tennina, Pierangelo Bellio, Patrizia Frascaria, Marco Rossi, Sabrina Viggioni, Moira Tucceri Cimini, Consuelo Scimia, Alessandra Piccirilli, Mariagrazia Perilli, Fabio Antonelli, Giuseppe Celenza

Abstract Objectives Using HbA 1c for diabetes diagnosis directly links analytical uncertainty to patient classification. Since traditional performance metrics provide limited insight into these clinical implications, we developed a probabilistic framework to translate HbA 1c concentrations and components of analytical uncertainty into clinically interpretable diagnostic risk. Methods The framework was applied to 100,472 HbA 1c results obtained from a real-world Laboratory Information System. Analytical bias, analyt …

03.09.2026journal-article

Cereal Chemistry

Influence of Milling Methods and Cold Plasma Treatment on the Functional and Baking Properties of the Pearl Millet Flour and Bread

Bindusri Naraharasetti, Snehasis Chakraborty, Kaliramesh Siliveru, P. V. Vara Prasad

ABSTRACT Background and Objective Pearl millet, a crop with excellent resilience to harsh environmental conditions, is gluten‐free, but hard to mimic the wheat bread textural attributes. Cold plasma treatment is a non‐thermal technology that can enhance the viscosity profile and functional properties of the cereal flour. The objective of the study is to evaluate the impact of milling methods (pin mill and hammer mill) and moisture conditioning (tempered and untempered grain) on the rheological and physical properti …

03.09.2026journal-article

Frontiers in Cell and Developmental Biology

Early diagnosis of radiation-induced renal injury: from lagging indicators to multimodal, pre-fibrotic detection

Yuanyuan Zhang, Eric P. Cohen, Sean V. Murphy, Tarek Zaho, Hongbing Liu, Heather Himburg, Michael Patrick Feloney, George William Schaaf, Anthony Atala, J. Mark Cline

Background Radiation-induced renal injury (RRI) is characterized by a prolonged latent phase from radiation exposure to clinical dysfunction. Conventional markers such as serum creatinine and blood urea nitrogen (BUN) may only increase after substantial nephron loss, thereby missing a critical therapeutic window during which renal injury may remain amenable to mitigation. Objective This review synthesizes emerging strategies for the early, pre-fibrotic detection of RRI, emphasizing molecular damage biomarkers, geno …

03.09.2026journal-article

Frontiers in Health Services

Patient misidentification and data integrity risks in ultrasound imaging: a case report using multi-framework incident analysis

Benedicta Osei-Donkor, Abdallah Hassoun, Md Shafiqur Rahman Jabin

Background Digital imaging workflows depend on accurate scheduling, patient identity reconciliation, and reliable metadata continuity to ensure safe image storage and retrieval. Disruptions in these processes may not directly affect image acquisition but can delay access to imaging information and pose significant patient safety risks. Objective To examine a recurrent ultrasound workflow failure that compromised downstream image availability and to identify practical strategies for preventing recurrence. Methods A …

03.09.2026journal-article

Frontiers in Dental Medicine

Curcumin as an adjunct in periodontal therapy: local effects, delivery systems, and clinical perspectives

Ana Carolina Aparecida Rivas, Mario Taba, Paola Gomes Souza

Curcumin, the active polyphenol in turmeric (Curcuma longa), is well-known for its anti-inflammatory, antioxidant, and antimicrobial properties, making it a promising therapeutic agent for a range of diseases, including neuroinflammatory conditions and periodontal disease. Periodontitis, a prevalent oral disease, is associated with chronic inflammation and bacterial infection. Curcumin has demonstrated antibacterial effects against periodontal pathogens such as Aggregatibacter actinomycetemcomitans, Porphyromonas g …

03.09.2026journal-article

Frontiers in Medicine

Time-Series modeling for predicting mortality risk in intensive care unit patients with pulmonary inflammation

Yihai Zhai, Ruixin Xu, Haisu Lu, Siying Lv, Liqin Mo

Objective This study aims to evaluate dynamic changes in pneumonia-related mortality risk among ICU patients using time-series models and develop interpretable predictive models for early mortality assessment. Methods Data were obtained from the MIMIC-IV and eICU Collaborative Research Database. The MIMIC-IV cohort was split into training and testing sets (7:3 ratio), with external validation conducted using the eICU cohort. Missing data were handled using forward filling and multiple imputation. LSTM was used to e …

03.09.2026journal-article

Frontiers in Medicine

Design, implementation, and evaluation of a programmatic assessment model in an emergency medicine residency: a mixed-methods study

İbrahim Ulaş Özturan, Dilek Kitapcioglu, Prattama Santoso Utomo, Cansu Alyesil Ozturan, Nurettin Özgür Doğan, Elif Yaka, Serkan Yılmaz, Murat Pekdemir, Levent Altıntaş

Background Programmatic assessment (PA) is widely endorsed in postgraduate medical education, but empirical accounts of real-world implementation in emergency medicine (EM) remain limited and are concentrated in North American settings. We piloted and evaluated the design, implementation, and outcomes of a PA model in an EM residency at a high-volume tertiary care center in Türkiye. Methods A mixed-methods study was conducted over an eight-month pilot (November 2024–June 2025). Program design and evaluation followe …

03.09.2026journal-article

Frontiers in Oncology

Analysis of clinical features and outcomes in a Chinese cohort with ALK fusion across pan-cancer: a retrospective study

Meng Zhang, Yi Feng, Xue Du, Changda Qu, Meizhu Meng, Meiying Ye, Min Liang, Ziran Yang, Wenjuan Gong, Xingyu Ma, Jialiang Guo, Wenmei Li, Shuqin Jia

Background ALK fusions are validated oncogenic drivers, yet their molecular heterogeneity and therapeutic implications remain poorly characterized. This study defined the landscape of ALK fusion partners, EML4-ALK variants, and co-mutations and their impact on treatment responses in a large Chinese pan-cancer cohort. Methods We retrospectively analyzed 16,335 consecutive pan-cancer patients via next-generation sequencing to identify ALK fusions. Clinical characteristics, fusion partners, co-mutations, and treatment …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Perimenopause as a potential window of cardiometabolic remodeling in heart failure with preserved ejection fraction: a missed opportunity for prevention

Faith Adedayo Adejumo, Oluwayimika Oluwatobi Obielodan, Fiyinfoluwa Adetoye, Nicholas Aderinto

Heart failure with preserved ejection fraction (HFpEF) disproportionately affects women and has emerged as one of the most prevalent forms of heart failure worldwide. Although the marked increase in HFpEF incidence after menopause is well recognized, the biological events that initiate disease development remain poorly defined. Most mechanistic and clinical investigations have focused on postmenopausal women or established HFpEF, leaving the menopausal transition comparatively underexplored despite growing evidence …

03.09.2026journal-article

Clinical Journal of the American Society of Nephrology

Predictive Value of Urine Tubular Biomarkers on Kidney Outcomes

Greco B. Malijan, William G. Herrington, Parminder K. Judge, Rebecca J. Sardell, Daniel Chapman, Michael Hill, Stewart Moffat, Doreen Zhu, Alfred K. Cheung, Dominik Steubl, Martin J. Landray, Christoph Wanner, Colin Baigent, Richard Haynes, Joachim H. Ix, Natalie Staplin, Michael G. Shlipak, on behalf of the EMPA-KIDNEY Collaborative Group

Background Urine tubular biomarkers have previously been associated with chronic kidney disease (CKD) progression independently of estimated glomerular filtration rate (eGFR) and albuminuria. We evaluated whether nine urine tubular biomarkers could improve prediction of kidney failure beyond serum creatinine and urine albumin-to-creatinine ratio among adults with CKD. Methods Among 5100 participants in EMPA-KIDNEY, a randomized trial which assessed the effects of empagliflozin 10 mg versus matching placebo among pa …

03.09.2026journal-article

PLOS One

Efficacy of different doses of oliceridine for Patient-Controlled Intravenous Analgesia in patients undergoing Total Laparoscopic Hysterectomy

Jiaojiao Deng, Baobao Ma, Kaihua Wei, Tao Wei, Liping Xie, Hong Zhang, Changxu Wang

Objective To evaluate the efficacy and safety of three oliceridine different doses for oliceridine for patient-controlled analgesia (PCIA) in patients undergoing during total laparoscopic hysterectomy, following the premature termination of the planned sufentanil control arm. Methods This prospective, randomized, double-blind trial was originally designed as a four-arm study. Due to operational challenges in patient recruitment and randomization within the single-center setting-specifically, significant reluctance …

03.09.2026journal-article

Journal of Cardiovascular Development and Disease

Multimodal Management of Chronic Thromboembolic Pulmonary Hypertension: A Narrative Review of Treatment Selection and Sequencing

Houda Gharsalli, Mohammed Alshahrani, Olfa Harbi, Nawal Alwadai, Abdalla M. Al-Asiri, Fatmah Alahmari, Amal Alqahtani, Najla Al-Jahash, Lobna Abbag, Saud Alqahtani, Khaled Abdulwahab Amer

Chronic thromboembolic pulmonary hypertension (CTEPH) is a treatable yet frequently underdiagnosed late complication of acute pulmonary embolism, in which incompletely resolved thromboemboli organise into fibrotic obstructions of the pulmonary arteries and, together with a secondary small-vessel arteriopathy affecting both obstructed and non-obstructed territories, raise pulmonary vascular resistance, impose right ventricular pressure overload, and—if left untreated—progress to right heart failure and death. Three …

03.09.2026journal-article

Journal of Clinical Medicine

The Impact of Glucagon-like Peptide-1 (GLP-1) Receptor Agonists on Body Composition in Individuals with Overweight and Obesity: A Systematic Review and Meta-Analysis

Miłosz Woźniak, Zofia Tarcz, Gabriela Pyczek, Julia Bogacka, Andrzej Diniejko, Alina Kuryłowicz, Artur Mamcarz, Daniel Śliż

Background/Objectives: Excess adipose tissue is associated with adverse changes in muscle metabolism and body composition. GLP-1 receptor agonists (GLP-1 RA) have transformed the treatment of obesity; however, concerns remain regarding the potential impact of treatment-associated weight loss on lean mass. This study aimed to evaluate the effects of GLP-1 RA on body composition in adults with obesity without type II diabetes mellitus (T2DM), with a particular focus on changes in lean mass. Methods: A database search …

03.09.2026journal-article

Clinical Genetics

Biallelic ABCA13 Loss‐of‐Function Variants in a Child With Neurodevelopmental Delay: A Case Report

Maya Atanasoska, Lubomir Balabanski, Daniela Avdjieva‐Tzavella, Tsvetina Veleva, Slavyana Yaneva Staykova, Irena Bradinova, Draga Toncheva, Radoslava Vazharova

ABSTRACT ABCA13 encodes ATP‐binding cassette subfamily A member 13, one of the largest members of the ABC transporter family. Rare ABCA13 variants have been reported in neuropsychiatric and neurodevelopmental phenotypes, including schizophrenia, bipolar disorder, autism spectrum disorder, intellectual disability, and developmental delay; however, the mode of inheritance remains uncertain, and most published cases have focused on heterozygous variants in the context of a possible dominant or susceptibility model. We …

03.09.2026journal-article

Journal of Medical Clinical Case Reports

Digital Distrust: Patient-Centred Communication and the Calibration of Epistemic Reliance in the Era of Online Self-Diagnosis and AI Symptom Checkers

Nonye Tochi Aghanya, Osinakachi Akuma Kalu

Background: Patients are coming to consultations informed by search engines, social media and generative AI. Clinicians may characterize this as distrust of clinicians. Actualities are messier, and our language for talking about how communication breaks down is limited. Purpose: Operationalize the concept of digital distrust, disambiguate it from related concepts with which it is often confused, and report a communication framework grounded in theory for clinical practice. Methods: Methodology is an interpretive co …

03.09.2026journal-article

Clinical Science

IRAP deficiency preserves renal function and attenuates pathology in aged mice

Sarah L Walton, Aneesa Ansari, Katrina M Mirabito Colafella, Lucinda M Hilliard Krause, Giannie Barsha, Michelle M Kett, Siew Yeen Chai, Vesna D Garovic, Kate M. Denton

Senescent cell accumulation and fibrosis play a fundamental role in kidney ageing. Our aim was to determine whether the angiotensin IV/insulin-regulated aminopeptidase (IRAP) axis of the renin-angiotensin system contributes to renal function decline, fibrosis and senescent cell accumulation in aged mice. We studied the role of IRAP in kidney aging using IRAP knockout mice, as well as in wildtype mice treated with an IRAP inhibitor. Complementary proximal tubule and collecting duct cell models were used to determine …