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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Addiction Science & Clinical Practice

Changing minds on MOUD: impact of messages to motivate expanded access to buprenorphine in primary care settings

Karen L. Roper, Melissa Zook, Kory Heier, Kristen McQuerry, Sarah Marks, Hannah K. Knudsen

Abstract Background Practitioners in primary care (PCPs) face significant barriers and lack of motivation for expansion of medications for opioid use disorder (MOUD) in their service. Educational videos specifically targeted at the primary care setting and utilizing key determinants of behavior change were assessed for impact on PCP viewer’s attitudes and intention to explore MOUD. Methods A rural-setting PCP scripted the videos, describing her extensive experience treating patients using buprenorphine. Content add …

03.09.2026journal-article

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH

Determinants of Quality Family Planning Services in Sokoto State, Nigeria

Suleiman Aliyu

This study examines determinants of quality family planning services in Sokoto State, Nigeria. Using a descriptive cross-sectional design, data were collected from 519 respondents and analyzed using descriptive statistics. Findings show that provider competence, socio-cultural beliefs, informed choice, and financial barriers significantly influence service quality and utilization the results indicate that provider competence is the strongest determinant of service quality, highlighting the importance of skilled hea …

03.09.2026journal-article

Journal of Global Social Transformation

Dissemination of Health Content through social media and its Acceptability by the Viewers

Nisar Ahmad Anjum, Imran Muslim

Increasing exposure to the different social media applications has led towards more dependency on social media influencers in general and especially on health-related content creators. This survey study is an attempt to investigate the reasons for this blind following and outcome of this faith on health content creators. 384 respondents were approached by researchers to collect the data by using a survey questionnaire. Results of the study show that health content in the form of short videos, especially through Ins …

03.09.2026journal-article

An Idea Health Journal

Factors Associated the Perceived Effectiveness of Seven-Jumps Problem with Based Learning Tutorials among Nursing Students: A Mixed-Methods Study

Ika Purnamasari, Candra Dewi Rahayu, Anisa Ell Raharyani

Background: Seven-Jumps Problem-Based Learning (PBL) tutorials are commonly implemented in nursing education to foster active learning, critical reasoning, and collaborative problem-solving. However, evidence on factors influencing students’ perceptions of tutorial effectiveness remains limited in Indonesian nursing education. Methods: An explanatory sequential mixed-methods design was employed. The quantitative phase included 70 fourth-semester undergraduate nursing students and utilized the Tutorial Group Effecti …

03.09.2026journal-article

Basic & Clinical Pharmacology & Toxicology

Macrophage FOXO1 Inhibition Protects Against Hyperglycaemia‐Associated Kidney Injury

Hejie Zhu, Qian Liu, Lunqiang Yang, Chenyu Zhang, Ying Zhang, Ruiqi Zhao, Zhongyuan Zheng, Xi Wang, Linlin Li, Long Zhang, Lu Tie

ABSTRACT Diabetic kidney disease (DKD) is one of the most significant microvascular complications of diabetes, characterized by high incidence and mortality; however, its pathogenesis remains unclear. Renal inflammation and macrophage infiltration play pivotal roles in driving DKD progression. The transcription factor forkhead box protein O1 (FOXO1) regulates the transcriptional expression of multiple pro‐inflammatory molecules and modulates macrophage polarization. Nevertheless, its specific role in DKD macrophage …

03.09.2026journal-article

American Journal of Audiology

Clinical and Demographic Characterization of Tinnitus and Factors Associated With Discomfort in a Large Sample of Patients Evaluated in Bogotá, Colombia

German Alejandro Pabón Ochoa, Miguel Humberto Parra Pinto

Purpose: The purpose of this study was to clinically and demographically characterize tinnitus in a large sample of patients evaluated in Bogotá, Colombia, and to analyze the factors associated with the level of discomfort. Method: A total of 763 medical histories of adults seen between 2018 and 2024 at a specialized tinnitus center were analyzed. Demographic, clinical, and audiological data were collected, in addition to scores from self-report instruments (Tinnitus Handicap Inventory, Tinnitus Reaction Questionna …

03.09.2026journal-article

World Journal of Traditional Chinese Medicine

Integration of Metabolomics and Transcriptomics Reveals the Mechanisms by Which Tetrandrine, Identified from Fangji Huangqi Decoction, Ameliorates Lipid Accumulation in Adipocytes

Jia-Ying Li, Jia-Qi Xie, Min Guan, Yan-Yan Qiu, Lu-Yu Yang, Si-Qi Zhang, Jian-Mei Huang, Jie Zhang, Can Wang

Abstract Objective: Fangji Huangqi decoction (FHD) is a classic clinical formula used in traditional Chinese medicine to treat obesity. In this study, we aimed to screen active substances in FHD that are effective in treating obesity and to elucidate the mechanisms underlying FHD-mediated amelioration of lipid accumulation in adipocytes. Materials and Methods: Ultra-high-performance liquid chromatography-Quadrupole-orbitrap mass spectrometry was used to identify the principal components and metabolites of FHD in ra …

03.09.2026journal-article

Journal of Patient Safety

Trends in Inpatient Patient Safety Indicators Before and After the Onset of the COVID-19 Pandemic in the United States: 2018 to 2022

Denise D. Quigley, Lucy B. Schulson, R. Travis Merrill, Marc N. Elliott, Andrew W. Dick

Objectives: The COVID-19 pandemic challenged hospitals. Yet, little is known about the extent of COVID-19’s impact on patient safety. We assessed change in Patient Safety Indicators (PSIs), which identify potentially preventable adverse events, before and after the onset of COVID-19 and when a hospital had a high proportion of COVID-19 admissions. Methods: Using Medicare Provider Analysis and Review data, our sample included 51,960,029 non-COVID-19 admissions eligible for inclusion in at least 1 PSI. This included …

03.09.2026journal-article

Health Promotion Journal of Australia

Food Processing Knowledge in Relation to Healthiness and Self‐Reported Understanding of the Health Star Rating in Australia

Jacqueline Penney, Tailane Scapin, Adrian J. Cameron, Christine M. White, David Hammond, Clara Gomez‐Donoso

ABSTRACT Issue Addressed This study aimed to examine Australians' food processing knowledge in relation to food healthiness and self‐reported understanding of the Health Star Rating (HSR), their association, and sociodemographic differences. Methods An online survey was completed by 3760 adults in Australia as part of the 2021 International Food Policy Study. Participants rated the healthiness of foods across four categories (grains, meat, dairy, fish), with three products presented per category representing increa …

03.09.2026journal-article

Frontiers in Digital Health

Hardware-aware knowledge-distilled CNN for real-time classification of plaque-associated angiographic findings on FPGA

Nazarkar Pravalika, Jabeena Afthab, Vetriveeran Rajamani

Coronary artery disease (CAD) is one of the leading causes of global mortality, necessitating accurate assessment of coronary artery stenosis and plaque-associated angiographic findings from coronary angiography images. Although deep learning-based diagnostic models have demonstrated high predictive capability, their deployment on resource-constrained embedded platforms remains challenging because of computational complexity and memory requirements. To address these limitations, this study proposes a knowledge-dist …

03.09.2026journal-article

Frontiers in Psychology

When chatbots are perceived as “understanding”: a study on how virtual agent persona styles and affective interaction promote mental health acceptance

Qi Wu, Shizhu Lu, Yuqi Yan, Lin Liu, Xiaojie Peng

Introduction Mental health challenges among university students have become increasingly prevalent, while existing digital interventions often struggle to sustain user engagement and provide meaningful emotional support. Although previous studies have proposed various explanations for the limited acceptance of AI-based mental health chatbots, the role of affective experience remains insufficiently understood. This study proposes an affect-centered framework to examine how different virtual agent persona styles (Lis …

03.09.2026journal-article

Frontiers in Psychiatry

Effect of traditional Chinese medicine on sleep and blood pressure in patients with comorbid hypertension-insomnia: a systematic review and meta-analysis

Yuchen Fan, Haijun Li, Yuezhen Ma, Shuangshuang Yin, Cuiping Xu

Introduction Hypertension and insomnia frequently occur together and share neurophysiological and vascular regulatory disturbances, which increase the risk of cardiovascular disease. Traditional Chinese Medicine (TCM) uses syndrome differentiation to guide the therapeutic selection for sleep disturbance and blood pressure regulation. This study evaluated whether syndrome-informed TCM improves the sleep quality and blood pressure in adults with comorbid hypertension and insomnia. Methods We systematically searched d …

03.09.2026journal-article

Dermatology and Skin Science

Fractionated Ablative Laser-Assisted Methyl Aminolevulinate Photodynamic Therapy with 532-nm KTP Activation for Multiple Basal Cell Carcinomas in Gorlin Syndrome: A Case Report

B. Kent Remington, Colton R. Jensen

Basal cell carcinomas (BCCs) in Gorlin syndrome are often numerous, recurrent, and difficult to manage with repeated surgery because cumulative procedures may produce substantial morbidity, scarring, and disfigurement. Methyl aminolevulinate photodynamic therapy (MAL-PDT) is an established tissue-sparing option for superficial BCC and selected thin nodular BCCs, with favourable cosmetic outcomes and the ability to treat multiple lesions during a single session. Unfortunately, conventional photodynamic therapy (PDT) …

03.09.2026journal-article

Academic Bulletin of Mental Health

Post-Amputation Psychological Trauma in Peripheral Arterial Disease: A Case Series

Suraj Pai, Suresh Pai, Aditya Kariwal

Peripheral arterial occlusive disease (PAOD) often leads to critical limb ischemia requiring amputation. While the physical consequences are well documented, the psychological sequelae remain underrecognized. We present a case series of three patients with PAOD who developed significant psychiatric manifestations following limb amputation. Clinical details, psychiatric evaluations, and management strategies are discussed. All three patients exhibited varying degrees of psychological trauma, including major depressi …

03.09.2026journal-article

Healthcare

Exploring the Interplay Between Emotions and Medical Decision-Making: Insights from an Empirical Patient-Centred Study

Nan Ji, Yong Liu, Ying Wang

Background: Patient-centred decision-making is shaped by clinical information as well as patients’ emotional and relational experiences during care. This cross-sectional study examined how positive and negative emotions, physician trust, perceived empathy, and patient involvement were associated with patient-reported decision outcomes. Methods: A structured 30-item questionnaire using 5-point Likert scales was administered to 600 adult patients recruited by convenience sampling from Wuxi Hospital of Traditional Chi …

03.09.2026journal-article

Frontiers in Public Health

Staff-mediated doll therapy in Chinese residential dementia care: an exploratory pilot and feasibility mixed-methods cluster randomized clinical trial

Zhenti Cui, Rongrong Guan, Tianrui Xue, Yongchang Sun, Maw Pin Tan, Mas Ayu Said, Yingdong Cao

Background Doll therapy is a person-centered intervention for behavioral and psychological symptoms of dementia, but evidence from Chinese nursing homes and information about implementation, medication use, and ethical acceptability remain limited. Methods We conducted an exploratory pilot and feasibility mixed-methods cluster-randomized clinical trial in six nursing homes in Zhengzhou, China. Homes were randomized 1:1 to a staff-mediated doll-therapy care package plus routine care or routine care alone. Residents …

03.09.2026journal-article

Frontiers in Public Health

Physical activity perceptions, barriers, and needs among nursing home residents: an explanatory sequential mixed-methods study

Jung-A. Kim, Haeyeon Kim, Hye-Young Jang

Background/objectives Physical activity is essential for maintaining health and preventing functional decline among older adults residing in nursing homes. However, engagement in physical activity remains suboptimal in this population due to multifactorial influences. This study aimed to examine the perceptions, barriers, and needs related to physical activity among nursing home residents. Methods An explanatory sequential mixed-methods design was employed from September to December 2024. In the quantitative phase, …

03.09.2026journal-article

Frontiers in Medicine

Clinical efficacy of the Galdakao-modified supine Valdivia position vs. the lithotomy position in FANS-UAS-assisted IPC-RIRS for renal calculi

Qiuhua Zhu, Yunxia Cai, An Wang, Jiansheng Xiao, Leming Song, Tairong Liu, Hua Chen

Objective To evaluate the clinical efficacy and safety of a modified Galdakao-modified supine Valdivia (GMSV) position combined with a flexible and navigable suction ureteral access sheath (FANS-UAS) in intelligent pressure-controlled retrograde intrarenal surgery (IPC-RIRS) for the treatment of renal calculi. Methods This single-center retrospective cohort study included 158 patients with renal calculi who underwent FANS-UAS-assisted IPC-RIRS between June 2023 and June 2025. Patients were categorized into the GMSV …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Novel predictors of late recurrence after catheter ablation for atrial fibrillation: from biomarkers to artificial intelligence models

Chiyu Chen

Atrial fibrillation (AF) is the most common sustained arrhythmia, and catheter ablation is an established rhythm-control strategy. However, late atrial arrhythmia recurrence remains common, limiting long-term procedural benefits. This review provides a structured and critical overview of current evidence on the predictors of late recurrence after AF catheter ablation across four domains: circulating biomarkers, imaging and electrophysiological substrate markers, genetic susceptibility, and artificial intelligence a …

03.09.2026journal-article

Frontiers in Oncology

Case Report: Iparomlimab and Tuvonralimab-based therapy for epithelioid malignant peritoneal mesothelioma: a three-case series

Zhijin Xu, Lehe Zhu, Ying Fang, Yiyan Jiang

Background Epithelioid malignant peritoneal mesothelioma (EMPM) is a rare and aggressive malignancy of serosal origin. Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy is generally reserved for carefully selected patients in whom adequate cytoreduction appears feasible, while evidence supporting systemic immunotherapy remains limited for patients with unresectable disease or those unable to tolerate intensive treatment. Iparomlimab and tuvonralimab (QL1706) is a fixed-ratio anti-PD-1/an …

03.09.2026journal-article

Frontiers in Public Health

The need for measurable targets in national action plans on antimicrobial resistance: opportunities for action

Uswa H. Shafaque, Arne Ruckert, Samuel Orubu, Kayla Strong, Suzanne Garkay Naro, Susan Rogers Van Katwyk, Mathieu J. P. Poirier

Antimicrobial resistance (AMR) represents a significant global health challenge that defies simple solutions and requires multisectoral coordination and interdisciplinary collaboration. National action plans (NAPs), which are built on the template of the World Health Organization’s Global Action Plan on AMR, offer a critical framework for addressing AMR. However, the lack of measurable targets within many NAPs hinders progress in mitigating AMR and setting up accountability and monitoring frameworks for tracking im …

03.09.2026journal-article

Frontiers in Oncology

The expression and clinical significance of SIRT5, H2A and TOP2A in cervical cancer

Fenghu Li, Xue Tian, Fan Mei, Yanjun Du, Lili Hu, Jiehui Li, Shengfa Su, Bing Lu

Objective To analyze the correlation between the expression of lysine deacetylase 5 (SIRT5), histone H2A and topoisomerase IIα (TOP2A) protein with clinical stage and survival in cervical cancer. Methods The expression levels of SIRT5, H2A and TOP2A proteins were detected by immunohistochemical two-step method in paraffin-embedded tissue blocks from 65 patients with cervical cancer (21 cases of stage IB, 9 cases of stage IIA and 35 cases of stage IIIC1p). The expression distribution and positive rate of SIRT5, H2A …

03.09.2026journal-article

Diagnostics

Limited Predictability of Traumatic Intracranial Hemorrhage from Routine Pre-CT Clinical Variables in Older Adults with Low-Energy Falls: A Systematic Benchmarking Study in a Retrospective Bicentric Cohort

Robert Stahl, Anna Theresa Stüber, Rebecca Wania, Michael Ingrisch, Maryam Ostadi Ataabadi, Marco Öchsner, Robert Forbrig, Christoph G. Trumm, Thomas Liebig, Wolfgang Böcker, Vera Pedersen

Background/Objectives: Traumatic intracranial hemorrhage (tICH) in older adults following low-energy falls (LEF) represents a common yet diagnostically challenging condition in the emergency department (ED), where predicting injury prior to computed tomography (CT) remains difficult. Machine learning (ML) has been proposed to support CT decision-making, but its feasibility using routinely available pre-CT clinical variables in this specific population remains unclear. This study presents a systematic exploratory be …

03.09.2026journal-article

Journal of Medicine and Health Research

Artificial Intelligence for Physiologically Informed Precision Care in Sickle Cell Disease: Diagnosis, Risk Prediction, Personalised Treatment and Equitable Implementation

Ogboh Rita Onyebuchi, Miracle Anike Olawuyi, Nitebhar Ikpokpo, Damilola Alabi, Okechukwu Oluchi Chioma

Sickle cell disease (SCD) is a monogenic haemoglobinopathy whose clinical expression is shaped by multiscale interactions among haemoglobin S polymerisation, erythrocyte rheology, haemolysis, inflammation, vascular dysfunction, organ reserve, treatment exposure and social context. Artificial intelligence (AI) is increasingly being applied to these heterogeneous data, but high algorithmic performance does not by itself establish clinical usefulness. This critical narrative review evaluates how AI can support physiol …