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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
18.08.2026journal-article

Cell Death & Disease

Reversing KDM6A phosphorylation-driven epigenetic suppression restores pyroptosis and synergizes with anti-PD-1 therapy in HNSCC

Yikang Ji, Xinran Zhao, Cheng Hu, Jun Chen, Zhiyin Li, Xin Hu, Mi Zhang, Qingqing Wan, Xinhua Pan, Yan Wei, Xu Wang

Abstract Immune checkpoint blockade (ICB) has revolutionized head and neck squamous cell carcinoma (HNSCC) treatment. Yet, a major barrier to response is that tumor cells are epigenetically reprogrammed to resist immunogenic cell death, particularly pyroptosis. To elucidate how tumor cells are pre-conFigured for pyroptosis resistance, we investigated the role of post-translational modifications on epigenetic regulators, focusing on the phosphorylation-dependent control of histone demethylase KDM6A. Through integrat …

18.08.2026journal-article

Journal of Occupational & Environmental Medicine

Effects of a worksite health promotion program on cardiometabolic risk factors among healthcare workers in Taiwan

Guo-Li Fabian Chong, Yu-Hsiang Lin, Yi-Chuan Chen, I-Ju Chen, Jau-Yuan Chen

Objective: To evaluate the effects of a 12-week worksite health promotion program on cardiometabolic risk factors among healthcare workers. Methods: A non-randomized controlled trial was conducted in Taoyuan, Taiwan (2019–2021), comparing an intervention group receiving active appointment surveillance and physical training referrals with a control group receiving conventional health education, with measurements taken at baseline and 12 weeks. Results: Among 94 eligible participants, the intervention group showed si …

18.08.2026journal-article

ACS Applied Polymer Materials

Low-Hysteresis Sericin-Based Composite Conductive Hydrogel as a Wearable Sensor for Joint Motion Monitoring in Rehabilitation Training

Fangrong Sun, Ajiao Zhao, Xiang Li, Jingyu Chen, Kunlin Chen

Abstract In flexible sensing applications, the long-term reliability of hydrogels is challenged by sustained and cyclic mechanical deformations. Exposure to forces such as bending and stretching ultimately diminishes sensing fidelity and accelerates material fatigue, shortening the functional lifetime. To improve hydrogel durability and minimize hysteresis, this study develops a composite hydrogel composed of a copolymer matrix of 3-methacrylamidophenylboronic acid and acrylamide integrated with polydopamine-modifi …

18.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Dissociable Effects of Dysarthria Etiology and Severity on the Minimally Detectable Change of Speech Intelligibility

Kelly E. Zdrowak, Antje S. Mefferd, Kaila L. Stipancic

Purpose: The minimally detectable change (MDC) provides a threshold for interpreting changes in outcome measures that are outside of measurement error. There is emerging evidence that dysarthria etiology and speech severity impact the MDC of speech intelligibility; however, an investigation of these factors is needed to determine the unique effects of dysarthria etiology and speech severity. The purpose of the current study was to calculate and compare MDCs of speech intelligibility across five dysarthria etiology …

18.08.2026journal-article

Terapevticheskii arkhiv

Evaluation of drug therapy in patients before major orthopaedic surgery from the perspective of a general practitioner: a real-world study

Elena A. Okisheva, Olga Iu. Trushina, Alexey V. Lychagin, Victor V. Fomin

Aim. To evaluate the structure of cardiovascular pharmacotherapy prescribed during the preoperative period including antihypertensive, antiarrhythmic, antianginal, lipid-lowering, and antiplatelet drugs and to analyze its compliance with clinical indications in patients scheduled for elective orthopedic interventions on the major joints of the lower extremities. Materials and methods. This prospective, single-center cohort study included 1,733 patients. In all patients, a detailed medical history was obtained, an a …

18.08.2026journal-article

JAMA

Implications of the 2026 Dyslipidemia Guideline for Primary Prevention Statin Therapy

Timothy S. Anderson, Linnea M. Wilson, Jeremy B. Sussman

Importance The 2026 American Heart Association/American College of Cardiology/multisociety guideline on the management of dyslipidemia issued new recommendations on estimating atherosclerotic cardiovascular disease (ASCVD) risk and on populations eligible for statins for primary prevention. Objective To assess the population health impact of the 2026 guideline on primary prevention statin therapy. Design, Setting, and Participants Nationally representative, cross-sectional sample of nonpregnant adults aged 30 to 79 …

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18.08.2026journal-article

Journal of Back and Musculoskeletal Rehabilitation

The association between depression and frozen shoulder: A systematic review and meta-analysis

Yi-Chuan Chan, Shu-Han Chuang, Tai-Yuan Chuang, Yi-Jie Kuo, Shun-Jen Cheng, Yu-Pin Chen

Background Frozen shoulder (FS), commonly known as adhesive capsulitis, is a disabling musculoskeletal condition frequently accompanied by psychological distress. This meta-analysis aimed to evaluate the association between FS and depression. Methods For this meta-analysis, a systematic literature search of EMBASE, PubMed, and the Cochrane Library was conducted through 2025 using the keywords “frozen shoulder”, “adhesive capsulitis” and “depression.” Data regarding study characteristics, participant information, an …

18.08.2026journal-article

The Egyptian Journal of Bronchology

Effectiveness of lung flute and acapella devices in pulmonary tuberculosis rehabilitation: a randomized controlled trial

Bhavna Sharma, Bhuvnesh Kumar, Meenakshi Verma, Sumedha Rabra, Mohit Kumar Gangania, Harsh Goyal

Abstract Background Pulmonary tuberculosis (PTB) is a major worldwide health concern, particularly in environments with limited resources, even while pharmaceutical therapies for active tuberculosis have improved outcomes, pulmonary function impairment and a lower quality of life are common post-treatment side effects. Though their relative effectiveness in PTB rehabilitation is yet unknown, devices like the Lung Flute and Acapella have demonstrated potential in enhancing pulmonary rehabilitation, especially in con …

18.08.2026journal-article

Asian Journal of Oncology

Neoadjuvant, adjuvant, and perioperative systemic therapy in urothelial cancers: Evolving paradigms and future directions

Praloy Basu

Radical surgery is the cornerstone of management for localized muscle-invasive urothelial carcinoma (MIUC), yet surgery alone cures only a proportion of patients because occult micrometastatic disease is common at diagnosis. Over the last two decades, perioperative systemic treatment has evolved from a cisplatin-based chemotherapy paradigm to a more complex framework incorporating immune checkpoint inhibitors, antibody-drug conjugates, biomarker-enriched strategies, and risk-adapted postoperative approaches. Cispla …

18.08.2026journal-article

Frontiers in Immunology

IgG glycosylation dynamics in active lupus nephritis during the first year of immunosuppressive therapy

Ana Cindrić, Dionysis Nikolopoulos, Natalia Sherina, Frano Vučković, Farah Tamirou, Anne-Marie Patenaude, Maja Pučić-Baković, Barbara Radovani Trbojević, Frédéric A. Houssiau, Gordan Lauc, Ioannis Parodis

Introduction Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE) characterized by immune dysregulation and kidney inflammation. Alterations in immunoglobulin G (IgG) glycosylation are known to influence immune responses and have been implicated in autoimmune diseases, including SLE and LN. This study aimed to investigate longitudinal changes in IgG glycosylation in patients with active LN, from before treatment to one year after immunosuppressive therapy initiation. Methods Serum sa …

18.08.2026journal-article

Journal of Back and Musculoskeletal Rehabilitation

Comparison of the effects of ultrasound-guided suprascapular nerve block and intra-articular shoulder injection on pain, functional status and range of motion in patients with adhesive capsulitis: Randomized, controlled trial

Mehmet Yalvaç, Pinar Özge Başaran, Ayşe Gülşen Doğan, Murat Doğan, Deniz İpek, Abdulrahim Dündar

Background Adhesive capsulitis (AC) is a common shoulder disorder. Ultrasound-guided intra-articular injection (IAI) and suprascapular nerve block (SSNB) are frequently used interventions for AC treatment; however, their comparative effectiveness remains unclear. Objective To compare the effects of SSNB and IAI on pain, functional status, and shoulder range of motion in patients with AC. Methods In this prospective, randomized, controlled, assessor-blinded trial, patients with AC were assigned to either ultrasound- …

18.08.2026journal-article

International Journal of Stroke

Molecular biomarkers in stroke recovery: Consensus-based core recommendations from the fourth Stroke Recovery and Rehabilitation Roundtable

Matthew A Edwardson, Robynne G Braun, Chad M Aldridge, Rufus Akinyemi, Stefan T Engelter, Israel Fernández-Cadenas, Cristina Gallego-Fabrega, Quentin Le Grand, Jane Maguire, Alexander H Nave, Rajiv Ratan, Bradford B Worrall, Huichun Xu, Amy Brodtmann, Steven C Cramer, Kathryn S Hayward, Arne G Lindgren

Rationale: The 2017 Stroke Recovery and Rehabilitation Roundtable (SRRR) consensus statement on biomarkers identified genetic and blood biomarkers as a developmental priority for stroke recovery and rehabilitation. While progress has been made, this nascent field still lags behind other medical disciplines. Further development is critical because molecular biomarkers hold great promise to provide key insights into the neurobiological mechanisms of both spontaneous and treatment-induced stroke recovery. Such insight …

18.08.2026journal-article

Oral Diseases

Tegafur‐Uracil ( UFUR ) as Maintenance Therapy in Resectable and Unresectable Head and Neck Squamous Cell Carcinoma: A Narrative Review

Hui‐Ching Wang, Pen‐Yuan Chu

ABSTRACT Head and neck squamous cell carcinoma (HNSCC) remains associated with high rates of locoregional recurrence and distant metastasis despite definitive treatment. Metronomic tegafur‐uracil (UFUR), an oral fluoropyrimidine comprising tegafur and uracil, has emerged as a potential maintenance strategy because of its cytotoxic, immunomodulatory, and anti‐angiogenic mechanisms mediated by 5‐fluorouracil (5‐FU) and gamma‐hydroxybutyric acid (GHB). This narrative review summarizes current evidence on UFUR maintena …

18.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Tobacco processing workers’ body mapping analysis identified occupational illnesses and assisted in investigating risk factors

Ancah Caesarina Novi Marchianti, Elvia Rahmi Marga Putri, Dwita Aryadina Rachmawati, Hairrudin Hairrudin, Saekhol Bakri, Athira Nandakumar

Background Despite its economic benefits, the tobacco processing industry poses health risks to workers due to occupational hazards. Body mapping can help gather evidence about the work effects on the body. Objective To assess the occupational health of tobacco processing workers by body mapping. Methods Body mapping data were collected from one hundred private industry tobacco processing workers in November, 2024. The other data were collected by health professional workers (body temperature, heart rate, blood pre …

18.08.2026journal-article

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH

Impact of Rational Emotive Behavior Therapy and Cognitive Behavioral Therapy on Drug Abuse Reduction Among NDLEA Rehabilitation Clients in Abuja, Nigeria

Fatima Abiola Popoola

Drug abuse remains a significant public health and psychosocial challenge globally, with Nigeria experiencing an increasing burden, particularly among youths and young adults. The growing prevalence of substance use disorders has necessitated the adoption of evidence-based psychological interventions to enhance rehabilitation outcomes. This study investigated the impact of Rational Emotive Behavior Therapy (REBT) and Cognitive Behavioral Therapy (CBT) on drug abuse reduction among clients in National Drug Law Enfor …

18.08.2026journal-article

Rehabilitation Oncology

Aquatic Exercise for Pain Intensity and Mechanical Pain Sensitivity in Women Surviving Breast Cancer: Systematic Review and Meta-Analysis

Victor Hugo G. Pinheiro, Tania Angelita I. Guesser, Antonio I. Cuesta-Vargas, Cristine L. Alberton

Background: Persistent pain after breast cancer treatment may involve self-reported pain intensity and mechanical pain sensitivity (MPS). Previous reviews of aquatic exercise in women surviving breast cancer mainly synthesized broad rehabilitation outcomes. This review aimed to evaluate the effects of structured aquatic exercise interventions on pain intensity and MPS in this population. Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidance, five databases were searched from …

18.08.2026journal-article

PLOS Computational Biology

Reassessing adult surfactant replacement therapy with mechanics-informed reinforcement learning

Philippe Meliga, Gregor Roncin, Alejandro Yepes Peñaranda, Elie Hachem

Surfactant replacement therapy (SRT) remains clinically limited to neonatal applications, in part because the mechanical feasibility of achieving efficient delivery in adult lungs is poorly understood. Previous computational studies have largely been descriptive or based on parameter sweeps, providing limited guidance on how to design efficient adult protocols under anatomical constraints. Here, we introduce a computational framework that integrates mechanistic modeling of surfactant propagation in anatomically mot …

18.08.2026journal-article

Journal of Back and Musculoskeletal Rehabilitation

Focused shock wave versus radial pressure wave therapy for musculoskeletal disorders: A systematic review and meta-analysis

Mariam Ismail Hassan, Ahmed Ibrahim Abdelhamed, Tasbih Emad, Mariam Hesham Sallam, Haidy Samy, Hadel Hesham Elkhodary, Mazen Mohamed Sayed

Background Focused shock wave therapy (FSWT) and radial pressure wave therapy (RPWT) are commonly used noninvasive modalities for managing musculoskeletal disorders (MSKDs), yet their distinct physical properties and inconsistent evidence make it unclear which modality provides better outcomes. Objective To compare the FSWT with the RPWT in terms of pain, function, strength, and range of motion (ROM) in patients with MSKDs. Methods We searched PubMed, the Cochrane Central Register of Controlled Trials, Web of Scien …

18.08.2026journal-article

International Journal of Sports Medicine

Metabolic and Arterial Stiffness Correlates of Aerobic Capacity in Male Occupational Personnel

Yuhang Liu, Michael J Conner, J Jay Dawes, Steve E Martin, Drew E Gonzalez, Richard B Kreider

To examine associations between body composition, physical performance, and inflammatory/oxidative stress biomarkers with aerobic capacity, indexed by VO₂peak, among tactical personnel, and to develop predictive models for health, performance, and readiness assessment. Complete case data were available for 102 occupational personnel. Variance inflation factors assessed multicollinearity. Linear models tested associations with VO₂peak, while generalized additive models explored nonlinear relationships. A 10-fold cro …

18.08.2026journal-article

Occupational and Environmental Medicine

Sleep disturbances and sleep duration as predictors of working life expectancy among adults aged 50 years and older in Finland

Saana Myllyntausta, Katriina Heikkilä, Jaana Pentti, Holendro Singh Chungkham, Sakari Suominen, Mika Kivimaki, Jussi Vahtera, Paola Zaninotto, Jenni Ervasti, Sari Stenholm

Objectives To examine the associations of sleep disturbances and sleep duration with working life expectancy (WLE; the estimated number of years an individual is expected to be in the workforce) from age 50 to 68. Methods Data of individuals ≥50 years were drawn from two cohort studies: the Finnish Public Sector (FPS) study involving public sector employees in 2000–2016 (n=70 339, 80% women) and the Health and Social Support (HeSSup) study in 1998–2013 initially representing the general working age population in Fi …

18.08.2026journal-article

JMIR Medical Education

Multiagent Large Language Model Framework for Psychotherapy Fidelity Assessment in Motivational Interviewing and Cognitive Behavioral Therapy Training: Cross-Sectional, Simulation-Based Evaluation Study

Mohammad Amin Kamaleddin, Mina Mirjalili, Reza Barzegar, Nghia Trung Le, Zachary Cote, Olga Winkler, Lisa Burback, Yanbo Zhang, Osmar R Zaiane, Candice Monson, Divya Sharma, Sri Krishnan, Andrew J Greenshaw, Richard Zeifman, Peter Selby, Venkat Bhat

Abstract Background Psychotherapy training is difficult to scale because manual rating of motivational interviewing (MI) and cognitive behavioral therapy (CBT) sessions is time-intensive, requires trained raters, and is subject to rater variability. Large language models (LLMs) may support simulation-based training and rubric-guided scoring, but early-stage evidence is needed before such systems can be applied to real learners. Objective This study aimed to conduct a simulation-based evaluation of a multiagent LLM …

18.08.2026journal-article

Proceedings of the National Academy of Sciences

The immunophenotype and proviral landscape of HIV-infected CD4 T cells during antiretroviral therapy

Cyrille L. Delley, Sakshi Shah, Kevin M. Joslin, Yujung P. Park, Benjamin Demaree, Michael P. Busch, Mars Stone, Steven G. Deeks, Eli A. Boritz, Adam R. Abate, Iain C. Clark

In individuals on effective antiretroviral therapy (ART), integrated HIV proviruses persist within CD4 T cells, forming a viral reservoir that rebounds if treatment is stopped. Identifying and targeting these rare, infected cells is critical for advancing therapies, but methods to study reservoir cells are limited, and their unique properties remain largely unknown. We applied DAb-seq, a high-throughput method that combines single-cell DNA and surface protein sequencing, to profile ~527,000 CD4 T cells from the blo …

18.08.2026journal-article

Journal of Pharmacy Practice

Standardized Bone Health Assessment and Treatment Among Prostate Cancer Patients on Androgen Deprivation Therapy in a Large Integrated Managed Care Delivery System

Michael J. Shulman, Brandon H. Horton, Joan C. Lo, Marilyn J. Meganck, Masy K. Miller, Jennifer J. Park-Sigal, Andrew L. Avins

Background: Bone-health risk assessment and treatment among prostate-cancer patients on androgen-deprivation therapy (ADT) is often inadequately completed in clinical practice. Objective: To determine the impact of a population-management program on bone-health risk assessment and bisphosphonate therapy among prostate-cancer patients on ADT. Methods: We used retrospective data from a large integrated healthcare system to identify men aged 41-89 years diagnosed with prostate cancer in 2011-2024 who received ≥1 ADT d …

18.08.2026journal-article

British Journal of Occupational Therapy

Effects of a short-term, low-frequency occupational participation programme on health-related quality of life in community-dwelling older adults: A multicentre quasi-experimental study

Shota Aoyagi, Ryota Izumi, Yohei Kurita, Tetsuya Sano, Kosuke Suzuki, Yuki Satake

Introduction: Promoting health-related quality of life in community-dwelling older adults is central to occupational therapy practice in super-ageing societies. However, evidence for short-term, low-frequency occupational participation programmes remains limited. Methods: A multicentre, non-randomised within-subject longitudinal study was conducted in Japanese community groups. Participants served as their own controls during a usual activity period, followed by a 3-month intervention comprising three monthly sessi …