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22 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Journal of Pediatric Hematology/Oncology

Implementation of a Digital Clinical Management Platform in a Tertiary Pediatric Hemato-Oncology Center: Impact on Clinical Outcomes and Patient Safety

Michal Singer, Uri Ilan, Guy Dolinski, Nitsan Halabi, Yuliana Edri, Nisim Rahman, Sigal Sina, Maor Sagi, Sivan Tam, Moshe Ashkenazi

Introduction: Healthcare delivery is increasingly challenged by rising demand, escalating costs, and the need for efficiency. Contributing factors such as the nursing workforce crisis, fragmented and excessive clinical data, outdated IT infrastructures, and the growing complexity of care exacerbate the risk of medical errors, treatment delays, and staff burnout. To address these challenges, we evaluated AMIT, a novel digital platform designed to support nursing practice in pediatric oncology. Methods: AMIT is a web …

28.08.2026journal-article

Cancers

C-Reactive Protein-Based Composite Indices for Predicting Tumor Overgrowth Restenosis After Partially Covered Duodenal Stenting in Gastric Cancer: A Cohort Study

Hyuk Lee, Young Eun Oh, Tae-Se Kim, Yang Won Min, Byung-Hoon Min, Jun Haeng Lee

Background/Objectives: Partially covered duodenal stents rapidly relieve malignant gastric outlet obstruction, but tumor overgrowth restenosis limits durability. We compared six preprocedural inflammatory, nutritional, and immune indices for predicting this outcome in patients with gastric cancer. Methods: We retrospectively analyzed 68 consecutive patients from a prospectively maintained cohort. The primary endpoint was endoscopically or radiologically confirmed tumor overgrowth restenosis. Discrimination was asse …

28.08.2026journal-article

CA: A Cancer Journal for Clinicians

The new (version 9) American Joint Committee on Cancer (AJCC) tumor‐node‐metastasis (TNM) staging protocol for carcinoma of the vulva

Alexander B. Olawaiye, Elliot A. Asare, Ian S. Hagemann, Priya R. Bhosale, Stephanie Gaillard, Brian Rous, Bunja Rungruang, Shitanshu Uppal, Gulisa Turashvili, Kaled M. Alektiar, Jonathan A. Cosin, Uma Krishnamurti, Lee‐may Chen, Keiichi Fujiwara, Matthew A. Powell, Mauricio A. Cuello, David G. Mutch

Abstract The American Joint Committee on Cancer (AJCC) tumor‐node‐metastasis (TNM) staging for all cancer sites has been updated periodically as a published manual for many years. The last update of the manual version, the eighth edition AJCC Cancer Staging Manual , went into use on January 1, 2018. The AJCC has since restructured and updated its processes for curating, analyzing, and publishing updates to the TNM staging system. All AJCC staging‐related data are now housed on its new application programming interf …

28.08.2026journal-article

Journal of Environmental Quality

Pesticide occurrence, transformation, and transport from wastewater treatment plants into stream networks with diverse land uses

Kyra Sigler, Matthew V. Russell, William Ford, Wayne Sanderson, Tiffany L. Messer

Abstract Neonicotinoid insecticides and strobilurin fungicides are detected in many environmental compartments and have been associated with negative environmental and human health implications. Wastewater treatment plants (WWTPs) are often hotspots for introducing such contaminants into the environment. Therefore, the occurrence of strobilurin fungicides, neonicotinoids, and their metabolites at two WWTPs with varying land uses and population sizes was investigated. Polar organic chemical integrative samplers were …

28.08.2026journal-article

Substance Use & Addiction Journal

Evaluation of an Online, Asynchronous Tobacco Treatment Specialist Training: A Mixed-Methods Analysis of Reach, Perceived Trainee Competency, and Training Quality

Tresza D. Hutcheson, Sharon Fitzgerald Wolff, MeLinda Lair, Kimber P. Richter, Babalola Faseru

Background: Although tobacco use disorder is the most prevalent substance use disorder in the United States and remains the world’s leading cause of preventable mortality, health care and social service providers receive little training in how to treat it during their formal education. To enhance access to Tobacco Treatment Specialist (TTS) training, we developed an online, self-paced, asynchronous training paired with a 1-day virtual workshop for skills building and demonstration. Methods: We calculated the reach …

28.08.2026journal-article

ACS Sensors

Reprogramming RNA Degraders as Intracellular Molecule Sensors for Tumor Cell Sensing and Manipulation

Pin-Ru Chen, Ying Han, Pei-Pei Qin, Ying-Yue Xu, Qian Tao, Bang-Ce Ye, Bin-Cheng Yin

Abstract Engineering transgene expression to respond specifically to intracellular cues holds transformative potential for monitoring cell states and modulating cellular functions. Here we introduce TRADER (Target-induced Transgene Activators via Reprogramming of dCas6-barnase Degrader), a versatile and modular platform that enables transgene activation in response to intracellular molecules at the post-transcriptional level. TRADER leverages a proximity-dependent RNA degrader system, in which a catalytically inact …

28.08.2026journal-article

Cancers

From Pixels to Stroma: AI-Driven Spatial Profiling of Cancer-Associated Fibroblasts on H&E and Its Implications for Immunotherapy

Dalani Tarun, Wong Kwun Hin Jerry, Jialin Wu, Xin Fang, Tiejun Feng, Fuda Xie, Muyang Huang, Yuanke Liang, Ka Fai To, Wei Kang, Haoyu Lin, Bonan Chen

Immune checkpoint blockade (ICB) has transformed cancer therapy, but clinical responses remain heterogeneous across tumor types and patient populations. Cancer-associated fibroblasts (CAFs) are key stromal components of the tumor microenvironment and can contribute to immunotherapy resistance through immune exclusion, extracellular matrix remodeling, chemokine signaling, and interactions with suppressive immune cells. Although CAF-directed strategies are under active investigation, their clinical translation is lim …

28.08.2026journal-article

Journal of The Society of Obstetricians and Gynaecologists of Pakistan

Diagnostic accuracy of visual inspection with acetic acid in diagnosing cervical cancer, taking histopathology as gold standard

Moiz Hassan, Hajira Masood, Tehreem Azhar, Seerat Tayyaba, Amara Malik

Objective: To compare the diagnostic accuracy of visual inspection with acetic acid (VIA) in screening cervical cancer, taking histopathology as the gold standard. Methodology: This analytical, cross-sectional study was performed at the Obstetrics and Gynecology Department of Nishtar Hospital, Multan, Pakistan, during June 2025 to November 2025. A total of 120 women, aged 45–70 years, with symptoms suggestive of cervical malignancy were analyzed through consecutive sampling. VIA was performed using 5% acetic acid u …

28.08.2026journal-article

Diagnostics

Veil-Based Collector Device Enabling Self-Collected Cervicovaginal Sampling for Site-of-Care Primary HPV-Based Cervical Cancer and Sexually Transmitted Infections Screening: A Pilot Feasibility Study in Romania

Madalina Ciuhodaru, Alina-Mihaela Calin, Bogdan-Florentin Nițu, Claudia Simona Cambrea, Ioana Denisa Popa, Cristian Bucsineanu, Ralph-Sydney Mboumba Bouassa, Juval Avala Ntsigouaye, Vincent Vernet, David Sebaoun, Franck Chaubron, Laurent Bélec

Background/Objectives: High-risk human papillomavirus (HR-HPV) causes cervical cancer, but other sexually transmitted infections (STIs) act as possible cofactors. We herein evaluated the feasibility, logistics, and epidemiology of a community-based screening program in Romania using an innovative veil-based self-sampling device and a digital platform. Methods: Adult women self-collected genital secretions using the Vaginal Veil Collector V-Veil UP2™ device (V-Veil-Up Production SRL, Pitesti, Romania). A digital pla …

28.08.2026journal-article

Cells

Cell-Free DNA Release Kinetics and Fragmentation Reflect Treatment Response and Resistance In Vitro

Alexandra Bartolomucci, Laura Kienzle, Sarah Tadhg Ferrier, Benjamin Forgie, Thupten Tsering, Kyle Dickinson, Lorenzo Ferri, Jonathan Cools-Lartigue, Julia V. Burnier

Background: Circulating tumor DNA (ctDNA) has emerged as a clinically valuable biomarker for cancer detection, treatment monitoring, and minimal residual disease assessment. Despite its growing clinical utility, the biological mechanisms governing ctDNA release remain incompletely understood. The objective of this study was to investigate how chemotherapy-induced cytotoxicity and chemoresistance influence the kinetics and fragmentation patterns of cfDNA released by cancer cells in vitro. Methods: Human lung adenoca …

28.08.2026journal-article

Frontiers in Veterinary Science

Proof of concept for low dose and delayed release of tigilanol tiglate in the treatment of equine sarcoids

Gideon P. Stemmet, Peter Parsons, Jenny Johns, Paul Reddell, Raphael Labens

Intra-tumoural administration of tigilanol tiglate has been shown effective in local treatment of cutaneous equine neoplasias. The drug causes rapid oncolysis and tumour slough, but may also be associated with comorbidities in sensitive and/or intricate anatomical sites due to its initial pro-inflammatory mode of action. Here we describe two approaches to optimise and further de-risk treatment of equine sarcoids with tigilanol tiglate, especially in difficult locations. Firstly, we provide preliminary clinical and …

28.08.2026journal-article

VNU Journal of Science: Medical and Pharmaceutical Sciences

Small Bowel Obstruction Caused by a Jackfruit Seed in a Patient With a History of Miles’ Operation for Rectal Cancer: The First Case Report in Vietnam

Tran Que Son, Trinh Ke Diep, Nong Ngoc Quang, Nguyen Chi Trung, Pham Anh Tuan, Vu Thi Thu, Tran Hoang Phuong Thao, Luong Thi Ngoc

Background: Small bowel obstruction secondary to fruit seed phytobezoars is a rare clinical entity, particularly in patients with a history of major abdominal surgery. Case Report: We report the case of an 83-year-old man who presented with abdominal pain, vomiting, and a non-functioning colostomy four days after accidentally ingesting a jackfruit seed. He had a history of Miles’ operation 15 years prior for rectal cancer. Abdominal computed tomography confirmed small bowel obstruction caused by a foreign body meas …

28.08.2026journal-article

Japanese Journal of Clinical Oncology

Clinical features and treatment outcomes of fibrous dysplasia: a report from the Bone and Soft Tissue Tumor Registry in Japan

Masayuki Morishita, Daisuke Kobayashi, Akira Ogose, Akira Kido, Akihiko Takeuchi, Kazu Matsumoto, Kota Watanabe, Yoji Furukawa, Michio Ozeki, Akira Kawai, Yoshihiro Nishida

Abstract Background Fibrous dysplasia (FD) is a benign bone disorder classified into monostotic (MFD) and polyostotic (PFD) forms. There is limited evidence available regarding the clinical management of FD, and no large-scale epidemiological or treatment reports have been published from Japan. Therefore, this study aimed to clarify FD epidemiology and management using data from the nationwide Bone and Soft Tissue Tumor (BSTT) Registry. Methods This study retrospectively analyzed patients with MFD and PFD registere …

28.08.2026journal-article

Clinical Cancer Research

Multicenter Phase I Study of Triapine in Combination with [177Lu]Lutetium-Dotatate in Patients with Well-Differentiated Neuroendocrine Tumors (ETCTN 10388)

Aman Chauhan, Heidi L. Weiss, Charles Kunos, Rani Jayswal, Bhavana Konda, Heloisa P. Soares, Daneng Li, Thorvardur R. Halfdanarson, Mary F. Mulcahy, Heather A. Jacene, Aman Khurana, Rakhi Modak, Donglin Yan, Jan H. Beumer, Susan M. Christner, Peter I-Fan Wu, Biswajit Das, Larry V. Rubinstein, Steven D. Gore, S. Percy Ivy, Elise C. Kohn, William E. Carson, Lowell B. Anthony, Susanne M. Arnold

Abstract Purpose: The next generation of theranostics studies is looking at novel combinations with radiation sensitizers to enhance peptide receptor radionuclide therapy’s efficacy. In this study, we present safety and efficacy data from a multicenter phase I study of a [177Lu]lutetium-dotatate–triapine combination in patients with gastroenteropancreatic (GEP) neuroendocrine tumors (NET). Patients and Methods: The study consisted of 2 phases (part A: dose escalation; part B: dose expansion) administering the recom …

28.08.2026journal-article

Micromachines

Artificial Versus Magneto-Aerotactic Bacterial Robots for Cancer Therapy

Sylvain Martel

The use of magnetotactic bacteria (MTB), proposed by the author about 25 years ago, allowed the implementation of embedded capabilities allowing the execution of specific complex tasks such as the target delivery of therapeutics in tumoral hypoxic zones that could not be implemented in artificial micro/nanorobots due to technological limitations at such a small scale. Since then, technology has evolved but the question remains about how long such superior advantage of using only certain types of live microorganisms …

28.08.2026journal-article

Applied Sciences

Fidelity-Constrained Rule-Based Knowledge Distillation of Random Forests for Compact Breast Cancer Grade Classification

Mert Büyükdede, Esma Gülfem Aktaş

Breast cancer is a highly heterogeneous disease at the histopathological and molecular levels, and histological grade is a key prognostic indicator reflecting tumor biology. Although Random Forest models effectively capture nonlinear patterns in high-dimensional gene expression data, the decision logic of large tree ensembles remains difficult to inspect directly. This study proposes a knowledge-distillation framework that transfers the probabilistic decision behavior of a Random Forest teacher model to a compact, …

28.08.2026journal-article

Frontiers in Medicine

Metachronous multifocal early gastric cancer after partial gastrectomy for synchronous multifocal early gastric cancer: a case report and literature review

Qiang Geng, Qing Yang, Shubei Chen, Wei Qiu, Xiaoling Liu, Changfeng Sun, Cunliang Deng, Ou Jiang

With the rapid advancement of digestive endoscopy techniques, an increasing number of early gastric cancers (EGCs) have been diagnosed and treated, substantially improving the 5-year survival rate of patients with EGC. Multifocal gastric cancer is a relatively uncommon subtype, and repeated occurrences of multifocal gastric cancer are even less frequently observed. The pathogenesis may involve persistent field cancerization of the background gastric mucosa and, in some patients, an inherited predisposition; evaluat …

28.08.2026journal-article

International Journal of Molecular Sciences

Dual Targeting of FGFR4 and PI3K–mTOR Suppresses Tumor-Associated Phenotypes in Pancreatic Ductal Adenocarcinoma

Joseph A. Goode, Savannah A. Harris, Deborah A. Altomare

Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive adaptive signaling plasticity and metabolic reprogramming that contribute to therapeutic resistance. While the PI3K–mTOR pathway is a central regulator of these processes, the role of the FGF19–FGFR4 axis and its interaction with PI3K-mTOR signaling remains incompletely defined in PDAC. This study investigated whether co-targeting FGFR4 and PI3K-mTOR signaling could overcome adaptive pathway reactivation and suppress tumor-promoting phenotypes. P …

28.08.2026journal-article

Advances In Social Humanities Research

Assessing The Severity of Oropharyngeal Dysphagia and its Relation to Quality of Life Status in Head and Neck Cancer Patients After Undergoing Chemoradiotherapy in DR Sardjito Public Hospital, Yogyakarta, Indonesia: A Cross Sectional Prospective Study

Anisa Haqul Khoiria, Agus Surono, Camelia Herdini

Head and neck cancer treatment frequently causes oropharyngeal dysphagia, which may impair nutritional status, psychological well-being, social functioning, and overall quality of life. This study aimed to assess dysphagia severity and swallowing-related quality of life, compare changes in these outcomes during early follow-up, and determine the relationship between dysphagia severity and quality of life among patients after chemoradiotherapy. A prospective observational study was conducted among 60 patients with h …

28.08.2026journal-article

Journal of Computer Assisted Tomography

Association of Imaging-Defined Deep Invasion and Tumor Volume With Clinical Cervical Lymph Node Metastasis in Hypopharyngeal Carcinoma

Hinano Anaba, Yohei Morishita, Ryo Ishii, Takuma Usuzaki, Tomo Kinoshita, Yoshitaka Toyama, Akira Ohkoshi, Yukio Katori, Kei Takase

Objective: Deep tumor invasion is a recognized pathologic risk factor for cervical lymph node metastasis in patients with hypopharyngeal carcinoma, but the relationship between imaging findings of the primary tumor and clinical lymph node metastasis has not been fully defined. In this study, we assessed whether imaging-defined deep invasion and tumor volume are associated with clinical lymph node metastasis. Methods: This retrospective study included 142 consecutive patients with newly diagnosed hypopharyngeal squa …

28.08.2026journal-article

Medicine

Association between thymidine kinase 1 and clinicopathological high-risk features in breast cancer

Yanze Liu, Jiaqi Liu

Thymidine kinase 1 (TK1) is a cell-cycle-regulated enzyme involved in DNA synthesis and is closely linked to tumor cell proliferation. This study investigated whether serum TK1 concentration is associated with clinicopathological high-risk features in breast cancer (BC) and whether TK1 changes after neoadjuvant chemotherapy (NACT). This retrospective single center cohort included 410 patients with invasive BC. Serum TK1 was analyzed according to age, lymph node metastasis (LNM), histological grade, Ki-67, circulati …

28.08.2026journal-article

International Journal of Health Management Review

COLORECTAL CANCER SCREENING STATUS AND ASSOCIATED FACTORS AMONG ADULTS IN CAN THO CITY, VIETNAM

Nguyen Huu Ky Phuong

Objective: To describe colorectal cancer (CRC) screening status and identify associated factors among adults aged 45-74 years in Can Tho City, Vietnam. Methods: This analytical cross-sectional study included 600 participants from 12 clusters. Frequencies, proportions, and adjusted odds ratios (aORs) were estimated using multivariable logistic regression with cluster-adjusted standard errors. Results: Overall, 159 participants (26.5%) were up to date with CRC screening. Among those screened, 59.1% had undergone colo …