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European Health Evidence

The European alternative to PubMed

EUVIMED is the European alternative to PubMed: a central, multilingual research platform for medicine, nursing, life sciences and healthcare. It brings together international and European literature sources, study registries, open-access full texts, citations and retraction notices in one search. Unlike pure bibliographic databases, EUVIMED supports the entire research process – from discovery and appraisal with LIVIA and CLARA to traceable evidence synthesis. European in focus, transparent, interoperable and designed for science and healthcare.

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EUVIMED Themenbrowser · Medizin · Seite 122

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Pharmacology

The clinical trial landscape of bispecific antibodies in non-small cell lung cancer: mechanistic trends and developmental strategies

Zunyuan Li, Xiyu Wang, Qin Shi, Yuhong Guo, Guirong Dong, Zhidan Liu

Background Non-small cell lung cancer (NSCLC) management remains constrained by acquired resistance to targeted therapies and refractoriness to immune checkpoint inhibitors (ICIs), the latter driven largely by the immunosuppressive tumor microenvironment (TME). Bispecific antibodies (bsAbs) represent a promising modality capable of circumventing these therapeutic hurdles through proximity-driven dual-targeting mechanisms that co-block bypass signaling pathways and reverse immunosuppression. This study systematicall …

03.09.2026journal-article

Frontiers in Surgery

Application of “parenchyma-first” approach in laparoscopic living donor left lateral sectionectomy

Hui Tang, Dongwei Wu, Kaining Zeng, Xiao Feng, Binsheng Fu, Qing Yang, Jia Yao, Yang Yang, Shuhong Yi

Objective This study aimed to evaluate the safety and feasibility of a “Parenchyma-First” approach for laparoscopic left lateral sectionectomy (LLS) in living donor hepatectomy, with the primary goal of minimizing vascular injury. Methods To avoid premature and excessive dissection of the portal vein and hepatic artery at the first hepatic hilum—which increases the risk of vascular injury—and to prevent torsion or occlusion of these mobilized vessels during parenchymal transection, we adopted a technique that prior …

03.09.2026journal-article

Frontiers in Endocrinology

Longitudinal clinical trajectories and vascular–inflammatory–neurophysiological associations in diabetic peripheral neuropathy: an exploratory analysis of a TENS-treated cohort

Qian Gao, Liwan Yang, Bin Wang, Lijuan Gao, Qing Yao, Jiangwei Hu

Background Transcutaneous electrical nerve stimulation (TENS) is used as an adjunctive treatment for diabetic peripheral neuropathy (DPN), but long-term clinical trajectories vary among patients. The biological characteristics associated with these different trajectories remain incompletely characterized. This study aimed to identify longitudinal clinical trajectory patterns and examine their associations with vascular, inflammatory, and neurophysiological measures. Methods Prospective 24-month data from 685 patien …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Connective tissue disorders and cardiac arrhythmias: genetic pathways, mechanistic bridges, and clinical implications

Luke Dreher, Hussein Abdul Nabi, Ramzi Ibrahim, Mahmoud Abdelnabi, Omar Baqal, Christopher N. Kanaan, Min Choon Tan, Linnea M. Baudhuin, Fadi E. Shamoun, Hicham Z. El Masry

Background Connective tissue disorders (CTDs) such as Marfan syndrome, Loeys-Dietz syndrome, and Ehlers-Danlos syndromes are traditionally defined by vascular fragility and aortic complications. Increasing evidence, however, demonstrates that CTDs also predispose to atrial and ventricular arrhythmias, often independent of overt cardiomyopathy or severe valvular disease. Content This review integrates emerging data on the arrhythmogenic substrates of CTDs. Four mechanistic bridges are emphasized: (1) diffuse myocard …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Integrating conformal prediction with machine learning for uncertainty-aware risk stratification in coronary artery disease

Shengnan Lin, Xuyang Hu, Yang Zhang, Qi Zhang, Xiaoning Wang, Yang Yang, Fuzheng Song, Yutong Li, Yushan Liu, Yuanpeng Zhao, Dingjian Zhao, Minghua Nan, Changchuan Bai

Background Predictive models are increasingly used in clinical decision-making in coronary artery disease (CAD). However, most existing models focus on discriminative ability while ignoring individual prediction uncertainty, which is particularly prominent in small-sample contexts, limiting clinical applications. Methods We developed an uncertainty-aware model integrating machine learning and conformal prediction (CP) for CAD prediction in a small-sample setting cohort ( N = 297). Logistic regression (LR) and rando …

03.09.2026journal-article

Frontiers in Dental Medicine

Case Report: Dental treatment under general anesthesia for a child with Ullrich congenital muscular dystrophy

SokIok Cheang, WeiYun Chen, Shuang Wang, XinXin Wang, Kuo Wan, Lin Ma

Background Ullrich congenital muscular dystrophy (UCMD) is a rare inherited myopathy caused by mutations in the COL6 gene and is frequently associated with multisystem complications affecting the respiratory and skeletal systems, which may increase airway and anesthetic risks during dental treatment. Case report This report describes a 4-year-old girl with UCMD who presented with pain in the left lower molar. After a comprehensive multidisciplinary evaluation by the Department of Stomatology, Anesthesiology, and Pe …

03.09.2026journal-article

Frontiers in Clinical Diabetes and Healthcare

Moisturizer formulations for diabetic foot xerosis: a systematic review and meta-analysis of randomized controlled trials

Karin Borgström, Sebastian Björklund, Petri Gudmundsson, Anna Ericsson, Stefan Acosta

Background Foot xerosis in people with diabetes increases the risk of skin fissuring, ulceration and complications like amputation, sepsis and death. Preventive skin care is therefore important, yet evidence-based guidance on the most effective formulations remains limited. This systematic review aimed to identify effective ingredients and formulations to treat diabetic foot xerosis. Methods A literature search was conducted in Medline, Cinahl, Embase, CENTRAL and Scopus. Randomized controlled trials (RCTs) involvi …

03.09.2026journal-article

Frontiers in Surgery

Latent class analysis–derived prediction model of shoulder function after arthroscopic repair for rotator cuff tear: a large retrospective cohort study

Tingting Ma, Yun Wu, Lujian Liang, Yumeng Tang, Yang Li, Rui Yin, Xia Ming, Liyan Bian

Objectives Considering the potential probabilities of shoulder function following arthroscopic rotator cuff repair (ARCR) was crucial for clinical decision-making and postoperative managements. This study aimed to identify distinct patterns of postoperative shoulder function and their prognostic factors. Methods Records of adult patients who underwent ARCR for the treatment of rotator cuff tear were reviewed from the electronic medical records. Constant–Murley scores were utilized to measure shoulder function at ba …

03.09.2026journal-article

Petroleum Engineering

INVESTIGATION OF THE FRACTIONAL COMPOSITION OF RESIN COMPONENTS OF HEAVY OIL UNDER STEAM-THERMAL TREATMENT

I.I. Mukhamatdinov, G.Kh. Sitdikova

In recent decades, the extraction and processing of heavy high-viscosity oil has become an urgent task for the oil industry. Such raw materials require additional preparation, including destruction of high molecular weight components to increase the yield of light fractions. The main share in it is occupied by resins and asphaltenes, the study of the structure of which is important both for understanding the processes of oil formation and for optimizing production, transport and processing. The paper studied the fr …

03.09.2026journal-article

Journal of the National Comprehensive Cancer Network

Comparative Cost-Effectiveness Analysis of First-Line Immunotherapy for Advanced Melanoma Based on 10-Year Clinical Outcomes

Guiyuan Xiang, Yin Sun, Xue Yang, Yao Liu

Background: Recently, the CheckMate 067, KEYNOTE-006, and RELATIVITY-047 trials demonstrated the long-term efficacy and safety of 5 first-line therapies for advanced melanoma, including nivolumab + relatlimab, with >10 years of follow-up. However, the long-term economic outcomes are still unclear. This study aimed to assess the comparative cost-effectiveness of these strategies from a US health care perspective using more than a decade of clinical trial data. Methods: Based on the data from clinical trial reports, …

03.09.2026journal-article

Nutrients

Unmetabolized Folic Acid: Biology, Epidemiology, and Clinical Consequences: A Systematic Review

Richard E. Frye, Daniel A. Rossignol

Background: Mandatory folic acid (FA) fortification prevents neural tube defects but generates unmetabolized folic acid (UMFA) in blood, because hepatic dihydrofolate reductase (DHFR) reduces FA only slowly. Whether UMFA itself, as distinct from high total folate, carries biological consequences is unresolved. Methods: We systematically searched six databases (January 1995–May 2026; PROSPERO CRD420261407616) and included 65 publications describing 61 unique primary studies, yielding 71 analytic contributions (15 me …

03.09.2026journal-article

Clinical Pharmacology & Therapeutics

Integrating Patient‐Centric Clinical Pharmacology and MID3 to Advance Biologic Development in Immune‐Mediated Inflammatory Diseases

Sihem Ait‐Oudhia, Li Zhang, Dipak S. Pisal, Brian Cicali

Advances in biologics and model‐informed drug discovery and development (MID3) are transforming the treatment of immune‐mediated inflammatory diseases (IMIDs). By integrating pharmacokinetics and pharmacodynamics, MID3 enables mechanism‐based, patient‐centered strategies to optimize therapies, strengthen benefit–risk assessment, and advance precision medicine. Innovations such as cytokine inhibitors, bispecific antibodies, antibody–drug conjugates, and mRNA therapies have expanded treatment options across dermatolo …

03.09.2026journal-article

Academic Journal of Education

Construction of a Traditional Chinese Medicine Cultural Education Practice System Driven by “Inheritance–Integration–Innovation”: An Exploration of Integrating Distinctive Traditional Chinese Medicine Resources with Modern Educational Technologies

Ran Zhang, Tao Ruan

Education in traditional Chinese medicine (TCM) culture is an important means of carrying forward China’s fine traditional culture. How to provide this process with a strong cultural foundation while ensuring that it conforms to the principles of educational development has become a key issue in establishing and improving the teaching system for knowledge-oriented courses. Taking “inheritance–integration–innovation” as its three analytical dimensions, this paper defines the practical education system in terms of bo …

03.09.2026journal-article

Clinical Dermatology Review

An Observational Study on Mucocutaneous Eruption Secondary to Mycoplasma pneumoniae: Alphabet Soup of Reactive Infectious Mucocutaneous Eruption or Mycoplasma pneumoniae-induced Rash and Mucositis

Swapnil Shah, Shibhani Sudheer Hegde, Chetan D. Rajput, Sandeep Kulkarni

Abstract Background: In 2015, diagnostic criteria for Mycoplasma pneumoniae -induced rash and mucositis (MIRM) were recommended, and currently, reactive infectious mucocutaneous eruption (RIME) is preferred. Due to the relatively recent introduction of this disorder, clinicians are still not extensively primed regarding the morphology and diagnosis of MIRM. Materials and Methods: A retrospective study was undertaken in a referral children’s hospital in Western India over 6 months where children concomitantly affect …

03.09.2026journal-article

Journal of Hospital Medicine

The implementation of an innovative just‐in‐time educational huddle for faculty development of academic hospitalists

Donna Coetzee, Suman Pal, Elizabeth Davis, Andrew P. J. Olson, Melissa Plesac

Abstract Academic hospitalists supervising residents on inpatient wards face the dual challenge of managing changing patient complexity and learner needs. Resident experience is highly dependent on supervising faculty; however, traditional faculty development often fails to respond to real‐time challenges of clinical teaching. To provide just‐in‐time faculty development, we implemented a weekly educational huddle for hospitalists rotating on resident ward teams using a Community of Practice model. The huddle emphas …

03.09.2026journal-article

Journal of Palliative Medicine

Palliative Surgery to Restore Function and Dignity: A Case of Massive Breast Tumor Debulking in Rural Uganda

Simran Kripalani, Howard Eison, Goretti Nassali, Prossy Nafula, Benjamin Schwarz, Randi Diamond

Background: Palliative surgery plays a critical role in alleviating symptom burden and thus improving quality of life in patients with advanced disease. Case Presentation: This is a case of a 23-year-old female in rural Uganda with an untreated, massive right breast mass present since infancy and progressive abdominal distention of unclear etiology. Over time, the breast mass impaired her mobility, rendering her largely homebound and dependent on others for basic movement. Despite evidence of profound malnutrition, …

03.09.2026journal-article

Artefactum - revista de estudos interdisciplinares

LONG COVID THROUGH A ONE HEALTH LENS: CLINICAL, SOCIAL, AND ENVIRONMENTAL FACTORS IN THE AMAZON

Ailson Almeida Veloso Junior, Luiz Fábio Magno Falcão, Junior da Silva Gomes, Yasmin Roque Sousa, Yasmin Barreiros da Silva, Valeria Gonçlaves da Mata, Naylane de Farias Caldas, Gabriele Farias Martins, Valeria Gonçalves da Mata

Objective: To characterize persistent manifestations following COVID-19 and analyze their associations with clinical, social, environmental, and psychosocial factors among individuals from the Brazilian Amazon from a One Health perspective. Methods: This observational, cross-sectional, analytical epidemiological study included a retrospective component addressing acute SARS-CoV-2 infection. The analysis comprised 98 participants. High symptom burden was exploratorily defined as four or more post-COVID manifestation …

03.09.2026journal-article

Ege Tıp Dergisi

Changes in public interest in plastic surgery over time: A comprehensive global perspective using google trends. No job, Yes Aesthetics?

Ecem Esma Yeğin, Mehmet Emre Yeğin

Aim: Google Trends has become an essential resource in health research, providing valuable insights into evolving public interest patterns. Social media platforms significantly influence public interest in cosmetic surgery, with effects observed across age groups. Research shows a clear connection between social media exposure and heightened public interest, serving as a means for surgeons to educate patients and market their services.Material and Methods: This study uses Google Trends data to analyze changes in in …

03.09.2026journal-article

Journal of Intensive Care Medicine

Hypoxic Hepatitis in Critically Ill Patients: Incidence, Clinical Characteristics, and Outcomes — A Systematic Review and Meta-Analysis

Carlos David Trevilla Martínez, Yeison Cruz Castillo, Mariela Denise Fermin Madera, Supritha Chintamaneni, Brenda Tatiana Camacho Ramirez, Laura A. Gray, Gabriela Flores Monar, Bansi Sutariya, Camila Sanchez Cruz, Ernesto Calderón-Martinez, Sushovan Guha, Rashmi Advani

Background Hypoxic hepatitis (HH), also termed ischemic hepatitis and historically described as shock liver, is an acute liver injury syndrome in critically ill patients characterized by a rapid and marked rise in aminotransferases in the setting of circulatory, cardiac, or respiratory failure, after exclusion of other causes of acute hepatic injury. Despite its clinical relevance, the true incidence and prognostic significance of HH remain unclear. This systematic review and meta-analysis aimed to determine the po …

03.09.2026journal-article

Emergency Medicine Australasia

Using Sydney Triage to Admission Risk Tool With Artificial Intelligence ( START ‐ AI ) to Predict Inpatient Admitting Specialty for Emergency Department Patients: Single Centre Deep Learning Analysis

Michael Dinh, Elizabeth Corbett, Thuy Truc Ngo, Eliot Salmon, Saleem Ahmed Khan, Farhana Pethani, Nicholas Moore, Irena Koprinska

ABSTRACT Objective To investigate whether the Sydney Triage to Admission Risk Tool with Artificial Intelligence (START‐AI) model could be used to predict specific inpatient admitting teams based on clinical notes. Methods This was a pre‐trained language model analysis using electronic medical record data from an inner‐city tertiary referral hospital emergency department (ED) in Sydney, Australia. All adult patients who were admitted to an inpatient ward between January 2023 and June 2025 were included. A fine‐tuned …

03.09.2026journal-article

JMIR Formative Research

Real-World Impact of Remote Patient Management on Care Consumption and Care Time in Heart Failure: Retrospective Cohort Study

Wessel William Nieuwenhuys, Mayke Maria Christina Josephina van Leunen, Jeroen Albert Adrianus van de Pol, Frederique Jantine Hafkamp, Rudolph Ferdinand Spee, René Anton Tio, Mathias Funk, Hareld Marijn Clemens Kemps

Abstract Background Remote patient management (RPM) is a strategy to track daily health data in patients with heart failure (HF) to enable early detection and treatment of decompensation to prevent hospital readmissions. The implementation of RPM alters standard care and redistributes provider responsibilities. Although randomized controlled trials demonstrate positive clinical outcomes, the impact of implementing RPM on patients’ health care usage, as well as the care time and workload of health care providers in …

03.09.2026journal-article

Journal of Clinical Nursing

Staff Confidence and Barriers to Complex Clinical Communication in Nursing Homes: A Convergent Mixed‐Methods Study

Silvia Gonella, Eugenia Malinverni, Luciano Orsi, Filippo Laurenti, Stefania Chiodino, Monica Seminara, Simona Operto, Dario Cencio, Marina Sozzi, Giovanna Marsico, Francesca Paruzzo, Mariagrazia Imperato, Jacopo Olagnero, Maria Rivolta, Ilaria Lovetro, Luigi Stella, Valerio Dimonte, Sara Campagna

ABSTRACT Aim To describe all nursing home staff members' confidence in engaging in complex clinical communication with residents and family carers, and to explore factors affecting their attitudes. Methods A convergent mixed‐methods study used questionnaires ( n = 288) and 15 group‐based discussions involving 278 professionals across nine nursing homes between April and May 2025. Quantitative data were analysed descriptively, and qualitative data underwent inductive thematic analysis. Findings from the two strands …

03.09.2026journal-article

Belügyi Szemle

Forenzikus pszichiátria és (előzetes) kényszergyógykezelés – a kriminalisztika piramismodelljének tükrében

Melinda Hengl

Cél: Bemutatni azokat a kapcsolódási pontokat a kriminalisztika piramismodellje, valamint a forenzikus pszichiátria és a(z előzetes) kényszergyógykezelés között, amelyek révén a modell kiegészíthető.Módszertan: A keretrendszer fogalmainak meghatározása után, összehasonlító elemzéssel a piramismodell tükrében a kapcsolódási pontok szemléltetése a forenzikus pszichiátriával és a(z előzetes) kényszergyógykezeléssel. Majd az elemzés irányát megfordítva, a forenzikus pszichiátria és a(z előzetes) kényszergyógykezelés fe …

03.09.2026journal-article

Frontiers in Medicine

Development and validation of an automatic machine learning-based myocardial contusion prediction model in rib fracture patients: a retrospective multicenter cohort study

Yan Yang, Ping Liu, Ni Jia, Yisha Xu, Peng Wu, Zhigang Zhang, Tingyong Han, Yan Jiang, Xianpeng Huang, Long Li

Objective This study aims to construct an automatic machine learning-based prediction model to accurately identify the risk of myocardial contusion in traumatic rib fracture patients, addressing the core limitations of insufficient sensitivity in traditional diagnostic methods and difficulties in clinical translation of existing prediction models. Methods A multicenter retrospective study design was adopted, including 1,038 rib fracture patients from 8 hospitals (training set: 808 cases; testing set: 230 cases) fro …