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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

BMC Pulmonary Medicine

Late pleural metastasis with immunophenotypic shift seven years after resection of shoulder synovial sarcoma: a case report

Chengjin Li, Longjie Pan, Wen Min

Abstract Background Synovial sarcoma is a soft tissue malignancy with a well-known propensity for late recurrence. Pleural metastasis occurring more than five years after primary resection in the absence of pulmonary involvement is exceptionally rare. Case presentation A 42-year-old man underwent local excision of a right shoulder synovial sarcoma in 2019 without adjuvant therapy or follow-up. In June 2026, he presented with right-sided chest pain and progressive dyspnea. Contrast-enhanced chest computed tomography …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Vitamin D Deficiency and Severe Dengue Fever: A Systematic Review and Meta-Analysis

Chuchun Zhuang, Xinxiaodi Yan, Yufeng Liang, Lihua Zhang, Lian Cai, Yukun Lin, Xiaowen Feng, Huacheng Yan

ABSTRACT. Vitamin D affects immune function and possibly, dengue severity, but evidence is inconsistent. Observational studies comparing vitamin D levels between severe and nonsevere dengue were systematically searched. A random-effects meta-analysis was conducted. Heterogeneity was quantified using I 2 . Subgroup and sensitivity analyses were performed. Six studies with 1,130 participants were included. The pooled odds ratio (OR) for severe dengue with vitamin D deficiency was 1.77 (95% CI: 0.75–4.16, P = 0.194) w …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Long-Term Mortality among Hospitalized Adults with Sepsis in Uganda: A Prospective Cohort Study

Abdullah Wailagala, Stephen Okello, Willy Kayondo, Rodgers R. Ayebare, David F. Olebo, Mubaraka Kayiira, Melissa Gregory, Stacy M. Kemigisha, Jeff W. Koehler, Randal J. Schoepp, Helen Badu, Nehkonti Adams, Prossy Naluyima, Charmagne Beckett, Mohammed Lamorde, Peter Waitt, Hannah Kibuuka, Danielle V. Clark, Paul W. Blair

ABSTRACT. Twelve-month mortality in sepsis survivors has not been previously characterized in sub-Saharan Africa. Hospitalized adults with ≥2 modified systemic inflammatory response syndrome criteria (temperature 38°C, heart rate ≥90 beats per minute, or respiratory rate ≥20 breaths per minute) were enrolled at a tertiary care center from October 2017 to August 2022. Multiple clinical blood and respiratory molecular and antigen assays were used to identify infectious etiologies. Baseline demographics were evaluated …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Comparative Effectiveness of Oral Ivermectin, 1% Permethrin Shampoo, and 4% Dimethicone Liquid Gel in Treatment of Pediculosis Capitis among School Children in Chachoengsao Province, Thailand

Arisa Vannaratha, Supanut Buakaew, Nitkamol Santiwananont, Thidaporn Srisub, Arthitaya Sutthithum, Sudarat Reugjui, Patanin Julsurang, Hatthakorn Lueang-urai, Wirakarn Liamsakul, Rungtawan Boonsombat, Patanawadee Luenpan, Supasek Thangto, Toon Ruang-areerate, Nuanlaong Kaeothaisong, Detchvijitr Suwanpakdee, Picha Suwannahitatorn

ABSTRACT. Pediculosis capitis remains a persistent public health issue, especially in developing countries where resistance to standard neurotoxic pediculicides like permethrin is increasingly prevalent. This study aimed to compare the effectiveness of alternative treatment options against the standard care in a resource-limited setting. We conducted a single-blind randomized controlled trial involving three primary schools in Chachoengsao Province, Thailand (ClinicalTrials.gov: NCT06332872). Eighty-five female par …

02.09.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

P-TAU217 COMO BIOMARCADOR SANGUÍNEO NO DIAGNÓSTICO PRECOCE DA DOENÇA DE ALZHEIMER: UMA REVISÃO DA LITERATURA

Paulo Eduardo Macedo de Moraes Filho, Victor Monteiro Campos, Ana Carolina de Moraes Bueno, Maria Eduarda Monteiro Pereira da Silva, Maria Aparecida de Almeida Souza Rodrigues

A doença de Alzheimer (DA) é uma enfermidade neurodegenerativa progressiva cuja fisiopatologia envolve, entre outros mecanismos, o acúmulo cerebral de β-amiloide, associado a alterações da proteína tau, sua hiperfosforilação e formação de emaranhados neurofibrilares, contribuindo para a disfunção sináptica e a perda neuronal. Essas alterações podem ocorrer anos antes do surgimento das manifestações clínicas, reforçando a necessidade de estratégias capazes de identificar a doença em estágios iniciais. Nesse contexto …

02.09.2026journal-article

International Innovations Journal of Applied Science

Development and Evaluation of Betalain-Rich Beetroot (Beta vulgaris L.) Root Extract as a Natural Staining Agent for Microscopic Bacterial Diagnosis

Hawraa Yahya Mohammed ALrubaiee, Khilowd Omran Ali

Bacterial staining is an important procedure in microbiological examination, but the frequent use of traditional chemical stains results in serious health and environmental problems. The research is focused on the efficiency of aqueous extracted “betalain” dyes from Beta vulgaris plant as a safe and viable alternative for staining environmental bacterial isolates. The method is based on preparation of aqueous extract at different concentrations (0.5%, 1%, 3%) and testing the effectiveness of the extract on heat-fix …

02.09.2026journal-article

Molecular Medicine

Extracellular cold-inducible RNA-binding protein in renal ischemia–reperfusion injury and its progression to chronic kidney disease

Max Brenner, Ping Wang

Abstract Acute kidney injury (AKI) from renal ischemia–reperfusion (IR) injury is a major cause of acute organ dysfunction with significant morbidity and mortality. Critically, up to 50% of AKI survivors progress to chronic kidney disease (CKD), yet the mechanisms driving this maladaptive transition remain incompletely understood, and effective therapies are lacking. Work from our group and others has now identified extracellular cold-inducible RNA-binding protein (eCIRP), a damage-associated molecular pattern, as …

02.09.2026journal-article

BMC Oral Health

Clinical evaluation of fixed prosthetic restorations requiring replacement and associated patient- and restoration-related factors: a cross-sectional study

Senem Güneykaya, Tuhfe Çelikkol, Ayşe Taş, Nelli Agbulut, Gülsüm Sayın Özel

Abstract Background Fixed prosthetic restorations may deteriorate through biological, mechanical, and patient-related factors. This study described the clinical condition of fixed prosthetic restorations presenting for replacement, and examined the patient-, restoration-, and clinician-related factors associated with their clinical acceptability, using modified United States Public Health Service (USPHS) criteria. Methods This cross-sectional study included 395 tooth-supported fixed prosthetic restorations from 346 …

02.09.2026journal-article

The Journal of ECT

Association of Pre-ECT Anxiety Symptoms With Electroconvulsive Therapy Treatment Efficacy in Schizophrenia

Birong Chen, Hasvinjit Kaur D/O Gulwant Singh, Nisha Chandwani, Jonathan Jie Lee, Shih Ee Goh, Xiao Wei Tan

Objectives: Pre-ECT anxiety symptoms are common among patients undergoing Electroconvulsive Therapy (ECT). In this retrospective observational cohort study, we aim to explore the association between pre-ECT anxiety symptoms and ECT treatment outcomes in patients with schizophrenia. Methods: We conducted a retrospective analysis of 979 patients with schizophrenia or schizoaffective disorder who received ECT at a tertiary public psychiatric hospital in Singapore. Patients were categorized into two groups based on the …

02.09.2026journal-article

Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine

Sodium-Glucose Cotransporter-2 Inhibitor Use and Outcomes Following Transcatheter Aortic Valve Replacement: A Propensity-Score Matched Analysis

Hritvik Jain, Dhiran Verghese, Jyoti Jain, Ramez M Odat, Ignacio Inglessis-Azuaje, Dhaval Kolte, Paul C Gordon, J Dawn Abbott, Saraschandra Vallabhajosyula

Background: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have been shown to improve outcomes across all heart failure (HF) phenotypes, but their role in patients undergoing transcatheter aortic valve replacement (TAVR) remains limited. Methods: Using the TriNetX Global Collaborative Network, we identified all adults undergoing TAVR (2019–2025). Patients were divided into 2 groups - those receiving SGLT2i within 1-year post-TAVR and matched controls not receiving SGLT2i. Propensity-score matching was applied a …

02.09.2026journal-article

Journal of Tropical Health

Acute Liver Failure Triggered by Haemolytic Crisis in a Glucose-6-Phosphate Dehydrogenase-Deficient Patient with Hepatitis A: A Case Report

Chathura Piyarathna, Lakitha Ratnaweera, Dulmini Thennakoon

Hepatitis A virus infection is one of the most common causes of acute viral hepatitis and usually results in a mild, self-limiting illness. (Biju Illolil Kuniyil) However, in rare cases it can progress to acute liver failure, particularly in vulnerable individuals. Glucose-6-phosphate dehydrogenase deficiency is one of the most common enzymatic disorders globally. This X-linked condition predisposes red blood cells to oxidative damage and acute hemolytic episodes triggered by infections, drugs, or foods. (Aradhana …

02.09.2026journal-article

F1000Research

Clinical Phenotype of Apoe Ɛ4 Carriers In Patients With Vascular Dementia: A Cross-Sectional Study From Indonesia

Siti Giranti Ardilia Gunadi, Yusran Ady Fitrah, Gita Vita Soraya, Alfi Raudatil Jannah, Andi Weri Sompa, Muhammad Iqbal Basri, Lilian Triana Limoa, Norikazu Hara, Akinori Miyashita, Takeshi Ikeuchi, Muhammad Akbar

Background Vascular dementia (VaD) is the second most common cause of dementia and exhibits substantial heterogeneity in cognitive, functional, and radiological manifestations. Despite the observed differences in clinical presentation, the factors responsible for this variability have not been clearly identified. While the apolipoprotein E ( APOE ) ε4 allele is widely known to increase the risk of Alzheimer’s disease, its contribution to the manifestation of VaD symptoms remains inadequately explored, particularly …

02.09.2026journal-article

Frontiers in Medicine

Individualized approach to palliative care integration for patients with metastatic non-small cell lung cancer

Carley Mitchell, Roshni S. Kailar, Melinda L. Hsu

Early integration of palliative care is recommended for all patients with advanced solid tumor malignancies. However, this practice has not been widely adopted for various reasons. Recent therapeutic advancements along with improved understanding of tumor biology have contributed to greater prognostic uncertainty and changes in symptom burden, highlighted nicely within the metastatic non-small cell lung cancer population. These changes call for a more nuanced approach to palliative care referral which could be faci …

02.09.2026journal-article

Journal of Medicine, Nursing and Public health

Determinants of Health Worker Adherence to National Diarrhoea Management Guidelines for Under-Five Children in Public Health Facilities in Embakasi Region, Nairobi County

Mwaura Josephine Wanjiku, Lilian Muiruri, Felistus Musyoka

Diarrheal diseases remain a leading cause of morbidity and mortality among children under five years in Kenya. To combat this, national diarrhoea management guidelines were established; however, inconsistent adherence by healthcare workers often leads to preventable complications, prolonged illness, and avoidable child deaths. This study assessed the factors influencing health workers' adherence to these national guidelines in public health facilities in the Embakasi Region of Nairobi County, specifically examining …

02.09.2026journal-article

Laryngoscope Investigative Otolaryngology

Burnout Syndrome Among Turkish Otolaryngologists Performing Rhinoplasty Surgery

Erkan Yıldız, Hüseyin Ruhullah Ercan, Orhan Kemal Kahveci, Abdulkadir Bucak, Fatih Çelenk, Selçuk Kuzu, Çağlar Günebakan

ABSTRACT Objectives Burnout syndrome represents a significant concern among physicians, particularly in surgical specialties. This study investigated burnout prevalence among Turkish otolaryngologists and examined the relationship between rhinoplasty practice and burnout dimensions. Methods A cross‐sectional survey was conducted from December 2024 to February 2025, distributing 200 surveys to Turkish otolaryngologists, of whom 84 (42%) completed the validated Turkish 22‐item Maslach Burnout Inventory (MBI) and a so …

02.09.2026journal-article

Physics in Medicine & Biology

Dynamic proton arc therapy sequencing optimization algorithm for brain stereotactic radiosurgery

Peilin Liu, Lewei Zhao, Gang Liu, Xiaoda Cong, Zerun Zhang, Xiaoqiang Li, Xuanfeng Ding

Abstract Objective: Proton arc (PAT) therapy combines the dosimetric advantages of protons with the efficiency of arc delivery, but current planning algorithms are based on a static delivery sequence. The discrepancy between the static plan and the actual delivery can result in dosimetric deviations during stereotactic radiosurgery (SRS), where precision is critical.

Approach: A dynamic arc delivery sequencing optimization framework was developed, consisting of three steps: (1) static irradiation and dynam …

02.09.2026journal-article

PLOS Global Public Health

Trends in advanced HIV disease, treatment interruption, and viraemia in KwaZulu-Natal, South Africa

Sanele S. Mbeje, Lilishia Gounder, Johan S. van der Molen, Lungile Hobe, Thulani Ngwenya, Mlungisi Khanyile, Kwena Tlhaku, Benjamin Chimukangara, Thokozani Khubone, Yukteshwar Sookrajh, Sharana Mahomed, Jennifer A. Brown, Nigel Garrett, Jienchi Dorward, Lara Lewis

Advanced HIV disease (AHD), treatment interruption and viraemia remain key challenges to effectiveness of HIV programmes in South Africa. Understanding the trends of these measures and their variation across geographic regions can inform more targeted and responsive interventions. We conducted a retrospective cohort study using routine, de-identified data from TIER.Net, a national HIV electronic register. We curated data from 116 primary care clinics in eThekwini, uMgungudlovu, and uMkhanyakude Districts in KwaZulu …

02.09.2026journal-article

Military Medicine

Characterization of a Novel Nutrition and Traumatic Brain Injury Data Repository for the U.S. Armed Forces and Beneficiaries, 2017 to 2024

Katrina S Monti, Zachary T Colburn, Michael T Fredericks, William R Conkright

ABSTRACT Introduction Traumatic brain injury (TBI) is a significant U.S. military health concern. Although emerging evidence suggests that nutrition may contribute to TBI outcomes, research on clinical nutrition interventions, especially within military populations, is limited because of a lack of data repositories that integrate the Nutrition Care Process, lifestyle factors, and clinical outcomes. Materials and Methods We established a novel Nutrition and TBI Data Repository, integrating TBI and nutrition care dat …

02.09.2026journal-article

Science Translational Medicine

Multifunctional antibody responses from a primate Shigella outbreak inform vaccine design

Robert M. Gallant, Paul Savarino, Sophia Pulido, Morgan S. A. Gilman, Ti Lu, Jennifer Hayes, Nicholas L. Xerri, Torrey Williams, Mark A. Ochoa, Zackary Dietz, Eric Peterson, Timothy Scott, Faye Hartmann, Stephen G. Baker, Robert W. Kaminski, Devin Sok, Andrew C. Kruse, Wendy Picking, Saverio V. Capuano, Hayden R. Schmidt

There is currently no approved vaccine for Shigella spp., a leading cause of diarrhea with increasing rates of antimicrobial resistance. Shigella vaccine development is complicated in part by an incomplete understanding of the structural and molecular determinants of immunity. To address this, we isolated monoclonal antibodies against candidate Shigella vaccine antigens using samples from a Shigella flexneri outbreak in a nonhuman primate (NHP) research facility. We found that antibodies targeting the Shigella O-an …

02.09.2026journal-article

Hepatología

Colestasis intrahepática del embarazo: de la fisiopatología al tratamiento

María Auxiliadora Ospino-Rodríguez, Marco Antonio Luján-Ramos

La colestasis intrahepática del embarazo es una entidad frecuente, aunque probablemente subdiagnosticada en nuestro medio debido al desconocimiento de la enfermedad y a la variabilidad de sus manifestaciones clínicas. Se caracteriza principalmente por prurito y elevación de ácidos biliares. Aunque su etiología no se encuentra completamente esclarecida, cada vez existen más teorías sobre los mecanismos implicados en su desarrollo, lo que podría ampliar futuras posibilidades terapéuticas. Su reconocimiento oportuno e …

02.09.2026journal-article

Journal of Population Therapeutics and Clinical Pharmacology

ANTIEPILEPTIC DRUG PRESCRIBING PATTERNS AND CLINICAL OUTCOMES IN PEDIATRIC SEIZURE DISORDERS: A CROSS-SECTIONAL STUDY FROM A TERTIARY CARE HOSPITAL IN KASHMIR

Rehana Tabassum, Asra Laraib, Shafat Ahmad Tak

Background: Anticonvulsant prescribing in children must balance seizure control against the vulnerabilities of a developing brain, yet drug utilization data from paediatric epilepsy populations in the Kashmir valley remain scarce. Objectives: To describe the demographic, clinical, and etiological profile of children admitted with seizure disorders; to characterize antiepileptic drug (AED) prescribing patterns; and to determine short-term clinical outcomes at discharge and their association with therapy pattern and …

02.09.2026journal-article

The Cleft Palate Craniofacial Journal

Three-Dimensional High-Resolution Mesh Analysis of Mixed-Dentition Intraoral Models for Predicting Future Orthognathic Surgery in Patients With Cleft Lip and/or Palate

Towako Tanimura, Chihiro Tanikawa, Takashi Yamashiro

Objective To evaluate the 3-dimensional (3D) geometric characteristics of mixed-dentition intraoral models and identify morphological features associated with later inclusion of orthognathic surgery (OGS), rather than camouflage treatment alone (non-OGS/NOGS), as a treatment option in patients with cleft lip and/or palate (CL/P). Design Retrospective cohort study. Setting Institutional study. Participants A total of 320 patients with unilateral or bilateral CL/P who received first-phase orthodontic treatment at age …

02.09.2026journal-article

Plastic & Reconstructive Surgery

“Smile Spontaneity Following Cross-Facial Nerve Grafting: A Systematic Review and Meta-Analysis”

Catherine F. Roy, Elizabeth McGonagle, José A. Correa, Roy Xiao, Tessa A. Hadlock

Background: Contemporary facial reanimation techniques increasingly aim to achieve smile spontaneity, defined by most as an unprompted smile triggered by positive emotions. This study aimed to 1) assess the rate of reporting of spontaneity outcomes and commonly used tools to elicit and assess spontaneity and 2) evaluate the published success rate in achieving spontaneity. Methods: A systematic review of the Ovid MEDLINE, Embase and Cochrane literature from January 1, 2005 to May 13, 2025 was performed. Original stu …

02.09.2026journal-article

Sexual Medicine

Age at first sexual intercourse and frailty: Mendelian randomization and population-based evidence from NHANES and UK Biobank

Kai-Xian Wang, Bao-Peng Liu, Jia-Ning Wang, Kai-Zheng Wang, Yi-Zhan He, Meng-Yao Yu, Zi-Ming Shao, Long Sun, Mei-Xia Xu

Abstract Introduction Age at first sexual intercourse (AFS) is an indicator of sexual initiation and may reflect broader life-course trajectories, but its relationship with frailty remains unclear. To examine genetic evidence for a potential association between AFS and frailty and to characterize nonlinear, threshold, and sex-specific patterns in population-based observational analyses. Methods We performed Mendelian randomization (MR) analyses using summary statistics for AFS and frailty. We further analyzed data …