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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
19.08.2026journal-article

Nature Cardiovascular Research

Alpha protein kinase 3 gene therapy restores heart function in mouse and human models of cardiomyopathy

James W. McNamara, Ellen B. Keen, Rebecca Sutton, Yinghan She, Hannah Huckstep, Lina H. H. Le, Neda R. Mehdiabadi, Madhavan S. Venkatesh, Brendan Griffen, Richard J. Mills, Christina V. Theodoris, James E. Hudson, Drew M. Titmarsh, Sean J. Humphrey, Enzo R. Porrello, David A. Elliott

Abstract Truncating variants in the ALPK3 gene (encoding alpha protein kinase 3) cause severe cardiomyopathy for which no curative treatment exists 1–3 . Here we establish an adeno-associated virus (AAV)-mediated gene replacement therapy to deliver full-length human ALPK3 . AAV- ALPK3 prevented disease in neonatal Alpk3- mutant mice and reversed established pathology in adults, with proteomic analysis demonstrating reversal of more than 95% of the molecular disease signature. Beyond ALPK3 deficiency, we explored br …

1 Zitationen
19.08.2026journal-article

Current Pharmaceutical Design

Exploring the Potential of CRISPR-Cas9 in Carcinoma Therapy: Advances, Challenges and Future Perspectives

Nikhil Rawal, Shruti Batra, Tanu Sharma, Sreeharsha Nagararja, Shailendra Singh, Rajeev Ranjan, Vikas Kumar, Ravi Raj Pal

Abstract: Gene editing has enormous potential in biomedical fields, including cancer and personalized medicine. CRISPR-Cas9 is a gene-editing system in which the Cas9 enzyme, guided by RNA derived from short palindromic repeats, alters DNA sequences to inhibit oncogenes through base and prime editing, thereby suppressing tumor growth. Despite significant advancements in anticancer therapies, limitations such as off-target effects, ethical concerns, and challenges in targeted delivery restrict its potential clinical …

19.08.2026journal-article

JIKES : Jurnal Ilmu Kesehatan

Penerapan Art Therapy pada Pasien Halusinasi Pendengaran dan Penglihatan di Rumah Sakit Jiwa

Dewi Purwati, Aat Sriati, Indra Maulana, Yofi Purnamagiri

Halusinasi, terutama halusinasi pendengaran yang memiliki prevalensi 70–80% pada pasien dengan gangguan psikotik, merupakan gejala yang sering ditemukan pada pasien skizoafektif dan dapat mengganggu fungsi sosial, perilaku, serta kualitas hidup. Manajemen halusinasi merupakan intervensi keperawatan penting untuk membantu pasien mengontrol gejala yang dialami. Tujuan penelitian ini adalah mendeskripsikan penerapan art therapy sebagai intervensi keperawatan pendukung dalam membantu pasien mengontrol halusinasi penden …

19.08.2026journal-article

Frontiers in Public Health

Workplace violence, occupational burnout, and post-traumatic stress among healthcare workers in Armenia

Meri Mkhitaryan, Armine Chopikyan, Armine Harutyunyan, Tatevik Arakelyan, Armen Muradyan, Artashes Tadevosyan

Background Workplace violence is a significant occupational hazard in healthcare systems worldwide and may have serious psychological consequences for healthcare workers. Exposure to violence can contribute to the development of occupational burnout and post-traumatic stress disorder (PTSD), negatively affecting both staff well-being and the quality of healthcare services. Aim To analyze the types of workplace violence, associated risk factors, and the relationship between exposure to violence, occupational burnout …

19.08.2026journal-article

Stem Cell Research & Therapy

Efficacy of multi-layered human iPS cell-derived cardiovascular cell sheets in a pacing-induced canine dilated cardiomyopathy model

Yu Shimoyama, Kenji Kakuta, Kiho Araki, Hyoe Komae, Minoru Ono, Jun K. Yamashita

Abstract Background Dilated cardiomyopathy (DCM) is a progressive, intractable disease that leads to heart failure. Heart transplantation is the only curative treatment; however, access is limited by donor scarcity. Induced pluripotent stem cell (iPSC)-based therapies are attracting attention for DCM, but suitable large-animal models and robust preclinical data have been limited. Methods We generated multi-layered cardiovascular cell sheets from human iPSCs by combining cardiomyocytes with endothelial and stromal c …

19.08.2026journal-article

American Journal of Speech-Language Pathology

Comparing the Community-Identified and Federally Funded Rehabilitation Priorities for Stroke Survivors With Aphasia

Mara L. Goodman, Alyssa N. Kelly, William S. Evans

Purpose: Person-centered rehabilitation for stroke survivors with aphasia (SSwAs) targets meaningful recovery goals using interventions supported by strong scientific evidence. To maximize clinical impact, aphasia research should provide evidence that directly supports person-centered recovery goals. The purpose of this project was to characterize and compare the rehabilitation priorities of SSwAs living in the United States to the research priorities of federally funded aphasia clinical trials. Method: Community-i …

19.08.2026journal-article

Revue économique

Immigration and Occupational Shortage in Western European Countries

Oksana Nezhyvenko, Majda Seghir

En Europe de l’Ouest, où l’immigration progresse et les pénuries de main-d’œuvre persistent, les travailleurs migrants peuvent contribuer à combler ces lacunes. Nous étudions 14 pays entre 2006 et 2018 et construisons un indice de pénurie professionnelle combinant cinq composantes d’offre et de demande, par pays et profession à deux chiffres. Notre modèle montre que les flux migratoires réduisent les pénuries, en complétant les travailleurs nationaux dans les métiers à forte demande et faible offre. Les migrants né …

19.08.2026journal-article

ACS Applied Materials & Interfaces

A Near-Infrared-Triggered Mn,Fe-Doped Polyoxometalate Nanozyme Combined with Lactobacillus for the Chemodynamic/Photothermal Therapy of Candida Vaginitis

Xiao Li, Jitao Li, Jing Ge, Liufeng Yang, Haiyan Zhao, Zhou Jie, Chunmeng Liu, Yaling Yang, Xiaomei Wu

Abstract Vulvovaginal candidiasis (VVC) is a common fungal infection that significantly affects women’s health worldwide. Antifungal agent therapies are not particularly effective for VVC and can further promote an imbalance in the vaginal microbiota, increasing recurrence. Nanozymes are currently being evaluated as an alternative therapy owing to their broad-spectrum antibacterial activity and negligible biological toxicity. However, their inherently low catalytic activity limits their antibacterial properties. In …

19.08.2026journal-article

Beilstein Journal of Nanotechnology

A redox-responsive viologen–cavitand nanocarrier for dual-function photodynamic therapy

Andrey A Maslennikov, Alexey Yu Usanyov, Amir A Shamsutdinov, Anna P Lyubina, Andrey A Parfenov, Alexandra D Voloshina, Irek R Nizameev, Marsil K Kadirov, Rezeda R Fazleeva, Vitaly V Yanilkin, Kseniya A Zhdanova, Natal’ya A Bragina, Albina Y Ziganshina, Igor S Antipin

Although photodynamic therapy selectively eradicates tumours via light-triggered reactive oxygen species (ROS) generation, conventional photosensitizers suffer from poor solubility and a reliance on short-wavelength light with limited tissue penetration. To address this, we developed a redox-responsive polymeric nanocarrier through free-radical polymerization of a pre-assembled micellar ensemble. This ensemble formed spontaneously in aqueous solution by encapsulating the hydrophobic photosensitizer meso -tetrakis( …

19.08.2026journal-article

Transdigital

Revisión sistemática sobre avances en el uso de Interfaces Cerebro-Computadora, prótesis mioeléctricas y tecnologías de rehabilitación asistida

Sofia Patricia Hernández Monroy, Adrian Ferrucio Garcia-Morales, Oscar Eduardo Ortiz-Contreras

La evolución de la tecnología en el ámbito médico ha traído consigo el desarrollo de herramientas innovadoras orientadas a la rehabilitación neurológica y a la mejora de la calidad de vida. Las Interfaces Cerebro-Computadora han emergido como una alternativa prometedora al permitir la restauración de funciones motoras, sensoriales y cognitivas en personas con discapacidades a través de señales neuronales. El presente trabajo se realizó conforme a la guía Preferred Reporting Items for Systematic reviews and Meta-Ana …

19.08.2026journal-article

The Laryngoscope

Virtual Reality‐Based Vestibular Rehabilitation for Vestibular Migraine: A Randomized Trial

Gulce Kirazli, Hale Uzumcugil, Sumeyye Kapusizoglu, Ece Cinar, Huseyin Nezih Ozdemir, Gulsum Saruhan Durmaz, Isa Kaya, Tayfun Kirazli, Figen Gokcay, Nese Celebisoy

ABSTRACT Objectives To evaluate whether virtual reality‐based vestibular rehabilitation (VR‐VestRehab) added to home‐based vestibular rehabilitation (HB‐VestRehab) improves postural control, symptom severity, and psychological outcomes in vestibular migraine (VM). Methods This prospective, single‐blind randomized controlled trial enrolled 40 patients (18–60 years) with definite VM (ICHD‐3), randomized 1:1. Both groups received 4 weeks of vestibular rehabilitation; the VR‐VestRehab group additionally underwent 8 cli …

19.08.2026journal-article

International Journal of Environmental Research and Public Health

The Applicability of Forest Therapy for Socially Isolated Young Adults: Parallel Changes in Psychological Distress and Mindfulness

Yeji Yang, Ji-Eun Pyo, Yongjun Lee, Beom Lee, Chang-Hyou Kim, Jeong-Ho Choi, Jina Yu, Jisoo Lee, Kee-Hong Choi

This study examined the applicability of forest therapy in alleviating psychological distress among socially isolated young adults, with a particular focus on their associations with the mindfulness. A total of 159 socially isolated young adults were recruited from the community and participated in a two-day, one-night forest therapy program. Psychological distress (depression, anxiety, loneliness, and stress) and mindfulness were assessed before and after the program. Multilevel analyses were conducted to examine …

21.08.2026journal-article

Occupational Safety – Science and Practice

Sterowane aplikacją urządzenie do sprawdzania skuteczności ochron słuchu – prezentacja rozwiązania

Centralny Instytut Ochrony Pracy - Państwowy Instytut Badawczy, Grzegorz Szczepański, Ewa Chojnowska, Emil Kozłowski

App-controlled device for verifying hearing protection effectiveness – solution presentation It is widely recognized that the effectiveness of earplugs based on the attenuation values declared by manufacturers differs from the actual level of hearing protection achieved under real working conditions. This discrepancy often results from improper insertion of earplugs into the ear canal. This article presents a newly developed laboratory model of a device designed to assess the correctness of earplug insertion. The d …

21.08.2026journal-article

Occupational Safety – Science and Practice

Ergonomiczne stanowisko komputerowe – jak pracujemy w Polsce?

Centralny Instytut Ochrony Pracy - Państwowy Instytut Badawczy, Joanna Kamińska, Łukasz Kapica

Ergonomic computer workstation – how do we work in Poland? Long-term sitting is the third most frequently reported risk factor in sectors such as finance, information and communication, and public administration, where work is primarily performed using visual display units. Consequently, such workstations should be designed in accordance with ergonomic principles and allow for adjustment to individual employee needs, including anthropometric dimensions and the nature of the tasks performed. This article presents th …

19.08.2026journal-article

Acta Sociologica

Beyond ethnic penalties in occupational attainment: Empirical evidence on native–immigrant inequalities in individual workplace experiences

André Van Hoorn

Although native–immigrant gaps in tangible labor market outcomes such as wages have been widely studied, people's experiences at work are also crucial for their wellbeing. This article considers two generic sources of native–immigrant differentials in desirable individual workplace experiences, especially job autonomy. Following the occupational segregation literature, the first is that foreign-borns and natives are recruited to do different types of jobs. This results in native–immigrant interoccupational segregat …

19.08.2026journal-article

International Journal of Research Publication and Reviews

The Latent Side of Incarceration: A Family-Inclusive Framework for Rehabilitation and Reintegration.

Faizan Ashraf, Umair Khan

Incarceration is formally imposed on an individual but its consequences frequently extend beyond the prison walls to families and communities. The financial, emotional and social consequences experienced by families of inmates remain comparatively less visible within conventional discussions of punishment and rehabilitation. This article examines the latent effects of incarceration on families of inmates in District Doda, Jammu and Kashmir and considers the implications of these effects for rehabilitation and reint …

19.08.2026journal-article

International Journal of Veterinary Medicine

A modern approach to antibiotic therapy in cows with genital mycoplasmosis (review)

R. M. Vasiliev

One of the directions of the implementation of the country’s food security program is the development of animal husbandry, as one of the sources of providing the population with high-quality food. Achieving this goal is closely linked to reducing the incidence of animal diseases and the cost of their veterinary care, which ensures a reduction in the cost of final products. A significant obstacle on this path is a group of diseases characterized by nonspecific symptoms and long-term latent course, which include geni …

19.08.2026journal-article

Pilot and Feasibility Studies

Personalised community based telerehabilitation post stroke to increase rehabilitation time and improve motor recovery (PRACTISE): study protocol for a randomised controlled feasibility trial

Colin B. Shore, Elaine H. Coulter, Lesley Scobbie, Lisa Kidd, Frederike Van Wijck, Carol Bugge, Helen Mason, Nicole Irvine, Mark Barber, Katie I Gallacher, Jacqui Morris, Graeme MacLennan, Pete White, Keith Jenkinson, Lorna Paul

Abstract Introduction Stroke is the second leading non-communicable cause of death and third leading cause of death and disability worldwide with prevalence expected to rise 120% between 2015 and 2035. The first 6 months after stroke is the optimum time for neuroplasticity and a critical period for rehabilitation. UK national clinical guidelines recommend stroke survivors should receive at least 3 h/day of multidisciplinary rehabilitation at least 5 days/week. Workforce shortages and service variability make achiev …

19.08.2026journal-article

Circulation: Arrhythmia and Electrophysiology

Pulsed Field Ablation Therapy Parameters: Enhancing Lesion Depth While Reducing Musculoskeletal Stimulation and Thermal Response in an Irrigated Tip Catheter: A Comprehensive Study Using In Silico, In Vitro, and In Vivo Models

Atul Verma, Chirag Barbhaiya, Daniel J. Friedman, Jonathan P. Piccini

BACKGROUND: Pulsed field ablation therapies need to be optimized to maximize lesion depth while mitigating heat and musculoskeletal stimulation. We describe the adjustment of biphasic pulsed field ablation parameters for an irrigated tip catheter. METHODS: Experimental models all used an 8F, flexible-tip, irrigated ablation catheter. Computer simulation models were designed to assess the effects of bipolar versus monopolar applications. A vegetal (potato) model was used to assess the effects of voltage, pulse width …

19.08.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Comparative analysis of isokinetic muscle function, anaerobic power, and physical fitness according to Asian BMI categories in youth male soccer players: a cross-sectional study

Min-Hyuk Park, Yu-Sun Min, Eun-Hee Park, Tae-Du Jung

Abstract Background Body composition significantly influences athletic performance, with Body Mass Index (BMI) commonly utilized to guide training programs. This study evaluates isokinetic muscle function, anaerobic power, and physical fitness in youth soccer players based on Asian-specific BMI categories. Methods Seventy-five male youth soccer players were classified into Asian-specific BMI groups: normal weight (18.5–22.9 kg/m², n = 25), overweight (23–24.9 kg/m², n = 25), and obese (≥ 25 kg/m², n = 25). Assessme …

19.08.2026journal-article

Current Pharmaceutical Design

Transforming Growth Factor β3 (TGF-β3) Signaling: A Potential Target for Cancer Therapy

Zan-Wen Zuo, Wen-Jing Tang, Qian Zhang, Rui-Hua Wen, Yu-liang Wang, Qi-Zhang Li

Abstract: Transforming growth factor β (TGF-β) signaling is essential for early embryonic development, tissue and organ formation, immune surveillance, tissue repair, and maintaining homeostasis in adults. The three isoforms of TGF-β, TGF-β1/2/3, share a structurally conserved secretion signal peptide and activate various downstream signaling pathways. While much research has focused on TGF-β1, there is increasing recognition of the important roles that TGF-β3 plays in cancer biology. TGF-β3 exhibits dual functions …

19.08.2026journal-article

International Journal of Veterinary Medicine

Genomic architecture of hereditary defects in beef cattle populations: from molecular diagnostics to innovative therapy approaches (review)

N. A. Bezborodova, O. V. Sokolova, O. S. Zaitseva, N. A. Martynov, A. V. Zverev, M. A. Pechenkina, P. V. Kulagina

The review article presents a comprehensive analysis of current data on hereditary anomalies in beef cattle breeds, including hypotrichosis (HY), dilutor (DL), idiopathic epilepsy (IE), mandibulofacial dysplasia (MD), and maple syrup urine disease (MSUD). The results of genomic studies that identified key mutations (in the KRT71, PMEL, CYP26C1, BCKDHA/BCKDHB genes) and their pleiotropic effects, impacting both phenotype and productive qualities of the animals, are summarized. Particular attention is paid to the dif …

19.08.2026journal-article

Healthcare

Psychosocial and Organizational Determinants of Perceived Occupational Exposure and Job Satisfaction Among Intensive Care Unit Nurses

Katarzyna Tomaszewska, Bożena Majchrowicz, Helena Kadučáková, Marcela Ižová, Piotr Kołodziej, Krystyna Kowalczuk

Introduction: Intensive care units are characterized by a high level of clinical and psychosocial demands. Previous research indicates that the work environment plays a significant role in shaping nurses’ occupational well-being; however, analyses that simultaneously consider organizational factors, perceived occupational exposure, and job satisfaction are still limited, particularly in the context of Central and Eastern European countries. Objectives: The aim of the study was to assess the relationships between ps …

19.08.2026journal-article

Physiotherapy Research International

Intensive, Multi‐Technology Rehabilitation Programme for Chronic Stroke Survivors: Outcomes of a Phase I Single‐Arm Repeated‐Measures Study

Andrew Kerr, Madeleine Grealy, Milena Slachetka, Dwight Tse, Philip Rowe

ABSTRACT Background Effective rehabilitation interventions are needed to support recovery in people living with long‐term post‐stroke disability. Cocreation has been proposed as a method for enhancing the acceptability of technology‐supported rehabilitation and may improve rehabilitation outcomes. Objective To observe changes in outcome following participation in a multi‐technology rehabilitation intervention for motor recovery in people with chronic stroke and to explore factors associated with differential respon …