Journal of the American Geriatrics Society
Comparative Effectiveness, Safety, and Costs of Gabapentinoids in Older Adults With Long‐Term Opioid Use
ABSTRACT Background It is unclear whether managing chronic pain with adjuvant gabapentin versus pregabalin can safely reduce long‐term opioid use among older adults. Our objective was to compare clinical effectiveness, safety, and costs of initiating gabapentin versus pregabalin. Methods We conducted a retrospective cohort study and target trial emulation in a US National sample of 2013–2018 Medicare fee‐for‐service and 2004–2024 Optum's de‐identified Clinformatics Data Mart Database (Optum CDM). Participants inclu …