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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
19.08.2026journal-article

Current Treatment Options in Neurology

Prism Therapy and Surgical Intervention for Oscillopsia

Elizabeth M. Bolton, Nicholas J. Volpe

Abstract Purpose of Review The purpose of this article is to present a critical appraisal of current therapeutic and surgical strategies for patients with nystagmus and associated oscillopsia. Different forms of nystagmus and associated oscillopsia as well as evidence supporting successful use of prism and surgical treatment of these patients are considered. Recent Findings Low power yoked prisms are effective and under-utilized in the treatment of infantile nystagmus syndrome (INS). Surgical treatments for INS and …

19.08.2026journal-article

Ear & Hearing

Spectro-Temporal Modulation Sensitivity Prospectively Predicts Speech-in-Noise Recognition in Cochlear Implant Users

Julia Erb, Malte Wöstmann, Jens Kreitewolf, Jan Peter Thomas, Christiane Völter, Jonas Obleser

Objectives: For cochlear implant (CI) patients, reliable predictors of speech outcome are desirable. In this longitudinal study, we examined the contributions of spectro-temporal sensitivity to successful speech recognition following cochlear implantation. Design: We assessed N = 46 recently implanted adult patients shortly after CI activation (T1) and 6 months later (T2) with an adaptive ripple discrimination paradigm where dynamic ripples varied around the temporal rate of 4 Hz and spectral scale of 0.5 cyc/oct. …

19.08.2026journal-article

JAMA

HIV Status Exclusion in Sickle Cell Gene Therapy

Daniel Prior, Lakshmanan Krishnamurti

This Perspective discusses the ethical, scientific, clinical, and manufacturing implications of excluding patients living with HIV from gene therapies for sickle cell disease.

19.08.2026journal-article

Acta Ophthalmologica

Proliferative vitreoretinopathy: An integrative, multi‐pathway perspective on pathogenesis and therapy

Koen A. van Overdam, J. Sebag

Abstract Proliferative vitreoretinopathy (PVR) remains the principal biological cause of failed retinal detachment repair. Classical pathogenic models centred on retinal pigment epithelium (RPE) dispersion, retinal injury responses or compartment‐restricted mechanisms do not fully explain the heterogeneity, biomechanical behaviour and clinical variability of PVR. We propose an integrative framework in which PVR is conceptualised as a biological process arising from the interaction of three interdependent pathways: …

19.08.2026journal-article

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy

Antihyperglycemic Drugs and Risk of Asthma Exacerbation in Patients With Asthma and Type 2 Diabetes: A Multinational Retrospective Cohort Study

Chun‐Tse Hung, Chen‐Yen An, Yao‐Cheng Tsai, Chi‐Won Suk, Chung‐Hsuen Wu

ABSTRACT Background Antihyperglycemic drugs have shown benefits in asthma control. However, evidence regarding the comparative effectiveness of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and sodium‐glucose cotransporter‐2 inhibitors (SGLT‐2is) in reducing asthma exacerbations remains inconsistent. Objective We aimed to evaluate the association of GLP‐1 RAs versus SGLT‐2is with risk of asthma exacerbation among patients with asthma and type 2 diabetes. Methods This retrospective cohort study used electron …

19.08.2026journal-article

Media of Health Research

The Implementation of Mind–Body Therapy–Based Complementary Midwifery Care on Reproductive Well-Being among Women of Reproductive Age

Hikmah Hikmah, Eka Mardiana Afrilia, Titin Martini

Reproductive well-being is influenced not only by physiological factors but also by psychological conditions such as stress and emotional imbalance. Mind–body therapy has emerged as a complementary approach that may enhance psychological regulation and overall well-being. This study aimed to examine the effect of mind–body therapy–based complementary midwifery care on reproductive well-being among women of reproductive age. Methods: A quasi-experimental study with a one-group pretest–posttest design was conducted a …

19.08.2026journal-article

Egyptian Rheumatology and Rehabilitation

Diagnostic value of nailfold capillaroscopy in suspected secondary Raynaud phenomenon: a cross-sectional analytical study

Yimy Medina, José S. Cortés, Manuel Pérez

Abstract Background Nailfold capillaroscopy (NFC) is a widely used rheumatology tool for assessing Raynaud phenomenon (RP). Nonspecific abnormal findings observed through NFC may appear in patients with primary RP, suspected secondary RP, secondary RP, and healthy individuals. Differentiating between these findings remains a subject of ongoing research. This study aimed to describe capillaroscopic alterations in patients with suspected secondary RP and compare them with healthy subjects. Methodology This was a cros …

19.08.2026journal-article

Journal of Marital and Family Therapy

Multi‐Family Therapy in East and Southeast Asia—A Systematic Review and Meta‐Synthesis

Ouyang Hanlai, Sufang Peng, Jue Chen, See Heng Yim

ABSTRACT This systematic review examined the characteristics, cultural adaptations, and effectiveness of multi‐family therapy in studies conducted in the Chinese Mainland, Hong Kong, and Singapore. Eighteen reports from 17 studies were included, covering quantitative, qualitative, and mixed‐methods designs. Quantitative findings showed that multi‐family therapy was more consistently associated with improvements in individual‐level outcomes (e.g., symptom severity, psychological distress, functioning), whereas effec …

19.08.2026journal-article

CHIMIA

Light-Induced Cancer Therapy

Lukas Schneider

Photodynamic therapy (PDT) and photothermal therapy (PTT) are promising light-induced approaches for cancer treatment. This article outlines the historical development of PDT and summarizes the underlying photophysical and photochemical mechanisms responsible for reactive oxygen species (ROS) generation and tumour destruction. Major classes of clinically approved and emerging photosensitizers (PSs) are discussed together with important design criteria and current limitations. In addition, the principles of PTT, inc …

19.08.2026journal-article

Общество: социология, психология, педагогика

Scientific Substantiation of Emotion-Image Therapy: A Theoretical Review

Ekaterina Yu. Prokopenkova

The article presents a systematic theoretical review of the scientific foundations of Emotion-Image Therapy (EIT) – a Russian psychodynamic method developed by N.D. Linde. Unlike previous works, which have been predominantly descriptive, this study integrates the conceptual framework of EIT into the broader context of fundamental psychological and neurophysiological theories. The central thesis of the article is that the key con-structs of EIT (the energetic metaphor of emotions, the image as a representation of co …

19.08.2026journal-article

Frontiers in Psychiatry

Network analysis of social isolation, loneliness, depression and anxiety among post-discharge rehabilitation patients

Yonglan Li, Dongsheng Wang, Shuangting Xu, Jing Xu

Background Patients undergoing inpatient or outpatient rehabilitation frequently experience substantial changes in physical functioning, social roles, and daily routines, which may increase vulnerability to social disconnection and psychological distress. This study applied network analysis to explore the interrelationships among social isolation, loneliness, anxiety, and depression in post-discharge rehabilitation patients. Aims This study aimed to characterize two network models of social isolation, loneliness, d …

19.08.2026journal-article

Journal of Cancer Research and Clinical Oncology

Profiling the tumor microenvironment of a hepatocellular carcinoma patient with primary resistance to immunotherapy plus anti-angiogenic therapy but exceptional response to chemotherapy plus bevacizumab

Qin Xu, Rui Zhu, Zirui Wang, Chengjian Zhao, Xiaofen Li, Nuerye Tuerhong, Wanting Hou, Yu Yang

Abstract Background Hepatocellular carcinoma (HCC) with extrahepatic metastasis (EHM) carries a poor prognosis, and treatment options after failure of anti-angiogenic targeted agents combined with immune checkpoint inhibitor (ICI) remain limited. Case Presentation An adult patient with advanced HCC exhibited primary resistance to three sequential immunotherapy-based regimens: first-line lenvatinib plus camrelizumab (progressive lung metastases), second-line atezolizumab plus bevacizumab (rapid tumor marker surge), …

19.08.2026journal-article

Nutrients

Resveratrol and Curcumin in Stroke Therapy: From Experimental Evidence to Clinical Perspectives

Mikołaj Grabarczyk, Aleksandra Szychowska, Weronika Szczepańska, Ewa Smolińska, Andrzej Glabinski, Piotr Szpakowski

Stroke remains one of the leading causes of death and long-term neurological disability worldwide, while currently available therapeutic strategies are limited by narrow treatment windows and incomplete neuroprotection. In this context, plant-derived polyphenols have attracted increasing attention as potential adjunctive agents because of their multimodal biological activity. This review focuses on resveratrol and curcumin, two of the most extensively investigated polyphenols, and evaluates their potential role in …

19.08.2026journal-article

Annals of Indian Academy of Neurology

A Retrospective, Single-Arm, Observational Study in Patients with Multiple Sclerosis in India Receiving Ocrelizumab Therapy for 1 Year

MV Padma Srivastava, Joy Dev Mukherji, Anshu Rohatgi, Sameer Arora

Abstract Background and Objectives: Ocrelizumab is an established therapy for multiple sclerosis (MS). However, real-world data from Indian clinical settings remain limited. Hence, the present study was conducted to evaluate the clinical effectiveness, radiological response, and safety profile of ocrelizumab over 12 months of therapy among patients with MS in India. Methods: This retrospective observational study included data from adults diagnosed with multiple sclerosis (MS) who received ocrelizumab for at least …

19.08.2026journal-article

Neurobiology of Language

Neural and Behavioral Predictors of Speech Motor Sequence Learning in Primary Progressive Aphasia

Hilary E. Miller, Michael Brickhouse, Daisy Hochberg, Alfonso Nieto-Castanon, Jason Tourville, Bradford C. Dickerson, Frank H. Guenther

Abstract This study investigated the clinical and neural correlates of speech motor sequence learning in primary progressive aphasia (PPA) to test specific predictions regarding the roles of the left posterior inferior frontal sulcus (pIFS) and left ventral premotor cortex (vPMC). A cohort of 26 participants with PPA completed a 2-day non-native consonant cluster learning paradigm. Participants also completed a battery of clinical speech-language assessments, including tests of phonological and motor programming ab …

19.08.2026journal-article

Earth

Assessing the Functional Suitability of Sewage Sludge-Derived Technosols for the Ecological Rehabilitation of Degraded Areas

Mattia Napoletano, Alessandro Bellino, Alessio Langella, Mariano Mercurio, Vincenzo Baldi, Antonio Ernesto Detta, Daniela Baldantoni

Urban and industrial activities have lasting effects on Earth ecosystems, impairing their functionality. Technosols offer a sustainable solution for restoring degraded urban and industrial ecosystems. In a 30-day microcosm experiment, a mixture of six pioneer plant species was sown in three substrates: a sewage sludge-based Technosol (GF), a zeolite-enriched Technosol (GZ), and a commercial potting mix control (GC). The plant population dynamics, final performance, and substrate biochemical properties were monitore …

19.08.2026journal-article

Frontiers in Psychology

Kinesiophobia and autonomous motivation for cardiac rehabilitation after cardiac surgery: sequential mediation by social support and psychological resilience

Ting Shen, Ting Leng, Qi Peng, Qiuhong Chen, Lin Luo, Xiahong Huang

Objective To examine whether social support and psychological resilience sequentially mediate the relationship between kinesiophobia (fear of movement) and autonomous motivation for cardiac rehabilitation (CR) among patients following cardiac surgery. Methods A cross-sectional survey was conducted with 167 adult patients recruited via convenience sampling from the Department of Cardiac Surgery at a tertiary hospital in China between January 2024 and June 2025. Eligible participants completed validated Chinese versi …

19.08.2026journal-article

Advanced Materials

ROS‐Scavenging Single‐Component Polymeric Nanocarriers for Precision siRNA Delivery in Pulmonary Fibrosis Therapy

Yuxin Yang, Hua Zhang, Jianjun Du, Wen Sun, Xiaojun Peng, Jiangli Fan

ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a progressive refractory lung disorder with limited effective therapies. Although RNA interference (RNAi) holds promise for IPF treatment, current delivery systems are hampered by complex preparation, redundant components, and an inability to modulate oxidative stress, which severely compromises their therapeutic outcomes. Herein, we design a single‐component, lung‐targeted nanosystem, PPN@siIL11, that simplifies formulation while integrating dual functions of efficie …

19.08.2026journal-article

Frontiers in Rehabilitation Sciences

Ethical reflections on the use of the category “children with disabilities” in quantitative research

Christian Møller-Skau

Quantitative research plays a vital role in informing public health policies concerning children with disabilities. However, the categorisation of children as ‘disabled’ in statistical analyses raises complex ethical questions. This perspective article offers a conceptual and normative reflection on the ethical implications of such categorisation, drawing on the frameworks of utilitarianism, deontology, and virtue ethics. It argues that while categorisation may be necessary for policy development and resource alloc …

19.08.2026journal-article

International Journal For Multidisciplinary Research

Telescopic Overdenture as a Conservative Prosthodontic Approach to the Rehabilitation of a Severely Resorbed Mandibular Ridge: A Case Report

Manish Bairwa, Dr Rajesh Kumar -, Dr Sunil Kumar M.V -

Abstract Background: Rehabilitation of a severely resorbed mandibular ridge can be challenging when conventional complete dentures provide inadequate support and stability. Preservation of strategically positioned natural teeth can improve prosthetic support and retention while maintaining proprioceptive feedback. Telescopic overdentures offer a conservative approach by integrating the remaining teeth into a removable prosthesis through primary and secondary coping systems. Case Presentation: A patient with a sever …

19.08.2026journal-article

Frontiers in Immunology

Impact of IL-6 and ferritin dynamics on clinical outcomes after anti-CD19 CAR-T cell therapy in diffuse large B-cell lymphoma patients

Ling Gao, Yanyan Mao, Cai Sun, Yize Li, Xing Xing, Yuqing Miao, Chunling Wang, Hongfeng Ge, Ziyuan Shen, Wei Sang

Background Interleukin-6 (IL-6) and ferritin are routinely monitored during chimeric antigen receptor T-cell (CAR-T) therapy; however, their temporal dynamics and outcome-specific relevance remain inadequately characterized. This study aimed to evaluate the value of IL-6 and ferritin at multiple time points in patients with diffuse large B-cell lymphoma (DLBCL) receiving anti-CD19 CAR-T therapy. Methods A total of 54 patients (median age 49.0 years; 64.8% male) were retrospectively analyzed. Post-infusion IL-6 and …

19.08.2026journal-article

JMIR Rehabilitation and Assistive Technologies

Impact of Emerging Technologies on Outpatient Care Quality: Mixed Methods Study

Inas Al Khatib, Mahmoud Awad, Abdulrahim Shamayleh

Abstract Background Digital transformation in health care, including telemedicine, wearable devices, robotic process automation (RPA), and electronic medical records (EMRs), is reshaping outpatient care delivery. However, consolidated evidence on how these technologies influence patient care quality (PCQ) remains limited. Objective This study evaluated the impact of emerging digital health technologies on PCQ dimensions in outpatient clinics through a systematic literature review combined with expert perspectives. …

19.08.2026journal-article

Frontiers in Psychology

Exploring the impact of teacher expectations on student behavior and academic performance using cognitive behavioral therapy

Yehui Jin, Qiang Zhou, XinJuan Li

This study evaluated the effectiveness of using a cognitive-behavioral therapy based teacher training program to change teachers’ expectations of students and improve student behavior and academic performance. This paper designs and uses a quasi experimental approach with a non equivalent control group for pre-test/post test. The participants consist of 115 third grade teachers and 356 third grade students from five primary schools. Teachers identified as having low expectations received a 12 week manual CBT traini …

19.08.2026journal-article

Journal of Clinical Medicine

Ultrasound-Based Biofeedback for Pelvic Floor Rehabilitation: A Systematic Review of Randomized Controlled Trials

César Garrido-Fernández, Eva Lantarón-Caeiro, Isabel Escobio-Prieto, Pablo Hernandez-Lucas

Pelvic floor dysfunctions are highly prevalent and can substantially impair quality of life. Physiotherapy is considered a first-line conservative treatment, and the integration of technologies such as ultrasound may enhance outcomes through visual biofeedback. Objectives: To evaluate the effectiveness of ultrasound as a biofeedback tool in physiotherapeutic interventions for pelvic floor dysfunctions across different populations. Methods: A systematic review was conducted following PRISMA guidelines and registered …