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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Frontiers in Oncology

The dual roles of Prevotella in gastrointestinal tumorigenesis: from molecular mechanisms to therapeutic prospects

Zixuan Lu, Dong Tang

Tumor microbiology is a prominent area of research that is reshaping cancer treatment paradigms. While most microbiological studies have focused on specific bacterial species such as Fusobacterium nucleatum , the genus Prevotella has emerged in recent years as a key research focus due to its notable functional duality in gastrointestinal tumorigenesis. The role of this genus is not unidirectional; specific strains of Prevotella have been associated with either pro-tumorigenic or anti-tumorigenic effects depending o …

28.08.2026journal-article

Frontiers in Oncology

Metabolic reprogramming and immune evasion interaction in the tumor microenvironment promote tumor progression

Hailun Wang, Hanyu Zhao, Xuelu Pu, Yandu He, Yajun Li

Emerging evidence demonstrates that tumor metabolic reprogramming not only supports tumor-cell proliferation but also promotes the establishment of an immunosuppressive tumor microenvironment (TME) by altering nutrient competition and metabolite accumulation. Therefore, metabolic reprogramming and immune evasion should be regarded as closely interconnected processes rather than independent phenotypes. By altering the metabolite composition of the TME and local metabolic programs, tumor metabolic reprogramming suppr …

28.08.2026journal-article

Annals of Surgical Oncology

Cavity Margins Sample Shaving as Part of Extended Vacuum-Assisted Breast Biopsy: A Potential Approach to Predict Percutaneous Breast Cancer Excision

Paula Clarke, Eduardo Carvalho Pessoa, Bertha Andrade Coelho, Daniel de Araújo Brito Buttros, Aleida Nazareth Soares, Bruna Torres Silvestre da Silva, Hélio Rubens de Carvalho Nunes, Carla Priscila Kamiya Carvalho Pessoa, Amanda Cristina Braga de Oliveira, Tereza Cristina de Oliveira Ferreira, Bernardo Ferreira de Paula Ricardo, Paola Hartung Toppa, André Mattar, Marcelo Antonini, Heverton Leal Ernesto de Amorim, Gustavo Machado Badan, Ruffo de Freitas Júnior, Marcus Nascimento Borges, Katyane Larissa Alves, Douglas de Miranda Pires, Shirley das Graças Ferreira, Gabriel de Almeida Silva Júnior, Romana Giordani Ribeiro Saliba, Ana Carolina Guglielmelli Mendonça, Larissa Barbosa Oliveira, Thais Paiva Moraes, Cristina Milene Barbosa Maynart Aragão, Felipe Marcondes de Oliveira Coelho, Letícia Martins de Araújo Campos Linhares, Heloisa Maria De Luca Vespoli, Annamaria Massahud Rodrigues dos Santos, Mayne Cardoso Cani, Henrique Lima Couto

Abstract Background Excision of small breast cancers has been reported by vacuum-assisted biopsy (VAB). Nevertheless, patients are submitted to surgery, because there is no way to predict excision. The purpose of this study was to evaluate extended vacuum-assisted biopsy (EVAB) associated with cavity margins sample shaving (CMSH) to predict breast cancer excision. Methods This is a retrospective database analysis of 120 cancers [both invasive breast cancers (IC) and ductal carcinoma in situ (DCIS)] diagnosed by EVA …

28.08.2026journal-article

HSS Journal®: The Musculoskeletal Journal of Hospital for Special Surgery

Arthrofibrosis After Total Knee Arthroplasty: Biological Mechanisms, Diagnosis, and Treatment: An International Consensus Symposium

Peter K. Sculco, Ronald E. Delanois, Gwo-Chin Lee, William A. Jiranek, Matthew P. Abdel, Laura Moore, Harold I. Salmons, Friedrich Boettner, Alberto V. Carli, M. El-Hassan, Alex Anatone, Yugo Morita, Thorsten M. Seyler, Cynthia Kahlenberg, Andrew M. Schneider, Katherine Mallett, Stefano Ghirardelli, Martin S. Davey, Jonggu Shin, Henry Somerby, Gregoire Micicoi, Alejandro Gonzalez Della Valle, Andrea Baldini, David J. Backstein, Josef Jolissaint

Arthrofibrosis following total knee arthroplasty (TKA) is a challenging complication that contributes to failure to achieve functional range of motion and results in physical impairment, pain, and revision surgery. Despite increasing recognition of arthrofibrosis as a biological disease process rather than a purely mechanical complication, there is no single document that integrates current evidence on diagnosis, surgical management, and preventive strategies. In June 2025, the Stavros Niarchos Foundation Complex J …

28.08.2026journal-article

Serican Journal of Medicine

AR-V7-Driven Mitochondrial Metabolic Reprogramming in Enzalutamide-Resistant Prostate Cancer: Mechanisms and Therapeutic Implications

Rongxin Chang, Zhuangzhuang Zhang

Enzalutamide resistance in castration-resistant prostate cancer (CRPC) is frequently driven by androgen receptor splice variant 7 (AR-V7), a prognostic biomarker that lacks the ligand-binding domain and evades enzalutamide inhibition; however, the downstream metabolic networks sustaining resistant-cell survival remain incompletely understood. This review summarizes AR-V7 structural features, non-canonical transcriptional programs, and resulting mitochondrial dysfunction. AR-V7 occupies distinct chromatin-binding si …

28.08.2026journal-article

Catalysts

Green-Synthesized Nanomaterials for Fenton and Fenton-like Degradation of Pharmaceutical Pollutants in Water Treatment

Ghazala Muteeb, Youssef Basem, Abdel Rahman Alaa, Maria Tamer, Mohammad Aatif, Mohd Farhan, Marysheela David, Doaa S. R. Khafaga

Pharmaceutical pollutants have emerged as a critical class of aquatic micropollutants due to their continuous release, persistence, and potential impacts on ecosystems and human health. Conventional wastewater treatment systems are often insufficient to achieve complete removal, necessitating the development of advanced oxidation processes (AOPs), such as Fenton and Fenton-like systems. These processes rely on the generation of reactive oxygen species (ROS), including hydroxyl radicals (•OH), superoxide species, si …

28.08.2026journal-article

Koloproktologia

Assessment of the effect of tube type on the cellular composition of centrifuged plasma and the rate of wound healing after surgical treatment of anal fissure combined with platelet-rich plasma injection

E. Yu. Lebedeva, M. A. Ignatenko, E. E. Zharkov, N. S. Abdullayeva, A. A. Ponomarenko, A. A. Mudrov, I V. Kostarev

OBJECTIVE: the aim of this study is the effect of PRP application on the outcomes of chronic anal fissure treatment and to analyze the factors associated with the rate of anoderm defect epithelialization. PATIENTS AND METHODS: a single-center prospective randomized controlled trial (NCT07268261) was conducted from September 2023 to November 2025. We compared the outcomes of fissure excision (FE) combined with botulinum toxin type A (BTA) injection at a dose of 40 units and platelet-rich plasma injection (FE+BTA+PRP …

28.08.2026journal-article

Surgeries

Transforming Liver Transplant Oncology: A Comprehensive Framework for Clinical Trial Design and Precision Transplantation

Purvaj Reddy Kandula, Harshini Maheswaran, Maheswaran Pitchaimuthu

Liver transplantation (LT) has evolved from a contraindicated procedure for malignancy into an established oncologic therapy for selected primary and secondary hepatic cancers. Advances in tumor biology, molecular profiling, immunotherapy, and peri-transplant management have expanded transplant indications beyond hepatocellular carcinoma (HCC) to include perihilar cholangiocarcinoma, intrahepatic cholangiocarcinoma, colorectal liver metastasis (CRLM), neuroendocrine liver metastasis (NELM), and rare hepatic maligna …

28.08.2026journal-article

Advanced Healthcare Materials

Targeted Lactic Acid Regulation via Engineered Exosomes for Synergistic Metabolic and Photodynamic Tumor Therapy

Sisi Zhou, Yu Cao, Xianbiao Wang, Songqin Liu

ABSTRACT Tumor cells exhibit a hyper‐glycolytic phenotype, resulting in massive lactic acid (LA) production that acidifies the tumor microenvironment (TME) and fosters immunosuppression. Current lactate‐targeted therapies often lack synergistic dual‐directional regulation. Herein, we engineer an exosomal nanoplatform, PpIX/siRNA@EXO‐LOD, to simultaneously disrupt intra‐ and extracellular LA homeostasis, thereby enabling synergistic metabolic and photodynamic therapy (PDT). The system integrates three key components …

28.08.2026journal-article

Nutrients

Evaluation of Postbiotics from Lactiplantibacillus plantarum and Bacillus mojavensis Fermented in Aguamiel on Their Cytotoxic Effect in Breast Cancer Cells, Their In Vivo Effects, and Processing by Spray Drying

Adelfo García-Ceja, Karen Tatiana Zuluaga-López, Rosa Isela Ortiz-Basurto, Daniel Tapia-Maruri, María de Lourdes Meza-Jiménez, Gabriel Abraham Cardoso-Ugarte, M. Jiménez-Fernández, Porfirio Nava, Beatriz Pérez-Armendáriz

Background/Objectives: Postbiotics derived from beneficial bacteria have emerged as promising bioactive ingredients owing to their enhanced stability, safety, and functional versatility relative to live microorganisms. Methods: The present study was structured in two complementary stages: (i) biological characterization of liquid microfiltrates obtained from Lactiplantibacillus plantarum and Bacillus mojavensis fermented in aguamiel, and (ii) technological stabilization of these postbiotics through microencapsulati …

28.08.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

MECANISMOS NEUROBIOLÓGICOS DA CETAMINA NO TRATAMENTO DA DEPRESSÃO RESISTENTE: O PAPEL DA NEUROTRANSMISSÃO GLUTAMATÉRGICA E DA NEUROPLASTICIDADE

Sabrina de Oliveira Silva, Maria Letícia de Araújo Cavalcante Sampaio, Louanne de Oliveira Moura, Elânia Cordeiro de Oliveira Soares, Maria Luíza de Almeida e Silva, Caliandra Santos de Vasconcelos

Esse artigo buscou analisar os mecanismos neurobiológicos envolvidos no efeito antidepressivo rápido da cetamina em pacientes com depressão resistente ao tratamento, com ênfase na neurotransmissão glutamatérgica e na neuroplasticidade. Trata-se de um estudo qualitativo, de natureza teórico-bibliográfica e abordagem analítico-reflexiva, desenvolvido a partir da análise de artigos científicos e produções acadêmicas relacionadas à utilização da cetamina e aos mecanismos associados à resposta antidepressiva. Foram cons …

28.08.2026journal-article

Chemical Science International Journal

Synthesis and Thermal Characterization of a Styrene–butadiene Rubber/Maleic Anhydride Oleogel for Potential Oil-contaminated Wastewater Treatment

Nasiba Temirovna Ernazarova, Mamlakat Furkatovna Khusanova

Aims: To prepare a styrene–butadiene rubber (SBR)/maleic anhydride formulation in heptane and characterise its thermal behaviour by simultaneous thermogravimetric and differential thermal analysis, with emphasis on the temperature regions relevant to subsequent sorbent development for oil-contaminated water. Study Design: Laboratory synthesis followed by instrumental thermal characterisation of the dried product. Place and Duration of Study: Tashkent Research Institute of Chemical Technology, Tashkent, Uzbekistan; …

28.08.2026journal-article

Comprehensive Physiology

THBS1 Targets Tumor‐Associated Macrophages to Regulate Gastric Cancer Peritoneal Metastasis via Metabolic Reprogramming

Zheyu Song, Yuanyu Wu

ABSTRACT Purpose This study aimed to identify the role of thrombospondin 1 (THBS1) in gastric cancer (GC) with peritoneal metastasis (PM) as a model of aberrant interorgan communication between gastric carcinoma and the peritoneal microenvironment. Methods Bulk, single‐cell, and spatial transcriptomics were performed to identify mechanisms underlying M2 macrophage‐mediated GC with PM. RNA immunoprecipitation confirmed binding between RNA‐protein and GC9811‐P cells. A GC9811‐P‐tumor‐associated macrophage (TAM) co‐cu …

28.08.2026journal-article

Journal of Clinical Medicine

Guselkumab in Inflammatory Bowel Disease: Mechanism, Clinical Efficacy, Safety, and Treatment Positioning

Laura White, Esha Sharma, Jimmy Limdi, Shahida Din, Kamal Patel, Sailish Honap

Guselkumab is a monoclonal antibody directed against the p19 subunit of interleukin-23 (IL-23), thereby preventing IL-23 binding to the IL-23 receptor. IL-23 is a key driver of immune dysregulation and chronic inflammation in inflammatory bowel disease (IBD), making selective IL-23 inhibition an established therapeutic strategy in both Crohn’s disease and ulcerative colitis. Guselkumab is the most recently approved IL-23p19 inhibitor for the treatment of both major forms of IBD. It is the first IL-23p19 inhibitor t …

28.08.2026journal-article

Advanced Science

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu

ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which advanced or metastatic disease presents limited therapeutic options. While RNA modifications are acknowledged as key regulatory elements in cancer, the role of 5‐methylcytosine (m 5 C) and its modifying enzymes in EC is still largely unstudied. Here, it demonstrates that the m 5 C methyltransferase NSUN6 is significantly upregulated in EC tissues, and its expression correlates with higher tumor grade and unfavorable prognosis. F …

28.08.2026journal-article

Frontiers in Oncology

Current status and future directions of multimodal deep learning normal tissue complication probability modelling in head and neck cancer radiotherapy

Victoria Butterworth, Tom Young, Andrew P. King, Teresa Guerrero Urbano

Normal tissue complication probability (NTCP) modelling is central to balancing tumour control and toxicity risk in radiotherapy (RT) for head and neck cancer (HNC). Despite major advances in radiation delivery and imaging, toxicity remains a major determinant of long-term quality of life in survivors. Classical NTCP models based on dose–volume histograms (DVHs) and phenomenological equations such as the Lyman–Kutcher–Burman model have provided clinically valuable guidance for decades but oversimplify the complex, …

28.08.2026journal-article

Current Oncology

KRAS in Colorectal Cancer: Tumorigenesis, Surgical Implications and Evolving Treatment Target

Sahar Iftikhar, Alexander H. Xiao, Zhaohui Jin, Emad H. Aly

Purpose: This review aims to provide an updated overview of Kirsten rat sarcoma viral oncogene homologue (KRAS) mutations in colorectal carcinoma (CRC), focusing on their role in tumorigenesis, prognostic implications, and recent advances in targeted therapy. Major findings: KRAS mutations occur in approximately 40% of colorectal cancers and play a central role in tumour initiation and progression through constitutive activation of MAPK pathways. Clinically, KRAS mutations are well established as predictors of resi …

28.08.2026journal-article

Journal of Geophysical Research: Atmospheres

Fast All‐Sky Hyperspectral Infrared Radiative Transfer With Physically Recursive Cloud Treatment

Yuxiang Ling, Chao Liu, Junyu Yan, Bin Yao, Dong Liu, Na Xu, Byung‐Ju Sohn, Peng Zhang

Abstract Clouds strongly modify thermal infrared radiances through absorption, emission, and multiple scattering, yet rigorous line‐by‐line (LBL) gas absorption coupled with multi‐stream scattering remains too expensive for large ensembles of all‐sky hyperspectral simulations. We present a fast monochromatic radiative transfer (RT) model for the thermal infrared spectrum that retains the physical structure and vertical flexibility of the layered RT problem while embedding type‐wise trained radiative response models …

28.08.2026journal-article

Medicine

Association between body roundness index and serum 25-hydroxyvitamin D in women with and without breast cancer

Yajuan Du, Meixiang Huang, Tingting Su, Xiaoyan Huang, Zhenbin Zheng

Breast cancer (BC) is the most prevalent tumor in women, ranking first in incidence and mortality in many countries. Previous studies have suggested that. Body Roundness Index (BRI) is positively correlated with BC risk and negatively correlated with serum vitamin D levels. But few well-designed studies have explored the full impact of BC status on the relationship between BRI and serum vitamin D. So we aimed to evaluate the relationship between BRI and serum 25-hydroxy vitamin D in women without or with BC. We use …

28.08.2026journal-article

Cancers

CT-Based Radiomics in Renal Tumors: Current Evidence, Methodological Challenges, and Future Perspectives for Precision Oncology

Anna Colarieti, Sergio Milazzo, Alessandro Pozzo Giuffrida, Alessandro Carriero

Background: CT-based radiomics may provide non-invasive imaging biomarkers for renal-tumor characterization and risk stratification. This systematic review evaluates the clinical evidence and translational readiness of radiomics in renal oncology and reports an exploratory methodological appraisal of a clearly delimited subgroup. Methods: PubMed/MEDLINE and Embase were searched from database inception through 15 August 2026 using controlled vocabulary and free-text terms for renal tumors, computed tomography, and r …

28.08.2026journal-article

JMIR Infodemiology

Investigating Online Discussions About Cancer Screening on Twitter (Subsequently Rebranded as X): Corpus Analysis

Martin-Pieter Jansen, Hanneke Hendriks, Suzan Verberne, Gert-Jan de Bruijn, Enny Das

Abstract Background While cancer screening is proven to be effective in the early detection of the disease and early detection enables better treatment options, screening uptake has been declining. Research shows that online health information helps people to make health-related decisions. However, not all online health information is credible, and misinformation might play a role in people’s choice to take part in screening. Objective This study aimed to analyze online discussions about cancer screening programs u …

28.08.2026journal-article

Colorectal Disease

Sexual dysfunction outcomes and reporting disparities after multimodal treatment for rectal cancer: A systematic review and narrative synthesis

Vignesh Lakshmanan, Jennifer Waterman, Alun Meggy, Jared Torkington, Julie A. Cornish

Abstract Background Sexual dysfunction is a recognised adverse outcome after rectal cancer treatments, yet reporting is predominantly male‐focused, with female sexual dysfunction less consistently assessed or reported. This systematic review aimed to assess sexual health domains studied, examine sex‐based reporting disparities, and identify limitations in the current evidence. Methods A systematic review and narrative synthesis were conducted in accordance with PRISMA and registered with PROSPERO (CRD420251178502). …

28.08.2026journal-article

New Zealand Medical Journal

Public support for cancer prevention and care policies in Aotearoa New Zealand: methods of a national survey

Bronwen McNoe, Andrew Gray, Ella Iosua, Rana Peniamina, Louise Signal

aim: Our aim was to describe the shared elements involving design, sampling, weighting and analytic framework of a national survey of public views on cancer prevention and care in Aotearoa New Zealand for the seven topic-specific brief reports in this issue of the New Zealand Medical Journal. methods: We conducted a nationwide, self-administered, cross-sectional online survey of adults aged 18 years or older between November and December 2025. Participants were recruited via an established online research panel usi …

28.08.2026journal-article

Frontiers in Immunology

Incident psoriasis in atopic dermatitis: a large-scale cohort study of disease- and treatment-associated risks

Florian Thaqi, Katja Bieber, Hatim Kerniss, Khalaf Kridin, Philip Curman, Ralf J. Ludwig

Background Clinical and genetic evidence on the association between atopic dermatitis (AD) and subsequent psoriasis remains conflicting, and it is unclear whether this risk is modified by systemic treatments. Recent reports suggest that type 2-targeted biologics may unmask psoriasis in patients with AD, but data are limited. We thus aimed to assess whether AD is associated with incident psoriasis and whether this risk differs by systemic treatment, particularly biologics versus conventional systemic immunosuppressa …