EUVIMEDEuropean Health Evidence
Uhr 10/10Sources Journal Tree
Easy Demo

EUVIMED Themenbrowser · Alter & Demenz · Seite 113

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
11.08.2026journal-article

Journal of Proteome Research

Urine and Serum Proteome and Lipidome Analysis of Naturally Aging Feline Species

Punyatoya Panda, Rodrigo Mohallem, Rita de Kassia Rodrigues Bezerra Filgueira, Niwako Ogata, Uma K. Aryal

Abstract Aging in companion animals such as cats closely relates to human aging in environmental exposures and disease manifestation, providing a valuable model for identifying biomarkers of age-associated decline. This study provides a combined proteomic and lipidomic analysis of serum and urine from naturally aging domestic cats aged 3.8–16 years, grouped as adult, old, and senior, to identify age-related molecular changes across biofluids. Label-free quantitative proteomics identified 901 urinary and 238 serum p …

11.08.2026journal-article

Frontiers in Aging Neuroscience

Plasma multi-miRNA models classify Alzheimer’s, Parkinson’s, and Lewy body dementia

Ursula S. Sandau, Jack T. Wiedrick, Trevor J. McFarland, Dora Yearout, Cyrus P. Zabetian, Shu-Ching Hu, Debby W. Tsuang, Joseph F. Quinn, Julie A. Saugstad

Introduction Differentiating Alzheimer’s disease (AD) from both Parkinson’s disease (PD) and Lewy body dementia (DLB) is difficult due to their clinical similarities. Plasma biomarkers offer an alternative to neuroimaging and cerebrospinal fluid analysis; however, there are limitations with respect to differential diagnosis of AD, PD, and DLB with current clinical assays. Methods Here we used machine learning to assess plasma miRNAs for their specificity in diagnosing AD vs. PD, and DLB. Our multi-center study assa …

11.08.2026journal-article

The British Journal of Social Work

‘I wasn’t aware what it was I was suffering from’: An evaluation of the impacts of the ‘empty nest’ on older adults and the potential implications for social work

Denise Turner

Abstract This article reports findings from a pilot study exploring the experiences of the ‘empty nest’ or ‘post-parental life phase’ among older adults in the UK, which highlight implications for social work practice. Drawing on a survey of fifty-three respondents, predominantly aged 60 and over, the study situates the empty nest within a life course framework, recognizing how midlife transitions may shape wellbeing in later life. The research is located within the context of a rapidly ageing UK population and inc …

11.08.2026journal-article

Buildings

Environmental Factors, Spatial Behavior, and Unit-Based Design in Dementia Care: A Case Study of Three Long-Term Care Facilities in Xi’an, China

Dian Zhou, Pengwen Wang

Older adults with dementia in long-term care facilities often become lost, enter unintended rooms, and develop greater dependence on care staff as a result of visuospatial impairment. However, existing dementia-friendly design studies have rarely distinguished among residents with different cognitive impairment characteristics. This exploratory cross-sectional study investigated 76 older adults with dementia and visuospatial impairment in three long-term care facilities in Xi’an, China. Neuropsychological assessmen …

11.08.2026journal-article

npj Aging

Social experiences and mortality risk: mediating roles of epigenetic aging, allostatic load, and health status

Holly G. Prigerson, Abigail J. Maciejewski, Paul K. Maciejewski, David Russell

Abstract Social environments affect health and longevity, yet biological pathways remain incompletely understood. Data from Midlife in the United States (MIDUS) study were used to examine whether social experiences predicted mortality and whether effects were mediated by epigenetic aging, allostatic load, and health status. Outcomes included epigenetic clocks (e.g., GrimAgeV2), allostatic load (e.g., immune/inflammatory biomarkers), health status, and all-cause mortality. Among 1309 participants, positive social ex …

01.09.2026journal-article

Otology & Neurotology Open

Access and Attrition Across Audiology and Cochlear Implant Care Among Older Adults with Bilateral Sensorineural Hearing Loss

Payal V. Patel, Varun Gopal, Divya Patel, Ryan G. Porter

Objective: To quantify progression through the hearing care pathway among US adults aged ≥65 years with bilateral sensorineural hearing loss (SNHL) and describe variation across geographic and community contexts. Study Design: Cross-sectional study. Setting: Epic Cosmos Database, January 1, 2021, through December 31, 2024. Patients: Adults aged ≥65 years with bilateral SNHL identified using International Classification of Diseases, Tenth Revision codes. Main Outcome(s) and Measure(s): Stage-specific unadjusted odds …

11.08.2026journal-article

Innovation in Aging

Stepwise development of ACTIVE-AGE@home: A home-based functional exercise program for frail older adults

Emma De Keyser, Jade Tambeur, Timothy Moreels, Dimitri Vrancken, Elke De Smedt, Kathleen Willems, Wim Peersman, Dominique Van de Velde, David Beckwée, Patricia De Vriendt

Abstract Background and Objectives Older adults with frailty often experience limitations in activities of daily living (ADL), threatening independence and quality of life. Existing exercise interventions rarely balance therapeutic validity with program adherence, often lacking ADL-specific training, meaningful goal integration, and co-creation with frail older adults. This study developed and evaluated ACTIVE-AGE@home (AA@H), a home-based functional exercise program co-created with frail older adults to address th …

11.08.2026journal-article

Affective Science

Amygdalar Pattern Similarity to Negative and Neutral Images, Ratings of the Images, and PET-Measured Amyloid and Tau Levels in Older Adults Without Dementia

Mingtong Liu, Lauren K. Gresham, Nikki A. Puccetti, Tobey J. Betthauser, Sterling C. Johnson, Stacey M. Schaefer

Abstract This study examines associations between brain levels of amyloid-β and tau with representational pattern similarity in amygdalar reactivity to negative and neutral images in older adults without dementia. 81 participants viewed affective images during functional magnetic resonance imaging (fMRI). Participants rated the images on valence and arousal outside the scanner. Amyloid-β and tau were measured with 11 C-Pittsburgh compound B and 18 F-MK-6240 positron emission tomography (PET) imaging. Representation …

11.08.2026journal-article

Technology and Disability

Scoping review of home environment-person interaction theories relevant to evaluating technology for people with dementia

Catherine Henderson, Sarah Jasim, Linda Clare, Sylwia Gorska, Rachael Litherland, Martin Knapp

Background This scoping review explored theoretical frameworks that explain how assistive technology (AT), including assistive and electronic devices and home modifications, affects people with dementia and their unpaid caregivers. Objective The review aimed to identify models linking home environments to themes of independence, sense of independence, social connectedness, safety and caregiver stress. Methods We searched eight databases and Google Scholar, identifying 26 frameworks across 82 papers. The search stra …

11.08.2026journal-article

Journal of Neurology

Association between mild action tremor and cognition in community dwelling older adults: results from the KORA-Age study

Gregor Kuhlenbäumer, Franziska Hopfner, Günther Deuschl, Karl-Heinz Ladwig, Birgit Linkohr, Annette Peters, Barbara Thorand, Marie-Theres Huemer

Abstract Background Essential tremor has been associated with cognitive impairment. Mild action tremor labelled physiological tremor is present in all humans. Tremor increases with age. It is unknown if mild action tremor is associated with cognitive performance in older people. Objective To test the hypothesis that mild—mostly non-pathological—action tremor is associated with reduced cognitive performance in community-dwelling older adults. Methods The Cooperative Health Research in the Region of Augsburg (KORA)-A …

11.08.2026journal-article

Menopause

Managing urinary tract infections in midlife and older women

Amanda Clark

Urinary tract infections (UTIs) in women are common, bothersome, and linked to considerable costs for patients and health systems. Patients often experience adverse reactions with antibiotic therapy, and frequent antibiotic use for the treatment of UTIs is a major contributor to growing bacterial resistance to antibiotics worldwide. The development of antimicrobial resistance may limit future treatment options for the individual patient, as well as for the community. Nonantibiotic prevention offers the potential to …

11.08.2026journal-article

Youth

Self-Managed Leisure and Volitional Development in Young People: A Study of Motivational Profiles and Relational Supports Among Spanish Youth

Idurre Lazcano, Joseba Doistua

Self-managed leisure is a key determinant of volitional development and the transition to adulthood in young people. This article examines the relationship between perceived family and social support environments and levels of self-management and motivation among young people aged 18 to 29. A quantitative descriptive-correlational design was used to administer the Self-managed Leisure Scale (SLS) [Escala de Autogestión del Ocio (SLS)] and the Environment Scale (ES) [Escala de Entornos (EE)] to a sample of 468 young …

11.08.2026journal-article

MedPharmRes

Potentially Inappropriate Prescribing among geriatric patients at a tertiary hospital: A cross-sectional study using STOPP/START criteria - version 3

Huu-Phuong Truong, Phuong-Nguyen Pham, Huong-Thao Nguyen

Introduction: Potentially Inappropriate Prescribing (PIP) is prevalent among older patients and may reduce treatment efficacy and safety. Our study aimed to identify the prevalence, clinical relevance of PIP in hospitalized geriatric patients, and factors associated with PIP occurrence. Methods: A cross-sectional study was conducted on medical records of patients aged ≥65 years, treated at Trung Vuong hospital, between September 1st and December 31st, 2023. PIP was identified using the STOPP/START criteria - versio …

11.08.2026journal-article

Infection and Immunity

Genitourinary microbiota in older women: a persistent knowledge gap that limits clinical and research progress

Sophie J. Miller, Jocelyn Choo, Luke Grundy, Steven Taylor, Geraint B. Rogers

ABSTRACT Genitourinary health in older women represents a poorly recognized clinical burden, marked by a high prevalence of conditions such as urinary incontinence, pelvic organ prolapse, genitourinary syndrome of menopause, and recurrent urinary tract infection. Current management strategies are largely extrapolated from reproductive-aged populations, overlooking important differences in physiology, comorbidity, and environmental exposures in later life. Emerging evidence implicates the genitourinary microbiome as …

11.08.2026journal-article

Frontiers in Aging Neuroscience

Change detection in audio-visual space: neural evidence for age effects

Benjamin Stodt, Daniel Neudek, Rainer Martin, Edmund Wascher, Stephan Getzmann

Introduction The ability to perceive spatial changes is crucial for everyday life. However, the effects of age on multisensory integration in spatial change detection are still less researched. Here, we investigated whether audio-visual stimulation enhances spatial change detection compared to auditory-only processing, and whether older adults benefit more from multisensory stimulation than younger adults. Methods In an active oddball task, younger and older participants had to detect spatial changes in azimuth (in …

11.08.2026journal-article

Frontiers in Endocrinology

Associations between novel triglyceride glucose and adiposity-related indices and risk of metabolic dysfunction-associated steatotic liver disease: the mediating role of biological aging and evidence from the UK Biobank

Kun Wang, Renfang Han, Yueqing Huang, Jingfen Cai, Xiadi Wu

Background Insulin resistance (IR) plays a critical role in the development and prognosis of metabolic dysfunction-associated steatotic liver disease (MASLD). However, evidence regarding associations between novel triglyceride glucose (TyG) and adiposity-related composite indices, serving as simple IR surrogates, and the risk of incident MASLD remains limited. This study aimed to evaluate associations between six novel TyG-related composite indices and MASLD risk, as well as the potential mediating role of biologic …

11.08.2026journal-article

Journal of Evidence-Based Medicine

Guideline for the Comprehensive Perioperative Management of Older Patients With Lung Cancer (2025)

Daiping Li, Rui Liang, Birong Dong, Lunxu Liu, Ning Ge, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University

ABSTRACT With the accelerating population aging, the number of older adult patients with lung cancer continues to increase. These patients often present with multiple chronic diseases and geriatric syndromes, resulting in more complex perioperative management and significantly increased surgical risks. This guideline was developed and reported on the basis of the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system and the Reporting Items for Practice Guidelines in Healthcare (RIGHT) che …

11.08.2026journal-article

Geriatrics

Lost in Translation: Interprofessional Variability in Understanding Pro Re Nata (PRN) Prescribing in Geriatric Practice—A Prospective Observational Study

Pauline Ripoche, Thomas Rodier, Marine Grangé, Dany Vythilingum, Zohra Mekerta, Aude Tarré, Patrick Hindlet, Laurent Lechowski, Hugues Michelon

Background/Objectives: Medication safety is a critical concern in older adults due to age-related vulnerability, multimorbidity, and polypharmacy. Pro Re Nata (PRN, “as needed”) prescribing is common in geriatric care but may be interpreted inconsistently across healthcare professionals, potentially increasing the risk of medication errors. This study aimed to evaluate PRN prescribing patterns in hospitalized older adults and assess interprofessional perceptions of the clarity and appropriateness of PRN prescribing …

11.08.2026journal-article

Microbiology

Interactions at the Streptomyces – animal interface: ecology, defence and disease

Ainsley D.M. Beaton, James T. Croxford, Alejandra C. Díaz de Aguinaga, Emily Horsburgh, David R. Mark, Lia S. McQueary, Kaisha R. Murray-Clelland, Samantha K. Tucker, Andrew J. Roe, Rebecca E. McHugh

Graphical Abstract Phylogenetic tree highlighting members of the kingdom Animalia with characterized Streptomyces interactions. Images have been coloured using stereoimages of Streptomyces colonies.

11.08.2026journal-article

Diabetes

Accelerated Brain Aging in Type 1 Diabetes Across Painful and Painless Peripheral Neuropathy: MRI-Based Brain Age Estimates From Deep Learning

Søren N.F. Hostrup,, Suganthiya S. Croosu,, Johan Røikjer,, Carsten D. Mørch,, Christina Brock,, Asbjørn M. Drewes,, Birgitte Brock,, Janusiya A. Muthulingam,, Tine M. Hansen,, Niels Ejskjaer,, Jens B. Frøkjær

Structural brain alterations, including accelerated brain aging, occur in diabetes, as seen via MRI. The brain age gap (BAG) is likely caused by a combination of factors, including mechanisms associated with diabetic peripheral neuropathy (DPN) and neuropathic pain. In this study, 178 participants with type 1 diabetes (T1D) (n = 79 without DPN, 53 with painless DPN, 46 with painful DPN) and 48 healthy control individuals underwent structural brain MRI. Whole-brain and regional BAG were derived from the volBrain pip …

11.08.2026journal-article

Frontiers in Nutrition

The longitudinal association between artificial sweetener intake and the risk of type 2 diabetes among adults aged 18 years and older: a systematic review and meta-analysis

Siyuan Lu, Yi Lu, Rui Xu, Wenfeng Hou, Ting Xu, Wei Tang

Background Artificial sweeteners are commonly used as sugar substitutes because they provide sweetness with little or no caloric content. However, the relationship between artificial sweetener consumption and type 2 diabetes (T2D) remains controversial. This meta-analysis was conducted to investigate the longitudinal association between artificial sweetener intake and T2D among adults. Methods Electronic databases in English and Chinese were searched for prospective studies published from inception to March 2025. U …

11.08.2026journal-article

International Journal of Older People Nursing

Views on Everyday Life and Reflections on Future Death and Dying Among Older Persons Residing in Nursing Homes: A Meta‐Ethnographic Synthesis

Peter Lundberg, Jane Österlind, Malin Olsson

ABSTRACT Introduction Life issues relating to identity, meaning and dignity are inherent to human existence and remain significant throughout the entire lifespan. To meet the needs of older persons residing in nursing homes, it is essential to understand their views on everyday life, particularly regarding the proximity of death, reflections on future death and dying, and the potential for meaning in everyday life. However, these views have received limited attention in research. The aim of this study was therefore …

11.08.2026journal-article

Tropical Medicine and Infectious Disease

Understanding Barriers to Uptake of TB Preventive Treatment Among People Living with HIV in Zimbabwe: A Qualitative Assessment of Healthcare Workers’ Perspectives

Tawanda Mapuranga, Collins Timire, Ronald T. Ncube, Sithabiso Dube, Nqobile Mlilo, Cynthia Chiteve, Owen Mugurungi, Tsitsi Mutasa-Apollo, Fungai Kavenga, Clorata Gwanzura, Manners Ncube, Nicholas Siziba, Selma Dar Berger, Talent Maphosa, Macarthur Charles, Riitta A. Dlodlo, Julia Ershova

People living with HIV (PLHIV) are at an increased risk of progressing from Mycobacterium tuberculosis (TB) infection to TB disease. Tuberculosis preventive treatment (TPT) is recommended for PLHIV; however, its uptake remains suboptimal. In Zimbabwe, three months of weekly rifapentine and isoniazid (3HP) and six months of daily isoniazid (6H) are the most commonly prescribed TPT regimens. We explored barriers to TPT uptake among PLHIV from the perspective of healthcare workers (HCWs) in Zimbabwe. Facility nurses w …

10.08.2026journal-article

Quality in Sport

Deprescribing in Primary Care Patients Aged 65 Years and Older Exemplified by Hypertension, Type 2 Diabetes, and Insomnia: A Literature Review

Zofia Biernacka, Urszula Kacprzak, Mikołaj Celmer, Mateusz Majchrzak, Julia Kossakowska, Marcin Ruszkowski, Norbert Piątkowski

Background. An aging population has become a fact around the world. It is estimated that by 2050, individuals over the age of 65 will constitute more than 56.7% of the European population. Aging involves a series of physiological changes and is a highly variable process among individuals. In elderly patients with hypertension, type 2 diabetes, or insomnia, treatment de-escalation is frequently required. This study identifies challenges physicians encounter in daily practice during the deprescribing process and high …