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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
19.08.2026journal-article

Journal “Ukrainian sense”

«ТРИ ПОБАЖАННЯ» Е.МАКРОНА В НОВОРІЧНІЙ ПРОМОВІ 2025 РОКУ: СЕМІОТИКО-НАРАТИВНИЙ АСПЕКТ

І. Кірковська

Постановка проблеми. Стаття присвячена дослідженню трансформацій у парадигмі політичної комунікації Франції на межі 2025–2026 років. У центрі уваги – феномен «макронізму» як стратегічного наративу, що в умовах глобальної нестабільності еволюціонує від технократичного дискурсу до формату ідеологічного маніфесту. Проблема полягає в дешифруванні прихованих технік переконання, що дозволяють владному суб’єкту мобілізувати суспільство через традиційні ритуальні тексти, зокрема новорічні звернення. Мета дослідження поляга …

19.08.2026journal-article

JAMA

Arginine Therapy for Sickle Cell Disease Acute Pain Episodes

Claudia R. Morris, Dunia Hatabah, Rawan Korman, Fahd A. Ahmad, Gladstone Airewele, Bolanle Akinsola, Noor Alzraikat, Nitya Bakshi, David C. Brousseau, Kathleen Brown, Andrew D. Campbell, T. Charles Casper, Todd P. Chang, Corrie E. Chumpitazi, Daniel Cohen, Keli D. Coleman, Laura Covelo, Andrea T. Cruz, Christopher Denton, Angela M. Ellison, Melanie Fields, Hailey Jensen, Sara Leibovich, Chris A. Rees, Allison Remiker, Nidhi Singh, Alexis Thompson, Elliott Vichinsky, Anthony Villella, Hagar Wilkinson, Bridget Wynn, Carlton Dampier, Pediatric Emergency Care Applied Research Network (PECARN)

Importance Acute pain episodes are the leading cause of emergency department visits and hospitalizations for patients with sickle cell disease (SCD), yet US Food and Drug Administration–approved drugs for acute pain episodes are lacking. During acute pain episodes, patients develop acute arginine deficiency associated with longer time to crisis resolution and greater total parenteral opioid use. Multiple single-center, phase 2 randomized clinical trials have shown that arginine is safe, is opioid sparing, improves …

19.08.2026journal-article

Blood Advances

American Society of Hematology 2026 Guidelines for Immune Thrombocytopenia (ITP): Initial and Second-Line Therapy in Adults with Primary ITP

Adam Cuker, Deirdra R Terrell, Honieh Sowdagar, Donald M Arnold, Sylvain Audia, James B. Bussel, Tomas Jose Gonzalez-Lopez, Rachael F. Grace, Camila Masias, Keith R. McCrae, Mirjana Mitrovic, Cindy E. Neunert, Sandhya Ramanathan Panch, Surbhi Shah, Brenda G Shy, Jessica VandeVelde, Douglas B. Cines, Sara K Vesely

Background: Since publication of the American Society of Hematology 2019 Guidelines for Immune Thrombocytopenia (ITP), new clinical trials have been completed and new treatments have become available. Objective: These evidence-based guidelines from the American Society of Hematology (ASH) are a focused update of the 2019 ASH ITP guidelines, centering on treatment of adults with primary ITP. Methods: ASH formed a multidisciplinary guideline panel including two patient representatives that was balanced to minimize po …

19.08.2026journal-article

Frontiers in Psychiatry

Effects of visual art therapy on cognitive function in older adults: a systematic review and meta-analysis

Zhenhua Guo, Yingcong Liu, Shan Zhu, Yupeng He

Objective To systematically review the evidence on the effects of visual art therapy on global cognitive function in older adults, and to examine its impact on verbal fluency, naming ability, and activities of daily living. Methods A systematic search was conducted in PubMed, Web of Science, Embase, the Cochrane Library, China National Knowledge Infrastructure (CNKI), the Chinese Biomedical Literature Database, Wanfang Database, and VIP Database for randomized controlled trials (RCTs) published from database incept …

19.08.2026journal-article

JOURNAL OF HUMANITIES AND SOCIAL POLICY

Effectiveness of REBT and CBT in Managing Drug Abuse Among Clients in NDLEA Rehabilitation Centers, Abuja, Nigeria

Fatima Abiola Popoola

This study examined the effectiveness of Rational Emotive Behavior Therapy (REBT) and Cognitive Behavioral Therapy (CBT) in managing drug abuse among clients in the National Drug Law Enforcement Agency (NDLEA) Rehabilitation Centre, Abuja, Federal Capital Territory. The study was guided by three research questions and three hypotheses and adopted a quasi-experimental, non-randomized pretest–posttest research design. The population comprised drug users undergoing rehabilitation at the NDLEA Centre, Abuja. A sample o …

19.08.2026journal-article

FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology

Comparative efficacy and safety of prolgolimab and nivolumab in first-line therapy for metastatic or unresectable melanoma: a systematic review, matching-adjusted indirect comparison, and cost-effectiveness analysis

I. A. Utyashev, I. V. Myslevtsev, O. N. Mironenko, V. D. Batorova, K. A. Katilova, K. V. Sapozhnikov, N. A. Sableva, A. A. Lazarev, D. G. Tolkacheva

Background . Metastatic and unresectable cutaneous melanoma (MM/uRCM) is an aggressive malignancy associated with high mortality due to its pronounced metastatic potential. Immune checkpoint inhibitors are used to treat MM/uRCM in the Russian Federation. These inhibitors include nivolumab and prolgolimab, which block the programmed cell death 1 (PD-1) receptor. However, there are no direct comparative data on their clinical and economic efficacy and safety as monotherapy, which complicates optimal therapeutic decis …

19.08.2026journal-article

Occupational Medicine

Occupational anaphylaxis induced by beta-lactam antibiotics exposure in a nurse

M Areia, C Coelho, P Barreira, J Q Gomes

Summary Healthcare workers are exposed to substances that may elicit allergic and irritant reactions, including anaphylaxis, a potentially life-threatening hypersensitivity reaction. We report the case of a nurse with pre-existing hand contact dermatitis who presented anaphylaxis following exposure to ceftriaxone and piperacillin/tazobactam during drug preparation. Diagnostic testing confirmed an allergy to both antibiotics and latex. The absence of prior therapeutic exposure, combined with skin barrier impairment …

19.08.2026journal-article

Frontiers in Psychology

Psychological rehabilitation of women with endometrial cancer: dynamics of quality of life after psychotherapeutic intervention depending on the type of surgical treatment

Ayazhan Janbayeva, Aliya Uteulova, Piko Bettina, Marat Assimov, Fatima Bagiyarova

Endometrial cancer is the most common gynecological malignancy among women, and its incidence has increased considerably over recent decades. Surgical treatment, chemotherapy, radiotherapy, and hormone therapy are frequently associated with psychological distress, impaired social functioning, and reduced quality of life. The present study aimed to examine changes in quality of life among women with endometrial cancer across different stages of treatment and rehabilitation, as well as to assess changes associated wi …

19.08.2026journal-article

Frontiers in Neurology

Glycosylation disorders in pediatric epilepsy: pathophysiology, imaging and precision therapy

Lijuan Fan, Yajun Shen, Jianjun Wang, Jing Gan

Epilepsy is a common neurological disorder in children and about 30% of children with epilepsy develop drug-resistant epilepsy. Epilepsy resulting from genetic variations and structural brain abnormalities has been extensively studied. Based on the current evidence, however, glycosylation, a major post-translational modification on over 70% of human brain proteins, is necessary for the stability of neural networks. This article delves into the many aspects of glycosylation abnormalities in epilepsy, including impai …

19.08.2026journal-article

JAMA Surgery

Incisional Negative Pressure Wound Therapy for Prevention of Surgical Site Infection

Shaan Patel, Shiva A. Nischal, Kush M. Kale, Akash Dubb, Srinivas K. Prasad, Daniel Refai

Importance Incisional negative pressure wound therapy (iNPWT) has been proposed as a nonantibiotic adjunct to standard dressings for preventing surgical site infection (SSI), but uncertainty remains regarding consistency across SSI subtypes and dressing-related harms. Objective To evaluate the efficacy and safety of iNPWT vs standard dressing in adults undergoing surgery. Data Sources PubMed, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) were searched from inception through March 7, 2026. Stu …

19.08.2026journal-article

International Journal of Advanced Multidisciplinary Research and Studies

The Influence of Occupational Stress on Police Officers’ Accountability in Service Delivery in Nairobi City County, Kenya

Ziphorah Mulimi King’oo, Dr. Merecia Ann Sirera, John Ndikaru Wa Teresia

Occupational stress is a significant concern in policing because of the demanding nature of police work and its potential implications for professional conduct and service delivery. This study examined the perceived influence of occupational stress on police officers’ accountability in service delivery in Nairobi City County, Kenya. The study was guided by the Job Demand-Control Theory and Cognitive Behaviour Theory and employed a cross-sectional descriptive survey design. Data were collected from police officers u …

19.08.2026journal-article

Journal of Parkinson’s Disease

Rehabilitation strategies for atypical parkinsonian syndromes: A scoping review of progressive supranuclear palsy, multiple system atrophy, corticobasal syndrome, and dementia with Lewy bodies

Hikaru Kamo, Satoru Amano, Isabelle K Gerzenshtein, Dinesh K Vuddandam, Koichi Nagaki, Mai Shimizu, My-Vy Tran, Arunmozhimaran Elavarasi, Nikolaus R McFarland, Aparna Wagle Shukla

Background Rehabilitation plays a crucial role in maintaining function and independence in neurodegenerative disorders. However, evidence on its effectiveness in atypical parkinsonian syndromes including progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal syndrome (CBS), and dementia with Lewy bodies (DLB) remains fragmented. Objective This scoping review aimed to comprehensively map the literature on rehabilitation interventions for PSP, MSA, CBS, and DLB, summarize intervention types …

19.08.2026journal-article

International Journal of Molecular Sciences

The Evolution of FAP-Targeted CAR T-Cell Therapy in Solid Tumors: From Immunotherapy to Immunotheranostic Applications

Hugo Boutier, Anja Feldmann, Michael Bachmann

Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment landscape of hematologic malignancies but has demonstrated limited efficacy in solid tumors, mainly due to the complex and immunosuppressive tumor microenvironment (TME). Among the strategies to overcome this challenge, targeting the tumor stroma rather than the tumor cells themselves has gained increasing interest. In this context, fibroblast activation protein alpha (FAP), a cell surface protease overexpressed by cancer-associated fib …

19.08.2026journal-article

Frontiers in Psychology

Bidirectional effects of speech and gesture: evidence from a novel levels-of-congruence paradigm

Laura Pissani, Vera Demberg

Introduction Previous research has shown that speech and gesture are integrated during comprehension, with differences in response times and electrophysiological activity observed between incongruent and congruent gesture—speech pairings. Beyond these incongruency effects, it remains unclear whether comprehenders use gestures to adapt or extend conventional interpretations for novel communicative purposes. Method The current study examined the bidirectional influence of speech and gesture by employing a novel level …

19.08.2026journal-article

International Journal of Health Sciences and Research

Retrospective Analysis of the Effectiveness and Safety of Pregabalin and Duloxetine Fixed-Dose Combination Therapy in the Management of Neuropathic Pain (RESET Study)

Nitin Kapure, Mayur Mayabhate, Akhilesh Sharma

Background: Neuropathic pain is a complex, chronic pain condition arising from somatosensory nervous system lesions or disease. Pregabalin and duloxetine are individually established pharmacological agents for neuropathic pain management; however, their combined efficacy as a fixed-dose combination (FDC) remains underexplored in real-world clinical settings. Objective: To retrospectively evaluate the effectiveness and safety of pregabalin–duloxetine FDC therapy in patients with neuropathic pain over a 3-month treat …

19.08.2026journal-article

Renal Replacement Therapy

Early serum creatinine trajectory phenotypes during the first 72 h after ICU admission and 1-year mortality in PCI-treated acute myocardial infarction: a retrospective cohort study

Hasan Burak Isleyen, Sevil Tugrul Yavuz, Sercan Bulut, Fatih Kizkapan, Cevahir Alioglu, Ali Arda Sozen, Mahsa Khanmohammadi

Abstract Background Static creatinine thresholds after percutaneous coronary intervention may miss early renal dynamics. We examined whether serum creatinine trajectory phenotypes during the first 72 h after intensive care unit admission were associated with mortality and renal outcomes in PCI-treated acute myocardial infarction. Methods We performed a retrospective cohort study using MIMIC-IV version 3.1. Adults with acute myocardial infarction who underwent percutaneous coronary intervention, had an intensive car …

19.08.2026journal-article

Cancers

First-Line Maintenance Therapy Patterns in BRCA Wild-Type, HRD-Negative or Biomarker-Unknown Advanced Epithelial Ovarian Cancer: A Five-Country European Real-World Study by APLUSA

Mario Uccello, Stergios Boussios, Christine Maï, Hilary Worton, Arthur Bazire, Bertrand de Buhren

Background/Objectives: First-line maintenance is established in advanced epithelial ovarian cancer (AEOC), but management remains uncertain for patients without a BRCA mutation or homologous recombination deficiency (HRD)-positive disease. We assessed real-world use of bevacizumab, poly(ADP-ribose) polymerase (PARP) inhibitors and active surveillance in France (FR), Germany (DE), Italy (IT), Spain (ES) and the United Kingdom (UK). Methods: Anonymised physician-reported charts were analysed from a retrospective, non …

19.08.2026journal-article

Jurnal Kesehatan Manarang

Effect of Home Visits and Family Centered Midwifery Care on Family Support and Maternal Weight Among Women with High Risk Pregnancies: A Quasi Experimental Study

Halisah Halisah, Intan Idiana Hassan, Farida Tandi Bara, Rezmaniar Rezmaniar

Low birth weight and poor maternal nutritional status remain important public health concerns, particularly among women with high-risk pregnancies. Limited family involvement may reduce adherence to nutritional recommendations and antenatal care, thereby contributing to suboptimal maternal outcomes. This study aimed to evaluate the association of structured home visits combined with family-centered midwifery care with family support and maternal weight among women with high-risk pregnancies. This quasi-experimental …

19.08.2026journal-article

Science Translational Medicine

Carboxyl-terminal blockade of sortilin binding enhances progranulin gene therapy in a mouse model of frontotemporal dementia

Shreya N. Kashyap, Stephanie N. Fox, Vivianna R. DeNittis, Katherine I. Wilson, Nicholas R. Boyle, Mary Bullock, Aniketh S. Tadepalli, Stephanie R. Miller, Jorge J. Palop, Yohannes A. Ambaw, Tobias C. Walther, Robert V. Farese, Charles F. Murchison, Andrew E. Arrant, Erik D. Roberson

Frontotemporal dementia is commonly caused by loss-of-function mutations in the progranulin gene. Potential therapies for this disorder have entered clinical trials, including progranulin gene therapy and drugs that reduce progranulin interactions with sortilin. Both approaches ameliorate functional and pathological abnormalities in mouse models of progranulin insufficiency. Here, we investigated whether modifying the progranulin carboxyl terminus to block sortilin interactions would improve the efficacy of progran …

19.08.2026journal-article

International Journal of Language & Communication Disorders

Phonological Awareness and Nonword Repetition in Children With and Without Speech Sound Disorders: A Comparative Analysis

Özlem Icoz, Esra Özcebe

ABSTRACT Objective This study aimed to compare phonological awareness and verbal working memory skills, as measured by a nonword repetition task, in children with speech sound disorders (SSD) and typically developing peers. It also examined the relationship between these two cognitive‐linguistic abilities within each group. Methods The study included 30 children aged 4 to 6 years diagnosed with SSD and 30 age‐matched typically developing children. Participants were recruited from a clinical population and their typ …

19.08.2026journal-article

Exercise Science

Nutritional Strategies to Mitigate Muscle Loss During Rehabilitation After Sports Injuries: A Narrative Review

Kihyuk Lee, Jooyoung Kim

Sports injuries frequently involve periods of reduced activity, immobilization, or unloading that accelerate skeletal muscle loss and delay functional recovery. This narrative review synthesizes current evidence on nutritional strategies to attenuate muscle loss during sports injury rehabilitation using a muscle-centered, phase-informed, and evidence-hierarchical perspective. Current evidence regarding energy availability, protein and amino acid strategies, creatine, and omega-3 fatty acids was qualitatively synthe …

19.08.2026journal-article

World Journal of Psychiatry

Effects of cognitive behavioral therapy-based group intervention on burnout and anxiety symptoms in operating room nurses

Chun-Ling Chen, Wen-Mei Liu, Rui-Ping Cai, You-Xian Zhong, Min Liang

BACKGROUND Operating room nurses are vulnerable to burnout and mental health issues related to high-intensity workloads, the complexity of technical operations, and the immense pressure of responsibility. Although cognitive behavioral therapy (CBT) has proven effective in the treatment of burnout and anxiety, there is a dearth of systematic research on option B, CBT-based group interventions targeting operating room nurses, as well as insufficient evidence for its long-term effects. AIM To evaluate the effects of C …

19.08.2026journal-article

Musculoskeletal Care

Rehabilitation Experiences and Support Needs of Patients With Hemiplegic Shoulder Pain Based on the ICF Framework: A Qualitative Study

Xingyu Li, Hualu Yang, Minghong Sui, Jiaqing Liu, Xin Wang, Xiaotian Liu, Guangfa Xiang, Rui Luo, Yanhong Chen, Beirong Mo

ABSTRACT Background Hemiplegic shoulder pain (HSP) multi‐dimensionally affects the rehabilitation process of stroke survivors. Although previous literature has explored post‐stroke functional recovery, empirical qualitative investigations into the authentic rehabilitation experiences and deep care needs of this specific population during hospitalisation remain to be further elucidated. Objective Guided by the International Classification of Functioning, Disability and Health (ICF) framework, this study aimed to exp …