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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Journal of Medical Internet Research

Consumer and Patient Health Information Seeking With Generative AI Tools: Scoping Review of Facilitators and Barriers

Lilach Alon, Inbar Levkovich

Background Generative AI (GenAI) tools powered by large language models (LLMs) are increasingly used by the public to seek health information. Unlike traditional web search, these systems generate conversational responses that may alter how users assess credibility, manage uncertainty, verify information, and decide whether to consult clinicians. As GenAI becomes more embedded in everyday health information practices, a clearer synthesis of the emerging empirical evidence is needed. Objective This scoping review ma …

02.09.2026journal-article

Acta Poloniae Pharmaceutica - Drug Research

Multidrug-Resistant Acinetobacter baumannii: an Overview of Therapeutic Options and Treatment Regimens

Paweł Sacha, Mateusz Modzelewski, Łukasz Korczak, Elżbieta Tryniszewska

Acinetobacter baumannii, a Gram-negative coccobacillus, is an opportunistic pathogen originating from the natural environment (soil, water, and plants). This bacterium is common in the human skin microbiota and is capable of colonizing diverse environments (e.g., hospital environments). A. baumannii is a bacterium naturally resistant to multiple antibiotic classes. In recent years, due to its ability to acquire resistance genes from other bacteria, it has become a critical threat, particularly in intensive care uni …

02.09.2026journal-article

Cancers

Impact of Post-Primary Treatment Hormone Replacement Therapy on Survival in Women with Cervical Cancer

Hee Joong Lee, Banghyun Lee

Background/Objectives: The effects of hormone replacement therapy (HRT) after primary treatment on survival outcomes in women with cervical cancer (CC) remain unclear. This nationwide cohort study evaluated the association between post-primary treatment HRT and overall survival (OS) in women with CC. Methods: We identified 15,261 women aged ≤60 years with CC who received primary treatment using the Korean Health Insurance Review and Assessment Service database. HRT users were defined as women who received HRT presc …

02.09.2026journal-article

Frontiers in Digital Health

VHealth-MFusion: a fusion-based multimodal deep learning framework for pneumonia tele-diagnosis in virtual hospital environments

Sara A. Alsalamah, Albatoul Althenayan, Mariam Almutairi, Shada AlSalamah, Hessah A. Alsalamah, Thamer Nouh, Bassam Mahboub, Laila Salameh, Moteeb Al Moteri, Chang-Tien Lu

Introduction Virtual hospital systems support remote triage and diagnosis across distributed healthcare environments by integrating radiographic imaging with structured clinical information for clinical decision making. However, many existing diagnostic frameworks do not fully address real world challenges commonly encountered in scalable virtual healthcare settings. These challenges include severe class imbalance, incomplete clinical attributes, heterogeneous multimodal inputs, and variability in data quality acro …

02.09.2026journal-article

QJM: An International Journal of Medicine

Targeting the Nrf2-SLC7A11/GPX4 Pathway to Inhibit Ferroptosis: Mechanism of Yiqi Fumai Formula in Acute Decompensated Heart Failure

Lu Fan, Yunfeng Jia, Yanyang Li, Zhihan Yang, Yiming Zuo, Haomin Zhang, Xuezheng Liu, Shichao Lv

Abstract Objective To elucidate the mechanism of Yiqi Fumai Formula (YQFM) in acute decompensated heart failure (ADHF) via the Nrf2/SLC7A11/GPX4 pathway in regulating ferroptosis. Methods Network pharmacology was employed to predict the underlying mechanisms of YQFM in ADHF. Rat models of ADHF were established, incorporating agonists or inhibitors of key ferroptosis pathways. The therapeutic mechanism of Yiqifumai Formula was investigated by assessing cardiac structure/function, myocardial injury biomarkers, lipid …

02.09.2026journal-article

Journal of Ophthalmology and Advance Research

Primary Orbital Mucinous Carcinoma in a Human Immunodeficiency Virus (HIV) Patient: A Case Report

Zahra A Markatia, George A Villatoro, Taimur Siddiqui, Debra J Shetlar, Michael T Yen

Mucinous carcinoma is a rare malignancy marked by abundant mucin production, typically found in organs like the breast, colon, and ovary, with orbital involvement being exceptionally rare. This case report presents a 55-year-old male with a history of well-controlled Human Immunodeficiency Virus (HIV) infection, oral squamous cell carcinoma, and recurrent papillomas of the conjunctiva and oropharynx, who developed a firm, enlarging mass in the left superomedial anterior orbit. Histopathology after surgical resectio …

02.09.2026journal-article

Journal of Clinical Medicine

Male Breast Cancer: An Analysis of Clinicopathological Features, Treatment Patterns, and Survival Outcomes over 10 Years from a Tertiary Center

Hüseyin Tepetam, Cemal Ugur Dursun, Mustafa Mert Hanilce, Solen Nasifoglu, Nursena Ciflik, Duygu Gedik, Sermin Kokten, Sule Karabulut Gul

Background/Objectives: Male breast cancer (MBC) is a rare malignancy accounting for less than 1% of all breast cancers, and current treatment recommendations are largely extrapolated from studies in women. We aimed to evaluate the clinicopathological characteristics, treatment patterns, survival outcomes, and prognostic factors of male breast cancer patients treated at a tertiary referral center. Methods: We retrospectively reviewed 45 patients with histopathologically confirmed MBC treated between January 2015 and …

02.09.2026journal-article

Journal of Clinical Medicine

Spermatocytic Tumor Arising in a Cryptorchid Testis: A Case Report and Narrative Review

Laurențiu Augustus Barbu, Stelian-Stefaniță Mogoantă, Liliana Cercelaru, Marius Cristian Marinaș, Nicolae-Dragoș Mărgăritescu, Mihai Popescu, Valentina Căluianu, Gabriel Florin Răzvan Mogoș, Liviu Vasile, Tiberiu Stefăniță Țenea Cojan

Background: Spermatocytic tumor (ST) is a rare non-GCNIS-derived testicular germ cell neoplasm that predominantly affects older men and generally follows an indolent course. Its occurrence in a cryptorchid testis is exceptionally uncommon. Methods: A narrative literature review was conducted using the PubMed database, including studies published up to August 2026. The search used combinations of the terms “spermatocytic tumor”, “spermatocytic seminoma”, “cryptorchidism”, “undescended testis”, “immunohistochemistry” …

02.09.2026journal-article

Journal of Clinical Medicine

Periodontitis and Glycaemic Dyscontrol Substantially Increase the Risk of Medication-Related Osteonecrosis of the Jaw: A Preclinical Study in Female Rats

João Martins de Mello-Neto, Luan Felipe Toro, Letícia Chaves Ferreira, Vinícius Franzão Ganzaroli, Leandro Lemes da Costa, Rodrigo Isaías Lopes Pereira, Arthur Michellim Kirasuke, Ana Beatriz Carreto, Isabella Zacarin Guiati, Valdir Gouveia Garcia, Letícia Helena Theodoro, Edilson Ervolino

Background/Objectives: There is limited understanding of how periodontitis progresses in individuals with diabetes who are undergoing antiresorptive drug therapy, particularly given that both are risk factors for medication-related osteonecrosis of the jaw (MRONJ). This study evaluated the effect of therapy with an oncological dose of zoledronate on the progression of experimental periodontitis (EP) in diabetic female rats. Methods: One hundred and eight female rats (12 months old) were assigned to four groups: VEH …

02.09.2026journal-article

Surgical and Radiologic Anatomy

Preoperative CT-based 3D analysis of middle colic vein anatomy for complete mesocolic excision in right-sided colon cancer: a retrospective cohort study from a prospective clinical trial

Vladimir Zivanovic, Dejan Ignjatovic, Javier Armando Luzon, Bojan Vladimir Stimec

Abstract Purpose Complete mesocolic excision requires central mesenteric dissection near the middle colic vein (MCV) confluence, where anatomic variability may increase operative risk. However, MCV multiplicity, confluence patterns, and relationships to the middle colic artery (MCA) are not sufficiently defined. Methods We performed a retrospective secondary analysis of 300 consecutive three-dimensional vascular reconstructions from a prospectively maintained database of patients undergoing surgery for right-sided …

02.09.2026journal-article

European Spine Journal

Large language models in the vertical integration of spine surgery workflow: a scoping review

Edwin H. Y. Lui, Ralph J. Mobbs

Abstract Purpose To evaluate current evidence regarding the clinical reliability and reasoning capabilities of Large Language Models (LLMs) and Multimodal Large Language Models (MLLMs) within the spine surgery workflow. This scoping review utilizes a novel Vertical Integration Maturity Scale (VIMS) to map model maturity across five stages of the vertical workflow, identifying persistent research gaps and technical prerequisites for clinical implementation. Methods A systematic search was conducted across PubMed, Em …

02.09.2026journal-article

Clinical Journal of the American Society of Nephrology

Effects and Safety of Henagliflozin on Cardiac Structure in Dialysis Patients with Heart Failure with Preserved Ejection Fraction

Hao Yan, Wei Wang, Wangshu Wu, Ying Li, Yinghui Qi, Yijun Zhou, Weiming Zhang, Shang Liu, Huihua Pang, Yan Fang, Zhenyuan Li, Zhiqing Qiao, Renhua Lu, Meng Jiang, Wei Fang, Jun Pu, Leyi Gu, on behalf of the HELD-HF study investigators

Background Few effective drug treatments exist for dialysis patients with heart failure with preserved ejection fraction (HFpEF). This study aimed to evaluate the effects of henagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, on cardiac structure, and its safety in such population. Methods In this multicenter, randomized, double-blind, placebo-controlled trial, dialysis patients with HFpEF were randomly assigned (1:1) to receive henagliflozin or placebo for 24 weeks. All enrolled participants receive …

02.09.2026journal-article

JAMA Surgery

An Exosomal Signature for Preoperative Detection of Occult Liver Metastasis in Pancreatic Cancer

Takayuki Noma, Jingyang Yin, Junfeng Zhang, Caiming Xu, Mitsuro Kanda, Song Cheol Kim, Yuji Morine, Mitsuo Shimada, Vincent Chung, Ali H. Zaidi, Daniel Von Hoff, Huaizhi Wang, Ajay Goel

Importance Early liver metastasis (early-LiM) after pancreatectomy represents an aggressive biological phenotype of pancreatic ductal adenocarcinoma (PDAC) and is associated with markedly poor survival. Reliable preoperative biomarkers to identify occult hepatic micrometastasis remain lacking. Objective To develop and externally validate a circulating exosomal microRNA (exo-miRNA)–based machine learning model for preoperative detection of occult early-LiM in PDAC. Design, Setting, and Participants This multicenter …

02.09.2026journal-article

Journal of Craniofacial Surgery

Outcomes and Satisfaction of Chin Augmentation With Expanded Polytetrafluoroethylene (ePTFE) Implants: A 12-Month Retrospective Study

Phung Nguyen Van, Nguyen Thanh Van

Aim: To evaluate the aesthetic outcomes, patient satisfaction, and safety of chin augmentation using expanded polytetrafluoroethylene (ePTFE) implants over 12 months. Methods: Of 152 patients who underwent intraoral ePTFE chin augmentation, 105 with complete 12-month follow-up were analyzed (85 women, 20 men; mean age 29.3 years; all with isolated microgenia and Angle Class I occlusion). The labiomental angle, chin projection, FACE-Q satisfaction score, and complications were assessed preoperatively and at 3, 6, an …

02.09.2026journal-article

Journal of Paediatrics and Child Health

Physiological and Cardiac Effects of Weight Loss in Adolescents With Atypical Anorexia Nervosa Versus Those Undergoing Bariatric Surgery: A Retrospective Comparative Study

Tomer Mevorach, Amit Goldstein, Orly Lavan, Shelly Shteinling, Adi Sela, Silvana Fennig

ABSTRACT Objective Adolescents with atypical anorexia nervosa (AAN) experience cardiac complications at rates comparable to typical anorexia nervosa, despite remaining within or above a normal weight range. The physiological mechanisms underlying this paradox remain poorly understood. This study is the first to compare cardiac outcomes between adolescents with AAN and those who underwent bariatric surgery, a population experiencing similarly rapid and substantial weight loss within a medically supervised context. M …

02.09.2026journal-article

AEM Education and Training

The Airway Dashboard: Harnessing Informatics for Targeted Assessment and Improvement of Airway Performance for Emergency Medicine Residents and Faculty

Christian R. W. Gerhart, Robbie Paulsen, William E. Freeman, Sam Ellsworth, Abby Orr, Aaron J. Lacy

ABSTRACT Background Airway management is a core competency for emergency medicine faculty and residents. Objective evaluation of procedural performance is crucial for assessment of competency and to guide further educational efforts. Here, we describe a dashboard capable of providing personalized, granular data specifically for airway management performance using the electronic medical record (EMR) to create a continuously updated database. Objective of Innovation The objective of this innovation was to utilize dat …

02.09.2026journal-article

British Journal of Midwifery

Patient safety culture in hospital maternity care: an integrative review of midwives and nurses

Nor Amal Hazirah Hassan, Damia Hazimah Asnawi, Amal Amirah Asri, Hanif Abdul Rahman, Khadizah H Abdul-Mumin

Background/Aims Safety is a central element of maternity care. Despite global efforts to reduce maternal harm, preventable adverse events can still take place at hospital maternity services. This integrative review consolidates research on midwives' and maternity nurses' perceptions of patient safety culture, identifying key practices, barriers and facilitators in hospital maternity care. Methods PubMed, Scopus, ProQuest and Google Scholar were searched for studies published between 2014 and 2024 that explored heal …

02.09.2026journal-article

Frontiers in Medicine

Co-occurrence of GATA2 deficiency and probable constitutional mosaic STAG2 alteration in a young adult with myelodysplastic syndrome: a case report

Onda-Tabita Calugaru, Daniel Coriu, Cerasela Jardan, Claudia Tarniceriu, Daniela Cristina Anghel, Iulia Ursuleac

Germline predisposition syndromes are increasingly recognized in young patients presenting with myelodysplastic syndromes (MDS) and bone marrow failure. Among these, GATA2 deficiency represents a well-established cause of hereditary susceptibility to myeloid malignancies, whereas constitutional STAG2 alterations are rare and mainly associated with cohesinopathies and neurodevelopmental disorders. We report the case of a 25-year-old male presenting with hypocellular MDS, recurrent severe infections, lymphedema, cyto …

02.09.2026journal-article

Problems of Gathering Treatment and Transportation of Oil and Oil Products

STABILIZATION OF MULTIPHASE HYDROCARBON FLOW IN OIL AND GAS GATHERING PIPELINES IN FIELDS WITH COMPLEX TOPOGRAPHY

E.F. Khamatdinov, G.E. Korobkov

Integrated oil and gas gathering and transportation systems have become widely used in the development of remote fields. These areas are often characterized by significant logistical and infrastructural constraints. When organizing joint collection of oil and gas via field gathering pipelines at oil and gas, as well as oil and gas condensate fields, certain factors may arise that adversely affect the stable transportation of multiphase hydrocarbon flows to wellstream treatment facilities.This creates tasks whose so …

02.09.2026journal-article

Archives of Orthopaedic and Trauma Surgery

Platform-specific learning curve and early tibial radiographic agreement of ROSA®-assisted medial unicompartmental knee arthroplasty in an experienced high-volume surgeon: a consecutive case series

Stefano Petrillo, Damiano Ardiri, Matteo Marullo, Sergio Romagnoli

Abstract Purpose To evaluate the platform-specific learning curve and early tibial radiographic agreement of imageless ROSA ® -assisted medial unicompartmental knee arthroplasty (UKA), with short-term clinical findings assessed exploratorily. Methods This retrospective consecutive case series included 30 patients who underwent ROSA ® -assisted medial UKA with the Persona ® Partial Knee implant between January and April 2026 at a high-volume arthroplasty referral centre. A continuous learning-curve cumulative summat …

02.09.2026journal-article

Clinical and Translational Gastroenterology

Impact of hepatitis C viremia on overall survival and hepatic decompensation among patients with unresectable HCC receiving immunotherapy

Eunice Y. Lee, Willis Tang, Jennifer C. Price, Robin K. Kelley, John D. Gordan, Jennifer C. Lai, Lawrence Fong, Neil Mehta, Michael Li

Introduction: Hepatitis C (HCV) is associated with an immunosuppressive liver microenvironment, but whether HCV affects immune checkpoint inhibitor (ICI) outcomes in unresectable hepatocellular carcinoma (HCC) remains unknown. Methods: We performed a single-center retrospective cohort study of patients with unresectable HCC treated with ICIs. In patients with a history of HCV, viremia was defined as a detectable viral load prior to immunotherapy. The primary outcome was overall survival (OS); secondary outcomes wer …

02.09.2026journal-article

Journal of Craniofacial Surgery

Free Fibula Flap With Chimeric Skin Paddles: Technical Tips and Clinical Experience

Ersin Gur, Batuhan Sencan, Ahmet Bicer, Yigit Ozer Tiftikcioglu, Zeyyat Cuneyt Ozek

Introduction: Advanced tumors and trauma may cause composite oromandibular defects involving the mandible, intraoral mucosa, and skin. Although these defects involve multiple components, they can be reconstructed simultaneously with a single flap. The free fibula flap with chimeric skin paddles provides single-stage, appropriate three-dimensional reconstruction of challenging composite defects of the oromandibular region. The authors present our experience with free fibula flaps with chimeric skin paddles for compo …

02.09.2026journal-article

Journal of Electronic Materials

HTL-Free Perovskite Solar Cells with a Carbon Electrode and Enhanced Stability, Through a Scalable Polymer Treatment Method

Maria Bidikoudi, Christina Tiflidis, Elias Stathatos

Abstract Perovskite solar cells with a carbon electrode (C-PSCs) are considered the most promising and viable structure for the upscaling and future commercialization of PSCs. With the ability to be fabricated with industrially compatible methods and with no need for employing hole transport materials, C-PSCs are not randomly moving to the forefront of PSC research at the moment. In this work, hole transport material (HTM)-free C-PSCs have been fabricated under entirely ambient conditions. The devices employ an add …

02.09.2026journal-article

Iranian Journal of Allergy, Asthma and Immunology

Clinical Characteristics, Diagnostic Challenges, and Therapeutic Outcomes in Non-eosinophilic Esophagitis Eosinophilic Gastrointestinal Diseases in Comparison with Eosinophilic Esophagitis

Azizollah Yousefi, Saeed Sepehry Vafa, Mina Mirzad, Fatemeh Elham Mahjoub, Behnam Shahsavand, Ebrahim Babaee, Fereshteh Karbasian, Mohammad Nabavi, Mohammad Hasan Bemanian, Sima Shokri, Saba Arshi, Morteza Fallahpour

Eosinophilic gastrointestinal diseases (EGIDs) are chronic, TH2-mediated conditions. Eosinophilic esophagitis (EoE) is the most common type, while non-EoE EGIDs affect other gut segments. This retrospective study of 111 patients (50 EoE and 61 non-EoE) from 2011 to 2022 compared the clinical aspects of these 2 types. Dysphagia and food impaction dominated in EoE, while abdominal pain, nausea, and diarrhea were more common in non-EoE EGIDs. Atopic comorbidities were frequent. Diagnostic delays>1 year were more commo …