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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
20.08.2026journal-article

International Journal of Research on Multidisciplinary Studies

From Clinical Treatment to Classroom Interventions: A Bibliometric Analysis of the Evolution of Speech Anxiety

Veren Lace M. Callueng, Prince Dave R. Llaneza

Speech anxiety serves as a significant barrier to language acquisition and communicative competence; however, a systematic mapping of its evolving research landscape remains limited. This study conducted a bibliometric analysis of speech anxiety literature from 1955 to 2025 to map keyword co-occurrence networks, publication trends, and influential works, capturing the field’s trajectory from early clinical investigations to contemporary educational applications. Using Harzing’s Publish or Perish software, 200 docum …

20.08.2026journal-article

PLOS One

Evaluation of antibacterial agent use in adult patients at a tertiary-level hospital in Jordan: A comparative analysis of defined daily dose and days of therapy in critical care units

Amjad Bani Hani, Walid Al-Qerem, Walaa Ashran, Farah Bani Hani, Sara Al-Raymoony, Salma Elshiekh, Miramar Haddad, Yarub Alsheyab, Ghada Alzyadat, Enas Khasawneh, Ali Heis, Tarek Gharibeh, Raghad Al-Shweiki, Awni D. Shahait

Objective To compare two measures of antibiotic stewardship: Defined Daily Dose (DDD) versus Days of Therapy (DOT). Methods Retrospective observational analysis of clinical data for adult ICU patients with antimicrobial exposure recorded from July 2023 to July 2024. The variables collected were the DDD and DOT. The DDD variable was defined according to the World Health Organization (WHO) standards for all antibacterial medications. For the DOT variable, DOTs reflected each day a drug was given, regardless of dose c …

20.08.2026journal-article

Journal of Radiation Research

Radiation-induced tumor following pencil beam scanning proton therapy for pediatric intracranial ependymoma: a pragmatic analysis of risk factors

Eymeric Le Reun, Arturs Meijers, Maria Teresa Romero-Expósito, Ilya Kotov, Daniel J Indelicato, Damien Charles Weber

Abstract Radiation-induced tumors (RITs) represent a rare yet serious long-term complication of ionizing radiation, particularly relevant in pediatric patients due to their long life expectancy. Proton therapy (PT) is widely used in children because of its favorable dose distribution compared to photon therapy. However, PT generates secondary neutrons that may contribute to RIT development. In a previously reported cohort of 119 children treated with pencil beam scanning (PBS) PT for intracranial ependymoma at the …

20.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Reading Comprehension and Orthographic Consistency: Modeling Direct and Indirect Pathways in Children With Reading Difficulties

Rachel Schiff, Ayelet Sasson

Purpose: This study examined how orthographic transparency shapes reading comprehension (RC) among third-grade students with reading difficulties (RD). Hebrew provides a within-language test case that features both transparent and opaque scripts, thus minimizing confounds that arise in cross-language comparisons. Method: Using path analysis, we modeled the direct and indirect associations of phonological awareness (PA), morphological awareness (MA), orthographic processing, morphosyntactic awareness (MSA), vocabula …

20.08.2026journal-article

Mediterranean Nursing and Midwifery

Integrating Technology and Care: Perioperative Nurses’ Knowledge and Influencing Factors on Medical Device–Related Pressure Injuries

Ayşe Gökce Işıklı

Objective: The aim of this study is to assess perioperative nurses’ knowledge regarding medical device–related pressure injuries and the factors affecting their knowledge. Methods: It was descriptively planned and conducted with 140 perioperative nurses. Research data were collected using the Medical Device–Related Pressure Injury Knowledge Assessment Test. It was analyzed using the Kruskal–Wallis test and the Mann–Whitney U-test. Results: The mean knowledge score of perioperative nurses was 9.83 ± 5.09 (0-16). The …

20.08.2026journal-article

Perspectives of the ASHA Special Interest Groups

A Preliminary Study of Speech-Language Pathologist and Parent Perspectives on Artificial Intelligence Use for Speech Sound Disorder Treatment

Zoe A. Baker, Taylor D. Snodgrass, Nina R. Benway, Jonathan L. Preston

Purpose: Artificial intelligence (AI) applications may expand the available intervention options for children with speech sound disorders (SSDs). The purpose of this study was to understand the needs and preferences of speech-language pathologists (SLPs) and parents of children with SSDs regarding AI-assisted interventions that can provide real-time feedback on children's speech production. Method: Twenty-two SLPs and 19 parents of children with SSDs took part in individual, virtual semistructured interviews to und …

20.08.2026journal-article

JOSPT Cases

Rehabilitation After Distal Radial Osteotomy for Kienböck’s Disease: A Case Report on the Integration of Mirror Therapy in Postoperative Management

Goutami Katage, Parchi Mutha

BACKGROUND: Kienböck's disease, avascular necrosis of the lunate, often requires surgical treatment such as distal radial osteotomy, yet postoperative rehabilitation literature is sparse. This case report describes mirror therapy integrated with conventional rehabilitation after a distal radial osteotomy to reduce pain, improve grip strength, and restore wrist function. CASE DESCRIPTION: A 51-year-old man presented one month after distal radial osteotomy for Stage III Kienböck's disease with persistent left wrist p …

20.08.2026journal-article

Acta Obstetricia et Gynecologica Scandinavica

Elevated cardiovascular risk associated with hormone replacement therapy: A comprehensive analysis of reproductive factors and atherosclerotic cardiovascular disease outcomes in the UK Biobank cohort

Mengchun Wang, Can Zhang, Chunlai Yang, Baosen Meng, Xiaohui Li, Qian Huang, Baibing Mi

Abstract Introduction The cardiovascular effects of hormone replacement therapy (HRT) remain controversial. This study investigated HRT‐associated atherosclerotic cardiovascular disease (ASCVD) risk, focusing on reproductive characteristics. Material and Methods This prospective cohort study analyzed 170 250 women aged 40–69 years from UK Biobank (2006–2024). Cox proportional hazards regression models were employed to estimate ASCVD risk, with stratification by reproductive characteristics (age at menarche, age at …

20.08.2026journal-article

Journal of Clinical Urology

Prostate size in transwomen on gender-affirming hormone therapy: Considerations for prostate cancer screening

Tatyana Yatsenko, Anne Yin, Kenan Celtik, Ariel Zisman, Dara Lundon, Miroslav Djordjevic, Rajveer S. Purohit

Introduction: The prostate is generally preserved in transfemales who undergo medical and surgical therapy for their gender dysphoria. Screening for prostate cancer and other pathologies like benign prostatic hyperplasia is important. We studied a cohort of transfemales to better understand the relationship between hormonal therapy, androgen deprivation status, and prostate size. Methods: A retrospective analysis of 60 transfemales was performed. Prostatic size and characteristics were assessed using ultrasound. Ho …

20.08.2026journal-article

Journal of Clinical Oncology

Allogeneic CD70-Targeted Chimeric Antigen Receptor T-Cell Therapy for Advanced Renal Cell Carcinoma: Results From the Phase I TRAVERSE Trial

Samer A. Srour, Jad Chahoud, Alexandra Drakaki, Brendan D. Curti, Geoffrey T. Gibney, Lily Tang, Yizhou Jiang, Sara Charmsaz, Paul B. Robbins, Jeff McLeroy, Christopher J. Severyn, John B. Le Gall, Zachary J. Roberts, Nizar M. Tannir, Sumanta Pal, Ritesh R. Kotecha

PURPOSE Treatment options for clear cell renal cell carcinoma (ccRCC) refractory to immune checkpoint inhibitors (ICIs) and targeted therapy are needed. ALLO-316 is an allogeneic chimeric antigen receptor (CAR) T-cell product that targets CD70-expressing ccRCC and resists immune rejection by targeting and eliminating patients' CD70 + alloreactive T cells. METHODS In the phase Ia/b TRAVERSE trial (ClinicalTrials.gov identifier: NCT04696731 ), patients with advanced ccRCC resistant to ICIs and vascular endothelial gr …

1 Zitationen
20.08.2026journal-article

Reviews in Cardiovascular Medicine

Mesenchymal Stromal Cell Therapy in Cardiovascular Disease: Reconsidering Clinical Inconsistency Through the Mechanism–Endpoint Relationship

Luca Bonanni, Nicola Ferri

Mesenchymal stromal cell (MSC) therapy has been investigated for more than two decades as a regenerative approach in cardiovascular disease. Preclinical studies have shown reproducible biological activity; however, clinical translation has been less convincing. Trials in acute myocardial infarction (AMI) and heart failure (HF) have established feasibility and an acceptable safety profile; however, effects on functional and imaging parameters remain modest, and a consistent impact on mortality, hospitalization, and …

20.08.2026journal-article

Cancers

Selective Internal Radiation Therapy (SIRT) for SDH-Deficient GIST Demonstrates Encouraging Durable Response Rates: An International Multicenter Case Series

Zachary T. Berman, Peter Hohenberger, Ramesh Bulusu, Steven C. Rose, Paul T. Fanta, Jonathan Evans, Steffen Diehl, Franka Menge, Nasim Ali, Jason K. Sicklick

Background/Objectives: Succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumors (GISTs) are a rare subgroup of GISTs and respond poorly to conventional systemic therapies. This study describes long-term outcomes after yttrium-90 (Y-90) selective internal radiation therapy (SIRT) for progression of unresectable SDH-deficient GIST hepatic metastases. Methods: We performed a retrospective review of consecutive patients treated with SIRT at three tertiary referral centers in Europe and the United States. …

20.08.2026journal-article

Applied Sciences

Analyzing Transcript, Emotion-Alignment, and Rhythm Cues for Fake Speech Detection Using Gated Fusion

Alaa Alsaeedi, Amal Almansour, Amani Jamal

Fake-speech detection is commonly studied through acoustic artifacts, speaker-level spoofing cues, or visual inconsistencies, while less attention has been given to meaning-level manipulation, where the spoken content is altered while the speech remains natural and speaker-consistent. This study investigates the relative and complementary contributions of interpretable speech-centered features for detecting meaning-level fake speech. Specifically, it examines transcript-level linguistic and psycholinguistic-style f …

20.08.2026journal-article

Journal of Speech, Language, and Hearing Research

The Validity, Reliability, and Accuracy of the European French Version of the Intelligibility in Context Scale

Léonor Piron, Andrea A. N. MacLeod, Christelle Maillart

Purpose: The Intelligibility in Context Scale (ICS) is a free parent report questionnaire assessing functional intelligibility. Although it has been translated into French, it lacks validation. This study addresses two main objectives. First, we aimed to establish the psychometric properties of the European French version of the ICS (ICS-EF). Second, we explored the ICS-EF as a measure of the functional impact of speech sound disorders (SSDs), specifically investigating how communication partner familiarity influen …

20.08.2026journal-article

BMJ

Head positioning after endovascular therapy for acute stroke due to large vessel occlusion (HeadSOAR): multicentre randomised controlled trial

Zhengzhou Yuan, Jianhua Peng, Long Gu, Fayun Hu, Gaoming Li, Jinglun Li, Chong Zheng, Changwei Guo, Bin Wang, Hongliang Zeng, Weizheng Xie, Kecheng Guo, Tianqi Tu, Guoyong Zeng, Tao Hao, Xiangping Cheng, Boyu Chen, Haoyue Wang, Jian Wang, Bin Han, Shuchun Huang, Hao Zhu, Xiurong Zhu, Tao Qiu, Yunbo Chen, Zhou Yu, Wei Rao, Junfeng Li, Li Yao, Xiangrong Sun, Dengxing Li, Yunfei Li, Wei Li, Zhaokun Li, Ye Xiong, Maojun Jiang, Chaoqun Li, Qin Liu, Zhibing Ai, Chao Li

Abstract Objective To determine whether an elevated head position (30-40°) improves functional outcomes compared with a flat head position (0-10°) in patients with acute ischaemic stroke caused by anterior circulation large vessel occlusion who have achieved successful reperfusion after endovascular thrombectomy. Design Multicentre, prospective, randomised, open label, blinded endpoint clinical trial. Setting 67 comprehensive stroke centres in China, between 16 November 2023 and 23 January 2025. Participants 1368 a …

1 Zitationen
20.08.2026journal-article

Rehabilitation Counseling Bulletin

Policy and Practice Initiatives in High-Performing States That Facilitate Quality Employment Outcomes for Persons With Intellectual and Developmental Disabilities

Lauren Avellone, Carol Schall, Christopher Claude, Whitney Ham, Karli Johansen

Individuals with intellectual and developmental disabilities (IDD) experience poor rates of competitive integrated employment (CIE). Understanding what policies and practices are used in high-performing states to promote CIE outcomes can help guide other states in how to allocate attention and resources. We used a Delphi method to survey policy and policy advocates in states with high rates of CIE for people with IDD to determine state and federal-level policies and practices that serve as facilitators and barriers …

20.08.2026journal-article

European Geriatric Medicine

Integrated rehabilitation and ambulatory recovery in older adults with hip fracture according to muscle strength and sarcopenia status: a secondary analysis of a randomized controlled trial

Seung-Kyu Lim, Jae-Young Lim

Abstract Purpose Sarcopenia and impaired muscle strength are common in older adults with hip fractures and are strongly associated with poor functional recovery. Although integrated multidisciplinary rehabilitation improves outcomes after hip fracture, whether its benefits differ according to baseline muscle strength or sarcopenia severity remains unclear. This study aimed to examine whether the functional benefits of Fragility Fracture Integrated Rehabilitation Management (FIRM) vary according to sarcopenia status …

20.08.2026journal-article

Head & Neck

Survival Outcomes With Concurrent Systemic Therapy in Patients With a Medical Contraindication to Cisplatin in the Non‐Operative Management of Locally Advanced HNSCC , an NCDB Study

Deniz Can Demircioglu, Sohil Singh, Johnny Belcher, Stuart J. Wong, Joseph Zenga, Musaddiq Awan

ABSTRACT Background Patients with locally advanced head and neck squamous cell carcinoma who are medically ineligible for cisplatin lack a standard concurrent systemic therapy. Methods We used the National Cancer Database to identify patients diagnosed from 2015 onward with non‐metastatic, locally advanced squamous HNSCC treated with definitive radiation therapy and concurrent systemic therapy, receiving either chemotherapy or cetuximab (using immunotherapy as a surrogate for cetuximab in the NCDB). Cisplatin‐ineli …

20.08.2026journal-article

Revista ft

Reabilitação fisioterapêutica do paciente crítico após ventilação mecânica prolongada: do desmame à recuperação funcional

Ana Lidia Lima Ferreira, Vitória Duarte Lenhardt, Raí da Silva Lopes

Prolonged mechanical ventilation is associated with diaphragmatic dysfunction, intensive care unit-acquired weakness and functional impairments that persist after discharge. This narrative review discusses the role of physiotherapy throughout the trajectory of the critically ill ventilated patient — from weaning to functional recovery — based on real, verifiable scientific literature, summarized in tables and descriptive charts. Inspiratory muscle training has shown benefits for weaning success in patients with dif …

20.08.2026journal-article

Revista ft

Saúde do trabalhador do SUS e precarização do trabalho: desafios para a garantia de direitos e condições dignas no sistema público de saúde

Laudenizia dos Santos Machado de Medeiros, Anelisa Soares Silva, Geraldo Antônio Ramos Malosto, Rafael Alexandre Jantorno, Cláudia Leoni de Oliveira Silva, Carla da Silva de Carvalho Nascimento, Flaviana Barbosa Gomes, Cleides Santos Barcelos, Manoel Honório Antunes Sobreira, Geraldo Márcio Giacomin Pereira, Nara Alves da Silva, Maria Gorete Meneghini

This article analyzes workers’ health within Brazil’s Unified Health System (SUS) in light of the challenges posed by the precarization of labor relations and working conditions, especially in hospital settings. It is based on the understanding that intensified workloads, insufficient human and material resources, flexible employment arrangements, and continuous exposure to occupational risks directly affect the health-disease process of health professionals. The aim of the study is to discuss working conditions in …

20.08.2026journal-article

Scandinavian Journal of Work, Environment & Health

From Arrow to evidence: health economics and occupational health in the Nordic context

Jarno Turunen

Modern health economics traces its origins to the 1960s, when Kenneth Arrow, an American Nobel laureate in economics, argued that healthcare differs fundamentally from goods traded in competitive markets, thus requiring special institutions and policies (1). His core ideas ─ uncertainty in health, the need for insurance, information asymmetry between actors, and limits to rational decision-making when health is at stake ─ laid the foundations for what is now known as modern health economics. The idea that healthcar …

20.08.2026journal-article

Journal of Leukocyte Biology

Circulating platelet-natural killer cell complexes are elevated in people living with human immunodeficiency virus on antiretroviral therapy

Brita Ostermeier, Amber Douglass, Tomas Raul Wiche Salinas, Sanchita Pandey, Cheryl Clarkson-Paredes, Gregory M Cresswell, Anastas Propratiloff, Marc Siegel, Conrad Russell Y Cruz, Mirko Paiardini, Sanjay B Maggirwar

Abstract Natural killer (NK) cells stand as a critical pillar in the innate immune defense against viral infections, particularly human immunodeficiency virus (HIV). However, during HIV infection, NK cells demonstrate profound dysfunction, undermining effective immune control and accelerating disease progression along with viral persistence. Understanding the mechanisms driving NK cell dysfunction is essential for the development of innovative therapeutic strategies. This study reveals a significant increase in cir …

20.08.2026journal-article

Angewandte Chemie

Metal‐Phenolic Networks: Emerging Nanoarchitectures for Cancer Therapy

Kecheng Huang, Ran Meng, Bei Li, Yunlu Dai

ABSTRACT Cancer is a complicated disease driven by multiple etiologies, necessitating urgent, multimodal, and integrated therapeutic strategies. Coined just over a decade ago, metal‐phenolic networks (MPNs) have emerged as broad and powerful platforms, demonstrating great potential in cancer therapy, with broad success achieved in animal models. MPNs are characterized by the network's formation via phenolic ligands and metal ion coordination and serve as versatile drug delivery platforms. Moreover, MPNs not only in …

20.08.2026journal-article

Journal of Pharmaceutical and Sciences

Complementary-Therapy Use, Neuropathic Screening Status, and Quality of Life in Patients with Hypertension or Diabetes: A Pre–Post Observational Study

Aynul Mardhiyah, Dwi Anggraini, Yuni Andriani, Chindiana Khautami

Introduction: Peripheral neuropathy contributes to pain, functional impairment, and reduced quality of life in patients with diabetes mellitus and hypertension. This study evaluated changes in neuropathic screening status and quality of life during the use of complementary therapies alongside standard pharmacotherapy. Methods: This uncontrolled pre-post observational study included 147 patients at RSUD Nurdin Hamzah: 65 with hypertension and 82 with diabetes mellitus. Neuropathic characteristics and quality of life …