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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
20.08.2026journal-article

Frontiers in Immunology

Multi-omics analysis identifies fibroblast IGFBP5 as a key target of anti-TNFα therapy in ulcerative colitis

Peihong Li, Yikun Zhang, Liuqin Zhao, Yiwen Wang, Hongyi Hu, Siqing Guo, Tingting Zhang, Zhancheng Lin, Jiang Lin, Kexin Zeng, Linda Zhong, Changqin Liu, Boyun Sun

Background Resistance to anti-TNFα therapy (e.g., infliximab) in ulcerative colitis (UC) remains a significant clinical challenge, with the underlying cellular and spatial mechanisms poorly understood. Methods We integrated bulk transcriptomics, single-cell RNA sequencing (scRNA-seq), and spatial transcriptomics (ST) from clinical cohorts to systematically map the cellular landscape and identify key determinants of treatment response, followed by validation in independent clinical cohorts and in vitro functional ex …

20.08.2026journal-article

Arthroscopy, Sports Medicine, and Rehabilitation

Lateral Extra‐articular Tenodesis Internet Search Trends Correlate to the Quantity of Publications From 2020 to 2024

Mia Lustig, Sean Hazzard, Mark Cote, Danielle Lonati, Peter Asnis

Purpose To investigate public internet search trends for lateral extra‐articular tenodesis (LET) and examine their potential relation to the peer‐reviewed literature on LET between 2020 and 2024. Methods Search term data from February 2020 to December 2024 was collected via the Google Trends feature. Worldwide weekly relative search volumes (RSVs) were populated based on the key terms: “lateral extra‐articular tenodesis” and “knee LET.” Concurrently, a literature search of the PubMed database was performed to quant …

20.08.2026journal-article

American Journal of Speech-Language Pathology

Social Isolation in Adults Who Stutter: A Mixed-Methods Investigation of Risk and Correlates

Seth E. Tichenor, Katie Gore, Scott Palasik, J. Scott Yaruss

Purpose: Social isolation is a commonly reported aspect of the stuttering experience. This study qualitatively explored adult stutterers' reports of social isolation while quantitatively examining possible correlates underlying the occurrence of social isolation in this population. Method: A sample of 264 adults who stutter were asked to share their experiences of social isolation and to complete measures of personality, stuttering role identity, social disconnectedness, and perceived isolation via an internet surv …

20.08.2026journal-article

Journal of Clinical Medicine

Cardiac Rehabilitation—Current Paradigms and Challenges Across the Cardiovascular Continuum

Eduardo M. Vilela, Marta Catarina Almeida, Andreia Coelho, Sofia Viamonte, Amanda Pereira, Madalena Teixeira, Ricardo Fontes-Carvalho

Cardiac rehabilitation (CR) is a central component of optimized secondary prevention. Since their inception, CR programmes have progressively evolved. These incorporate several components in a multidisciplinary setting, aimed at addressing the diverse needs of the complex cardiovascular patient. From ischaemic heart disease to heart failure and cardio-oncology, CR has shown its relevance across various moments of the cardiovascular continuum. Notably, data has underscored the importance of an individualized assessm …

20.08.2026journal-article

Open Forum Infectious Diseases

Clinically Relevant Risk of Hepatitis B Virus Infection and Reactivation in People With HIV After Withdrawal of Anti-HBV–Active Antiretroviral Therapy in Japan

Eisuke Adachi, Aiko Okazaki, Yoshiaki Kanno, Michiko Koga, Hiroshi Yotsuyanagi

Abstract Background In people with HIV-1 (PWH), antiretroviral therapy (ART) containing anti-HBV drugs provides protection against hepatitis B virus (HBV) infection. However, the risk of HBV infection or reactivation after switching to ART without anti-HBV activity remains unclear, particularly in settings with recent implementation of universal HBV vaccination. Methods We conducted a single-center retrospective cohort study of PWH who received ART regimens without anti-HBV activity between January 2005 and March 2 …

20.08.2026journal-article

Dermatologic Surgery

Keratinocyte Carcinoma Risk: Antithymocyte Globulin vs. Other Induction Therapy in Solid Organ Transplant Patients

Rishab Revankar, Urmila Sivagnanalingam, Mary Rojas, Christine Wu, Melissa Pugliano-Mauro

BACKGROUND Induction immunosuppression reduces early rejection after solid organ transplantation but may increase long-term malignancy risk, including keratinocyte carcinoma. Antithymocyte globulin is commonly used as a lymphocyte-depleting induction agent, yet its relative risk compared with other strategies remains unclear. OBJECTIVE To evaluate the association between antithymocyte globulin induction therapy and keratinocyte carcinoma risk in adult solid organ transplant recipients compared with no induction, no …

20.08.2026journal-article

OTJR: Occupational Therapy Journal of Research

Assessing Motor Imagery Vividness in Children Using a Visual Analog Scale: Convergent Validity and Responsiveness

Akira Nakashima, Miyu Murata, Yuma Ishida, Rinto Tomonaga, Toshio Higashi, Ryoichiro Iwanaga

Assessing motor imagery (MI) vividness for specific tasks is essential for effective MI training; however, no task-specific method is available for children. This study examined the usefulness of the Visual Analog Scale (VAS) for assessing MI vividness in children. Thirty-three right-handed typically developing children participated in two sessions meant to assess VAS convergent validity and responsiveness. To assess convergent validity, a shirt-donning task was assigned, and Pearson’s correlation was used to test …

20.08.2026journal-article

Laser Medicine

Efficacy of photodynamic therapy in the management of patients with VIN I–III

V. S. Levchenko, S. V. Zinoviev, E. A. Kolesnikova, M. D. Ter-Ovanesov, A. A. Kazakov, E. V. Filonenko, S. V. Gamayunov

Photodynamic therapy (PDT) is an effective technique for treating precancerous conditions and cancers of various locations with a minimal risk of damaging normal tissues. The article presents results of using photodynamic therapy with chlorine-based photosensitizer Photoditazin in 50 patients with VIN I-III. The photosensitizer was administered intravenously at dose 1 mg/kg of body weight. PDT session was made in 2-2.5 hours after that. A diode laser with wavelength 662 nm was used as the radiation source. To deliv …

20.08.2026journal-article

JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY

Hematopoietic stem cell transplantation in an adult patient with primary hemophagocytic lymphohistiocytosis

Sthephanie de Lima Zielak, Simone Cunha Maradei, Tiago de Oliveira Boechat

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory condition characterized by uncontrolled immune activation and excessive production of pro-inflammatory cytokines, which may rapidly progress to multiorgan failure. Despite efforts to simplify the diagnosis and treatment of this entity, it remains a major challenge in clinical practice, especially in adults. We report a case of suspected primary HLH in an adult patient with a prolonged history of recurrent inflammatory episodes and a fu …

20.08.2026journal-article

International Orthopaedics

Investigating the impact of Glucagon-like peptide-1 therapy on total shoulder arthroplasty outcomes

Peter Chebi, Apurva Choubey, Ryan Rutherford, Joseph Michalski, Marcelline Kemmy, Kristina Casos, Etienne Flamant, Peter Cirrincione, Benjamin Goldberg

Abstract Purpose The increasing prevalence of Glucagon-like peptide-1 receptor agonists (GLP-1 RA) has raised concerns about their perioperative impact. Although database studies on GLP-1 RAs in total shoulder arthroplasty (TSA) have been published for diabetic and general TSA patients, results are conflicting, and the effects on patients across various obesity classes remain unexplored. This study aims to fill this gap. Methods The PearlDiver database was used to identify patients who underwent primary TSA, groupe …

20.08.2026journal-article

Language, Speech, and Hearing Services in Schools

The Effect of Phonology and Semantics on Reading and Memorizing Written Sentences in Chinese Prelinguistic Deaf People

Junyao Chen, Yang Xu, Da Zhang, Jiawei Huang, Jianqi Fan, Lu Lu

Purpose: The purpose of this study was to investigate the processing differences of phonological interference (tongue twisters) and semantic interference (subject–object interchange/double-object interchange) between prelingual deaf Chinese speakers and normal-hearing speakers during sentence reading and memory, to test the deficit phonemic awareness hypothesis and the deficit structure awareness hypothesis of deaf reading, and to provide theoretical basis for deaf education strategies. Method: Twenty-two prelingua …

20.08.2026journal-article

Research, Society and Development

Reconstrução da parede abdominal e reabilitação funcional: controle da dor e recuperação da força do core no pós-operatório — Uma revisão narrativa

Matheus Antônio dos Santos Araújo, Ana Carolina de Campos Souza, Andre Souza Veiga de Paula, Barbara Sthefanie Menezes de Oliveira, Joao Vitor Montenegro, Julia Godoi Teixeira, Maria Fernanda Sarmento Oliveira

A reconstrução da parede abdominal constitui um procedimento complexo destinado à restauração da integridade anatômica e funcional da parede abdominal, sendo frequentemente indicada em pacientes com hérnias incisionais, defeitos complexos e alterações estruturais decorrentes de procedimentos cirúrgicos prévios. O objetivo desta revisão narrativa é discutir as principais estratégias relacionadas ao controle da dor no pós-operatório da reconstrução da parede abdominal e sua relação com a recuperação da força do core …

20.08.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Effects of tDCS combined with unstable resistance training on knee muscle strength and neuromuscular control in community-dwelling older adults: a randomized controlled trial

Di Peng, Shengnian Zhang, Yu Zhang, Han Wu, Xu Zou, Guanyue Zhang, Yuan Ma, Tongxin Ma, Lejun Wang

Abstract Background Age-related declines in knee muscle strength are not fully explained by muscle loss and may also involve alterations in neuromuscular control. Unstable resistance training (URT) increases stabilization and sensorimotor demands during exercise. Transcranial direct current stimulation (tDCS) may modulate corticospinal excitability during training. This study investigated whether tDCS combined with URT enhances knee strength and electromyography (EMG)-derived neuromuscular control in older adults. …

20.08.2026journal-article

International Journal of Scientific Reports

Atypical bullous erythrodysesthesia mimicking fixed drug eruption during cabozantinib therapy: a case report

Nurcan Metin, Hatice Korkmaz

Cabozantinib is a multi-targeted tyrosine kinase inhibitor used in the treatment of advanced renal cell carcinoma. Palmar-plantar erythrodysesthesia (PPES) is a well-recognized cutaneous adverse effect of tyrosine kinase inhibitors; however, atypical bullous presentations are extremely rare. We report a 79-year-old man who developed painful, pruritic, well-demarcated bullous lesions on the distal fingers of both hands and the left heel three weeks after initiating cabozantinib therapy. Unlike classic PPES, the lesi …

20.08.2026journal-article

JAMA Network Open

Symptom Worsening in Mindfulness-Based Cognitive Therapy

Simon B. Goldberg, Otto Simonsson, Fiona C. Warren, James E. Pustejovsky, Matthew J. Hirshberg, Shufang Sun, Françoise Jermann, Anne Speckens, J. Mark G. Williams, Tim Dalgleish, Jesus Montero-Marin, Willem Kuyken

This meta-analysis evaluates individual participant data from randomized clinical trials to investigate whether mindfulness-based cognitive therapy is associated with worsening symptoms of depression.

20.08.2026journal-article

Proceedings of the National Academy of Sciences

Primary amine–functionalized radially amphiphilic polypeptides target bacterial phospholipids in polyanionic matrices for biofilm therapy

Yuhao Zhang, Yu Huang, Yeqing He, Xinshuang Zhang, Qianyu Ma, Jiawen Chen, Chanjuan Su, Huosheng Zhou, Songyin Huang, Houbing Zhang, Dong Luo, Yan Bao, Yuqin Shen, Shiyan Xiao, Menghua Xiong

Bacterial biofilm infections, a key contributor to antibiotic resistance, pose a critical global health challenge. Although antimicrobial peptides are promising candidates, their cationic amphipathic structures often lead to nonspecific sequestration by polyanionic biofilm matrix components. Here, we report a class of primary amine–functionalized radially amphiphilic antimicrobial polypeptides (paRAPs) that achieve potent antibiofilm activity by selectively targeting bacterial phosphatidylglycerol (PG) in polyanion …

20.08.2026journal-article

Australasian Journal of Dermatology

Patient Perspectives on Dupilumab Therapy for Atopic Dermatitis: Experiences, Expectations and Treatment Impact

Nadine Abu‐Ghazaleh, Gayle Ross, Vanessa Morgan

ABSTRACT Background Atopic dermatitis ( AD ) is a chronic inflammatory skin disease characterised by epidermal barrier dysfunction and type 2 immune dysregulation. Dupilumab was the first biologic approved for severe AD and has transformed management of moderate‐to‐severe disease. Although clinical trials and international real‐world studies have demonstrated sustained efficacy and acceptable tolerability, Australian data describing patient‐reported experience with dupilumab remain limited. Methods We conducted a c …

20.08.2026journal-article

ETERNAL (English Teaching Journal)

Finding Confidence in Spontaneity: Pre-Service English Teachers’ Experiences with Impromptu Speech Activities

Khansa Khalila Wijaya, Made Frida Yulia

This study examined how impromptu speech practice helps pre-service English teachers build classroom communication confidence, alongside the key factors driving this growth. Through observations and semi-structured interviews with four student teachers, the collected data underwent thematic analysis. Results indicated that off-the-cuff speech exercises noticeably boosted participants’ fluency, poise, and spontaneous delivery skills. While performance anxiety did not completely disappear, consistent exposure allowed …

20.08.2026journal-article

Biomacromolecules

Poly( l -glutamic Acid)-Based Microgels with Long-Term Synergistic Lubrication and MMP-Responsive Anti-Inflammatory Delivery for Osteoarthritis Therapy

Rong Wu, Yanyang Chen, Junyu Wu, Kaixuan Ren, Wenguo Cui, Jingbo Yin

Abstract Osteoarthritis (OA) is a degenerative joint disease characterized by the failure of cartilage lubrication and persistent inflammation induced by friction-generated debris. Therefore, an effective OA treatment strategy should simultaneously enhance joint long-term lubrication and suppress inflammation. Toward this goal, we developed durable Lipo/PADM microgels via multiple cross-linking to integrate sustained lubrication with matrix metalloproteinase (MMP)-responsive dexamethasone release. The microgels mai …

20.08.2026journal-article

Noise & Vibration Worldwide

Informational counselling on occupational noise-induced hearing loss among construction workers in South Africa: gaps in health and safety communication and implications for hearing conservation

Bongiwe Magubane, Katijah Khoza-Shangase

Background Occupational noise-induced hearing loss (ONIHL) is a preventable yet highly prevalent occupational disease, particularly in the construction sector where workers are routinely exposed to hazardous noise levels. In South Africa and other low- and middle-income countries (LMICs), health and safety training is implemented; however, limited evidence exists on whether such training adequately supports effective hearing conservation. Examining the nature and content of informational counselling provided to con …

20.08.2026journal-article

International Journal of Innovative Technologies in Social Science

AGE-RELATED HEARING LOSS AS A RISK FACTOR FOR DEPRESSION AND DEMENTIA: MECHANISMS, SOCIAL CONSEQUENCES, AND HEARING REHABILITATION

Kamila Zmysłowska, Kornelia Tyczka, Anna Szatkowska, Malwina Kwaśniewska, Adam Hajdaniak, Jan Mateusz Kiersztyn, Aleksandra Grabowska, Natalia Seńcio, Klaudia Stadnik

Age-related hearing loss (ARHL), or presbycusis, is one of the most common sensory disorders affecting older adults and may have consequences extending beyond impaired auditory perception. This narrative review aimed to examine the associations of ARHL with depression and cognitive decline, including dementia, with particular attention to underlying mechanisms, psychosocial consequences, and the potential role of hearing rehabilitation. Relevant literature was identified through searches of PubMed and Google Schola …

20.08.2026journal-article

Siberian Herald of Agricultural Science

Rehabilitation of fallow lands in the mixed-grass meadow stage

N. S. Yakovlev, G. K. Rassomakhin, S. M. Ugaj, V. E. Shushpannikov

A field experiment on returning previously abandoned arable land to the mixed-grass meadow stage was conducted on a plot of land belonging to the Siberian Research Institute of Fodder Crops during the summer, when the grass had reached a height of over 40 cm. A disc harrow does not completely eradicate these weeds; once covered by soil, they regrow in high humidity. Effective weed control after disking can be achieved using a cultivator stubble plough equipped with ring rollers that comb out the weeds cut by the pa …

20.08.2026journal-article

Gastroenterologie a hepatologie

Klinický logopéd ako „tajná zbraň“ gastroenterológa v boji proti dysfágii

Iveta Fillová, Martin Ďuriček, Štefan Plutko, Branislav Malý, Ján Mikler, Romana Richterová, Peter Bánovčin, Branislav Kolarovszki

Dysfágia predstavuje klinicky závažnú poruchu prehĺtania s potenciálom významne ovplyvniť respiračnú bezpečnosť, hydratáciu, nutričný stav a celkovú kvalitu života pacienta. V gastroenterologickej praxi sa dysfágia najčastejšie manifestuje pri podozrení na ezofageálnu etiológiu, avšak klinický obraz je v súčasnosti čoraz viac determinovaný aj orofaryngeálnou a funkčnou zložkou porúch prehĺtania. Z tohto dôvodu je diagnostika a manažment dysfágie podmienený interdisciplinárnym prístupom, v rámci ktorého má zásadné p …

20.08.2026journal-article

The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences

The Respective Roles of Negative and Positive Views of Aging in Predicting Rehabilitation Outcomes

Asil Mansour, Yaakov Hoffman, Amit Shrira

Abstract Objectives Subjective views of aging (VoA) predict health outcomes, yet most studies rely on specific measures of VoA in relatively healthy samples. Referring to multidimensional (generalized and personal) and multidirectional (negative and positive) VoA constructs, we examined whether these VoA differentially predict rehabilitation outcomes among older adult patients coping with hip fracture and stroke. Methods One hundred and fifty-eight geriatric rehabilitation patients (mean age=77.15, SD=6.71) reporte …