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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
12.08.2026journal-article

Frontiers in Oncology

Mortality trends of gallbladder cancer in middle-aged and older adults in the United States: a CDC WONDER analysis from 1999 to 2023

Qiuxuan Yang, Xu Chen, Yao Xiao, Qun Xiao, Xiaoli Li

Background Gallbladder cancer (GBC) is a rare but highly lethal malignancy, often diagnosed at advanced stages due to the absence of early symptoms. Although its incidence is relatively low in the United States, marked demographic and geographic disparities persist, and long-term national mortality trends remain insufficiently characterized. Methods We analyzed gallbladder cancer·–related deaths (ICD-10 code C23) among U.S. adults aged 45 years and older from 1999 to 2023 using the CDC WONDER database. Age-adjusted …

12.08.2026journal-article

International Internal Medicine Journal

Public Understanding of Dementia and Modifiable Risk Factors: A Conceptual Public Health Review

Peter Carey

Dementia is a major global public health challenge characterised by heterogeneous neurocognitive disorders and a growing evidence base for prevention through modifiable risk factors. Public understanding of dementia, however, remains limited, with persistent misconceptions regarding its inevitability, causes, and prevention potential. This conceptual review synthesises evidence on public dementia literacy, focusing on understanding of dementia subtypes and awareness of modifiable risk factors. The available evidenc …

12.08.2026journal-article

Journal of Viral Hepatitis

Attendance Among People With Hepatitis B in UK Secondary Care: A Scoping Review

Emma Victoria Shiel, Bini George, Arpana Verma, Norina Gasteiger

ABSTRACT Chronic Hepatitis B disease requires lifelong monitoring to prevent complications such as cirrhosis and hepatocellular carcinoma. Despite structured care pathways, non‐attendance within UK secondary care remains challenging. This scoping review aimed to synthesise existing evidence on factors influencing non‐attendance at secondary care appointments and strategies to improve appointment adherence among people living with Chronic Hepatitis B. Eligibility Criteria: Peer‐reviewed sources examining adults with …

12.08.2026journal-article

Biology of Sex Differences

Effects of sexual differentiation and APOE genotype on the development of Alzheimer-related pathology in female EFAD mice

Amy Christensen, Ana C. Valencia-Olvera, Helena Xeros, Elizabeth T. Nguyen, Marlene Lopez, Rojan Javaheri, Leon M. Tai, Mary Jo LaDu, Christian J. Pike

Abstract Apolipoprotein E ε4 genotype ( APOE4 ), the most significant genetic risk factor for late-onset Alzheimer’s disease (AD), is associated with sexually dimorphic effects whereby higher risks are generally observed in women. Sex differences can arise in part from developmental processes of sexual differentiation, which yield permanent sex-specific phenotypes that can impact adult trajectories and vulnerabilities to various conditions. We investigated the potential contributions of sexual differentiation to th …

12.08.2026journal-article

Cancers

Relative Melatonergic Status and Systemic Inflammatory, Oxidative, and Biological Aging Burden in Adults: An Exploratory Cross-Sectional Biomarker Analysis

Alexandre Tavartkiladze, Levan Tavartkiladze, Russel J. Reiter, Michel Burnier, Engin Ulukaya, Revaz Turmanidze, Pati Revazishvili

Background/objectives: Melatonin has circadian, antioxidant, mitochondrial, and immunomodulatory functions, but human data linking relative melatonergic status to coordinated systemic biomarker burden remain limited. We examined this association and tested its internal robustness to alternative score construction, outlier handling, and missing-data assumptions. Methods: We performed an adult-only cross-sectional secondary analysis of a deidentified biomarker dataset. Of 322 source records, six participants younger …

12.08.2026journal-article

eLife

Aging-associated increase of GATA4 levels in articular cartilage is linked to impaired regenerative capacity of chondrocytes and osteoarthritis

Meagan J Makarczyk, Yiqian Zhang, Alyssa Aguglia, Olivia Bartholomew, Sophie Hines, Kate Li, Suyash Sinkar, Silvia Liu, Craig Duvall, Hang Lin

Although the causal association between aging and osteoarthritis (OA) has been documented, our understanding of the underlying mechanism remains incomplete. To define the regulatory molecules governing chondrocyte aging, we performed transcriptomic analysis of young and old human chondrocytes from healthy donors. The data predicted that GATA-binding protein 4 (GATA4) may play a key role in mediating the difference between young and old chondrocytes. Results from immunostaining and western blot showed significantly …

12.08.2026journal-article

Age, Culture, Humanities: An Interdisciplinary Journal

On Life Transitions, Loss, and Frailty

Laura Cayrol-Bernardo

Between 1447 and 1470, the Florentine patrician Alessandra Macinghi negli Strozzi (1408-1471) composed numerous letters to her sons, Filippo, Lorenzo, and Matteo, 73 of which have been preserved. Throughout her correspondence, she frequently referenced age and aging, expressing her own experiences of growing older, commenting on the ages of others, and framing people's appearances or behaviors in terms of age. This article explores how Alessandra perceived and articulated the experience of aging in her letters, she …

12.08.2026journal-article

Journal of Alzheimer’s Disease

Development and validation of machine learning models to predict risk of undiagnosed dementia using healthcare claims and electronic health record data

Deborah E. Barnes, Cynthia Benjamin, W. John Boscardin

Background Approximately half of people living with Alzheimer's disease and related dementias are undiagnosed. Objective To develop and validate algorithms that predict risk of undiagnosed dementia using electronic health record (EHR) and/or healthcare claims data. Methods Study participants were adult patients aged 65 years or older without evidence of dementia (diagnosis/medication) at baseline in two U.S. data sources: 1) Medicare claims (2010 to 2021); 2) EHR and claims from a primary care network (2016 to 2023 …

12.08.2026journal-article

Frontiers in Aging Neuroscience

Dual-task gait and gait-cognition coupling in patients with Parkinson’s disease versus healthy older adults: moderation by cognitive status

Bora Jin, Sang-Myung Cheon

Background Gait impairment and cognitive decline frequently co-occur in Parkinson’s disease (PD), yet how cognitive status modulates dual-task gait-cognition relationships remains poorly characterized. Objective To compare spatiotemporal gait parameters and dual-task costs (DTCs) between drug-naïve PD and healthy older adults (HO), and to examine how cognitive status modulates gait-cognition associations within PD. Methods One hundred twenty-four participants (65 PD, 59 HO) were prospectively enrolled. PD patients …

12.08.2026journal-article

Journal of VitreoRetinal Diseases

Aging-Related Choroidal Heterogeneity and Loss: An Investigative Global Human Choroidal Thickness Review (ARCHLIGHT Study)

Abbie Lai, Mariam Issa, Ahmad Ali, Austin Pereira, Alaa Al Ali, Jay Chhablani, Peng Yan

Purpose: To synthesize current evidence on the pathophysiology, clinical relevance, and implications for age-related choroidal thinning. Methods: A systematic literature search of relevant publications was conducted across MEDLINE, Embase, and Cochrane Library, up to and including May 2024. Identified studies reported choroidal thickness changes with aging. Data on subfoveal choroidal thickness, choroidal vascularity index, and associated factors (ethnicity, systemic disease, axial length) were analyzed (PROSPERO I …

12.08.2026journal-article

Biomolecules

Polycomb Repressive Complex 2 (PRC2): A Context-Dependent Epigenetic Regulator of Brain Aging

Maria A. Katsianou, Eleni-Kyriaki Vetsika, Mariam Markouli, Christina Piperi, Antonios N. Gargalionis

Brain aging is characterized by extensive and dynamic epigenetic changes that reshape chromatin architecture and influence gene regulatory networks, leading to deregulation of transcriptional programs essential for neuronal survival, synaptic plasticity, and cognitive function. Emerging studies highlight the pivotal regulatory role of the Polycomb Repressive Complex 2 (PRC2) in brain aging, functioning mainly as an epigenetic silencer through the establishment of the H3K27me3 histone mark at gene promoters and enha …

12.08.2026journal-article

Revista Teias

Discurso e sentido:

Andrea Silva Domingues, Giselle Assunção Monteiro

Este artigo objetiva analisar os diferentes discursos dos materiais didáticos utilizados na alfabetização da modalidade da educação de jovens e adultos do município de Cametá-PA, na Amazônia do Baixo Tocantins. Metodologicamente, a pesquisa fundamentou-se na análise do discurso e na prática da história oral, em que foram analisadas imagens de cada matriz curricular do livro didático, e recortes da entrevista com perguntas abertas e semiestruturada realizada com uma professora que atua na 2ª etapa da EJA da EMEF São …

12.08.2026journal-article

Ageing International

The Interplay Between Health and Age Determines Home Care Types. Findings from a Cross-Sectional Study on Older Adults in Switzerland

Barbara Masotti, Daniele Zaccaria, Daniela S. Jopp, Stefano Cavalli

Abstract Family and professional care providers are essential to allow individuals to remain at home until very old age. However, limited research is available that distinguishes among the multiple domains in which community-dwelling older adults need support. This paper aims to analyse the interplay of health and age in shaping the probability of receiving specific types of care. Analysis is based on a subsample of people aged 65 and older who participated in the Swiss Vivre/Leben/Vivere survey ( N = 2916). We ran …

12.08.2026journal-article

Dentistry Journal

Impact of Thermocycling and Artificial Aging on the Flexural Strength and Fracture Resistance of CAD/CAM Dental Ceramics: A Systematic Review and Meta-Analysis

Joyce Michel Mora Bayas, Luis Chauca Bajaña, Carol Ortiz Bustamante, Andrea Ordoñez Balladares, Laly Viviana Cedeño Sánchez, Ricardo Saltos Noboa, Diana Carolina Sandoval Benalcázar, Thalia Gabriela Alvarez Centeno, Ivonne Carrion Bustamante, Carlos Salazar Minda, David Alfredo Flor Ronquillo, Byron Velasquez Ron

Background: CAD/CAM dental ceramics are widely used for indirect restorations because of their favorable esthetic properties, biocompatibility, and mechanical performance. However, long-term exposure to thermal fluctuations, moisture, and cyclic loading may compromise their structural integrity. This systematic review and meta-analysis evaluated the effect of artificial aging protocols on the mechanical properties of CAD/CAM dental ceramics. Methods: A systematic search was conducted in PubMed, Embase, Scopus, Web …

12.08.2026journal-article

ISPRS International Journal of Geo-Information

A Visual-Attention-Driven Framework for Quantifying Wayfinding Cue Strength for Pedestrians in Urban Scenes: A Pilot Study of Older Adults in Hong Kong

Yijia Liu, Wenzhong Shi, Shuyu Zhang, Anshu Zhang, Linya Peng

In urban environments, wayfinding is a fundamental task through which individuals access essential services. Quantifying the strength of perceived cues that facilitate wayfinding can inform urban design interventions aimed at reducing potential wayfinding difficulties. This study develops a visual-attention-driven computational framework to measure such cue strength from street-view images. In implementation, the framework adopts an image-inpainting-based strategy and incorporates a task-specific eye-tracking fine- …

12.08.2026journal-article

Journal of Psychopharmacology

Impact of adjunctive dihydropyridine calcium channel blockers on mental health outcomes in people with severe mental illness: A target trial emulation in English electronic health records

Naomi Launders, Alvin Richards-Belle, Stephanie M. Wu, Kenneth K. C. Man, Ian C. K. Wong, David P. J. Osborn, Joseph F. Hayes

Background: Dihydropyridine calcium channel blockers have been implicated in both symptom improvement and exacerbation in pre-existing severe mental illness (SMI). We aimed to test the hypothesis that blood-brain barrier penetrant dihydropyridines (DHPs) reduce rates of mental health hospitalisation and self-harm compared to non-penetrant DHPs. Methods: We used English electronic health records (Clinical Practice Research Datalink) to conduct a target trial emulation study in people with schizophrenia, bipolar diso …

12.08.2026journal-article

Frontiers in Psychiatry

Longitudinal association between insulin resistance and depressive symptoms in older adults: the mediating role of inflammation in the ELSA cohort

Yiming Ma, Zhiyong Hou, Bei Yao, Ran Jia, Yanan Yu, Jun Liu, Zhong Wang

Background Insulin resistance (IR) has been implicated in depression, yet the dynamic interplay between concurrent changes in IR and depressive symptoms over time, and whether systemic inflammation mediates this relationship, remains unclear. Methods Data were obtained from 3,404 older adults (aged ≥50 years) in the English Longitudinal Study of Ageing (ELSA) across Waves 2, 4, and 6. IR was assessed using the estimated glucose disposal rate (eGDR). Depressive symptoms were measured with the CES-D scale (0-8). C-re …

12.08.2026journal-article

International Journal of Advanced Multidisciplinary Research and Studies

Employer Signals and Pre-Application Attraction Among Young People Considering Tourism Employment in Ho Chi Minh City

Bui Duc Sinh

This study examines whether five perceived employer signals are associated with pre-application attraction and pursuit intention among young people who had applied to, or were considering applying to, tourism companies in Ho Chi Minh City. A cross-sectional online survey was conducted from January to March 2025 with a purposively recruited sample of 306 respondents aged 18-25. The proposed five-predictor model was estimated using partial least squares structural equation modeling. Employer reputation, social-media …

11.08.2026journal-article

Obesities

Temporal Patterns and Cross-Sectional Correlates of BMI-Defined Weight Status Among Mexican Adults Aged 50 Years and Older

Alberto Retana-Guzman, Israel Rico-Alba, Jessie Nallely Zurita-Cruz, Horacio Marquez-González, Elena García, Rodrigo Peña

Background: Fluctuations in body mass index (BMI) have been associated with frailty, functional decline, and increased morbidity and mortality. However, evidence on the longitudinal evolution of weight status in aging populations remains limited. This study aimed to characterize population-level patterns and individual longitudinal fluctuations in BMI-defined weight status among Mexican adults aged 50 years and older between 2001 and 2021 and to examine factors associated with BMI categories across survey waves. Me …

11.08.2026journal-article

Journal of Global Responsibility

From profit to people: mapping the rise of social sustainability in supply chains through a scientometric analysis

Monica Singhania, Gurmani Chadha

Purpose This study aims to conduct a comprehensive scientometric review of social sustainability in supply chains, analyzing 970 articles published between 2002 and 2024 from Web of Science (WoS). The research addresses the critical gap in understanding social sustainability aspects compared to environmental dimensions in supply chain literature. Design/methodology/approach The study uses CiteSpace software to create structure-based visualizations and networks, analyzing prominent authors, documents, keywords, jour …

11.08.2026journal-article

Working with Older People

Caregivers’ perspectives on elderly welfare programmes, support needs and the role of government in Malaysia: a qualitative thematic analysis

Azleen Ilias, Nasrudin Baidi, Erlane K. Ghani, Rahida Abdul Rahman

Purpose Malaysia is projected to become an ageing nation by 2030, with the population aged 60 years and above expected to rise from 11.6% in 2024 to over 17% by 2040. This demographic shift places growing pressure on both formal elderly welfare programmes and the informal caregivers who provide the majority of day-to-day care. This study aims to explore the perspectives of caregivers of older persons in Malaysia on three fronts: suggestions for improving existing elderly welfare programmes, the additional support c …

11.08.2026journal-article

Working with Older People

Service evaluation project: a journey through dementia distress management

Charlotte Natasha Procter, Ian Asquith

Purpose Care home (CH) residents with dementia may exhibit distressed behaviours due to unmet needs, with non-pharmacological interventions being the first line intervention. This study aims to evaluate the efficiency of the Distressed Behaviour Pathway (DBP), delivered to care homes by a specialist NHS team, using a mixed-methods design. Design/methodology/approach Retrospective clinical data from 99 patients referred to the DBP (October 2021–December 2022) was reviewed. Missing data was quantified. The Challengin …

11.08.2026journal-article

ACS Applied Energy Materials

Distinct Functions of Additives during Thermal Aging in Vacuum-Flash-Assisted Perovskite Solar Cells

Siyeon Seo, In Hwa Cho, Hyo Jung Kim, Kukhyun Jo

Abstract Additive engineering has been widely used to improve the efficiency and stability of perovskite solar cells; however, the roles of additives in film formation and degradation behavior during VASP processing after spin coating under humid ambient conditions remain insufficiently understood. In this study, we aimed to compare, in real time using in-situ grazing-incidence X-ray scattering analysis, the differences in film formation and degradation behavior depending on OAm, NH4Cl, and NH4I additives in perovs …

11.08.2026journal-article

The Gerontologist

Andean voices on Ageing Well: a biographical study with older Aymara adults

Lorena P Gallardo-Peralta, María Teresa Martín-Palomo, Herminia Gonzálvez- Torrablo, Alicia Raín-Rain, Viviana Rodríguez-Venegas

Abstract Background and Objectives Scarce attempts have been made to meet the challenge of understanding the features of successful indigenous ageing in Latin America and the Caribbean. This study examines the dimensions underpinning the concept of Ageing Well among the Aymara people, based on the following questions: What conception do older Aymara adults have of Ageing Well? What are its central elements? How does Ageing Well juxtapose with Living Well? Research Design and Methods This study involved the particip …