EUVIMEDEuropean Health Evidence
Uhr 10/10Sources Journal Tree
Easy Demo

EUVIMED Themenbrowser · Therapie & Reha · Seite 107

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
20.08.2026journal-article

Pharmaceutics

Telmisartan Repurposing Targets Novel Biomarkers for Precision Colorectal Cancer Therapy

Sarah Hunachagi, Hoor Hashim Alqudihi, Sayed AbdulAzeez, J. Francis Borgio, Dana Almohazey

Background/Objectives: Colorectal cancer (CRC) remains a leading cause of cancer-associated mortality worldwide. The current therapeutic interventions are heavily constrained by the development of resistance and severe systemic toxicity. To address these challenges, this study integrated a multi-disciplinary framework involving high-throughput in silico screening followed by in vitro experimental validation to identify novel genetic targets of CRC and evaluate the efficacy of FDA-approved drugs. The primary objecti …

20.08.2026journal-article

Healthcare

Factors Associated with Meeting Physical Activity Guideline Recommendations in a Single Community Rehabilitation Center in Singapore: An Exploratory Study

Llewelyn Yi Chang Tan, Lisa Wu, Chin Jung Wong, Jia Qian Goh, Matthew Rong Jie Tay

Background: Physical exercise is a vital component of cancer rehabilitation, with demonstrated improvements in cancer health-related outcomes, relapse rates, mortality and overall survival, yet global participation remains low. In Singapore, uptake of community cancer rehabilitation is limited despite high prevalence of treatment-related impairments. Methods: A cross-sectional study was conducted among adults (≥21 years) enrolled in the Singapore Cancer Society Rehabilitation Center between December 2021 and March …

20.08.2026journal-article

IIARD INTERNATIONAL JOURNAL OF ECONOMICS AND BUSINESS MANAGEMENT

Comparative Efficacy of Rational Emotive Behavior Therapy (REBT) And Cognitive Behavioral Therapy (CBT) In the Treatment of Drug Users in NDLEA Rehabilitation Centre, Federal Capital Territory, Abuja, Nigeria

Abiola Popoola Fatima

This study examined the comparative efficacy of Rational Emotive Behaviour Therapy (REBT) and Cognitive Behavioural Therapy (CBT) in the treatment of drug users in the National Drug Law Enforcement Agency (NDLEA) Rehabilitation Centre, Federal Capital Territory (FCT), Abuja, Nigeria. The study was guided by three research questions and three hypotheses. A quasi-experimental research design involving a non-randomized pre-test and post-test control group design was adopted. The population of the study comprised sixty …

20.08.2026journal-article

Blood

Astatine 211–based conditioning with a humanized CD45 antibody for autologous hematopoietic stem cell gene therapy

Stefan Radtke, George S. Laszlo, Kyle Swing, Andrea Repele, Jacob W. Barton, David J. King, Dnyanada Pande, Mark R. Enstrom, Junyang Li, Carl B. Wolf, Liatris Reevey, Nicholas E. Petty, Greta Kanestrom, Keith R. Loeb, Camryn M. Pettenger-Willey, Megan Othus, Allie R. Kehret, Frances M. Cole, Margaret C. Lunn-Halbert, Donald K. Hamlin, D. Scott Wilbur, Brenda M. Sandmaier, Hans-Peter Kiem, Roland B. Walter

Abstract Successful transplantation of autologous gene-modified hematopoietic stem and progenitor cells (HSPCs) requires efficient ablation of resident hematopoietic stem cells. Considering that conventional myeloablative conditioning regimens are associated with nonhematologic toxicities, we evaluated CD45-directed radioimmunotherapy (RIT) using the α-emitter astatine 211 (211At) before the transplantation of ex vivo gene-edited autologous HSPCs in nonhuman primates as an alternative. We humanized the CD45 antibod …

20.08.2026journal-article

ACS Nano

Living Microbe-Driven Bioorthogonal Catalysts Enables Cytotoxin Generation, Cuproptosis and Lactate Depletion for Synergistic Tumor Therapy

Lili Xia, Xiangxuan Chao, Zitong Zhao, Xiaozhen Zhou, Chenyao Wu, Xinran Song, Wenli Zhou, Yuyao Li, Wei Feng, Yu Chen

Abstract Bioorthogonal chemistry provides a compelling strategy for in situ cytotoxin generation. However, the clinical translation of conventional bioorthogonal catalysts is impeded by poor tumor accumulation, insufficient targeting specificity, limited in vivo catalytic efficiency, and inadequate spatiotemporal control. Meanwhile, excessive lactate accumulation in the tumor microenvironment (TME) drives metabolic reprogramming, malignant progression, and therapeutic resistance. Here, we develop a living bacterial …

20.08.2026journal-article

Healthcare

Exploring Service Users’ Experiences of Activities Used During Their Occupational Therapy Treatment in South Africa

Mahlako Makhubela, Eunice Seekoe, Jayne Donaldson, Frank Kronenberg, Lieketseng Ned, Elelwani Ramugondo

Background/Objectives: Occupational therapy theories, models, and frameworks appear to be developed in Western countries. The philosophical framework for occupational therapy in South Africa appears to have relied upon various models, predominantly stemming from Western and European origins, with vague and fleeting references to African knowledge systems and philosophies. The objectives of the study were to explore how service users understand occupational therapy following their engagement in occupational therapy …

20.08.2026journal-article

Advanced Science

Toward Personalized Theranostics: A Modular PET Platform for Antibody‐Based Imaging and Therapy

Delphine Vivier, Megane Grah Kple, Julen Ariztia, Marion Leroux, Mathieu Moreau, Michael Claron, Maxime Cheveau, Adam Laouafa, Agnieszka Kownacka, Camille Petitot, John Simonet, Alexandre M. M. Dias, Sophie Poty, Charles Truillet, Bertrand Collin, Alexandra Oudot, Franck Denat

ABSTRACT The expansion of personalized medicine is encouraging the development of platforms capable of supporting individualized imaging and therapeutic strategies. The combination of antibodies, with their intrinsic selectivity, and a modular molecular probe provides a strong foundation for such approaches. In this context, a versatile platform enabling positron emission tomography (PET) imaging followed by copper‐free click‐based functionalization is developed. A DFO–Lysine–DBCO probe is synthesized and site‐spec …

20.08.2026journal-article

Frontiers in Medicine

Exploring medication adherence and risk factors in elderly patients with hepatocellular carcinoma undergoing oral targeted therapy: a cross-sectional observational study

Hong Feng, Zhixin Meng, Xian Li

Background Oral targeted therapy is now integral to the management of older adults with hepatocellular carcinoma (HCC), yet suboptimal adherence persistently undermines its real-world effectiveness. Although the Health Belief Model (HBM) is widely applied to explain health behaviors, its integration with self-efficacy theory—particularly in the HCC context, where the volitional gap between belief and action frequently dictates clinical outcomes—remains inadequately characterized. Objectives To elucidate factors ass …

20.08.2026journal-article

Advanced Materials

Targeting Nonclassical Monocytes via Artificial Cell‐Microneedles for Precision Psoriasis Therapy

Qian Chen, Xiaodong Zhou, Tian Sun, Hantao Li, Siqi Mai, Yong Miao, Sirong Chen, Jinhong Qin, Xunru Liang, Xin Li, Pengchao Zhao, Liming Bian

ABSTRACT Current therapies for inflammatory skin diseases predominantly rely on broad systemic immunosuppression and lack precision toward defined immune‐cell subsets. Here, we identify CX3CR1 + nonclassical monocytes (NCMs) as an inflammatory monocyte subset that contributes to the amplification of psoriasiform inflammation, as supported by integrated analyses of human single‐cell transcriptomics, genetic depletion, and adoptive‐transfer models. To preferentially engage these disease‐associated NCMs, we engineer a …

20.08.2026journal-article

International Journal of Molecular Sciences

Context-Dependent Mechanisms of Oncologic Photodynamic Therapy: A Framework Linking Treatment Parameters to Cellular, Vascular, and Immune Responses

Xuewu Zhang, Xujia Wang, Chengbo Zhang, Yongmei Hu, Zhangyu Jia, Junyi Li, An Jiang

Photodynamic therapy (PDT) combines a photosensitizer (PS), light, and molecular oxygen to generate cytotoxic reactive species, but nominally similar regimens can produce different biological responses because prescribed inputs do not directly specify the biologically active exposure state. Here, this intermediate state is treated as a multidimensional profile defined by PS localization and photoactive availability, the intratissue light field, oxygen dynamics, and vascular conditions at illumination. The relative …

20.08.2026journal-article

Frontiers in Immunology

Welding fume exposure and respiratory innate immune activation: metal-rich particles, inflammatory biomarkers, and immune-informed occupational prevention

Junjie Wei, Haoyang Ren, Hui Zhang

Welding fumes are widely recognized occupational aerosols, yet their effects on respiratory immune pathways remain incompletely integrated into exposure-oriented assessment. Generated by welding materials, process parameters, surface conditions, and ventilation, welding fumes contain fine and ultrafine particles that can deposit in the respiratory tract and interact with epithelial cells, alveolar macrophages, neutrophils, monocytes, and circulating immune cells. This Mini Review examines welding fume exposure as a …

20.08.2026journal-article

Renal Replacement Therapy

Timing of kidney replacement therapy in critically ill adults: an umbrella review of systematic reviews and meta-analyses

Es-Saad Ounci, Loubaba Ech-Chaqrouni, Youssef Motiaa, Oussama Lamzouri, Adnane Berdai, Hicham Sbai, Smaël Labib

Abstract Background In critically ill adults with acute kidney injury (AKI) and no urgent indications, the optimal timing of kidney replacement therapy (KRT) initiation remains unresolved. Systematic reviews have reached conflicting conclusions, and no trial has prospectively validated a structured deferred strategy. We conducted an umbrella review to map the totality of evidence and appraise the certainty of findings on this question. Methods We searched PubMed, Scopus, Web of Science, and the Cochrane Library (20 …

20.08.2026journal-article

ASM Case Reports

Persistent Campylobacter jejuni enterocolitis after CAR T-cell therapy in a patient with hypogammaglobulinemic follicular lymphoma

Dina Oulkadi, Florian Van Oers, Leen Vanden Driessche, Sarah Vandamme, Veerle Matheeussen, Célestin Mairesse, Delphine Martiny, Sébastien Anguille, Thomas Demuyser

ABSTRACT Background Campylobacter jejuni is a leading cause of bacterial gastroenteritis worldwide and typically results in self-limiting enterocolitis in immunocompetent individuals. In contrast, immunocompromised patients are at risk for severe, recurrent, or persistent infection. Chimeric antigen receptor (CAR) T-cell therapy targeting CD19 induces prolonged B-cell aplasia and hypogammaglobulinemia, predisposing patients to atypical infections. We report the first case of persistent and disseminated C. jejuni in …

20.08.2026journal-article

Scientific Reports

Green analytical methods for quantification of a new combination therapy for amyotrophic lateral sclerosis: assessment by EPPI framework

Faten M. Aboukhalil, Essam F. Khamis, Mahmoud A. El-Sayed, Rasha M. Youssef, Amira F. El-Yazbi

Abstract Amyotrophic lateral sclerosis is a progressive neurodegenerative disorder characterized by the degeneration of upper and lower motor neurons, leading to progressive muscle weakness, paralysis, and respiratory failure. The recently proposed combination therapy consisting of celecoxib and ciprofloxacin hydrochloride has emerged as a potential treatment for amyotrophic lateral sclerosis and other neurodegenerative disorders. The present study aimed to develop and validate simple, sensitive, environmentally fr …

20.08.2026journal-article

Biomacromolecules

DNA Molecular Robot for Osteosarcoma Therapy and Bone Regeneration

Junbo Dang, Panqi Sun, Junhui Jiang, Tianhao Zhao, Ruifu Lv, Hongbo Wang, Minna Ma, Dahui Sun, Mei Zhang

Abstract Preventing tumor recurrence while promoting bone regeneration remains a major challenge for osteosarcoma implants after limb-salvage surgery. Herein, we developed a DNA molecular robot (DMR) that converts tumor microenvironment (TME) and near-infrared (NIR) stimuli into integrin-mediated mechanical forces, generating microtubule-targeting activity without drugs. The DNA–polypeptide chimera contains RGD peptides for integrin anchoring and allosteric DNA switches with tunable piconewton sensitivity. Under ac …

20.08.2026journal-article

Spine Research

Scientific literature landscape analysis of researches on rehabilitation in scoliosis over the last 30 years

Yunzhong Cheng, Jixuan Huang, Lijin Zhou, Yong Hai

Background: This study systematically present the overall landscape and evolutionary trends of international research in the field of scoliosis rehabilitation over the past 30 years. Methods: This study used the Science Citation Index Expanded (SCI-E) database of the Web of Science Core Collection as the data source. Target literature was screened according to pre-set criteria, and bibliometric analysis platforms, VOSviewer 1.6.11 and CiteSpace software 6.1.R6 were employed to conduct a quantitative analysis and vi …

20.08.2026journal-article

Medical Sciences

The Evaluation of the Clinical Effectiveness and Safety of Biologic Therapies in Psoriasis–Real-World Evidence up to 64 Weeks of Therapy

Patrycja Lemiesz, Julia Nowowiejska-Purpurowicz, Tomasz W. Kaminski, Iwona Flisiak

Background: Biological treatment of psoriasis has revolutionized the therapy of this disease, in most cases enabling complete remission of skin lesions. Methods: This study aimed to analyze real-world evidence from 165 patients (mean age 38.1 ± 5.66) treated with 11 biological drugs at our Dermatology Department. Results: Skin lesion severity, expressed by Psoriasis Area and Severity Index (PASI) and Body Surface Area (BSA), improved significantly throughout the treatment, along with the quality of life, expressed …

20.08.2026journal-article

Cells

NaF-PET Imaging for Detection of Early Arterial Microcalcification and Monitoring of Targeted Therapy: A Narrative Review

Reza Piri, Sepita Taghizadeh, Poul Flemming Høilund-Carlsen

Ischemic heart disease is currently diagnosed mainly through cardiac computed tomography (CT) angiography and functional testing, both of which detect only advanced arterial macrocalcification, at a stage when treatment can merely slow disease progression rather than reverse it. Yet, macrocalcification represents the end product of a much earlier molecular process, which is microcalcification. This process is driven by smooth muscle cell and macrophage apoptosis, matrix vesicle release, and osteogenic phenotypic tr …

01.09.2026journal-article

Infectious Diseases in Clinical Practice

Neutropenia During Meropenem and Vancomycin Therapy for Clinically Presumed Brain Abscess

Ying-Fang Zheng, Shuichi Okaya, Hiroshi Ito, Nobutake Shimojo, Satoru Kawano

Neutropenia is a recognized adverse event associated with antimicrobial therapy, particularly β-lactams and glycopeptides. Although carbapenems, including meropenem, can also cause neutropenia, the number of reported cases is limited. We report a case of clinically presumed brain abscess in a 74-year-old man who developed neutropenia during treatment with high-dose meropenem and short-term concomitant vancomycin. After the antimicrobial regimen was changed to levofloxacin, the neutrophil count gradually normalized …

20.08.2026journal-article

ARACÊ

METUOSE COMO VIA EFICAZ DE MORTE CELULAR NA TERAPIA ANTINEOPLÁSICA DE TUMORES SÓLIDOS: UMA REVISÃO DE ESCOPO

Letícia Cavalcante Gondim, Elinton Nascimento Castelo, Luan Daher Fernandes, Elzelis Muller Da Silva, Vitória Nazaré Costa Seixas, Vera Regina da Cunha Menezes Palácios, Patrícia Danielle Lima De Lima, Jorge Rodrigues De Sousa

A morte celular é essencial para a manutenção da função dos órgãos. A metuose é uma forma de morte celular não apoptótica caracterizada por macropinocitose excessiva e tem emergido como um potencial alvo para a terapia antineoplásica. Este estudo teve como objetivo analisar os avanços nos tratamentos antineoplásicos baseados na indução da metuose, identificando as neoplasias sólidas investigadas, as vias farmacológicas envolvidas e os resultados de estudos in vitro e in vivo. Foi realizada uma revisão de escopo nas …

20.08.2026journal-article

The Natural Products Journal

Unraveling Phytopharmacological Insights into Scutellaria barbata (Ban Zhi Lian) for Anticancer Therapy: Bridging Traditional Chinese Medicine and Modern Pharmacology

Misbah Hamid Shaikh, Akhilesh Patel, Vijay Nath, Mohd Abid Malik, Arpan Kumar Tripathi, Shamim Shamim, Shadab Ali

Introduction: Scutellaria barbata (Ban Zhi Lian) is a traditional Chinese herb commonly used for detoxification and heat-clearing. According to recent pharmacological research, it has anticancer potential. Bioactive molecules, flavonoids, diterpenoids, and polysaccharides, have been shown to control key molecular signalling pathways, such as PI3K/AKT, NF-κB, and TGF-β/Smad, to manage tumour growth, survival, and metastasis. Methodology: The review combines ethnopharmacological, phytochemical, and preclinical and cl …

20.08.2026journal-article

International Journal For Multidisciplinary Research

Narrative Review of -Physiotherapy Prospects of Lordosis

Jasmina Yasmin, Aminul Ahmed, Rekib Ahmed, Pooja Saikia

Lordosis is a spinal postural deformity characterized by an excessive inward curvature of the lumbar or cervical spine, with lumbar hyperlordosis being the most prevalent form. Objective: The purpose of this narrative review is to critically examine the current literature on lordosis and to evaluate the scope, effectiveness, and clinical prospects of physiotherapy interventions in improving spinal alignment, reducing pain, restoring function, and enhancing quality of life among affected individuals. Methods: A comp …

20.08.2026journal-article

Revista Psicopedagogia

Reabilitação neuropsicológica nas funções executivas de crianças com TDAH

Juciane de Holanda Santos

O Transtorno de Déficit de Atenção e Hiperatividade (TDAH) é uma condição do neurodesenvolvimento caracterizada por déficits de atenção, impulsividade e hiperatividade, frequentemente acompanhados de prejuízos nas funções executivas, em especial na memória de trabalho. Esta pesquisa tem como objetivo investigar as contribuições da reabilitação neuropsicológica no aprimoramento da memória operacional de crianças com TDAH, analisando evidências sobre intervenções e estratégias que favorecem o desempenho cognitivo e c …