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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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22 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
29.08.2026journal-article

Cell Death Discovery

ApoA2 promotes tumor metastasis and drug resistance in hepatocellular carcinoma by activating the HMGB1/IL-17A axis

Zhou Fu, Fuyi Zhu, Zhendong Fu, Chengmeng Wang, Tao Guan, Yudong Yuan, Su Zhang, Ti Zhang

Abstract Anti-angiogenic therapy is a standard first-line treatment for advanced hepatocellular carcinoma (HCC), but drug resistance remains a major obstacle to its long-term efficacy. Our previous study found that apolipoprotein A2 (ApoA2) was highly expressed in anti-angiogenic drug-resistant HCC. However, the mechanism underlying ApoA2-mediated resistance to anti-angiogenic therapy remains unclear. Here, ApoA2 overexpression markedly promoted HCC cell proliferation, inhibited lenvatinib-induced apoptosis in vitr …

29.08.2026journal-article

The Turkish Journal of Pediatrics

Long-term outcomes and prognostic factors in pediatric Wilms tumor: a 47-year single-center experience

Oğuz Salih Dinçer, Alper Uygun, Ayhan Dağdemir, Merve Ecem Öğretici Çolak, İbrahim Kartal

Introduction. Wilms tumor is the most common renal malignancy in children. Survival rates now exceed 90% with multimodal therapy. This study aims to retrospectively analyze 104 pediatric Wilms tumor patients diagnosed over a 47-year period at our institution, examining demographic characteristics, tumor staging, treatment modalities, complications, recurrence rates, and survival outcomes. Materials and Methods. This retrospective single-center study included 104 pediatric patients diagnosed with Wilms tumor between …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Chemotherapy Outcomes Among Pediatric Cancer Patients with Active COVID-19 Infection in a Tertiary Hospital

Meg B Tuazon, Mary Crist D Jamora

Abstract Background The impact of COVID-19 on pediatric cancer patients undergoing chemotherapy remains a significant concern due to their immunocompromised state. Balancing the risks of chemotherapy-induced immunosuppression against the dangers of delaying cancer treatment is a critical challenge, with limited evidence to guide practice. Objective This study aimed to describe the clinico-demographic characteristics and determine the post-chemotherapy outcomes of pediatric cancer patients with active COVID-19 infec …

29.08.2026journal-article

Polymers

Localized Hydrogel-Based Therapeutics: A Strategic Approach to Mitigating Postoperative Recurrence in Breast Cancer

Kiran Kainat, Muhammad Saif Ur Rahman, Muhammad Shoaib, Shanshan Xu

Cancer remains one of the leading causes of death globally, and breast cancer is the most frequently diagnosed cancer in women. Even though surgical excision is the main treatment of solid tumors, recurrence and metastasis to another location postoperatively provide lasting therapeutic challenges. Systemic adverse effects and a lack of sufficient drug bioavailability at the resection site can often hinder traditional adjuvant modalities, especially chemotherapy and radiotherapy. To address these drawbacks, localize …

29.08.2026journal-article

Fluctuation and Noise Letters

Numerical Treatment of Stochastic-Deterministic SIRS Epidemic Differential Model with Impact of Saturated Incidence Using Implicit/Stochastic RK and Euler–Maruyama Computing Paradigm

Nabeela Anwar, Iftikhar Ahmad, Hijab Javaid, Adiqa Kausar Kiani, Muhammad Shoaib, Muhammad Asif Zahoor Raja

This paper involves the numerical exploration of both stochastic and deterministic SIRS epidemic models with saturated incidence rates. The implicit Runge–Kutta method, Euler–Maruyama method and stochastic Runge–Kutta methods are employed to analyze the dynamic patterns of the epidemic. The deterministic model is formulated using an ordinary differential system and is deep-seated in the well-established classical SIRS epidemic framework. A stochastic model is formulated by incorporating the elements of white noise …

29.08.2026journal-article

Journal of Gastrointestinal and Liver Diseases

C-reactive Protein Apheresis: A Novel Treatment Approach in Acute Necrotising Pancreatitis

Felix Götzinger, Michael Kunz, Felix Mahfoud, Michael Böhm, Andreas Link

Acute necrotizing pancreatitis is a severe condition associating with high morbidity and mortality. In most cases, supportive therapy is the only available therapeutic option. Herein, we report a case of a 29-year-old male who presented with severe acute necrotizing pancreatitis caused by hypertriglyceridemia, who consequently developed acute respiratory distress syndrome and multi-organ failure. We used an off-label C-reactive protein apheresis to target the sterile inflammatory reactions additional to optimal sup …

29.08.2026journal-article

International Journal of Research in Medical Sciences

A comparative analysis on safety and efficacy of telmisartan and ramipril in treatment of hypertension in a tertiary care hospital

Wajid Gulzar, Mudasir Manzoor Dar, Amritpal Singh, Peer Samiq Masoodi, Shah Samreen, Uma Jyoti

Background: Hypertension is a major global health challenge and an important risk factor for cardiovascular disease. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are commonly used first-line antihypertensive agents. This study evaluated the safety and efficacy of telmisartan and ramipril in patients with hypertension at a tertiary care hospital. Methods: This prospective observational study included 113 adult patients with hypertension who received either telmisartan (n= …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Clinical Characteristics and Outcomes of Respiratory Viral Infections in Pediatric Cancer Patients, Single center experience

Mona Mohammed, Yassin Taher, Maha Mohammed, Naiven Mohamed, Nehad Abd Elfatah, Marwa Jamal, Omnya Ahmed, Amira Sameh, Mohamed Kamal, Youssef Madney

Abstract Background Respiratory viral (RV) infections cause morbidity and mortality in immunocompromised pediatric patients undergoing cancer treatment. The burden of RV infections in pediatric oncology populations from low- and middle-income countries (LMICs) remain limited. We aimed to detect the prevalence of viruses causing respiratory infections among pediatric patients with cancer and guide empiric therapy and improve patient outcomes. Methods Retrospectively we collected nasopharyngeal swabs and clinical and …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Epidemiology of and antibacterial resistance in Gram-negative bloodstream infections among children with cancer and hematopoietic cell transplant recipients

Alexander Pruett, Jose Ferrolino, Ronald Dallas, Yilun Sun, Elisabeth Adderson

Abstract Background Bacteremia occurs in up to 30% of febrile neutropenic children receiving cancer therapy or hematopoietic cell transplant (HCT) and 14% of patients with non-neutropenic fever. Increasing antimicrobial resistance among Gram-negative pathogens is a challenge to providers, who seek to limit broad-spectrum antibacterial use while providing timely and effective empiric therapy. Experts recommend that the epidemiology of GN bloodstream infections (GNBSI) should be considered in developing guidelines fo …

29.08.2026journal-article

Angewandte Chemie

An Engineering‐Editable Hybrid Membrane‑Camouflaged DNA Origami Drug Enables Checkpoint Blockade and Immune Activation for Triple‐Negative Breast Cancer Immunotherapy

Xiaqing Gong, Han Yuan, Ying Fang, Mingming Song

ABSTRACT The clinical response to immunotherapy in triple‐negative breast cancer (TNBC) is often limited by the immunosuppressive microenvironment, immune cell exhaustion, and multidrug resistance. Through a high‐throughput screen of 2,500 FDA‐approved drugs using a three‐dimensional tumor organoid platform, we identified thonzonium bromide (THO) as an inducer of gasdermin D (GSDMD)‐mediated pyroptosis, which results in the release of damage‐associated molecular patterns (DAMPs) to activate antitumor immunity. To a …

29.08.2026journal-article

Risk Analysis

A Bayesian Model for Estimation of Virus Reduction in Potable Reuse Treatment Trains and Quantitative Microbial Risk Assessment of Waterborne Viral Pathogens

Jack F. Schijven, Peter F. M. Teunis, Walter Q. Betancourt

ABSTRACT Understanding virus occurrence and reduction at advanced treatment facilities for potable water reuse constitutes a high‐priority research need to protect human health and to enhance available water supply alternatives. The objectives were to (1) determine log reduction values (LRVs) of 15 viruses by advanced wastewater treatment; (2) evaluate suitability of the final wastewater effluent for potable reuse; (3) evaluate viruses or groups of viruses as indicators of wastewater treatment efficiency. Reduction …

29.08.2026journal-article

Children

Implementation and Delivery of a Comprehensive Bereavement Program in Pediatric Palliative Oncology

Yash C. Jani, Anna Lange, Miracle Naylor, Katherine Lee, Linda M. Radbill, Katharine E. Brock

Background/Objectives: Bereavement care is widely endorsed as a standard of pediatric oncology and palliative care, yet it remains inconsistently implemented across pediatric oncology programs in the United States, and few programs have reported longitudinal delivery metrics. We aim to describe the iterative development and delivery of a multi-component bereavement program within an outpatient pediatric palliative oncology (PPO) program, characterize the population served, and benchmark delivery against national gu …

29.08.2026journal-article

Journal of Orthopaedic Science and Research

The Role of Biopsy Accuracy in the Treatment of Musculoskeletal Tumors

Hannah Werner, Bennie Lindeque

Background: The accurate treatment of Musculoskeletal (MSK) tumors necessitates appropriate timely biopsy of the mass of interest. With regards to malignant neoplasms biopsy plays a crucial role in the direction of treatment courses and patient outcome. Methods: This is a retrospective single-center chart review of 924 biopsies from 2013-2023. Patients included were between 18-85 with MSK tumors that necessitated biopsy and subsequent surgical treatment. Biopsy and final resection histopathology reports were compar …

29.08.2026journal-article

Turkish Journal of Cerebrovascular Diseases

Disease of cervical arteries: contemporary imaging, medical management and endovascular treatment

Ezgi Yılmaz, Alper Eren, Özlem Aykaç, Yasemin Dinç, Nazım Kızıldağ, Demet Funda Baş, Talip Asil

Cervical artery diseases, encompassing both atherosclerotic and non-atherosclerotic disorders of the carotid and vertebral arteries, remain a major cause of ischemic stroke and transient ischemic attack (TIA) worldwide. Although luminal stenosis has traditionally guided diagnostic and therapeutic decision-making, recent advances have shifted the focus toward comprehensive vascular assessment, incorporating plaque vulnerability, vessel wall pathology, inflammatory activity, and individualized cerebrovascular risk st …

29.08.2026journal-article

The American Surgeon™

Predictive Value of Preoperative Chest Computed Tomography-Measured Diaphragm Thickness Combined With Pulmonary Function for Postoperative Pulmonary Complications After Anatomic Lung Resection in Elderly Patients With Clinical Stage I Non-Small Cell Lung Cancer

Zhenqiang Wei, Dongshan Wei, Kai Wu

Background Postoperative pulmonary complications (PPCs) remain a major cause of adverse recovery after lung resection in elderly patients with early-stage non-small cell lung cancer (NSCLC). This study evaluated the predictive value of preoperative chest computed tomography (CT)-measured diaphragm thickness combined with pulmonary function for PPCs after anatomic lung resection. Methods In this single-center retrospective study, 248 patients aged 65 years or older with clinical stage I NSCLC who underwent lobectomy …

29.08.2026journal-article

Journal of Clinical Questionon

Bispecific Antibodies Targeting PD-1/PD-L1 and VEGF in Non-Small Cell Lung Cancer

Aleena Kuriakose, Salem Gogah, Elina Beleva

Immune checkpoint inhibition has transformed the treatment of advanced non-small cell lung cancer (NSCLC), but primary and acquired resistance remain common. Vascular endothelial growth factor (VEGF) contributes to both tumor angiogenesis and immune suppression by promoting abnormal vasculature, limiting lymphocyte trafficking, and fostering an immunosuppressive tumor microenvironment. These complementary mechanisms provide a rationale for simultaneously targeting the programmed cell death protein 1 (PD-1)/programm …

29.08.2026journal-article

JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI)

The Use of Health Education Media to Improve Knowledge and Treatment Adherence among Tuberculosis Patients at the Pringsewu Community Health Center, Lampung

Dinda Annisa, Iga Mayola Pisacha, Mida Pratiwi, Sulistia Suryaman

Tuberculosis (TB) remains a serious public health problem. Low levels of knowledge and non-adherence to treatment are major factors contributing to treatment failure and an increased risk of drug resistance. This study aims to analyze the effect of education on the knowledge and adherence of tuberculosis patients. A pre-experimental study design with a one-group pre-test and post-test design was used, employing total sampling of 35 patients. Data were collected using a validated TB knowledge questionnaire and the M …

29.08.2026journal-article

Journal of the Pediatric Infectious Diseases Society

Candidemia Among Pediatric Cancer Patients: Clinical Features, Resistance Pattern, and Treatment Outcome

Youssef Madney, Reham Khedr, Hanfy Hafiz, Naglaa Adel, Mervat Elanany, Khaled Alsheshtawi, Lobna Shalaby, Alaa El Haddad

Abstract Background Candidemia presents a significant challenge for pediatric cancer patients, especially with the increasing incidence of echinocandin-resistant Candida and breakthrough candidemia. Recent data highlight a notable shift in the epidemiology of candidemia, with a predominance of non-albicans species, such as C. glabrata, C. parapsilosis, and C. tropicalis, over C. albicans. The incidence of invasive disseminated candidiasis among children ranges from 9% to 10% and is linked to mortality rates between …

29.08.2026journal-article

The Turkish Journal of Pediatrics

Frequency of gastroptosis and gastroparesis in children with treatment-resistant dyspepsia and duodenogastric reflux: a prospective study

Melike Arslan, Edibe Gözde Başaran, Coşkun Fırat Özkeçeci, Bekir Nihat Doğrul, Necati Balamtekin

Background. Studies on gastroptosis and gastroparesis in children are limited. This prospective study aimed to evaluate the frequency of gastroptosis and gastroparesis and their association with duodenogastric reflux (DGR) and treatment-resistant dyspeptic symptoms in children. Methods. The study evaluated pediatric patients aged 2-18 years with dyspepsia who underwent upper gastrointestinal endoscopy between March 2020 and June 2022. Fluoroscopy and gastric emptying scintigraphy were performed in 88 patients (50 w …

29.08.2026journal-article

Mathematics

Can IL-10 Inhibitor Therapy Alongside MDT Enhance Leprosy Treatment? A Comprehensive Mathematical Study

Salil Ghosh, Huina Zhang, Satyajit Mukherjee, Xianbing Cao, Amit Kumar Roy, Priti Kumar Roy

Leprosy is characterized by complex biological and cellular interactions, driven primarily by the interplay between Th1 and Th2 cells. In this study, we develop a deterministic mathematical model to investigate the interactions among healthy and infected Schwann cells, M. leprae bacteria, and Th1–Th2 immune responses. The positivity and boundedness of the proposed five-dimensional system are established, and the disease persistence condition is characterized in terms of the basic reproduction number (R0). The exist …

29.08.2026journal-article

International Journal of Research in Medical Sciences

Clinical readiness and generalizability of artificial intelligence in implant dentistry: a systematic review of diagnostic accuracy, treatment planning, prognosis and external validation

Rohit Raghavan, Shajahan P. A., Akash R.

Artificial intelligence (AI) is increasingly being incorporated into digital dentistry. In implant dentistry, machine-learning and deep-learning systems have been investigated for radiographic diagnosis, anatomical segmentation, treatment planning, prosthetically driven implant positioning, and prediction of implant-related outcomes. To systematically evaluate the clinical applications of AI in implant dentistry, with particular emphasis on diagnostic accuracy, treatment planning, prognosis, external validation, ge …

29.08.2026journal-article

SAS Journal of Medicine

Iron Deficiency Anemia in Children and Adolescents: Epidemiology, Risk Factors, Clinical Manifestations, Diagnosis, Treatment, and Prevention

Mohammad Koblan Abedraboh Alshwawreh, Nader Emad Mousa Hijazeen

Iron deficiency anemia (IDA) is the most common nutritional deficiency and the leading cause of anemia worldwide, affecting infants, children, and adolescents disproportionately. IDA remains a significant public health concern because of its high prevalence and its potential impact on growth, neurodevelopment, cognitive function, physical performance, and quality of life. The etiology of pediatric IDA is multifactorial and includes inadequate dietary iron intake, increased iron requirements during periods of rapid …