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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
20.08.2026journal-article

Manager Zdravookhranenia

Clinical and organizational issues in the early diagnosis of occupational sensorineural hearing loss.

D. I. Shubin, D. O. Roshchin

Background. Occupational sensorineural hearing loss (OSNHL) remains one of the leading nosological entities in the structure of occupational morbidity in the Russian Federation, demonstrating an upward trend. Despite the existence of approved federal clinical guidelines regulating the diagnosis and patient routing, their systematic non-compliance by medical organizations during periodic medical examinations (PME) is frequently observed in real clinical practice, which significantly reduces the effectiveness of earl …

20.08.2026journal-article

Neurorehabilitation and Neural Repair

Analysis of Home-Based Rehabilitation Robotics: Lessons Learned from Nationwide Direct-to-Consumer Deployment

Russell Jeter, Steven L. Wolf, Stephen N. Housley

Introduction: Millions of stroke survivors in the US have sensory-motor impairments that significantly impact quality of life and place a long-term burden on families, communities, and the healthcare system. Neurorehabilitation aims to improve function, typically through repetitive practice of movements and task-related activities where doses are regularly titrated by skilled clinicians. Unfortunately, these highly intensive, skilled interventions are challenging to implement at the scale needed to serve the needs …

20.08.2026journal-article

American Journal of Physical Medicine & Rehabilitation

Morphological and Morphometric Analysis of the Motor Branches of the Tibial Nerve Above the Soleus Arch

Julien Le Roux, Arthur Dubois, Antoine Dias, Thomas Krebel, Apolline Saulnier, Stéphane Ploteau, Antoine Hamel, Cyrille Decante, Céline Salaud

Objective: Motor branches of the tibial nerve are variable, and have implications for tibial neurotomy in the management of spastic equinovarus foot. The aim of the study is to detail these branches through an analysis of their morphology and their topographical relationships with a bony landmark. Design: Fifty-one legs from cadaveric specimens were dissected. A morphological classification was established. The distance between their origin from the TN and a line passing through the fibular head was measured. Resul …

20.08.2026journal-article

Language, Speech, and Hearing Services in Schools

Upholding Children's Communication Rights by Ensuring Access to Full and Appropriate Language Assessments and Corresponding Evidence-Based Interventions

Katharine Beals, Caroline Bowen, Lucy Bryant, Gaenor Dixon, Bronwyn Hemsley

Purpose: This commentary is motivated by Articles 23 (children with disabilities) and 28 (right to education) of the United Nations Convention on the Rights of the Child (CRC). Article 23 upholds the rights of children to education and training, leading to “the fullest possible social integration and individual development. … ” A key component of social integration and individual development, and thus a key target of education and training, is communication and literacy skills. Article 28, indeed, includes combatin …

20.08.2026journal-article

Advanced Materials

Cilia‐Structured Lipiodol Droplets Enable Long‐Term Transarterial Embolization Therapy by Nano‐Interlocking Adhesion

Sen Zhang, Han Bao, Xiaowei Chen, Shuang Zhu, Si Gao, Yuzhe Wang, Xinyi Shen, Haibo Shao, Zhanjun Gu, Shutao Wang

ABSTRACT Transarterial embolization (TAE) offers an effective and minimally invasive therapy for unresectable hepatocellular carcinoma (HCC), one of the most lethal malignancies globally, but being limited by short‐term embolization failure for example recanalization due to weak interfacial adhesion. Herein, we report cilia‐structured lipiodol (CS‐lipiodol) droplets by self‐assembling dual‐asymmetric microparticles with hydrophilic cilia‐structured hemispheres and hydrophobic plain hemispheres at the lipiodol–water …

20.08.2026journal-article

Journal of Endovascular Therapy

Single Center Experience using Fiber Optic RealShape (FORS) Technology in Patients Treated with Complex Endovascular Aneurysm Repair

Charlotte C. Lemmens, Barend M.E. Mees, Marie-José P.J. Vleugels, Anna Prent, Jorinde H.H. van Laanen, Michiel W. de Haan, Michael J.H.M. Jacobs, Geert W.H. Schurink

Purpose: Fiber Optic RealShape (FORS) is a novel technology using light instead of X-rays to visualize guidewire and catheters during endovascular procedures. A 3D-Hub allows visualization of conventional catheters when used in combination with the FORS guidewire. This study evaluates the FORS performance and radiation exposure during visceral target vessel (TV) catheterization in complex endovascular aortic repair (cEVAR). Materials and Methods: Single-centre data were retrieved from the prospective FORS Learn Reg …

20.08.2026journal-article

Journal of Endovascular Therapy

Carotid Artery Stenting in Symptomatic Carotid Stenosis With Chronic Kidney Disease: A Single-Center Retrospective Study

Shanshan Liu, Siyu Liu, Juan Chen, Fei Li, Xiaomin Zhang

Objective: To investigate the short- and long-term event-free survival (EFS) in patients with chronic kidney disease (CKD) undergoing carotid artery stenting (CAS) for the treatment of symptomatic carotid artery stenosis. Method: The single-center retrospective study included 1363 patients, who were categorized into CKD stages 2, 3, 4, and 5 based on their glomerular filtration rate. The primary endpoint was long-term EFS from the occurrence of stroke, myocardial infarction (MI), or death within a 10-year follow-up …

20.08.2026journal-article

Frontiers in Public Health

A proposal of good manufacturing practices (GMP) laboratory for CAR T-cell therapy in Latin America and the Caribbean: challenges and opportunities

Sergio Camilo Cabrera-Salcedo, Luis Gabriel Parra-Lara, Monica Fernandes-Pineda, Alejandro Toro-Pedroza, Juan Sebastian Victoria Hincapie, Lady J. Rios-Serna, Alexandre Loukanov, Joshua Ortiz-Guzman, Juan Esteban Garcia-Robledo, Carlos A. Cañas, Gustavo Adolfo Cruz-Suarez, Felipe Ocampo Osorio, Michael P. Gustafson, Juan Guillermo Restrepo, Andres Mosquera, Valentina Hoyos, Juan C. Baena

Chimeric antigen receptor (CAR) T-cell therapy is a transformative modality for refractory hematologic malignancies; however, its adoption in Latin America and the Caribbean (LAC) is severely constrained by prohibitive manufacturing costs, limited specialized infrastructure, and fragmented regulatory frameworks. To address this translational gap, we propose a pragmatic, cost-adapted model for establishing Good Manufacturing Practice (GMP) laboratories tailored to the socioeconomic realities of LAC. This model advoc …

20.08.2026journal-article

Rehabilitation Science

Satisfaction with Physiotherapy Services Among Parents of Cerebral Palsy in Rehabilitation Centers of Kathmandu Valley: A Cross-Sectional Study

K. Smita, Gautam Sarthak, Sigdel Kripa, Maharjan Sukrina, Tenzing Lama

Background: Patient satisfaction reflects the extent to which individuals perceive that their needs and expectations have been met in relation to the cost and quality of healthcare services received. Satisfied patients are more likely to adhere to treatment plans, seek continued care, and provide constructive feedback, all of which are particularly important in the management of children with Cerebral Palsy (CP), a lifelong condition requiring long-term rehabilitation. As children with CP are often unable to adequa …

20.08.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Competitive level is associated with dietary practices but not sports nutrition knowledge in collegiate athletes: associations with body composition profiles

Mohamed Osama, Mohamed Bakr, Mahmoud Al Sayed

Abstract Background Sports nutrition knowledge may influence athletes’ dietary practices, but its relationship with dietary intake and body composition remains unclear, particularly across different competitive levels. This study examined the associations among sports nutrition knowledge, dietary intake, and body composition and compared these variables between amateur and elite collegiate athletes. Methods This cross-sectional study included 100 male collegiate athletes (60 amateur and 40 elite). Sports nutrition …

20.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Kinematic Features of Laryngeal Motor Control in Parkinson's Disease

Dilys C. Tan, Hasini R. Weerathunge, Manuel Diaz-Cadiz, Cara E. Stepp, Jenny Vojtech

Purpose: Laryngeal kinematics were examined under high-speed videoendoscopy to examine laryngeal motor control of persons with Parkinson's disease (PD). Method: A retrospective analysis was performed on 24 people with idiopathic PD and 24 age- and sex-matched controls as they produced repetitions of the utterance /ifi/ at self-induced levels of vocal effort (typical, mild, moderate, and maximum effort). Two kinematic measures of laryngeal motor control were measured during vocal fold adduction: spatiotemporal index …

20.08.2026journal-article

SECURITY AND PRIVACY

Privacy‐Preserving Federated Audio‐Visual Saliency Analysis and Data Sharing Architecture for Rehabilitation of People With Disabilities

Ning Fang

ABSTRACT Privacy constraints on facial, movement, and voice data restrict centralized model training across rehabilitation institutions. This study presents a privacy‐preserving federated audio‐visual saliency architecture, termed PPFAV, for edge‐based rehabilitation assessment. A three‐stream encoder represents speech instructions, dynamic action sequences, and static visual cues, while a self‐supervised cross‐modal alignment objective links synchronized instructions and movement responses. Before aggregation, cli …

20.08.2026journal-article

Australian Health Review

Patient flow implications of delayed access to inpatient rehabilitation in Australian acute hospitals

Jane Wu, Yuriko Watanabe, Christine T. Shiner, Abraham Arulanandam, Swee-Ling Toh, Louise Sellars

Objective Delays in transferring patients from acute care to inpatient rehabilitation contribute to hospital exit-block; however, the magnitude of rehabilitation-related delays is poorly quantified in contemporary health systems. This study aimed to quantify the time spent waiting for inpatient rehabilitation in Australian acute hospitals. Methods Secondary analysis of a prospective observational cohort study of consecutive adult patients accepted for inpatient rehabilitation across two metropolitan tertiary hospit …

20.08.2026journal-article

Safety

Fuzzy Logic-Based Aggregated Risk Values in Occupational Safety Risk Assessment: A Systematic Review

Zoltán Herényi, Andrea Tick, Tihomir Dovramadjiev, Gyula Szabó

Occupational safety risk assessment combines measured data, qualitative observations, and expert judgment to prioritize preventive action. Fuzzy logic can structure linguistic and uncertain information, but poorly justified variables, membership functions, rules, or weights can embed bias, while aggregation can obscure hazard-specific differences. Following a PRISMA-aligned selection process, this systematic review examined 30 fuzzy-based occupational safety studies, focusing not only on technical design but also o …

20.08.2026journal-article

Blood Advances

Impact of cytoreductive therapy in myeloproliferative neoplasm-associated splanchnic vein thrombosis

Douglas Tremblay, Amica Kurniati Ko, Pavlina Chrysafi, Joan How, Rebecca L. Zon, Damon E Houghton, Atefeh Ghorbanzadeh, Dahniel Sastow, Sai Swetha Alladi, Maria Georgen, Abishta Prabhu, Vrushali Pachpande, Sai Sudha Valisekka, Balkrishna N Jahagirdar, Sargam Kapoor, Andrew Peseski, Radhika Gangaraju, Ruchi Desai, Guoliang Zheng, Shreyash Dalmia, Vinai Chander Bhagirath, Alejandro Godoy, Alessandra Iurlo, Daniele Cattaneo, Paola Guglielmelli, Alessandro M Vannucchi, Valentina Boldrini, Valerio De Stefano, Silvia Betti, Elena Rossi, Walter Ageno, Jonathan Berry, Margherita Maffioli, Mukul Aggarwal, Amiya Ranjan Nayak, Rishi Dhawan, Thita Chiasakul, Kristen Sanfilippo, Gabriela S Hobbs, John O. Mascarenhas

Myeloproliferative neoplasm (MPN) patients are at risk of splanchnic vein thromboses (SVT). Prior studies have failed to demonstrate a benefit of hydroxyurea therapy in preventing recurrent thrombosis after SVT, but are limited by small sample sizes and inability to account for starting, stopping, or switching of cytoreductive therapies. To better assess the impact of cytoreductive therapy on thrombosis recurrence, we performed a retrospective cohort study of MPN-SVT patients from the international GASTRO-MPN Conso …

20.08.2026journal-article

BMC Urology

Comparative efficacy and safety of silodosin (Silorap®) versus tamsulosin (Tamsolin®) for medical expulsive therapy of distal ureteral stones

Salman El Khalid, Muhammad Hammad Ali Mithani, Hafiz Shahzad Ashraf, Liaquat Ali, Javed Altaf, Ghulam Mahboob Subhani, Hayat Kakar, Muhammad Nasir Jamil, Muhammad Nawaz, Sayyed Ali Imran Zaidi, Aziz Abdullah, Irfan Nazir, Asad Ullah Langove, Shahbaz Hanif Mehar, Shahzad Anwar, Abdul Hafeez Qureshi, Aziz Ur Rehman, Arshia Khan, Mahaveer Maheshwari, Jahanzeb Kamal Khan

Abstract Purpose The study objective was to compare the efficacy and safety of Silodosin (Silorap ® ) versus Tamsulosin (Tamsolin ® ) in facilitating the passage of acutely obstructing distal ureteral stones. Methods This multicenter, randomized, comparative study enrolled 336 adult patients with a single distal ureteric calculus (5–10 mm) across sixteen tertiary care centers in Pakistan. Participants were randomized to receive Silodosin (Silorap ® ) or Tamsulosin (Tamsolin ® ) and followed for 30 days. Primary out …

20.08.2026journal-article

Pharmaceutics

Telmisartan Repurposing Targets Novel Biomarkers for Precision Colorectal Cancer Therapy

Sarah Hunachagi, Hoor Hashim Alqudihi, Sayed AbdulAzeez, J. Francis Borgio, Dana Almohazey

Background/Objectives: Colorectal cancer (CRC) remains a leading cause of cancer-associated mortality worldwide. The current therapeutic interventions are heavily constrained by the development of resistance and severe systemic toxicity. To address these challenges, this study integrated a multi-disciplinary framework involving high-throughput in silico screening followed by in vitro experimental validation to identify novel genetic targets of CRC and evaluate the efficacy of FDA-approved drugs. The primary objecti …

20.08.2026journal-article

Healthcare

Factors Associated with Meeting Physical Activity Guideline Recommendations in a Single Community Rehabilitation Center in Singapore: An Exploratory Study

Llewelyn Yi Chang Tan, Lisa Wu, Chin Jung Wong, Jia Qian Goh, Matthew Rong Jie Tay

Background: Physical exercise is a vital component of cancer rehabilitation, with demonstrated improvements in cancer health-related outcomes, relapse rates, mortality and overall survival, yet global participation remains low. In Singapore, uptake of community cancer rehabilitation is limited despite high prevalence of treatment-related impairments. Methods: A cross-sectional study was conducted among adults (≥21 years) enrolled in the Singapore Cancer Society Rehabilitation Center between December 2021 and March …

20.08.2026journal-article

IIARD INTERNATIONAL JOURNAL OF ECONOMICS AND BUSINESS MANAGEMENT

Comparative Efficacy of Rational Emotive Behavior Therapy (REBT) And Cognitive Behavioral Therapy (CBT) In the Treatment of Drug Users in NDLEA Rehabilitation Centre, Federal Capital Territory, Abuja, Nigeria

Abiola Popoola Fatima

This study examined the comparative efficacy of Rational Emotive Behaviour Therapy (REBT) and Cognitive Behavioural Therapy (CBT) in the treatment of drug users in the National Drug Law Enforcement Agency (NDLEA) Rehabilitation Centre, Federal Capital Territory (FCT), Abuja, Nigeria. The study was guided by three research questions and three hypotheses. A quasi-experimental research design involving a non-randomized pre-test and post-test control group design was adopted. The population of the study comprised sixty …

20.08.2026journal-article

Blood

Astatine 211–based conditioning with a humanized CD45 antibody for autologous hematopoietic stem cell gene therapy

Stefan Radtke, George S. Laszlo, Kyle Swing, Andrea Repele, Jacob W. Barton, David J. King, Dnyanada Pande, Mark R. Enstrom, Junyang Li, Carl B. Wolf, Liatris Reevey, Nicholas E. Petty, Greta Kanestrom, Keith R. Loeb, Camryn M. Pettenger-Willey, Megan Othus, Allie R. Kehret, Frances M. Cole, Margaret C. Lunn-Halbert, Donald K. Hamlin, D. Scott Wilbur, Brenda M. Sandmaier, Hans-Peter Kiem, Roland B. Walter

Abstract Successful transplantation of autologous gene-modified hematopoietic stem and progenitor cells (HSPCs) requires efficient ablation of resident hematopoietic stem cells. Considering that conventional myeloablative conditioning regimens are associated with nonhematologic toxicities, we evaluated CD45-directed radioimmunotherapy (RIT) using the α-emitter astatine 211 (211At) before the transplantation of ex vivo gene-edited autologous HSPCs in nonhuman primates as an alternative. We humanized the CD45 antibod …

20.08.2026journal-article

ACS Nano

Living Microbe-Driven Bioorthogonal Catalysts Enables Cytotoxin Generation, Cuproptosis and Lactate Depletion for Synergistic Tumor Therapy

Lili Xia, Xiangxuan Chao, Zitong Zhao, Xiaozhen Zhou, Chenyao Wu, Xinran Song, Wenli Zhou, Yuyao Li, Wei Feng, Yu Chen

Abstract Bioorthogonal chemistry provides a compelling strategy for in situ cytotoxin generation. However, the clinical translation of conventional bioorthogonal catalysts is impeded by poor tumor accumulation, insufficient targeting specificity, limited in vivo catalytic efficiency, and inadequate spatiotemporal control. Meanwhile, excessive lactate accumulation in the tumor microenvironment (TME) drives metabolic reprogramming, malignant progression, and therapeutic resistance. Here, we develop a living bacterial …

20.08.2026journal-article

Frontiers in Medicine

Exploring medication adherence and risk factors in elderly patients with hepatocellular carcinoma undergoing oral targeted therapy: a cross-sectional observational study

Hong Feng, Zhixin Meng, Xian Li

Background Oral targeted therapy is now integral to the management of older adults with hepatocellular carcinoma (HCC), yet suboptimal adherence persistently undermines its real-world effectiveness. Although the Health Belief Model (HBM) is widely applied to explain health behaviors, its integration with self-efficacy theory—particularly in the HCC context, where the volitional gap between belief and action frequently dictates clinical outcomes—remains inadequately characterized. Objectives To elucidate factors ass …

20.08.2026journal-article

Advanced Science

Toward Personalized Theranostics: A Modular PET Platform for Antibody‐Based Imaging and Therapy

Delphine Vivier, Megane Grah Kple, Julen Ariztia, Marion Leroux, Mathieu Moreau, Michael Claron, Maxime Cheveau, Adam Laouafa, Agnieszka Kownacka, Camille Petitot, John Simonet, Alexandre M. M. Dias, Sophie Poty, Charles Truillet, Bertrand Collin, Alexandra Oudot, Franck Denat

ABSTRACT The expansion of personalized medicine is encouraging the development of platforms capable of supporting individualized imaging and therapeutic strategies. The combination of antibodies, with their intrinsic selectivity, and a modular molecular probe provides a strong foundation for such approaches. In this context, a versatile platform enabling positron emission tomography (PET) imaging followed by copper‐free click‐based functionalization is developed. A DFO–Lysine–DBCO probe is synthesized and site‐spec …