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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
12.08.2026journal-article

Journal of Alzheimer’s Disease

Progression from mild cognitive impairment to dementia in Alzheimer's disease: Whole cortex voxelwise functional connectivity analysis with multivariate distance matrix regression

Luiz Kobuti Ferreira, Eric Westman, Lars-Olof Wahlund, Rosaleena Mohanty, for the Alzheimer's Disease Neuroimaging Initiative

Background Differentiating individuals with mild cognitive impairment who convert to dementia due to Alzheimer's disease (MCI-C) from those who do not convert (MCI-NC) is increasingly important. Functional connectivity (FC) derived from resting state functional MRI (rs-fMRI) has been investigated as a potential biomarker. However, improved data analysis strategies are needed. One underexplored approach is pairwise voxel-to-voxel analysis. Objective To describe differences in FC between amyloid positive MCI-C and MC …

12.08.2026journal-article

Revista de Geopolítica

TÍTULO CENTRAL: GESTÃO DE PESSOAS E PSICOLOGIA ORGANIZACIONAL: DIÁLOGOS, DESAFIOS E POSSIBILIDADES NO CONTEXTO ATUAL

Aline Santos Soares, Caline Rodrigues de Sousa, Gabriele Vidal de Queiroz, Maria Ingrid Oliveira dos Santos, Michelle Fernandes Marinho, Milanya da Silva Souza, Talita Raquel Garcia Dantas

O presente estudo teve como objetivo compreender a atuação do psicólogo organizacional na área de Gestão de Pessoas. Além disso, analisar os principais desafios e aspectos positivos do psicólogo organizacional na área em questão. O estudo adota uma abordagem qualitativa, descritiva e exploratória. Para coletar os dados, foi realizada uma entrevista semiestruturada, com uma psicóloga que atua na área, contendo perguntas alinhadas aos objetivos do presente estudo. Nisto, o estudo deixa explícito que a atuação do psic …

12.08.2026journal-article

Electricity

Operational-Cost-Oriented Day-Ahead BESS Scheduling in Active Distribution Networks: An AC-Feasible Framework with Post-Dispatch Battery-Aging Assessment

Kevin Alexander Leyton-Valencia, Luis Fernando Grisales-Noreña, Fiderman Machuca-Martínez

This paper presents an integrated day-ahead battery energy storage system (BESS) scheduling framework for radial active distribution networks with photovoltaic generation. Its main contribution is a reproducible evaluation chain combining non-ideal state-of-charge (SoC) feasibility correction, sequential AC power-flow verification, consistent metaheuristic benchmarking, and post-dispatch battery-aging analysis. The operating-cost objective coordinates hourly BESS active-power exchanges while enforcing storage and A …

12.08.2026journal-article

Journal of the Kenya National Commission for UNESCO

Kenya’s Government Policies on Income Generating Activities for People Living with HIV/AIDS in Nyakach and Nyando Sub-Counties, Kisumu County

George Kwenya

Globally HIV/AIDS remains a major public health and socio-economic challenge particularly in poverty-striven regions. In Sub-Saharan Africa Countries HIV/AIDS, prevalence remains high In Kenya, the HIV/AIDS epidemic significantly affects the livelihoods of those living with the virus, affecting their health, food security, economic stability, and social structures. The pandemic has created challenges in accessing healthcare, food, and other essential resources, particularly for women and those in rural areas. The g …

12.08.2026journal-article

Frontiers in Nutrition

Orally administered scallop-derived plasmalogens improve cognitive function in healthy middle-aged and older adults: a randomized, double-blind, placebo-controlled trial

Mina Fukuchi, Mizuho Tanaka, Masafumi Nagata, Tsuyoshi Takara, Yasuhiro Sasuga

Background Plasmalogens (Pls) are ether phospholipids enriched in the brain that help maintain synaptic integrity and support cognitive function. However, evidence of their cognitive benefits in otherwise healthy individuals remains limited. This randomized, double-blind, placebo-controlled trial examined whether supplementation with scallop-derived Pls (sPls) improves cognitive performance in cognitively healthy Japanese adults aged ≥40 years with below-average verbal memory at baseline. Methods Of 168 individuals …

12.08.2026journal-article

AGING MEDICINE

Evaluation and Ranking for Scientific, Transparent and Applicable of Chinese Geriatrics Guidelines and Consensus Published in 2023

Daiping Li, Chao Gao, Xiaoli Huang, Ling Kang, Birong Dong, Jirong Yue, the Specialized Committee for Geriatric Medicine of the STAR

ABSTRACT Objectives This study aims to evaluate the Scientific, Transparent, and Applicable Rankings (STAR) of guidelines and consensus published in Chinese geriatric medicine journals in 2023. Methods The working group conducted a systematic search in eight major Chinese and English databases for guidelines and consensuses published by Chinese scholars in the field of geriatric medicine in 2023. The selected guidelines and consensuses were rated using the STAR rating tool, and the rating results were analyzed. Res …

12.08.2026journal-article

Frontiers in Nutrition

The interaction between sugar-sweetened beverage consumption and emotional status with subjective cognitive decline among rural older adults: a cross-sectional study

Yahong Guo, Jing Shi, Xinjin Li, Cailing Yang, Weijuan Kong, Meiman Li, Yuxin Mao, Min Jia, Ruixue Liu, Yanhua Ning

Objectives This study explored the interactive and joint effects of Sugar-Sweetened Beverage (SSB) consumption, positive and negative affect with Subjective Cognitive Decline (SCD) among rural older adults, providing empirical evidence for formulating targeted strategies for the early intervention of cognitive decline in the rural older population. Methods This cross-sectional study recruited 485 valid participants from rural areas of Ningxia, China, using a stratified cluster sampling method. Key indicators were a …

12.08.2026journal-article

Frontiers in Public Health

Associations between digital health literacy and health inequalities among middle-aged and older adults: an urban–rural disparity perspective

Jian Wu, Pingping An, Ning Chen

Background In the digital age, digital health literacy has emerged as a critical factor influencing the physical and mental well-being of middle-aged and older adults. However, the relationship between digital health literacy and health inequalities remains underexplored. This study aims to investigate this association among middle-aged and older adults in urban and rural settings. Methods Data were obtained from the 2021 Chinese General Social Survey (CGSS). The final analytical sample consisted of 1,672 responden …

12.08.2026journal-article

Inquietud Empresarial

Capabilities, people and knowledge: three lenses on organizational transformation

Fabio Blanco-Mesa

Dear readers, authors and reviewers, Volume 26_1 contains eleven articles. Each has been peer-reviewed independently and originates from five different countries. The articles range from bibliometric studies to research papers. Each presents different approaches centred on a common theme: the competencies organizations need to continue functioning when their operating conditions are more unstable. The methodologies used are diverse, including, for example, qualitative comparative analysis of fuzzy sets, panel-corre …

12.08.2026journal-article

Journal of Community Medicine and Health Solutions

Early Alzheimer’s Detection through Blood Testing: Relevance to Aging Populations in Low- and Middle-income Countries

Afifa Syed, Alishba Mirza, Areeba Bhatti

Alzheimer’s disease is a leading cause of dementia worldwide, with timely diagnosis remaining a challenge, especially in low- and middle-income countries (LMICs). Limited access to specialized services, high costs of neuroimaging and cerebrospinal fluid analyses, and low public awareness delay recognition and treatment. This underscores the need for accessible, affordable, and scalable tools to identify individuals at risk earlier in the disease course.The Triglyceride-Glucose (TyG) index, derived from routine bloo …

12.08.2026journal-article

Pilot and Feasibility Studies

A peer-group programme for people with severe mental illness to reduce risk of cardiometabolic disease (PEGASUS): protocol for a feasibility study

Jessica Catchpole, Jerry Padfield, Vanessa Kellermann, Cathryn Salisbury, Jayati Das-Munshi, Steve Gillard, Kyriaki Giorgakoudi, Graham A. Hitman, Richard I. G. Holt, Werner Leber, Natalie Mark, Stanton Newman, Yunli Ou, Clare Robinson, Frank Röhricht, Lauren Walker, Victoria Bird, Jacqueline Sin, Bethan Hatherall

Abstract Background People diagnosed with severe mental illness (SMI) die around 15–20 years prematurely compared with people without these conditions, partially to a 50% increased risk of developing Cardiovascular disease (CVD). Treatment and diagnosis rates of CVD and metabolic disease (together called Cardiometabolic disease) are lower in people diagnosed with SMI, at a considerable cost to individuals and their families, health services, and society. Previous trials have shown that Behaviour change intervention …

12.08.2026journal-article

INTERNATIONAL JOURNAL OF ENGLISH LANGUAGE AND COMMUNICATION STUDIES

Pidginization as a Communication Tool for National Cohesion: A Case Study of Chinua Achebe’s A Man of The People

Uchenna Enyia

Nigeria is a heterogeneous society with over five hundred languages used for communication among the various and diverse ethnic groups. Consequent upon the language and cultural differences of these groups, English language, bequeathed on Nigerians by the colonialists to facilitate communication, became the lingua franca. It is used for official purposes, commerce and industry, media and advertisement, politics, teaching and learning. However, Nigerian Pidgin (NP), otherwise known as Pidgin or Broken English, has i …

12.08.2026journal-article

Hematology Reports

Is There Still a Role for Autologous Stem Cell Transplantation in Older Adults with AML?

Saveria Capria, Clara Minotti, Massimo Breccia, Maria Laura Bisegna, Ida Carmosino, Patrizia Chiusolo, Luca Di Marino, Giovanni Luzi, Sabrina Mariani, Giovanni Marsili, Leonardo Marabitti, Elettra Ortu La Barbera, Lorena Scollo, Maurizio Martelli, Silvia Maria Trisolini

Introduction: Autologous stem cell transplantation (ASCT) is regaining interest as a consolidation strategy for acute myeloid leukemia (AML) patients with favorable/intermediate risk and measurable residual disease (MRD) negativity. In fit older adults, its role remains debated due to concerns regarding toxicity and stem cell collection. Aim: To evaluate the long-term outcomes of ASCT in AML patients aged ≥60 years in first complete remission (CR1). Methods: We retrospectively analyzed 43 non-M3 AML patients (media …

12.08.2026journal-article

Life

Serial Presepsin Measurement as a Predictor of In-Hospital Mortality in Older Adults with Hip Fractures

Bünyamin Arı, Fatmagül Can, Umur Batak, Turan Cihan Dülgeroğlu

Serial presepsin measurements were evaluated for their prognostic value compared with conventional laboratory markers in predicting in-hospital mortality among older adults with hip fractures. This prospective observational study included 85 patients aged ≥65 years admitted with acute hip fractures between December 2025 and May 2026. Residual serum remaining after routine clinical laboratory sampling was obtained on admission (Day 1), Day 3, and Day 5; serum presepsin was measured by commercial ELISA, and routine p …

12.08.2026journal-article

Frontiers in Aging Neuroscience

The delta-opioid receptor: a therapeutic target for Alzheimer's disease

Yuan Xu, Wei Guan, Yilin Yang, Yujiao Yang, Ying Xia, Ya Peng

Alzheimer's disease (AD) presents a complex pathogenesis involving amyloid-β (Aβ) plaques, tau tangles, and neuroinflammation. Recent evidence highlights δ-opioid receptor (DOR) as a unique and promising therapeutic target for AD. This review summarizes current knowledge on DOR's multifaceted neuroprotective role in AD pathology. While its involvement in Aβ regulation appears context-dependent, DOR activation consistently attenuates tau hyperphosphorylation, modulates microglial dysfunction, suppresses harmful neur …

12.08.2026journal-article

BMC Neurology

Spatiotemporal dynamics and climate correlates of Parkinson disease mortality among older U.S. adults: national trends and forecasts to 2035

Zhongke Huang, Wenkai Pan, Meng Xia, Gege Zhao, Jian Wang, Hongjie Hu

Abstract Background Parkinson disease (PD) is an increasing cause of mortality among older adults, but national studies have generally examined mortality trends, forecasts, spatial variation, or environmental associations separately. We integrated these components to characterize U.S. PD mortality and its regional climate correlates. Methods This ecological time-series study used CDC WONDER mortality data for U.S. adults aged 65 years or older from 1999 to 2024. Joinpoint regression, exponential smoothing state-spa …

12.08.2026journal-article

Formosan Journal of Musculoskeletal Disorders

Outcomes Following Geriatric Hip Fracture Surgery in Diabetic Patients: A Nationwide Population-based Matched Cohort Study

Yuan-Pei Lin, Su-Ju Lin, Tien-Hsing Chen, Liang-Tseng Kuo, Wei-Hsiu Hsu

Abstract Background: Hip fracture is a common disease for older people, and operative management provides more benefits than conservative treatment. However, the optimal surgical options for geriatric patients with hip fractures remain debated. Objectives: To compare the clinical outcomes of hemiarthroplasty versus internal fixation in diabetic patients with a fragility hip fracture. Materials and Methods: This retrospective cohort study utilized data from the Taiwan National Health Research Insurance Database. Pat …

12.08.2026journal-article

Journal of Psychopharmacology

Psychotropic medication prescribing to children and young people mental health inpatient services: An English national study

David Branford, Anne Webster, Marinos Kyriakopoulos, Shermin Imran, Prathiba Chitsabesan, Tina Irani, Teresa Randon, Kirsten Peebles, Rohit Shankar

Background: Mental disorders frequently begin in childhood or adolescence. Worldwide, psychotropics are commonly prescribed for under-18s to stabilise behaviour, mood or thoughts. Psychotropics could cause long-term effects on children and young people (CYP) health, growth and development. There is a knowledge gap about psychotropic prescribing in CYP mental health inpatient units. Aims: To understand and compare psychotropic prescribing patterns in England mental health inpatient units for CYPs and to solicit CYP …

12.08.2026journal-article

Genetics and Molecular Research

CLINICAL EVALUATION OF PERIOPERATIVE ANALGESIA USING ULTRASOUND-GUIDED FASCIA ILIACA BLOCK WITH LOW-DOSE SPINAL ANAESTHESIA VERSUS CONVENTIONAL SPINAL ANESTHESIA IN GERIATRIC PATIENTS UNDERGOING HIP SURGERY: A PROSPECTIVE COMPARATIVE INTERVENTIONAL S

Sunil J Valand, Arpan Piyushbhai Patel, Manish R Shah

Introduction: Conventional spinal anaesthesia causes hemodynamic instability in up to 33% of elderly patients. Combining ultrasound-guided Fascia Iliaca Compartment Block (FICB) with low-dose spinal anaesthesia may offer superior perioperative analgesia with enhanced cardiovascular stability. Aim: To evaluate the clinical effectiveness of perioperative analgesia using ultrasound-guided FICB combined with low dose spinal anaesthesia versus conventional low-dose spinal anaesthesia alone in geriatric patients undergoi …

12.08.2026journal-article

The Clinical Journal of Pain

The Effect of Behavioural Interventions that Include Goal Setting on Pain, Disability, and Physical Activity in People With Chronic Musculoskeletal Pain

Andrew R. Natoli, Mitchell T. Gibbs, Isha Mishra, Jack Devonshire, Jade O’Brien-Smith, James H. McAuley, Aidan G. Cashin, Matthew D. Jones

Objectives: This systematic review and meta-analysis aimed to assess the effect of behavioural interventions that include goal setting on pain, disability, and physical activity in people with chronic musculoskeletal pain. Methods: Five electronic databases (PubMed, CENTRAL (Cochrane Library), PEDro, PsycINFO, CINAHL) and three clinical trial registers (ClinicalTrials.gov, ANZCTR, ISRCTN) were searched from inception to August 2025 for randomised controlled trials of behavioural interventions with goal setting comp …

12.08.2026journal-article

Frontiers in Aging Neuroscience

Impact of ultrasound-guided nerve block on postoperative delirium in elderly patients undergoing diabetic foot surgery: a propensity score-matched retrospective study

Zhu Wen, JiaLi Zheng, Jing Huang, Juan Li

Background Postoperative delirium (POD) is a common and serious complication in elderly patients undergoing diabetic foot surgery, often linked to excessive opioid use and systemic neuroinflammation. This study aimed to evaluate whether ultrasound-guided nerve block (NB) reduces the incidence of POD compared to general anesthesia (GA) in this high-risk population. Methods We conducted a propensity score-matched (PSM) retrospective cohort study involving 137 patients. The primary outcome was the incidence of POD, wh …

12.08.2026journal-article

Stomatology

Features of the dentoalveolar system in children with premature aging syndromes

A.L. Kungurtseva, Z.V. Sinkina, Yu.V. Tikhonovich, N.A. Sholokhova, A.V. Vitebskaya

Objective. To carry out a comprehensive analysis of dental manifestations and identify the features of the dental system in children with premature aging syndromes. Material and methods. The study included 7 patients with premature aging syndromes: a boy and a girl with Hutchinson—Gilford syndrome, 2 girls with Cockayne syndrome type A and B, one girl each with neonatal progeroid syndrome, Penttinen syndrome and mandibular hypoplasia, deafness, progeroid features and lipodystrophy (MDPL syndrome). During a clinical …

12.08.2026journal-article

Research, Society and Development

Avaliação do comprometimento neuropático em membros inferiores de pessoas com Diabetes mellitus: Estudo transversal

Giovana Rossi Figueirôa, Antônio Gabriel Vigas Marques

Introdução: A neuropatia periférica diabética é uma complicação frequente do diabetes mellitus, associada à perda de sensibilidade, alterações motoras e maior risco de ulcerações e amputações de membros inferiores. Objetivo: Identificar a frequência e analisar a distribuição do comprometimento neuropático em membros inferiores em indivíduos com diabetes mellitus tipo 2 (DM2). Métodos: Estudo observacional transversal e descritivo, realizado com 27 pacientes com DM2, atendidos em um programa de extensão universitári …