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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

International Journal of Molecular Sciences

Metabolic Dysfunction and Related Dietary Exposures in Relation to Pancreatic Cancer Risk: A Review of the Evidence

Junsu Yang, Yicong Huang, Artitaya Lophatananon, Kenneth R. Muir

Pancreatic cancer is a highly lethal malignancy with an increasing global incidence. Although metabolic dysfunction has been implicated in pancreatic cancer risk, the strength and consistency of evidence across different metabolic traits remain uncertain. Evidence for dietary exposures related to metabolic regulation is also less clearly established. This umbrella review synthesised evidence from systematic reviews, meta-analyses, and umbrella reviews evaluating metabolic dysfunction and related dietary exposures i …

28.08.2026journal-article

Cancer Discovery

Deconvolving SARS-CoV-2 mRNA Vaccine Impact on Immunotherapy-Related Survival

Justin Jee, Jiajia Zhang, Jessica A. Lavery, Michele Waters, Christoper J. Fong, Andy J. Minn, Michael S. Glickman, Katherine S. Panageas, Charles L. Sawyers, Nikolaus Schultz

Abstract Real-world data suggest that SARS-CoV-2 mRNA vaccines, administered within 100 days of immune checkpoint inhibitor (ICI) treatment (“peri-ICI vaccination”), may improve ICI effectiveness through synergistic immune priming. In an independent real-world cohort and reanalysis of a published cohort, both from tertiary cancer centers in the United States, multiple analyses did not support a treatment-synergy hypothesis. Applying a prior analytic framework, although longer survival with peri-ICI vaccination was …

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28.08.2026journal-article

United European Gastroenterology Journal

Artificial Intelligence‐Estimated Intrapancreatic Fat and Its Relationship to Familial and Germline Pancreatic Cancer Risk

Tom Konikoff, Laurens P. Janssens, Hiroaki Takahashi, Garima Suman, Fred Nugen, Anup Mishra, Panos Korfiatis, Erin E. Carlson, William R. Bamlet, Aishwarya Pradeep, Kelly Harper, Karen A. Doering, Adriana Delgado, Bradley J. Erickson, Ajit H. Goenka, Naoki Takahashi, Ann L. Oberg, Shounak Majumder

ABSTRACT Background Family history of pancreatic cancer (PC), pathogenic germline variants (PGVs), and increased intrapancreatic fat (IPF) are individually associated with increased PC risk. Whether IPF is elevated in high‐risk individuals (HRIs) with PC family history or PGVs is unknown. Although MRI is the preferred modality for IPF measurement, region‐of‐interest–based approaches are prone to sampling bias because pancreatic fat is heterogeneously distributed. We aimed to compare IPF among HRIs and matched non‐H …

28.08.2026journal-article

Cancer Research

Antibody–Drug Conjugates Synergize with Agonist Anti-CD137 Monoclonal Antibodies in Solid Tumors

Gabriel Gomis, Claudia Herrero, Saioa Arrieta-Aranzueque, Efrén Juarez-Curiel, Yufei Zheng, Raquel Cuesta, Carlos Luri-Rey, Paula Molero-Glez, Arantza Azpilikueta, Elixabet Bolaños, Angie Molina, Inmaculada Rodríguez, Belén Palencia, Álvaro López-Janeiro, Carlos E. de Andrea, José Medina-Echeverz, Álvaro Teijeira, Pedro Berraondo, Ignacio Melero

Abstract Antibody–drug conjugates (ADC) show clinical efficacy against several solid malignancies, inducing cytotoxic effects in malignant cells accompanied by changes in the composition of the tumor stroma. The therapeutic effects of some ADCs have been shown to be potentiated by combination with anti–PD-(L)1 checkpoint inhibitors, highlighting the potential of combining ADCs and immunotherapy. In this study, we investigated the potential of combining ADCs with agonist monoclonal antibodies targeting CD137 (4-1BB) …

28.08.2026journal-article

ACS Omega

Fabrication and Characterization of Green-Synthesized Zinc Oxide Nanoparticles Loaded into Dissolving Microneedles: A Potential Delivery Platform for Breast Cancer Therapy

Haneen Faris Al-Shawabkeh, Rafa Aburayya, Haneen A. Basheer, Ahlam Zaid Alkilani, Maram A. Alhusban, Rania Hamed

Abstract Green-synthesized zinc oxide nanoparticles (ZnO NPs) can be used to explore their anticancer applications. Therefore, this study aimed to synthesize ZnO NPs using an eco-friendly method by combining Phoenix dactylifera (P. dactylifera) root hair extract with 0.8 M zinc acetate dihydrate at a volume ratio of 4:1. The ZnO NPs had an average size of 24.01 ± 1.70 nm, a polydispersity index (PDI) of 0.25 ± 0.02, and a zeta potential of −18.45 ± 1.80 mV. The X-ray diffraction analysis revealed the crystalline st …

28.08.2026journal-article

Clinical and Translational Medicine

Pattools‑implemented methylation vector analysis reveals aberrant subtype‑specific methylation in lung cancer across tissue and plasma cfDNA

Zehua Dong, Yifeng Luo, Tingting Hu, Yihang Cheng, Qiaoling Ren, Li Xu, Yuan Tan, Wei Li, Yaoxiang Sun, Mingzhi Chen, Zhonghua Shen, Bin Zhang, Youhuang Bai, Yue Tao, Zhihong Cao, Deqiang Sun

Abstract Introduction Lung cancer is characterised by high mortality and encompasses various subtypes with markedly different treatment outcomes. While individual subtypes have been studied, comprehensive genome‐wide and fine‐scale DNA methylation analyses across subtypes remain unexplored. This study aims to identify true subtype‐specific aberrant methylation by developing a novel method that eliminates cell‐origin and immune confounding, moving beyond traditional approaches. Methods We assembled an in‐house cohor …

28.08.2026journal-article

Pediatric Emergency Care

The Emergency Medical Treatment and Active Labor Act

Maneesha Sakhuja, Caleb Ward, Vanessa Madrigal, Joseph Shapiro

The Emergency Medical Treatment and Active Labor Act (EMTALA), enacted in 1986, established the legal foundation for access to emergency medical care in the United States. This review examines EMTALA’s historical origins, core requirements, and implications for pediatric emergency practice. The law emerged in response to widespread patient dumping practices in the 1980s, when hospitals routinely transferred or refused care to uninsured patients. In the 4 decades since, amendments and regulatory clarifications have …

28.08.2026journal-article

Frontiers in Oncology

Uncharted phytochemical frontiers: a systematic review of novel bioactive compounds from underexplored aromatic plants for cancer therapy

Biswabhusan Dash, Himadri Tanaya Behera, N.G. Unnoottee, Swagat Mohanty, Divaker Shukla, Sudipta Jena, Asit Ray, Pratap Chandra Panda, Sanghamitra Nayak, Ambika Sahoo

Introduction Cancer continues to cause a high degree of morbidity and mortality worldwide, making it essential for new, safer, and more effective therapies to be developed. Aromatic plants provide researchers with diverse secondary metabolites that may have useful pharmacological effects. This systematic review examines several aromatic plants that were used medicinally in the past but have not been examined recently for their potential to produce new bioactive molecules with anticancer activity. Methods The protoc …

28.08.2026journal-article

ASEAN Journal of Chemical Engineering

Formation of TiO2-Based Nanostructures via Alkaline Hydrothermal Treatment : Effect of Synthesis Parameters

Dessy Ariyanti, Aprilina Purbasari, Farah Marda Yesica Putri, Herma Dina Setiabudi, Wei Gao

Titanium dioxide (TiO2) is broadly applied as both a photocatalyst and an adsorbent for dye degradation. Textile dye wastewater contributes ~100 tons of pollutants annually, causing severe ecological damage even at trace concentrations. Conventional TiO2 photocatalysts suffer from rapid charge carrier recombination, while systematic studies linking hydrothermal synthesis parameters to morphology and controlled adsorbents remain limited. In this research, free-standing TiO2 nanostructures (FSTNS) were synthesized us …

28.08.2026journal-article

Journal of Attention Disorders

What Matters to Caregivers of Youth With ADHD: Defining the Minimum Clinically Important Difference for Sleep Treatment

Alison E. Pritchard, Rebecca Warwick, Allison E. Gornik

Objective: Sleep problems are common among youth with ADHD, and they worsen symptoms as well as day-to-day functioning. As a result, they are of significant concern to caregivers, who are often the ones making treatment decisions. The goal of this study is to understand what caregivers of youth with ADHD and sleep problems want out of treatment. Methods: One hundred caregivers of clinically-referred youth ages 5 to 18 with a diagnosis of ADHD and reported sleep difficulties completed a 29-item survey covering three …

28.08.2026journal-article

Journal of Neurosurgery: Spine

Mortality risk after traumatic fractures in autofused spines from ankylosing spondylitis or DISH: age may matter more than treatment

Abdelrahman M. Hamouda, Zach Pennington, Mohamed M. El-Gohary, Nikita Lakomkin, Seth Ransom, Stanley Dennison, Derrick Obiri-Yeboah, Michael L. Martini, Nicholas Kendall, Orod Gharibi, Virgenal Owens, Michelle J. Clarke, William E. Krauss, Melvin D. Helgeson, Ahmad N. Nassr, Arjun S. Sebastian, Anthony L. Mikula, Jeremy L. Fogelson, Brett A. Freedman, Benjamin D. Elder

OBJECTIVE Multisegmental pathological autofusion is a hallmark feature of ankylosing spondylitis (AS) and diffuse idiopathic skeletal hyperostosis (DISH), creating a rigid, brittle spine highly susceptible to three-column fractures and devastating neurological injury. This study aimed to evaluate survival outcomes in this patient population and identify clinical and demographic predictors of mortality. METHODS Adults with DISH or AS who sustained a fracture and were admitted to a single tertiary care center for spi …

30.08.2026journal-article

Česká gynekologie

Personalized approach to infertility treatment in a patient with polyendocrine metabolic ovarian syndrome and chronic pancreatitis

Soňa Šimová, Lenka Mekiňová, Michal Ješeta, Eva Lousová, Robert Hudeček

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in fertile women, with an estimated prevalence of 10–15%. It is a heterogeneous disease characterized by a complex pathogenesis. Genetic predisposition, neuroendocrine regulation disorders, and environmental influences play a key role. Dysregulation of the hypothalamic–pituitary–ovarian axis occurs with subsequent chronic anovulation, hyperandrogenemia, and metabolic abnormalities. Phenotypic variability reflects different pathophysiological mec …

28.08.2026journal-article

Frontiers in Oncology

Risk factors for postoperative intensive care unit admission after minimally invasive esophagectomy following neoadjuvant chemoimmunotherapy in patients with esophageal squamous cell carcinoma: a retrospective cohort study

Zhen Chen, Zhi-jing Liu, Qiu-xia Liu, Peng-fei Chen, Yu-cai Jiang

Introduction Patients with esophageal squamous cell carcinoma (ESCC) who undergo minimally invasive esophagectomy (MIE) after neoadjuvant chemoimmunotherapy (nCIT) and subsequently require postoperative intensive care unit (ICU) admission may experience a greater economic burden and poorer clinical outcomes. This study aimed to identify perioperative factors independently associated with postoperative ICU admission in patients with ESCC treated with nCIT followed by MIE. Methods We conducted a retrospective cohort …

28.08.2026journal-article

Frontiers in Oncology

Acquired TPM3::NTRK1 fusion as a novel off-target resistance mechanism to selpercatinib in RET-positive lung adenocarcinoma: a case report

Ritwika Choudhury, Mansi Sharma, Abhinav Dewan, Sabeena K. Choudhary, Priyanka Venkatraman, Vivek Subbiah, Ullas Batra

Acquired resistance remains a major challenge in RET fusion-positive non-small cell lung cancer treated with selective RET inhibitors. NTRK fusions represent a rare off-target resistance mechanism in this setting, with limited clinical data to guide management. We report the first case of an acquired TPM3::NTRK1 fusion as a resistance mechanism to selpercatinib in KIF5B::RET-positive lung adenocarcinoma. A male in his late 40s, a non-smoker, underwent surgical resection for NSCLC after incidental detection of a pul …

28.08.2026journal-article

British Journal of Haematology

Functional assessment of inherited myeloid neoplasm‐associated SAMD9L germline variants via Monoallelic CRISPR modelling

Elena Vuelta, Alessandro Liquori, Matias Morín, Lucia Soletto, Miguel Ángel Marugal, Marta Santiago‐Balsera, Miguel Gallardo, Miguel Ángel Moreno‐Pelayo, José Cervera, Alejandra Sanjuan‐Pla

Summary While the majority of myeloid neoplasms are sporadic, the increasing application of germline genetic testing has led the World Health Organization to designate ‘ Myeloid malignancies with germline predisposition’ as a distinct clinical entity, carrying major implications for clinical care and research. Germline variants in the Sterile alpha motif domain‐containing 9‐like ( SAMD9L) gene are specifically associated with an increased risk for these malignancies. In this study, we functionally modelled two nove …

28.08.2026journal-article

Frontiers in Cell and Developmental Biology

Concurrent expression of glucose-6-phosphate dehydrogenase and secreted phosphoprotein 1 characterizes an aggressive and immunosuppressive tumor state in hepatocellular carcinoma

Guangjie Han, Lili Mi, Jianfei Shi, Jinfeng Wang, Fei Yin

Introduction Despite improved outcomes with combined hepatic arterial infusion chemotherapy (HAIC) and systemic therapy in hepatocellular carcinoma (HCC), therapeutic resistance is frequently driven by the tumor microenvironment. We aimed to explore biological features associated with therapeutic resistance in HCC. Methods We integrated single-cell transcriptomics of a therapy-progressive lesion with large-scale bulk transcriptomic modeling and independent clinical validation. We performed immunohistochemistry in a …

28.08.2026journal-article

Clinical Cancer Research

EZH2 Inhibition and Myeloid Risk: A Feature of On-Target Biology

Joshi J. Alumkal, Leigh Ellis

Abstract In March 2026, Ipsen voluntarily withdrew the enhancer of zeste homolog 2 (EZH2) inhibitor tazemetostat (Tazverik) from all markets and indications following results from the confirmatory phase Ib/III SYMPHONY-1 trial demonstrating hematologic second primary malignancies (SPM) in 5.7% of treated patients, compared with none in the control arm. The most frequently reported SPMs were myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Although this finding may be interpreted as an idiosyncratic …

28.08.2026journal-article

Pakistan Journal of Pharmaceutical Sciences

Albiflorin suppresses breast cancer via the HINT2/NLRP3 signaling pathway

Yunpeng Hu

Abstract: Background: Breast cancer (BC) remains a significant global health threat with complex pathogenesis often linked to chemotherapy resistance and inflammatory microenvironments. Histidine triad nucleotide-binding protein 2 (HINT2) is a mitochondrial protein involved in metabolism and immunity, but its specific role in BC and potential as a therapeutic target require further elucidation. Objectives: This study aimed to identify novel therapeutic targets for BC and evaluate the anti-tumor efficacy and molecul …

28.08.2026journal-article

American Journal of Epidemiology

Structural Limitations of Early–Late Treatment Comparisons Under Target Trial Emulation: A Simulation Study

Atsushi Takayama, Shiro Tanaka, Koji Kawakami

Abstract Early versus Late (E–L) treatment initiation comparisons, which are prone to immortal time bias, are widely considered amenable to causal inference through target trial emulation (TTE) using clone–censor–weighting (CCW). However, whether standard CCW yields a well-defined causal estimand for the E–L comparison under ideal implementation conditions has not been formally examined. We conducted a structural simulation study to evaluate CCW-based TTE for E–L comparisons. The design varied along three dimension …

28.08.2026journal-article

The Journal of International Advanced Otology

Efficacy of Treatment with Platelet-Rich Concentrate on Temporalis Fascia Myringoplasty for Managing Tympanic Membrane Perforation Due to Chronic Otitis Media: A Systemic Review and Meta-analysis

Do Hyun Kim, David W. Jang, Se Hwan Hwang

This meta-analysis assessed the efficacy of temporalis fascia myringoplasty (TFM) combined with platelet-rich concentrate (PRC) on tympanic membrane (TM) healing in TM perforation due to chronic otitis media (COM), compared to TFM alone. A comprehensive search was conducted across PubMed, SCOPUS, EMBASE, Web of Science, and the Cochrane Library. The intervention group underwent TFM with the addition of PRC, while the control group received TFM alone. Key outcomes measured included the success rate (complete TM heal …

28.08.2026journal-article

MedComm

SPR‐UPLC‐QTOF/MS‐GNPS‐Guided Discovery of Hypermonol J as a Novel Tumor Necrosis Factor‐Binding Small‐Molecule Lead for Inflammatory Storm Intervention

Yongqi Li, Weiguang Sun, Xingpiao Jin, Lanqin Li, Xiaotian Zhang, Pingping Fan, Yahui Huang, Chaohu Xiong, Jinsheng Wang, Jiangchun Wei, Yonghui Zhang, Zhengxi Hu

ABSTRACT This study developed an integrated strategy combining surface plasmon resonance (SPR) for real‐time biomolecular interaction analysis, ultra‐performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry (UPLC‐QTOF/MS) for compound profiling, and Global Natural Products Social Molecular Networking (GNPS)‐based molecular networking for structural annotation in complex herbal systems. Using this platform, we identified hypermonol J (HPJ), a polycyclic polyprenylated acylphlorogluc …

28.08.2026journal-article

Processes

Integrated MF–UF Treatment of Poultry Pre-Chiller Wastewater: Pollutant Removal, Fouling Behavior and Hydraulic Resistance Analysis

Itiana Lauer, Lucas do Nascimento, Gabriela Bruel, Bianca Oldoni, Rúbia Mores, Clarice Steffens, Rogério Dallago, Juliana Steffens

Poultry pre-chiller wastewater contains high concentrations of organic matter, suspended solids, proteins, and lipids that promote severe membrane fouling. This study investigated fouling development in an integrated microfiltration–ultrafiltration (MF–UF) system treating poultry pre-chiller wastewater, focusing on hydraulic performance, resistance evolution, fouling mechanisms, and membrane surface characterization. This study provides an integrated assessment of treatment performance and fouling mechanisms in a s …

28.08.2026journal-article

Journal of Plant Protection Research

Seed treatment strategies combining Bacillus amyloliquefaciens and insecticides for management of the emerging soil pest Scutigerella immaculata in soybean

Adilson Moraes Santos, João Batista Coelho Sobrinho, Yamile Salvatierra Nuñez, Luciana Barboza Silva, Matheus Henrique dos Santos Oliveira, Allison Samara Zabala Ramos, Lucas Adjuto Ulhoa, Jardel Lopes Pereira, Luiz Leonardo Ferreira, Alexandre Igor Azevedo Pereira

Scutigerella immaculata (Symphyla: Scutigerellidae) causes increasing problems in soybean-producing areas of Brazil, particularly in MATOPIBAPA, one of the country’s most recent agricultural frontiers. This study evaluated soybean seed treatments for the control of S. immaculata, using Bacillus amyloliquefaciens applied alone or combined with chemical insecticides, and assessed pest sampling methods and soybean responses to these treatments. Soybean seeds were treated on the day of planting in the municipality of A …