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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Frontiers in Medicine

Early detection of microcirculatory changes using simultaneous heated and unheated transcutaneous blood gas monitoring: a proof-of-concept study in a porcine lipopolysaccharide model of systemic inflammation

Maud A. Hoofs, Louwrina H. te Nijenhuis, Norani H. Gangaram-Panday, Patricia A. C. Specht, Egbert G. Mik, Floor A. Harms, Irwin K. M. Reiss, Willem van Weteringen

Introduction Early detection of microcirculatory failure in septic patients has the potential to improve clinical outcomes. The microcirculation regulates the oxygen (O 2 ) supply and carbon dioxide (CO 2 ) washout in tissues and changes early during severe inflammation and sepsis. Transcutaneous blood gas sensors measure tissue O 2 and CO 2 levels at the skin surface, or when warmed use the vasodilatory response to approximate arterial levels. In addition to differences in measured O 2 and CO 2 values, systemic in …

01.09.2026journal-article

Advances in Autism

Effectiveness of mentalisation-based treatment for improving social cognition and emotional regulation in adults with borderline personality disorder or autism spectrum disorder: a systematic review

Sofía Fernández Medina, Janay Vidal Gutierrez, Andrea Duarte Díaz

Purpose This study aims to evaluate the effectiveness of mentalisation-based treatment (MBT) for emotional regulation and social cognition in adults with borderline personality disorder (BPD), and to determine the extent and quality of the available evidence on MBT in adults with autism spectrum disorder (ASD), characterising the imbalance in the evidence between these two diagnostic groups. Design/methodology/approach A systematic review was conducted in accordance with Preferred Reporting Items for Systematic Rev …

01.09.2026journal-article

Journal of Medical Internet Research

Partially Virtual vs In-Person Care in Cardiovascular Conditions—Time Trends, Patient Characteristics, and Medication Management: Cohort Study

Sebastian Kinnberg Nielsen, Alessandra Meddis, Paul Frédéric Blanche, Mads Hashiba, Morten Schou, Ulrik Bak Kirk, Lars Kayser, Christian Torp-Pedersen, Nina Nouhravesh, Signe Stelling Risom, Anders Holt, Morten Kjøbek Lamberts

Abstract Background Despite growing initiatives to promote partially virtual care, there is still a lack of comprehensive data describing its use, patient characteristics, and medication management practices. Objective This study aimed to examine the use of partially virtual care in the management of cardiovascular disease. Methods We used nationwide Danish registries to identify all patients with a first-time diagnosis of atrial fibrillation (AF), heart failure (HF), pulmonary embolism (PE), or acute coronary synd …

01.09.2026journal-article

Journal of Comparative Effectiveness Research

Methodological pitfalls in indirect treatment comparisons: insights from a recent systematic review and analysis for C3 glomerulopathy

Brian Hutton, James Fotheringham, Andrew Ervin, Raisa Sidhu, Corey Lourenco, Imtiaz A Samjoo, Chris Cameron, Bridget Dunne

Aim: Indirect treatment comparisons (ITCs), as outlined in NICE and ISPOR guidance, require careful evaluation of cross-trial heterogeneity to ensure valid comparisons, particularly in rare diseases with limited evidence. C3 glomerulopathy (C3G) is an ultra-rare, complement-mediated kidney disease with high unmet need, making appropriate application of ITC frameworks especially critical. This appraisal evaluates the feasibility of applying ITC principles to compare Phase III trials of iptacopan (APPEAR-C3G) and peg …

01.09.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

TRATAMENTO FARMACOLÓGICO DE ARRITMIAS CARDÍACAS COM O USO DA DIGOXINA

Analluyza Nunes Coelho Inocêncio, Ana Beatriz Dantas das Mercês

A pesquisa tem como objetivo relacionar dados científicos sobre o efeito farmacológico da digoxina no tratamento das arritmias cardíacas, abordando vias de administração, efeitos terapêuticos, colaterais e impactos na qualidade de vida. Trata-se de uma revisão integrativa da literatura realizada em seis etapas, com busca na Biblioteca Virtual em Saúde (BVS), abrangendo as bases LILACS, MEDLINE e BDENF. Utilizou-se a estratégia PICo para formular a pergunta norteadora. O recorte temporal compreendeu artigos publicad …

01.09.2026journal-article

Clinical Case Reports

Squamous Cell Carcinoma Arising in a Mature Cystic Teratoma of the Ovary Presenting With a Ruptured Sister Mary Joseph Nodule: A Rare Case Report From Northern Tanzania

John Lugata, Caleigh Smith, Onesmo Mrosso, Jaynes Kabuhaya, Lily Severn, Krizia Nsoh Nji, Tecla Lyamuya, Elizabeth Skinner, Gilbert Nkya, Eusebious Maro, Alex Mremi, Bariki Mchome

ABSTRACT Squamous cell carcinoma arising from malignant transformation of a mature cystic teratoma is an exceptionally rare ovarian malignancy, and metastatic umbilical involvement is particularly uncommon. Diagnosis and treatment planning are challenging due to overlapping presentation with epithelial ovarian cancer, particularly in settings with limited access to ancillary pathology, molecular testing, and specialist oncology services. We report a 54‐year‐old postmenopausal woman from northern Tanzania who presen …

01.09.2026journal-article

INTERNATIONAL JOURNAL OF COMPUTERS COMMUNICATIONS & CONTROL

Scalable Distributed Deep Learning for Lung Disease Diagnosis: A Spark–Elephas Cross-Modality Framework with GPU Cluster Scalability Analysis

Zeineb Ben Messaoud, Maher Baccar, Heni Bouhamed, Monia Hamdi

The rapid growth of large-scale medical imaging datasets has exposed critical limitations of single-node deep learning workflows for clinical decision support in lung disease diagnosis. We present a unified, Spark-based distributed framework for scalable multi-class lung disease classification from both chest X-ray (CXR) and computed tomography (CT) images. Our approach integrates Apache Spark with Elephas to enable synchronous and asynchronous data-parallel training of Keras models via a parameter-server architect …

01.09.2026journal-article

Journal of Clinical Investigation

CD8⁺ Regulatory T Cells Shorten Neutrophil Lifespan to Reduce Hemorrhagic Transformation After Ischemic Stroke

Jianan Lu, Qia Zhang, Jiarui Chen, Huaming Li, An Ping, Ziyang Jin, Xiaotao Zhang, Yichen Gu, Xuejiao Dai, Zihong Chen, Yajun Qian, Guoqiang Zhang, Jun Yu, Jianmin Zhang, Ligen Shi

The neutrophil-to-lymphocyte ratio (NLR) is associated with unfavorable prognosis and hemorrhagic transformation (HT) in patients with ischemic stroke, yet the underlying mechanisms remain unclear. Using patient samples and a murine stroke model, we identified CD8⁺ regulatory T cells (CD8 Tregs) key regulators of neutrophil homeostasis after ischemic stroke, thereby limiting endothelial disruption and HT. Loss of CD8 Tregs expanded circulating neutrophils by extending their lifespan rather than altering proliferati …

01.09.2026journal-article

Journal of Pharmacy and Pharmacology

Research progress in traditional Chinese medicine for lymphoma: multi-pathway and multi-drug combination approaches

Yanfang Wu, Lei Zhong, Qiaoliang Wu, Liying Han, Dafei Fang

Abstract Objectives Lymphoma is a prevalent hematologic malignancy with complex pathogenesis involving dysregulated signaling pathways and high treatment resistance. Traditional Chinese medicine (TCM), with its multi-component and multi-target characteristics, has shown unique value in lymphoma treatment. This review systematically summarizes the latest progress in TCM-based lymphoma therapy, focusing on its anti-cancer mechanisms and clinical application prospects. Methods A comprehensive literature search was con …

01.09.2026journal-article

Life

Clinical Performance Evaluation of Demographic-Based Liver Volumetry

Yasaman Anbari, Benjamin P. Lopez, Armeen Mahvash, Ali Yousefi, Srinivas C. Kappadath

Patient demographic-based standard liver volume (SLV) models are widely used to estimate patient-specific hepatic metabolic demand and support future liver remnant assessment after hepatectomy. These formulae rely on anthropometric variables such as weight, height, and body surface area; however, their accuracy for individual patients remains uncertain. In an exploratory single-center study, we evaluated ten published SLV formulae and one in-house multivariable regression model against CT-derived liver volumes as t …

01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Cultivating Emotional Intelligence among Indian Medical Students: Perceptions and Experiences

Rutam B Vaishnav, Darshankumar Dharaiya, Alvis Keisham, Anusha Prabhakaran, Jagdish Varma

Introduction: Emotional Intelligence (EI) is a critical attribute for medical professionals, encompassing self-awareness, selfregulation, motivation, empathy, and social skills. Indian medical students face exceptional stress due to intense academic competition, hierarchical structures, and limited mental health resources. Although structured EI interventions have demonstrated promise internationally in reducing burnout and improving clinical performance, systematic EI training remains largely absent from Indian me …

01.09.2026journal-article

Journal of Korean Medicine

Effect of Herbal Medicine, Acupuncture and Moxibustion for Obese Polycystic Ovary Syndrome Patients with Infertility: A Systematic Review and Meta-analysis

Yu-Jin Kim, Ji-Yeon Lee

Objectives: This study aimed to evaluate the efficacy and safety of herbal medicine, acupuncture, and moxibustion for infertile women with obesity-associated polycystic ovary syndrome through a systematic review and meta-analysis.Methods: Studies were retrieved from PubMed, CENTRAL, EMBASE, CNKI, OASIS and KISS. RCTs evaluating herbal medicine, acupuncture and moxibustion for obese PCOS patients with infertility were included in the systematic review and meta-analysis. The Revised Cochrane risk-of-bias tool for ran …

04.09.2026journal-article

Pediatrics Open Science

Clinical and Demographic Characteristics of Pediatric Lichen Sclerosus: A Retrospective Study

Sydney Kenney, Emily Whitcomb, Ki-Young Yoo, Qiaowu Li

OBJECTIVE Pediatric vulvar lichen sclerosus (VLS) is an inflammatory dermatosis that often presents with pruritus, dysuria, and constipation and can lead to long-term sequelae including scarring. Epidemiologic and clinical data in diverse US pediatric populations are limited. We aimed to characterize demographic and clinical features of pediatric VLS in a large health maintenance organization. METHODS Retrospective cohort study of female patients aged 0 to 18 years diagnosed with VLS in Kaiser Permanente Southern C …

04.09.2026journal-article

Molecular Genetics & Genomic Medicine

Genomic Profiling of Anophthalmia/Microphthalmia‐Associated CNVs Reveals Complex Genotype–Phenotype Correlations and Incomplete Penetrance

Dong Wu, Mengting Zhang, Qian Zhang, Fengyang Wang, Qiaofang Hou, Hongyan Liu, Shixiu Liao, Hai Xiao

ABSTRACT Background Anophthalmia/microphthalmia (A/M) is a severe congenital ocular malformation characterized by the complete absence or small size of the eye bulb. Interpreting copy number variations (CNVs) in A/M is challenged by variable genotype–phenotype correlations and reduced penetrance. This study investigated the genetic etiology of A/M‐associated CNVs. Methods Genomic profiling was performed on four unrelated families presenting with ocular anomalies or harboring A/M‐susceptible CNVs. Variants were eval …

01.09.2026journal-article

Sage Open Medicine

Timing of lactated Ringer’s administration relative to Sepsis-3 diagnosis and 28-day mortality: A retrospective propensity score-matched cohort study

Yujie Huang, Jiayue Zou

Background Balanced crystalloids are preferentially recommended over saline for sepsis resuscitation; however, the optimal timing of administration remains to be defined. Methods This retrospective cohort study utilized the Medical Information Mart for Intensive Care IV (MIMIC-IV) database to analyze adult patients meeting Sepsis-3 criteria. Patients were stratified by Lactated Ringer’s (LR) administration timing relative to documented Sepsis-3 onset: Group A (LR initiation ≤24 h after onset), Group B (LR initiatio …

04.09.2026journal-article

Clinical Case Reports

Transition From Pulmonary to Gastrointestinal Hemorrhage: A Rare Case of Hematemesis in an Adolescent With Chronic Pulmonary Hypertension and Valvular Regurgitation

Bilal Ashraf, Muhammad Ubaid Hussain, Abdal Zahid, Fatima Sohail, Shan e Ali Shoukat, Modibo Yattassaye, Noreen Ashraf

ABSTRACT Pulmonary hypertension is a chronic cardiopulmonary disease with increased pulmonary arterial pressure and right‐sided heart overload, and early symptoms often include dyspnea with hemoptysis. Hematemesis, as the presentation of gastrointestinal bleeding, is a remarkably unusual, underappreciated form of the disease, especially in children, along with valvular heart disease. We present a 15‐year‐old boy with preexisting chronic pulmonary hypertension and a history of pulmonary/aortic valvular regurgitation …

01.09.2026journal-article

Journal of Clinical Sport Psychology

Longitudinal Associations Between Sleep and Needs Satisfaction on Mental Health Outcomes in Athletes

Stephen Shannon, Christopher Knowles, Noel Brick, Gavin Breslin

Introduction : Sleep problems are linked to the occurrence and exacerbation of mental ill-being. Yet, scant research has been conducted in athletes and is hindered by a lack of theoretical grounding and mainly cross-sectional study designs. Method : Underpinned by self-determination theory, the present study incorporated a two-wave longitudinal design across a competitive sporting season. Three statistical models tested cross-lagged associations between needs satisfaction and sleep across adjacent time points, alon …

01.09.2026journal-article

JAIDS Journal of Acquired Immune Deficiency Syndromes

Hepatitis B and C Prevention, Screening, and Diagnostic Services at HIV Treatment Sites: International Epidemiology Databases to Evaluate AIDS

Mark H. Kuniholm, Gad Murenzi, Niharika Samala, Evy Yunihastuti, Gilles Wandeler, H. Nina Kim, Marie K. Plaisy, Hugo Perazzo, Christella Twizere, Francesca Odhiambo, Rohan Bopage, Guy Muula, Vincent Lo Re, Albert Minga, Alvaro López-Iñiguez, Dominique M. Nsonde, Charles Kasozi, Dewi K. Wati, Matthew P. Fox, Gregory D. Kirk, Eugene Messou, Carina Cesar, Peter V. Ebasone, Helen Byakwaga, Jeremy Ross, Cleophas Chimbetete, George A. Yendewa, Antoine Jaquet, Regina C. M. Succi, Fernanda Maruri, Ellen Brazier, on behalf of IeDEA

Background: Prevention, screening, and diagnostic services for hepatitis B virus (HBV) and hepatitis C virus (HCV) can prevent morbidity and mortality in people receiving HIV care. However, there is limited information about the availability of HBV and HCV services at HIV clinics globally. Methods: The International epidemiology Databases to Evaluate AIDS (IeDEA) conducted surveys of service delivery and practices at participating HIV treatment centers from 7 regions. We used 2023 survey data to measure availabilit …

01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Gastric Adenocarcinoma and Thyroid Follicular Adenoma with Oncocytic Features: A Rare Synchronous Presentation Managed with Single-stage Surgery

Anjana Naga Jampala, Suganya Palanivel, Rajendran Shanmugasundaram

Synchronous tumours involving anatomically and histologically distinct organs are uncommon and present considerable diagnostic and therapeutic challenges. The co-existence of gastric adenocarcinoma and a thyroid neoplasm is particularly rare. A 74-yearold male presented with vomiting, progressive abdominal fullness, anorexia, and significant unintentional weight loss. Upper gastrointestinal endoscopy revealed partial gastric outlet obstruction with a suspicious pyloric lesion. Contrast-Enhanced Computed Tomography …

01.09.2026journal-article

Journal of the American Veterinary Medical Association

Historical perspectives guide advances in equine minimally invasive soft tissue surgery

Meagan Rockow, Anna Gongaware, Dean Hendrickson, Jeremiah Easley, Lauren Luedke, Lynn Pezzanite

Abstract Equine minimally invasive soft tissue surgical techniques have increased in demand and frequency with concurrent expansion of training programs under the oversight of the American College of Veterinary Surgeons. Benefits of recent advances in laparoscopic techniques include reduced cost and risk associated with general anesthesia and anesthetic recovery, improved visualization of the surgical field relative to open procedures, and more rapid return to performance, further improving patient welfare and limi …

01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Comparative Evaluation of the Disinfection Efficacy of Herbal Formulation, 2% Glutaraldehyde, and Electrolysed Oxidising Water on Clinically Derived Polyvinyl Siloxane Impressions: An In-vivo Experimental Study

Abhishek Torane, Saee Deshpande, Neelam Pande, Srushti Ghagas, Dheeraj Bhoyar, Shubham Bhavane

Introduction: Dental impressions are frequently contaminated with saliva, blood and microorganisms, posing a risk of crossinfection. Polyvinyl Siloxane (PVS) impressions require effective disinfection without compromising material properties. Although glutaraldehyde is widely used, concerns regarding toxicity and environmental impact have encouraged the exploration of safer alternatives such as Electrolysed Oxidising Water (EOW) and herbal formulations. However, limited comparative evidence exists regarding their a …

01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Management of Complex Zygomaticomaxillary Fracture with Frontal and Orbital Wall Involvement Associated with a Crushed Globe: A Case Report

Krishna Balaji Pampatwar, Bhushan Mundada, Nitin Bhola

Zygomaticomaxillary Complex (ZMC) fractures are among the most common midfacial injuries and are frequently caused by highvelocity trauma, particularly road traffic accidents. These fractures frequently affect nearby structures including the orbit, maxilla, and frontal bone, leading to serious problems with function, appearance, and vision. To restore orbital integrity, facial symmetry, and functional outcomes, prompt diagnosis and appropriate surgical intervention are essential. A 17-year-old male presented with s …

01.09.2026journal-article

Medicine & Science in Sports & Exercise

Why Is the Vertical-Kilometer of Fully (Switzerland) So Fast? Physiological and Mechanical Benefits of Stair Ascent on Extreme Uphill Slopes

Louis Finiel, Valentin Luc, Tristan Cardillo, Davide Malatesta, Fabio Borrani

Purpose: The world's fastest vertical kilometer course in Fully (Switzerland) is comprised of stairs at a very steep grade (~31°). The aim was to determine whether stair ascent, with and without poles, lowered physiological, mechanical, and neuromuscular demands compared with continuous uphill ramp locomotion at VK-relevant slopes. Methods: Twenty-two endurance-trained participants completed randomized treadmill trials at a constant vertical speed (800 m·h−1) in three conditions: uphill ramp (R), stairs (S), and st …

01.09.2026journal-article

Annals of Surgery

Xenotransplantation

Léo Bühler, Xiaowei Hu, Kefeng Dou, Shaoping Deng, Antonio Pinna, Pierre-Alain Clavien

Objective: To review the current state of liver xenotransplantation and evaluate emerging strategies using genetically modified porcine organs for the management of acute liver failure. Background: The shortage of donor organs continues to limit transplantation, with substantial waitlist mortality, especially in acute liver failure. Progress in the last decades has been driven by advances in gene editing and immunomodulation, allowing for clinical solid-organ xenotransplantation trials since 2021, with early kidney …