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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Cancer Medicine

Prognostic Value of Hemoglobin, Albumin, Lymphocyte, and Platelet Score in Locally Advanced Nasopharyngeal Carcinoma

JunMei Song, Lan Luo, Ting Liu, YuQing Lv, Qiulin Huang, Rensheng Wang, Jun Bie

ABSTRACT Objective To investigate the prognostic value of the hemoglobin, albumin, lymphocyte, and platelet (HALP) score in patients with locally advanced nasopharyngeal carcinoma (LANPC) receiving concurrent chemoradiotherapy (CCRT), and to clarify its predictive significance for overall survival (OS), progression‐free survival (PFS), locoregional failure‐free survival (LRFFS), and distant metastasis‐free survival (DMFS). Methods Clinical data of 295 patients with LANPC who received CCRT between April 2021 and Apr …

02.09.2026journal-article

BMJ Open

Exploring primary care providers’ perspectives on clinical decision support for venous thromboembolism diagnosis: a qualitative study

Veysel Karani Baris, Alexandra Frost, Michael Sainlaire, Jin Chen, Minakshi Shukla, Md Shifatul Apurba, Ann Hurley, Patricia C Dykes

Objectives Diagnosing venous thromboembolism (VTE) in primary care is challenging due to non-specific symptoms and competing clinical demands. Although clinical decision support (CDS) tools are often proposed to improve diagnostic accuracy, their adoption remains inconsistent. This study aims to explore primary care providers’ (PCPs’) perspectives on diagnosing VTE and identify factors influencing the design, implementation and potential use of a VTE-specific CDS system in primary care. Design Qualitative interview …

01.09.2026journal-article

ASEAN Journal of Rehabilitation Medicine

Improvements in Six-Minute Walk Distance and Functional Status following Phase II Cardiac Rehabilitation

Panida Poolpipat, Rachawan Suksathien

Objectives: To evaluate changes in 6-minute walk distance (6MWD) and New York Heart Association (NYHA) functional class (FC) among patients participating in an outpatient phase II cardiac rehabilitation (CR) program Study design: Retrospective analytic study Setting: Maharat Nakhon Ratchasima Hospital, a tertiary care hospital in Thailand Participants: A total of 112 patients enrolled in the CR program between January 2022 and September 2024 and who had at least two 6MWD results available were included. Patients wi …

01.09.2026journal-article

Journal of Neurosurgery

Probabilistic tractography of the optic radiation to improve prediction of visual outcomes following temporal lobe epilepsy surgery: an international multicenter study

Samuel Wreghitt, Jian Chen, Alexandra Roche, Timothy Williamson, Philip Pruckner, Kurt Schilling, Andrew Neal, Joshua Laing, Terence J. O’Brien, Dario J. Englot, Victoria L. Morgan, Matthew J. Gutman, Joseph Yuan-Mou Yang

OBJECTIVE Postoperative visual field deficits (VFDs) following anterior temporal epilepsy surgery often result from Meyer’s loop (ML) injury. Optic radiation (OR) tractography aids surgical planning, but accuracy varies by method. Deterministic diffusion tensor imaging (Det-DTI) tractography underrepresents fiber complexity, whereas constrained spherical deconvolution with probabilistic tracking (Prob-CSD) resolves crossing fibers and improves anatomical fidelity. The aim of this study was to compare Det-DTI and Pr …

03.09.2026journal-article

Journal of Orthopaedic Surgery

The clinical, functional and oncological outcomes of patients with giant cell tumour of bone. A long-term review

Kye Sheng Yeo, Vivek Ajit Singh, Rupini Devi Santharalinggam, Nor Faissal Yasin

Introduction Giant cell tumour of bone is a benign but locally aggressive condition associated with a risk of recurrence and functional impairment. This study aimed to evaluate the clinical presentation, functional outcomes, and oncological outcomes of patients with giant cell tumour of bone treated at a tertiary orthopaedic oncology centre, with particular emphasis on local recurrence, pulmonary metastasis, surgical management, and survival. Methods A single-centre retrospective cohort study was conducted involvin …

04.09.2026journal-article

Orthopaedic Journal of Sports Medicine

Epidemiology, Mechanisms, and Treatments of Musculoskeletal Injuries in Beach Volleyball

Rishi Trikha, Luis Ornelas, Christian L. Blough, Mia McCarthy, Orr Limpisvasti, Michael B. Banffy

Background: Beach volleyball is a globally popular sport that places unique biomechanical and tactical demands on athletes. Although there is some literature on the epidemiology of indoor volleyball injuries, the injury patterns associated with beach volleyball remain comparatively understudied. Purpose/Hypothesis: The purpose of this study was to characterize the epidemiology, mechanisms, and treatment of musculoskeletal injuries sustained by beach volleyball athletes. The authors hypothesized that knee and should …

01.09.2026journal-article

JAIDS Journal of Acquired Immune Deficiency Syndromes

Brief Report: Sustainability of the Effects of Linkage Case Management on Posthospitalization HIV Outcomes: The Daraja Randomized Clinical Trial

Megan Willkens, Benson Issarow, Godfrey A. Kisigo, Severin Kabakama, Elialilia Okello, Thomas Rutachunzibwa, Derick Deogratias, Daniel W. Fitzgerald, Philip Ayieko, Myung Hee Lee, Lisa R. Metsch, Sean M. Murphy, Saidi Kapiga, Robert N. Peck

Introduction: In this prespecified analysis of a clinical trial to assess the effect of linkage case management on posthospital outcomes in people with HIV, we sought to evaluate the sustainability of the intervention effects from 12 to 24 months. Methods: Participants in the Daraja trial were followed 12 months beyond the primary end point of 12 months to assess the sustainability of HIV outcomes 24 months after hospital discharge. Study outcomes were continuity in HIV care, persistent ART adherence, and sustained …

01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Effectiveness of a Nutrition Promotion Intervention on Glycaemic Control among Patients with Type 2 Diabetes Mellitus: A Quasi-experimental Study

A Farida Fahhima, I Praveen Kumar, B Nisha

Introduction: Type 2 Diabetes Mellitus (T2DM) is one of the global health concerns that needs effective management of blood glucose levels to avoid the complications. Nutritional interventions for the control of diabetes mellitus have been promising, yet studies assessing their effectiveness are few. Aim: To assess the effectiveness of nutrition promotion intervention in controlling blood glucose levels in T2DM patients Materials and Methods: The present quasi-experimental study was conducted from November 2025 to …

01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Aetiological Classification of Abnormal Uterine Bleeding using the FIGO PALMCOEIN System: A Retrospective Observational Study

Naga Seshu Dasari, Rishitha Devarakonda, Sivani Medidhi, Pavan Kumar Yanamadala, Shaik Jaheda Begum, Swarupa Rani Karumuri, Rama Rao Nadendla

Introduction: Abnormal Uterine Bleeding (AUB) has a profound impact on the reproductive health and overall quality of life of women. Although many causes have been identified, the role of regional, sociodemographic, and clinical factors is still not thoroughly examined in India. Aim: To assess the aetiological classification of AUB by employing the FIGO PALM-COEIN system. Materials and Methods: The present retrospective observational study investigated 384 cases of AUB at the Department of Obstetrics and Gynaecolog …

01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Efficacy of Salmusta Yoga versus Tablet Metformin in Type 2 Diabetes Mellitus (Madhumeha): A Research Protocol for Randomised Controlled Trial

Diksha J Gaikwad, Sadhana Misar Wajpeyi, EAA Gamulea Andrei Florin

Introduction: Diabetes mellitus is a metabolic disorder that can be correlated with Madhumeha, a type of Prameha in Ayurveda. This is a Santarpanajanya Vyadhi (Diseases caused by overnutrition), caused by Medo Dushti (disruption in fat metabolism) affecting Medovaha Strotas. Salmusta yoga, containing Sal (Shorea robusta), Musta (Cyperus rotundus), and Kampillaka (Mallotus philippensis) in Yogratnakar for the management of Prameha (Diabetes mellitus). Need of the study: Type 2 Diabetes Mellitus (T2DM) is a rapidly i …

01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

ACL Reconstruction with Enhanced Physiotherapy Interventions and Early Rehabilitation: A Narrative Review

Faiyazuddeen Kuthbudeen, Muthukumaran Jothilingam

Anterior Cruciate Ligament Reconstruction (ACLR) is a common surgical knee procedure that requires intensive postoperative rehabilitation by the patient. Although ACLR restores the knee’s mechanical stability, patients often experience postoperative limitations. This study aimed to examine the supplementary physiotherapy interventions incorporated into standard rehabilitation programs that enhance early-stage ACLR rehabilitation. In October 2025, a literature review was performed utilising electronic databases. The …

01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Extreme Hyperferritinaemia in Adult-onset Still’s Disease Mimicking Infection and Malignancy: A Case Report

Ankit Notwani, Ramachandran Viswanathan, Kishore Hemanth Kumar

Adult-Onset Still’s Disease (AOSD) is a rare systemic inflammatory disorder characterised by quotidian fever, evanescent rash, and inflammatory arthralgia. It often presents as a diagnosis of exclusion due to its clinical heterogeneity and lack of specific diagnostic markers, particularly in patients presenting with Fever of Unknown Origin (FUO). Hyperferritinaemia is a well-recognised laboratory feature, with markedly elevated levels reflecting severe systemic inflammation. However, extreme hyperferritinaemia is n …

01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Post-COVID-19 Three-year Trends of Clinical Profile and Outcome of Infants (1-12 months) Hospitalised at the Paediatric Department of a Tertiary Care Teaching Hospital of Gujarat, Western India: A Retrospective Study

Prapti R Chaudhari, Nirali M Sheth, Dipkala Jayswal, Rahul Tandon, Saumya K Shah, Krutika Rahul Tandon

Introduction: The post-neonatal period (1-12 months) also represents a critical vulnerability window in child health. Despite substantial global progress in reducing under-five mortality, infant hospitalisations beyond the neonatal period continue to pose considerable challenges, particularly in developing countries where 10-15% of hospitalised infants succumb to preventable conditions. Understanding the clinical profile, temporal trends, and outcomes of hospitalised infants is essential for both, clinicians as wel …

01.09.2026journal-article

The Bone & Joint Journal

Total ankle arthroplasty via lateral transfibular approach with and without concomitant subtalar arthrodesis

Serban A. Constantinescu, Agustin Barbero, Carla Carfi, Nicholas Crippa Orlandi, Chiara Bonzano, Cristian Indino, Camilla Maccario, Federico G. Usuelli

Aims Concomitant subtalar pathology may require arthrodesis at the time of total ankle arthoplasty (TAA), yet direct comparisons of isolated TAA versus TAA + subtalar joint arthrodesis (STJA) via a lateral transfibular approach, using the same implant, remain limited. We compared ≥ five-year radiological, functional, and range of motion (ROM) outcomes. Methods This retrospective single-centre cohort included 119 patients from January 2015 to December 2020 with ≥ five-year follow-up: 50 underwent TAA with concomitan …

01.09.2026journal-article

Archives of Hand and Microsurgery

Dual-linking free-flap reconstruction for above-knee amputation stump coverage in an older patient: a case report

Chang Hoon Jeong, Jeonghee Kim, Hyeokjae Kwon, Sunje Kim, Seung Han Song, Sang-Ha Oh, Yooseok Ha

Durable soft tissue coverage is essential for prosthetic rehabilitation after major lower-limb amputation. We report circumferential above-knee amputation (AKA) stump reconstruction using dual-linking free flaps in an 86-year-old man with bilateral lower-extremity crush injuries. The right AKA stump developed circumferential soft tissue loss with near-total femoral exposure. After debridement, reconstruction was performed using a muscle-sparing latissimus dorsi (msLD) flap and an anterolateral thigh (ALT) flap. The …

01.09.2026journal-article

Journal of Pharmacy and Pharmacology

Research progress in traditional Chinese medicine for lymphoma: multi-pathway and multi-drug combination approaches

Yanfang Wu, Lei Zhong, Qiaoliang Wu, Liying Han, Dafei Fang

Abstract Objectives Lymphoma is a prevalent hematologic malignancy with complex pathogenesis involving dysregulated signaling pathways and high treatment resistance. Traditional Chinese medicine (TCM), with its multi-component and multi-target characteristics, has shown unique value in lymphoma treatment. This review systematically summarizes the latest progress in TCM-based lymphoma therapy, focusing on its anti-cancer mechanisms and clinical application prospects. Methods A comprehensive literature search was con …

01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Cultivating Emotional Intelligence among Indian Medical Students: Perceptions and Experiences

Rutam B Vaishnav, Darshankumar Dharaiya, Alvis Keisham, Anusha Prabhakaran, Jagdish Varma

Introduction: Emotional Intelligence (EI) is a critical attribute for medical professionals, encompassing self-awareness, selfregulation, motivation, empathy, and social skills. Indian medical students face exceptional stress due to intense academic competition, hierarchical structures, and limited mental health resources. Although structured EI interventions have demonstrated promise internationally in reducing burnout and improving clinical performance, systematic EI training remains largely absent from Indian me …

01.09.2026journal-article

Clinical Case Reports

Squamous Cell Carcinoma Arising in a Mature Cystic Teratoma of the Ovary Presenting With a Ruptured Sister Mary Joseph Nodule: A Rare Case Report From Northern Tanzania

John Lugata, Caleigh Smith, Onesmo Mrosso, Jaynes Kabuhaya, Lily Severn, Krizia Nsoh Nji, Tecla Lyamuya, Elizabeth Skinner, Gilbert Nkya, Eusebious Maro, Alex Mremi, Bariki Mchome

ABSTRACT Squamous cell carcinoma arising from malignant transformation of a mature cystic teratoma is an exceptionally rare ovarian malignancy, and metastatic umbilical involvement is particularly uncommon. Diagnosis and treatment planning are challenging due to overlapping presentation with epithelial ovarian cancer, particularly in settings with limited access to ancillary pathology, molecular testing, and specialist oncology services. We report a 54‐year‐old postmenopausal woman from northern Tanzania who presen …

01.09.2026journal-article

Journal of Clinical Investigation

Menopause and “leaky gut”: implications for midlife women’s health

Brandilyn A. Peters

Menopause may have important consequences for gut barrier health. The roles of estradiol and progesterone in immune and mucosal barrier homeostasis have been well studied in the female reproductive tract. However, few human studies have described these hormones’ corresponding regulation in the gastrointestinal tract or how the menopausal transition affects gut barrier integrity. In this issue of the JCI , Shieh et al. report that markers of gut epithelial barrier dysfunction and microbial translocation–related immu …

01.09.2026journal-article

Frontiers in Cardiovascular Medicine

Minimally invasive hybrid retrieval of a fractured sion guidewire during transcatheter coronary intervention: a case report of multidisciplinary collaborative management

Xianliang Dai, Jiming Han, Yijing Guo, Gang Zhao, Chengxing Shen

Background Guidewire fracture during percutaneous coronary intervention (PCI) is rare but serious, with management dependent on fracture characteristics. We report an innovative minimally invasive hybrid approach for this complication. Case summary A 59-year-old male with diabetes/hypertension developed Sion guidewire fracture during LAD PCI. Percutaneous retrieval failed; conservative therapy was initially given. A minimally invasive hybrid “trans-brachial arteriotomy with endoluminal traction” retrieved the fragm …

01.09.2026journal-article

Frontiers in Medicine

Comparative analysis of adverse drug reaction reports for leukotriene receptor antagonists mainly indicated for allergic rhinitis and asthma: a WHO VigiAccess study

Youlin Dong, Zhigang Xia, Weimin Gao

Background Leukotriene receptor antagonists (LTRAs), including montelukast, pranlukast, and zafirlukast, are generally well tolerated and widely used for asthma and allergic rhinitis, but they may cause adverse drug reactions (ADRs). We compared their real-world reporting profiles to identify potential agent-specific safety differences. Methods We conducted a descriptive and disproportionality analysis of World Health Organization (WHO) VigiAccess data retrieved on August 1, 2025. Reports were included from each dr …

01.09.2026journal-article

Frontiers in Clinical Diabetes and Healthcare

Social determinants of health influencing diabetes self-care behaviors among immigrants: a scoping review

Rie Kudoh, Taiga Shibayama

Background As globalization accelerates, immigrants face diabetes management challenges that are a public health concern. Although Social Determinants of Health (SDOH) are recognized as key drivers of health status and access to care, their role in diabetes self-care behaviors among immigrants remains unclear. Objectives This scoping review aimed to identify and map SDOH influencing diabetes self-care behaviors among immigrants in host countries. Methods PubMed and Web of Science were searched for peer-reviewed emp …

01.09.2026journal-article

Frontiers in Medicine

Early detection of microcirculatory changes using simultaneous heated and unheated transcutaneous blood gas monitoring: a proof-of-concept study in a porcine lipopolysaccharide model of systemic inflammation

Maud A. Hoofs, Louwrina H. te Nijenhuis, Norani H. Gangaram-Panday, Patricia A. C. Specht, Egbert G. Mik, Floor A. Harms, Irwin K. M. Reiss, Willem van Weteringen

Introduction Early detection of microcirculatory failure in septic patients has the potential to improve clinical outcomes. The microcirculation regulates the oxygen (O 2 ) supply and carbon dioxide (CO 2 ) washout in tissues and changes early during severe inflammation and sepsis. Transcutaneous blood gas sensors measure tissue O 2 and CO 2 levels at the skin surface, or when warmed use the vasodilatory response to approximate arterial levels. In addition to differences in measured O 2 and CO 2 values, systemic in …

01.09.2026journal-article

INTERNATIONAL JOURNAL OF COMPUTERS COMMUNICATIONS & CONTROL

Scalable Distributed Deep Learning for Lung Disease Diagnosis: A Spark–Elephas Cross-Modality Framework with GPU Cluster Scalability Analysis

Zeineb Ben Messaoud, Maher Baccar, Heni Bouhamed, Monia Hamdi

The rapid growth of large-scale medical imaging datasets has exposed critical limitations of single-node deep learning workflows for clinical decision support in lung disease diagnosis. We present a unified, Spark-based distributed framework for scalable multi-class lung disease classification from both chest X-ray (CXR) and computed tomography (CT) images. Our approach integrates Apache Spark with Elephas to enable synchronous and asynchronous data-parallel training of Keras models via a parameter-server architect …