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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

International Journal of Cancer

High‐Risk Human Papillomavirus Prevalence and Detection of Anal Intraepithelial Neoplasia in Women Undergoing Screening Colonoscopy: A Prospective Study

Carlo Vivaldi, Hanna Schmitten, Matthias Schmid, Hartmut Schäfer

ABSTRACT The incidence of anal cancer in older women has risen significantly in recent decades, yet no standard screening strategy exists. Screening aims to detect potentially precancerous lesions, anal intraepithelial neoplasia (AIN), which can be treated to prevent cancer progression. In this prospective study, we assessed the prevalence of high‐risk human papillomavirus (hrHPV), abnormal anal cytology, and AIN confirmed by high‐resolution anoscopy (HRA)‐guided biopsy. Women aged ≥ 40 undergoing routine screening …

28.08.2026journal-article

Farabi Tıp Dergisi

Micronutrient and Lipid Profile in Gestational Diabetes: Zinc, Triglycerides, and Pharmacological Treatment Requirement

Meryem Kececi Oguzhanoglu, Kürşat Oğuzhanoğlu

Objective: To characterize serum zinc and a broader micronutrient panel in gestational diabetes mellitus (GDM) versus normoglycemic controls, and to evaluate associations between serum zinc, pharmacological treatment requirement and triglyceride concentration within GDM.Material and Methods: In this observational study with a one-week prospective follow-up component, 100 women with GDM and 100 frequency-matched controls were studied at a tertiary center. A nine-analyte micronutrient panel was compared with Benjamin …

28.08.2026journal-article

APS Open Science

Conjecture of classical e-h liquid for understanding the FLASH modality of radiation cancer treatment

Diana Shvydka, Victor Karpov, Nilendu Gupta

We consider physics behind the FLASH modality of cancer radiation treatment, where extremely short treatment times are achieved with ultrahigh dose rates maintaining the conventional antitumor effectiveness and yet substantially reducing damage to normal tissues (sparing effect). The difference in responses between normal and tumor tissues is attributed here to the structure transformation rates related to their morphologies: ordered in the normal tissues versus disordered in tumor tissues. Correspondingly differen …

28.08.2026journal-article

Pharmacoepidemiology and Drug Safety

Dementias in Older Women With Early‐Stage HER2 ‐Negative Breast Cancer Treated With Anthracycline Plus Taxane Versus Taxane‐Based Chemotherapy Regimens

Nguyen Le, Nirupama Anne, Chan Shen, Ratnakishore Pallapothu, Yan Liu, Chanhyun Park

ABSTRACT Background Anthracycline plus taxane (ATAX) regimens are associated with improved survival in HER2‐negative breast cancer (HBC) compared to taxane‐based (TAX) regimens. However, anthracyclines are known for their cardiotoxicity, which could increase the risk of neurocognitive deficits, raising concerns about neurocognitive safety, particularly in older adults. Limited evidence exists comparing neurocognitive outcomes between these two regimens. Objective To compare the incidence of Alzheimer's disease and …

28.08.2026journal-article

ARACÊ

EFEITOS DA MUSICOTERAPIA COMO INTERVENÇÃO COMPLEMENTAR NO TRATAMENTO DE PACIENTES COM DEPRESSÃO: UMA ABORDAGEM CLÍNICA

Janete Maria de Oliveira Praxedes Lira Costa

Contexto: A depressão é um transtorno mental de alta prevalência associado a comprometimentos significativos na qualidade de vida. Perante as limitações dos tratamentos convencionais, a busca por abordagens complementares e não farmacológicas vem se tornado essencial. Objetivo: Analisar os efeitos da musicoterapia como intervenção complementar no tratamento de pacientes com depressão, a partir de uma perspectiva clínica. Metodologia: Trata-se de uma revisão de escopo (scoping review), de abordagem qualitativa e car …

28.08.2026journal-article

Oncologie

Gut microbiota-mediated programmed cell death in colorectal cancer: implications for precision medicine

Wei Liu, Wei Zhang

Abstract Colorectal cancer (CRC) remains a major global health burden, with marked interindividual variability in disease progression and therapeutic response. Emerging evidence suggests that the gut microbiota shapes CRC biology not only through inflammation and metabolism, but also by regulating programmed cell death (PCD) pathways that may influence tumor cell fate and treatment sensitivity. This review summarizes recent advances in microbiota-mediated regulation of major PCD modalities relevant to CRC, includin …

28.08.2026journal-article

Frontiers in Oncology

Combination therapy with Nifuroxazide and Lenvatinib exerts superior anti-hepatocellular carcinoma effect by enhancing the anti-tumor immune response

Jing Yang, Jiaxin Geng, Yue Yin, Kangle Wang, Leyao Tian, Jingyi Wang, Huijie Jia, Lei Wang, Yongxi Zhang, Tiesuo Zhao

Background Lenvatinib is a first-line multi-target tyrosine kinase inhibitor for hepatocellular carcinoma (HCC) that exerts anti-angiogenic effects by blocking VEGF signaling. However, its clinical efficacy is often compromised by adaptive resistance. Nifuroxazide, an anti-diarrheal agent, has been identified by our group as a potent inhibitor of PD-L1 expression in HCC. Objective This study aimed to evaluate the therapeutic potential and underlying molecular mechanisms of nifuroxazide combined with lenvatinib agai …

28.08.2026journal-article

Sustainability

Spent Coffee Grounds and Their Derivatives as Biosorbents in Wastewater Treatment and Gas Purification

Yi Hu, Juan Li, Zhiyong Qi, Yiping Wu, Rui Yang

Spent coffee grounds (SCGs), a ubiquitous and renewable agricultural waste, have emerged as a promising biosorbent for environmental remediation. This review provides a comprehensive overview of the application of SCG-derived materials in wastewater treatment and gas purification. We systematically summarize their physicochemical characteristics, adsorption performance towards diverse contaminants, and underlying mechanisms. Specifically, modification strategies of raw SCGs are discussed in detail, including chemic …

28.08.2026journal-article

Frontiers in Molecular Biosciences

Crucial role of telomere maintenance-related genes in survival prediction and subtype identification in colorectal cancer

Feng Huang, Jung-Yin Fong, Chin Tat Ng, Karthikkumar Venkatachalam, Mohammed Abdullah Alshawsh, Chun-Wai Mai, Yik-Ling Chew, Muralidharan Anbalagan, Ravishankar Ram Mani, Malarvili Selvaraja

Background Telomere maintenance-related genes (TMRGs) are implicated in Colorectal cancer (CRC) development, but their prognostic value and clinical relevance remain insufficiently explored. This study aims to develop a TMRG-based prognostic model and elucidate its clinical utility in CRC management. Methods The Cancer Genome Atlas database was utilized to download RNA-seq data from 638 CRC and 51 control samples. Differential expressed genes were screened and intersected with 2086 TMRGs, resulting in the identific …

28.08.2026journal-article

International Journal of Molecular Sciences

Circulating Tumor DNA and Circulating Tumor Cells in Liquid Biopsy as Post-Treatment Prognostic Biomarkers in Early Breast Cancer: A Systematic Review and Meta-Analysis

Einas M. Yousef, Motaz Talaat Elghnam, Hiba Elhassan, Malak Hassan, Saifeldin Yousef, Hend Aabed, Noha Mitwally

Despite advances in systemic therapy, many early breast cancer patients experience recurrence due to subclinical minimal residual disease (MRD). Circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) have emerged as promising liquid biopsy markers for post-treatment MRD detection. This pre-registered systematic review and meta-analysis (PROSPERO/PRISMA 2020) evaluated their comparative prognostic significance. Seven databases were searched from inception to March 2026. Eligible studies included early brea …

28.08.2026journal-article

Cancer

The burden of male breast cancer (MBC) in the GBD Central, Eastern, and Western Europe Regions from 1990 to 2023: Results from the Global Burden of Disease Study 2023

Roberto Passera, Elisa Fabbro, Giulia Zamagni

ABSTRACT Purpose Male breast cancer (MBC) is underrepresented in cancer statistics: this study aimed to assess the burden of MBC in Central, Eastern, and Western Europe from 1990 to 2023, using data from the Global Burden of Disease (GBD) Study 2023. Methods Estimates from GBD 2023 were analyzed to determine the MBC incidence, mortality, and disability‐adjusted life years, their all‐ages and age‐standardized rates, and the 1990 through 2023 annual percent change. These estimates were compared to those for the GBD S …

28.08.2026journal-article

SCRIPTA SCORE Scientific Medical Journal

Dynamic Digestive Health Surveillance System (DDHSS): A Conceptual Framework for Longitudinal Colorectal Cancer Surveillance

Aisyah Aulia Az-Zahra Ikhsan, Akmal Hisyam, Raihansyah Harris Nasution, Muhammad Zain Ardiansyah

Background: Colorectal cancer (CRC) remains a leading cause of cancer-related morbidity and mortality worldwide. Although fecal immunochemical tests (FIT) and colonoscopy effectively detect precancerous lesions and early-stage CRC, current screening strategies remain predominantly age-based and episodic. Such approaches inadequately capture longitudinal changes in individual risk profiles. Recent advances in electronic health records (EHRs), longitudinal healthcare databases, and artificial intelligence (AI) provid …

28.08.2026journal-article

Odovtos - International Journal of Dental Sciences

Artificial Intelligence in Endodontic Diagnosis and Treatment: A Bibliometric and Science-Mapping Analysis

María Mihaela Iuga, Tatiana Ramírez-Mora, Fernando Mauricio Espada Salgado

This study aimed to map global research trends, intellectual structure, and emerging themes in artificial intelligence (AI) applications for endodontic diagnosis and treatment using bibliometric and science-mapping approaches. A comprehensive search of the Web of Science Core Collection was performed on July 20, 2025, without time restrictions. Records were independently screened by two reviewers according to predefined inclusion and exclusion criteria. Bibliometric data were analyzed using Microsoft Excel, RStudio …

28.08.2026journal-article

Nutrients

Whole-Blood Fatty Acid Phenotypes and Subsequent Quality-of-Life Changes Among Cancer Survivors

Lin Lv, Juan Xia, Xinyu Zhu, Luxin Wang, Chen Lv, Yanyi Fu, Donghui Yu, Jinming Yu

Background/Objectives: Whole-blood fatty acid composition provides an objective biomarker of fatty acid status, but its relationships with nutritional characteristics and subsequent quality-of-life (QoL) changes among cancer survivors remain incompletely understood. We aimed to identify whole-blood fatty acid phenotypes and examine their associations with nutritional characteristics, cross-sectional QoL profiles, and subsequent QoL changes in an overlapping longitudinal subcohort. Methods: In this cohort study, the …

28.08.2026journal-article

Journal of Neuro-Oncology

CAR-T cell therapy: potential for paediatric brain tumours—an update

Alexandra Zehner, Benjamin Draper, Darren Hargrave, Laura K. Donovan, John Anderson

Abstract Central nervous system (CNS) tumours are the deadliest cancer for children and currently present limited treatment options. Chimeric antigen receptor (CAR)-T cell therapies have emerged as an innovative approach supported by encouraging clinical results. Current clinical trials using CAR-T cells in the treatment of paediatric CNS cancers differ in a number of variables, including the CAR-T cell route of delivery, presence of lymphodepletion, identified target antigen, and CAR engineering features. Consider …

28.08.2026journal-article

Nano

Microneedle-mediated delivery of DNA and mRNA therapeutics for cancer immunotherapy: advances, design strategies and translational challenges

Haowei Liu, Qiong Yi, Ling Mei, Yantao Wang

Nucleic acid therapeutics, particularly DNA and messenger RNA (mRNA), provide programmable platforms for cancer vaccination, local expression of immunomodulatory proteins, and gene regulation. Their therapeutic performance, however, is strongly constrained by extracellular degradation, route-dependent biodistribution, inefficient cellular uptake, and limited delivery to antigen-presenting cells. Microneedle (MN) systems offer a minimally invasive means of depositing nucleic acids in the epidermis and dermis, where …

28.08.2026journal-article

Koloproktologia

Colorectal cancer incidence in Siberia and the Far East

L. D. Zhuikova, O. A. Ananina, G. A. Kononova, L. V. Pikalova

OBJECTIVE: to analyze the incidence of colon cancer in the Siberian (SFD) and Far Eastern Federal Districts (FEFD) for 2019–2024. MATERIALS AND METHODS: a retrospective descriptive study of depersonalized data on the incidence of colorectal cancer (colon (C18), rectosigmoid junction (C19), rectum, anus and anal canal (C20-21) — ICD-10 codebook) was conducted for the period from January 2019 to December 2024 according to absolute data (the number of malignant neoplasms detected for the first time in life (table 2000 …

28.08.2026journal-article

Pakistan Journal of Pharmaceutical Sciences

Development of a biomarker-guided chemotherapy response model using combined CEA and CA19-9 profiles in esophageal cancer: A real-world pharmacotherapeutic study

Orcun Can

Abstract: Background: Esophageal adenocarcinoma is associated with poor survival despite advances in systemic therapy. Readily available serum biomarkers may improve risk stratification; however, their combined role in biomarker-guided treatment decisions remains insufficiently investigated. Objectives: To evaluate the prognostic significance of combined baseline carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) levels and explore their utility for biomarker-based risk stratification in patients …

28.08.2026journal-article

International Journal of Public Health and Medical Research

Research Advances and Future Directions of Biotechnology in the Treatment of Myasthenia Gravis

Jiaqi Lin

Myasthenia gravis (MG) is an autoimmune disease with a core pathological mechanism involving specific attacks by the immune system on proteins at the neuromuscular junction. This study reveals that our understanding of its pathogenesis has expanded beyond mere neuromuscular transmission dysfunction to encompass multiple aspects, including the dysregulation of immune regulatory networks, abnormal activation of the complement system, and damage mediated by specific autoantibodies. While conventional pharmacological t …

28.08.2026journal-article

Molecular Pharmaceutics

A Diazaborine-Based ROS Switch Enables Copper Transfer for Tumor-Specific Prodrug Activation and Therapy

Zeqian Huang, Yaqing Ding, Shengzhi Wang, Zijun Lin, Conghan Wang, Dong Zheng, Tao Zhang, Chunshun Zhao

Abstract Reactive oxygen species (ROS) are significantly elevated in tumor cells, providing an intrinsic trigger for selective drug activation and tumor-specific therapy. However, commonly used ROS-responsive linkers, such as thioketals and boronates, often suffer from limited sensitivity or poor physiological stability, and the development of new ROS-responsive motifs remains scarce. Herein, we develop a hydrazide-derived diazaborine (DAB) scaffold and establish it as a general ROS-responsive linker for small-mole …

28.08.2026journal-article

Journal of Experimental & Clinical Cancer Research

Overcoming immune checkpoint inhibitor-mediated T-cell exhaustion with a TCR β chain-directed selective dual T-cell activator

Shantel Angstadt, Lucas A. Horn, Kristen Fousek, Nika Rajabian, Haiyan Qin, Miriam M. Medina-Enriquez, Marcus D. Kelly, Nicole Hsiao-Sanchez, Thomas J. Meyer, Jacques Moisan, Madan Katragadda, Andrew Bayliffe, Zhen Su, Jeffrey Schlom, Claudia Palena

Abstract Background Resistance to immune checkpoint inhibition (ICI) using antibodies against the PD-1/PD-L1 axis remains a significant clinical challenge. Here, we report that combination of anti-PD-1 with a bifunctional fusion molecule, anti-TCRβ-IL-2, comprised of a monovalent Fab that binds and activates the T-cell receptor (TCR) through distinct variable beta (Vβ) chain residues and an IL-2 molecule, mediates robust anti-tumor control in the context of ICI resistance. Methods Syngeneic murine models with varyi …

28.08.2026journal-article

Frontiers in Oncology

Cancer screening utilization among insured beneficiaries in Saudi Arabia, 2023–2024: a national analysis of trends, calendar variation, and distribution across breast, cervical, and colorectal screening programs

Abdurahman Alloghbi

Background Breast, cervical, and colorectal cancer (CRC) screening uptake in Saudi Arabia has been reported as consistently low, but no national longitudinal description of insurance-linked screening utilization has been published. This study examined temporal trends, calendar variation, and demographic distribution of cancer screening among privately insured beneficiaries in Saudi Arabia. Methods We analyzed six publicly available Council of Health Insurance datasets reporting monthly breast, cervical, and colorec …

28.08.2026journal-article

British Journal of Health Psychology

Acceptability, perceived outcomes and underlying mechanisms of a professionally led support group intervention for women with breast cancer using a qualitative method approach

Andreia Soares, Diogo Carreiras, Bruna Veloso, Ana Pereira, Priscyla Costa, Mind Project Team, Helena Moreira, Inês A. Trindade

Abstract Objectives Breast cancer (BC) remains the most diagnosed cancer among women worldwide and its growing survivorship population faces numerous long‐term physical and psychological challenges. Cancer support groups emerge as promising interventions to promote comprehensive management of the disease and survivorship needs, emotional well‐being and social connection. Accordingly, this study aimed to analyse the acceptability and perceived impact of the Mind Support Group (MSG), a professionally led support grou …