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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Clinical and Experimental Medicine

Prognostic stratification in MDS/MPN syndromes other than CMML: an Italian multicenter real-world study

Luca Guarnera, Giuseppe Gaetano Loscocco, Massimo Breccia, Mara Memoli, Bruno Fattizzo, Marta Riva, Ambra Di Veroli, Michelina Santopietro, Giovanni Iaquinta, Annalisa Biagi, Sabrina Leonetti Crescenzi, Caterina Tatarelli, Roberto Latagliata, Paola Grammatico, Sabrina Mariani, Anna Lina Piccioni, Emilia Scalzulli, Costanza Andriola, Lorenzo Rizzo, Prassede Salutari, Gianluca Albanese, Francesca Romana Iovene, Alfredo Molteni, Novella Pugliese, Francesco Muriano, Federica Catania, Alessandro Andriani, Katia Paciaroni, Antonio Spadea, Paola Guglielmelli, Alessandro Maria Vannucchi, Emiliano Fabiani, Maria Teresa Voso, Adriano Venditti, Luca Maurillo

Abstract MDS/MPN syndromes comprise a heterogeneous group of myeloid neoplasms. While CMML has been extensively characterized, data on other MDS/MPN entities remain limited, particularly in real-world settings. We conducted a nationwide, multicenter retrospective study including adult patients with MDS/MPN syndromes other than CMML from 17 Italian centers. Patients were classified as MDS/MPN with SF3B1 mutation and thrombocytosis ( SF3B1 -T), atypical chronic myeloid leukemia/chronic neutrophilic leukemia (aCML/CNL …

01.09.2026journal-article

Orthopaedic Surgery

Osteoarthritis Therapeutics: From Microenvironment Understanding to Regenerative Intervention—Current Advances and Future Perspectives

Yongbiao Meng, Shenghua Wu, Quanchun Liu

ABSTRACT Osteoarthritis (OA) is a prevalent, chronic degenerative joint disease characterized by progressive cartilage degeneration and impaired joint function. Its rising global incidence poses a significant health and socioeconomic burden. Traditional therapies primarily offer symptomatic relief but fail to halt disease progression and are associated with notable limitations. The contemporary understanding of OA pathogenesis has evolved from a model of mechanical wear to one emphasizing systemic imbalance within …

01.09.2026journal-article

Diagnostics

Urinary Biomarkers in Urological Oncology: From Biological Origin to Clinical Decision-Making—A Narrative Review

Aliya Nurmukhanbetova, Kassymkhan Sultanbekov, Khussan Umurzakov, Zie Gassanov, Altyn Duisenbayeva, Alimkhan Talas, Lazzat Shaikenova, Aidos Bolatov

Urinary biomarkers are promising tools in urological oncology because urine can be collected non-invasively and repeatedly during diagnosis, treatment, and surveillance. Despite extensive biomarker discovery, their adoption in routine practice remains limited. Biomarker performance depends not only on analytical accuracy but also on the clinical decision, anatomical route into urine, biological source of the signal, specimen fraction, and timing and conditions of sampling. This review evaluates urinary biomarkers a …

01.09.2026journal-article

European Journal of Nuclear Medicine and Molecular Imaging

Comparative analysis of PSMA-RADS Version 2.0 versus bone uptake metastatic probability (BUMP) score for characterising focal bone uptake on [18F]PSMA-1007 PET/CT in prostate cancer – a multicentre evaluation

James Cairns, Salman Arain, Amarnath Challapalli, Amalia Stavropoulos, Tamir Ali, Daniel Ward, John Sage, Georgia Ionescu, Julien M. Y. Willaime, Russell Frood, Amit Bahl, George Petrides, Andrew Scarsbrook

Abstract Purpose Prostate-specific membrane antigen (PSMA) PET/CT is widely used in prostate cancer management, but unspecific bone uptake (UBU) remains a diagnostic challenge particularly with [18F]PSMA-1007. Bone uptake metastatic probability (BUMP) score - a composite imaging-clinical model, was compared with PSMA Reporting and Data System (PSMA-RADS, Version 2) for predicting skeletal metastases in UBU. Methods A real-world cohort of [18F]PSMA-1007 PET/CT scans performed at three tertiary cancer centres was ret …

01.09.2026journal-article

Frontiers in Cardiovascular Medicine

Regulatory mechanisms and interactions of mitophagy and ketone body metabolism in cardiac metabolism

Shujun Ding, Yuna Hu, Qin Zhang, Xinyi Liu, Xuan Zhao, Yajing Zhao, Wen Zhang

Cardiac function depends on tightly regulated energy metabolism, with mitochondria serving as key sites of cellular energy production. Mitophagy, a selective form of autophagy that maintains mitochondrial quality, has received growing attention for its role in cardiomyocyte metabolism. Under specific physiological and pathological conditions, the myocardium increases its use of ketone bodies as energy substrates, and ketone body metabolism is closely linked to mitochondrial function. However, the relationship betwe …

01.09.2026journal-article

Bone & Joint Open

Early recognition of limb necrotizing fasciitis and surgery within six hours is associated with a lower mortality risk and improved patient-reported outcomes

Andrew D. Ablett, Chryssa Neo, Tony Feng, Nick D. Clement, Andrew D. Duckworth, Timothy O. White

Aims Necrotizing fasciitis (NF) is a rapidly progressive surgical emergency. The effects of time from hospital presentation to theatre on short- and long-term outcomes, as well as specific modifiable aspects of the care pathway that would enable early surgery, remain poorly defined. Methods A retrospective cohort study of all suspected cases of limb NF presenting across a large health board region over ten years (January 2015 to April 2025) was undertaken. Early surgery was defined as ≤ six hours from presentation …

01.09.2026journal-article

Sumatera Medical Journal

Patient Specific Titanium Implant Post Maxillectomy: The Evolution of Surgical Reconstruction

Jeeven Velayutham, Liew Yew Toong, Sakina Ghauth

Background: Malignancies arising from paranasal sinus account for 0.2-0.8% of all malignant neoplasms and 3% of the malignant neoplasms occurring in the head and neck. Surgical treatment of maxillary sinus carcinoma often consists of an open sub-total or total maxillectomy with a subsequent significant defect. Besides, the proximity of the maxillary sinus with complex anatomical structures make reconstruction a major challenge for head and neck surgeons. Reconstruction with temporalis myofascial flap along with tit …

01.09.2026journal-article

Frontiers in Medicine

Risk factors and prediction model for mortality risk in older adults septic patients

Shao-Zhen He, Lu-Zhen Qiu, Yong-Xiang Li, Zhao-Bin Yang, Xiao-Mei Cheng

Background The early identification of septic patients at high risk of mortality is essential for improving clinical outcomes. This study aimed to investigate the risk factors associated with 28-day mortality among older adults septic patients admitted to the intensive care unit (ICU) and to develop a predictive model based on these factors. Methods A total of 165 older adults septic patients admitted to the ICU of our hospital between April 2022 and March 2025 were included in this study. Multivariate logistic reg …

01.09.2026journal-article

Frontiers in Oncology

Case Report: Metastatic melanoma with initial ctdna decline and radiographic response during self-directed antiparasitic use: treatment effect or spontaneous regression?

Ricky Cheng, Daniel V. Araujo

A 74-year-old man with nodular melanoma of the right lateral neck presented with nodal and hepatic metastases at staging. He declined guideline-directed therapy and instead pursued lifestyle modifications alongside self-administered ivermectin and fenbendazole. On serial imaging, his disease initially demonstrated reduced metabolic activity and size without new sites of involvement, paralleled by a decline in tumor-informed ctDNA (Signatera) from 2.04 to 0.18 MTM/mL. Both subsequently worsened, with ctDNA rising to …

01.09.2026journal-article

Frontiers in Neurology

Associations of nine composite inflammatory indices with clinical outcomes after mechanical thrombectomy for acute ischemic stroke: a single-center retrospective study

Min Yuan, Hui He, Longyi Zheng, Yueyue Tang, Shuang Tang, Jia Duan, Wenli Xing, Ao Qian

Objective This study aims to explore the associations of nine common composite inflammatory indices with hemorrhagic transformation (HT), unfavorable outcome, and all-cause mortality in patients with acute ischemic stroke (AIS) following mechanical thrombectomy (MT). Methods A retrospective study was conducted with composite inflammatory indices, including systemic immune-inflammation index (SII), systemic inflammation response index, pan-immune-inflammation value, neutrophil-to-lymphocyte ratio (NLR), platelet-to- …

01.09.2026journal-article

Modern Rheumatology

Methotrexate and Malignancy in Rheumatoid Arthritis: Evidence, Risks, and Clinical Considerations

Shigeru Iwata, Masahiro Tada, Ryuji Koike, Yuji Yamanishi, Mie Fusama, Haruka Tsuchiya, Kunihiro Yamaoka, Hideto Kameda

Abstract In this review, we summarized the current evidence on the risks of incident malignancy and cancer recurrence in patients with rheumatoid arthritis (RA) treated with methotrexate (MTX). Before considering the effect of MTX, it is important to recognize the malignancy risk associated with RA itself. The overall risk of malignancy in patients with RA modestly increased, as per two meta-analyses, although Japanese studies report inconsistent findings, with one showing a slightly decrease and another a slight i …

01.09.2026journal-article

Journal of Veterinary Internal Medicine

Presentations of idiopathic hemorrhagic diarrhea syndrome in dogs in relation to meteorological factors

Michelle Karnstedt, Amna Asif, Terence Z Sibanda, Romy M Heilmann

Abstract Background Causes for idiopathic acute hemorrhagic diarrhea syndrome (AHDS) in dogs remain uncertain. Recent discoveries suggest a role for enterotoxin-producing Clostridium perfringens, but the triggers for toxin production and AHDS onset are unknown. Meteorological factors have not been examined as a possible AHDS trigger. Hypothesis/Objectives Retrospective case–control study aiming to examine the effects of weather conditions and weather changes on the prevalence of idiopathic AHDS. Animals Dogs (n = 4 …

01.09.2026journal-article

World Journal of Surgery

Association of Whole Blood Transfusion With Survival Among Patients Achieving ROSC After Prehospital Traumatic Cardiac Arrest

Hui Li, Caitlyn Braschi, Meghan R. Lewis, Demetrios Demetriades

ABSTRACT Background While whole blood (WB) is increasingly utilized to mitigate trauma‐induced coagulopathy, evidence supporting its use in blunt trauma–associated prehospital cardiac arrest (PHCA) remains scarce. We compared the association of WB versus component therapy (CT) with mortality and early resuscitation balance among patients who achieved return of spontaneous circulation (ROSC). Methods This retrospective cohort study used National Trauma Data Bank data from 2020 through 2024. Adults aged 16 years or o …

02.09.2026journal-article

Scandinavian Journal of Medicine & Science in Sports

Biomechanics of Copenhagen Adduction Exercise and Eccentric Hip Adductor Exercises on a Novel Isokinetic Dynamometer With Within‐Session Repeatability

J. Marušič, O. Cvjetičanin, M. Supej, J. Babič, N. Šarabon

ABSTRACT This study biomechanically evaluated the eccentric phase of short and long lever Copenhagen adduction exercise (CAE) and compared them with unilateral and bilateral eccentric hip adductor exercises performed on a novel eccentric hip adductor dynamometer (EHAD). Fifteen participants completed two CAE variations and five EHAD exercises. Three‐dimensional kinematics and force data were collected to compute peak hip joint torque, range of motion (ROM), and angle at peak torque as the primary dependent variable …

01.09.2026journal-article

Journal of Vascular Anomalies

Reproductive Considerations In Patients Undergoing Treatment For Complex Lymphatic Anomalies

Adriana N. Vest, Selena U. Park, Kiley Hunkler, Luciana Daniela Garlisi Torales, Kwabena Aboagye, Deena Zeltser, Andrea Bowling, Clarisa R. Gracia, Alan DeCherney, Sarah E. Sheppard

Complex lymphatic anomalies (CLAs) are a spectrum of lymphatic malformations affecting multiple organ systems. These disorders are characterized by wide variability in presentation features, which often delays accurate diagnosis and complicates characterization and differentiation. Little is known about the gynecologic and reproductive effects of CLAs or their associated treatments, such as long-term systemic immunosuppressive medications and repurposed single-molecule inhibitors. In this case report, we discuss a …

01.09.2026journal-article

Journal of Korean Medicine

Damjeok Syndrome (U87.7): Significance of Its Inclusion in the KCD-9 and Contemporary Biomedical Perspectives

Chang-Gue Son, Seo-Hyung Choi

Objectives: Damjeok syndrome (DJS) is a traditional Korean medicine–based clinical construct that was recently incorporated into the 9th revision of the Korean Standard Classification of Diseases (KCD-9) under code U87.7. This review summarizes the implications of the KCD-9 inclusion of DJS and discusses its significance and contemporary biomedical interpretation.Methods: Relevant literature regarding the proposed diagnostic framework of DJS, its clinical characteristics, and its relationship with conventional func …

01.09.2026journal-article

Journal of Korean Medicine

Comparative Effectiveness of Acupoint-to-Acupoint Penetrating Needling Technique for Post-Stroke Spasticity: A Systematic Review and Meta-Analysis

Sul Gi Yoon, Mikyung Kim, Chang-ho Han

Objectives: This study aimed to systematically evaluate the efficacy and safety of acupoint-to-acupoint penetrating needling (AAPN) technique compared with conventional acupuncture for patients with post-stroke spasticity.Methods: Randomized controlled trials (RCTs) were searched in PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, ScienceON, Research Information Sharing Service, and Oriental Medicine Advanced Searching Integrated System. The primary outcomes were spasticity measured by the …

01.09.2026journal-article

Journal of Korean Medicine

Legal Issues and Policy Improvement Measures Regarding the Use of Medical Devices by Korean Medicine Doctors: A Comparative Study of Japan, China, and the United States

Junchul Kang

Objectives: This study examines the legal ambiguity and policy challenges surrounding the use of medical devices by Korean medicine doctors within Korea’s dual medical system. It seeks to clarify unresolved issues related to scope of practice and to propose institutional reforms through a systematic analysis of judicial precedents and comparative health law frameworks.Methods: A doctrinal legal analysis was conducted focusing on domestic judicial precedents concerning the use of medical devices by Korean medicine d …

01.09.2026journal-article

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

A Five-year Antimicrobial Susceptibility Trend among Bacterial Isolates from Blood Culture at a Tertiary Health Care Facility: A Retrospective Study

Satabdi Sahu, ayanti Prava Behera, Snigdha Rani Panigrahy, Swapna Mahapatra, Abinash Panda, Sandipta Subadarshani, Sanghamitra Padhi

Introduction: Antimicrobial Agents (AMA) frequently used to treat Bloodstream Infections (BSI) when inappropriately used give rise to Antimicrobial Drug Resistance (AMR). Monitoring blood culture isolates with Antimicrobial Susceptibility Testing (AST) determines pattern of antibiotic resistance can help to promote its rational use. Aim: To estimate clinicodemographic associates and trend of Antimicrobial Susceptibility among bacterial blood culture isolates over five-years (2019-2024). Materials and Methods: This …

02.09.2026journal-article

Cancer Medicine

Prognostic Value of Hemoglobin, Albumin, Lymphocyte, and Platelet Score in Locally Advanced Nasopharyngeal Carcinoma

JunMei Song, Lan Luo, Ting Liu, YuQing Lv, Qiulin Huang, Rensheng Wang, Jun Bie

ABSTRACT Objective To investigate the prognostic value of the hemoglobin, albumin, lymphocyte, and platelet (HALP) score in patients with locally advanced nasopharyngeal carcinoma (LANPC) receiving concurrent chemoradiotherapy (CCRT), and to clarify its predictive significance for overall survival (OS), progression‐free survival (PFS), locoregional failure‐free survival (LRFFS), and distant metastasis‐free survival (DMFS). Methods Clinical data of 295 patients with LANPC who received CCRT between April 2021 and Apr …

02.09.2026journal-article

Indian Journal of Pharmacology

A rare intravenous paraquat exposure presenting with novel and atypical severe clinical manifestations

Vrushali M. Patil, Shirish Shantaram Inamdar, Nikhil Sunil Jadhav, Dipak Pralhad Mali

Abstract: Paraquat is a highly toxic bipyridyl herbicide that continues to be used in several countries despite restrictions elsewhere. While ingestion is the most common route of poisoning, intravenous administration is rare and associated with extremely high mortality. We report the case of a 26-year-old male who attempted suicide by self-injecting 10 mL of 24% paraquat dichloride intravenously into the dorsal metacarpal region. Within hours, he developed hematemesis, diaphoresis, giddiness, chills, agitation, an …

01.09.2026journal-article

Cancer Diagnosis & Prognosis

Co-expression of the Mammaglobin (SCGB2A2) Gene With hsa-miR-184 and hsa-miR-190b Indicates Its Possible Role in Oncogenic Pathways in Breast Cancer

JUAN FELIPE ABELLA-DUQUE, LILIANA LÓPEZ-KLEINE, RAFAEL PARRA-MEDINA, SANDRA RAMÍREZ-CLAVIJO, CÉSAR PAYÁN-GÓMEZ

Background/Aim: Breast cancer is the most common cancer in women worldwide, and early detection remains a significant challenge. Recent studies have identified increased expression of Mammaglobin A (Q13296, Gene: SCGB2A2) mRNA in breast cancer, suggesting its potential as a disease marker, although its function is not fully understood. To elucidate Mammaglobin’s role, this study sought to identify co-expressed miRNAs and analyze the biological pathways they regulate. Materials and Methods: Using TCGAbiolinks and Fi …

01.09.2026journal-article

Journal of Nursing Advances in Clinical Sciences

Exploring pedagogical approaches for gender-based violence education in nursing: A qualitative study of nurse lecturers' perspectives in South Africa

Siphesihle Delani Hlophe, Vasanthrie Naidoo, Nellie Naranjee

Gender-based violence (GBV) is a significant public health issue in South Africa, placing nurses in a critical frontline role. However, nursing curricula often lack sufficient training to prepare graduates for the complexities of GBV care. This study aimed to explore the teaching strategies and methodologies recommended and employed by nurse lecturers to prepare undergraduate nursing students for managing GBV in South Africa. A qualitative study was employed, involving semi-structured interviews with six nurse lect …